遺伝子 : 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (BEND)

遺伝子情報

ID	NRULE_0082
遺伝子ID	BEND
作成日	2012/11/21
タンパク質名	Protein name Full 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase EC EC 1.3.1.25 Synonym Full 2-hydro-1,2-dihydroxybenzoate dehydrogenase Cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase
遺伝子名	benD
遺伝子条件	BLASTP; P07772; hit=1; score=490; pid=40
参照	Gene Ontology GO GO:0047116, F:1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity, IEA:EC GO:0000166, F:nucleotide binding, IEA:InterPro GO:0019439, P:aromatic compound catabolic process, IEA:UniProtKB-KW GO:0043640, P:benzoate catabolic process via hydroxylation, IEA:UniProtKB-UniPathway Phylogenomic databases eggNOG COG1028, - KO K05783, - ProtClustDB PRK12823, - Enzyme and pathway databases UniPathway UPA00156, UER00255 Family and domain databases InterPro IPR002198, DH_sc/Rdtase_SDR IPR002347, Glc/ribitol_DH IPR016040, NAD(P)-bd_dom IPR020904, Sc_DH/Rdtase_CS Pfam PF00106, adh_short, 1 PRINTS PR00081, GDHRDH PR00080, SDRFAMILY PROSITE PS00061, ADH_SHORT, 1
配列の特徴	P07772 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1). ACT_SITE 156 Proton acceptor (By similarity). BINDING 145 Substrate (By similarity).
注釈	Function Degradation of 2-hydro-1,2-dihydroxy benzoate (DHB) to catechol Catalytic activity (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) = catechol + CO(2) + NADH Pathway Aromatic compound metabolism; benzoate degradation via hydroxylation; catechol from benzoate: step 2/2 Subunit structure Homodimer Sequence similarities Belongs to the short-chain dehydrogenases/reductases (SDR) family
参考文献	P07772 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1). 1740120 cis-diol dehydrogenases encoded by the TOL pWW0 plasmid xylL gene and the Acinetobacter calcoaceticus chromosomal benD gene are members of the short-chain alcohol dehydrogenase superfamily. (Eur J Biochem. 1992) Q93HW2 Rhodococcus jostii (strain RHA1). 11673430 Cloning and characterization of benzoate catabolic genes in the gram-positive polychlorinated biphenyl degrader Rhodococcus sp. strain RHA1. (J Bacteriol. 2001)

関与する機能

機能名
Benzoate degradation (via hydroxylation by dioxygenase)

該当CDS

学名	NBRC番号	CDS	タンパク質名
Acinetobacter radioresistens	102413	ACRAD_20_00050	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
Acinetobacter sp.	100985	ACT4_038_00430	2-hydro-1,2-dihydroxybenzoate dehydrogenase
Corynebacterium ammoniagenes	12612	HMPREF0281_01036	oxidoreductase, short chain dehydrogenase/reductase family protein
Corynebacterium callunae	15359	H924_10135	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
Corynebacterium efficiens	100395	CE2308	putative dehydrogenase
Corynebacterium glutamicum	12168	Cgl2407	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Corynebacterium glutamicum	12153	KIQ_00470	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
Cupriavidus metallidurans	102507	Rmet_4885	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
Enterobacter aerogenes	13534	EAE_19880	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
Escherichia fergusonii	102419	EFER_1485	cis-diol dehydrogenase
Geodermatophilus obscurus	13315	Gobs_1299	Oxidoreductase FAD-binding domain protein
Gordonia aichiensis	108223	GOACH_07_01220	benzoate 1,2-dioxygenase reductase subunit/2-hydro-1,2-dihydroxybenzoate dehydrogenase
Gordonia alkanivorans	16433	GOALK_047_00140	benzoate 1,2-dioxygenase reductase component
Gordonia amicalis	100051	GOAMI_40_00490	hypothetical protein
Gordonia bronchialis	16047	Gbro_4160	oxidoreductase FAD/NAD(P)-binding domain protein
Gordonia namibiensis	108229	GONAM_25_00290	benzoate 1,2-dioxygenase reductase component/2-hydro-1,2-dihydroxybenzoate dehydrogenase
Gordonia polyisoprenivorans	16320	GOPIP_011_00750	benzoate 1,2-dioxygenase reductase component
Gordonia rhizosphera	16068	GORHZ_062_00810	benzoate 1,2-dioxygenase reductase component/2-hydro-1,2-dihydroxybenzoate dehydrogenase
Gordonia rubripertincta	101908	GORBP_060_00750	benzoate 1,2-dioxygenase reductase component/2-hydro-1,2-dihydroxybenzoate dehydrogenase
		GORBP_095_00090	benzoate 1,2-dioxygenase reductase component/2-hydro-1,2-dihydroxybenzoate dehydrogenase
Gordonia sihwensis	108236	GSI01S_28_00270	hypothetical protein
Gordonia sputi	100414	GOSPT_141_00310	benzoate 1,2-dioxygenase reductase component/2-hydro-1,2-dihydroxybenzoate dehydrogenase
Gordonia terrae	100016	GOTRE_125_00140	benzoate 1,2-dioxygenase reductase component/2-hydro-1,2-dihydroxybenzoate dehydrogenase
Klebsiella pneumoniae	14438	KPR_2933
Klebsiella pneumoniae subsp. rhinoscleromatis	105682	HMPREF0484_4608	oxidoreductase, short chain dehydrogenase/reductase family protein
Marinomonas mediterranea	103028	Marme_1558	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
Pseudomonas putida	100650	PP_3164	cis-diol dehydrogenase
Rhodococcus opacus	108011	ROP_21010	2-hydro-1,2-dihydroxybenzoate dehydrogenase
Saccharomonospora cyanea	14841	SaccyDRAFT_1687	2-polyprenylphenol hydroxylase-like oxidoreductase
Saccharomonospora viridis	12207	Svir_19240	dehydrogenase of unknown specificity, short-chain alcohol dehydrogenase like protein
Saccharopolyspora erythraea	13426	SACE_4377	oxidoreductase FAD-binding region
Shimwellia blattae	105725	EB105725_23_00420	putative oxidoreductase
Sphingomonas wittichii	105917	Swit_2636	short-chain dehydrogenase/reductase SDR
		Swit_5024	Dehydrogenase with different specificities
Streptomyces ghanaensis	15414	SSFG_07174	toluate 1,2-dioxygenase electron transfer component