Rule : Aminodeoxychorismate lyase (PABC)

Rule Description

ID	NRULE_0162
Rule name	PABC
Created	2013-02-26
Protein name	Protein name Full Aminodeoxychorismate lyase EC EC 4.1.3.38 Synonym Full 4-amino-4-deoxychorismate lyase Short ADC lyase ADCL
Gene name	pabC
Rule Trigger	TIGRFAMs; TIGR03461; hit=1
Cross Reference	Gene Ontology GO GO:0008696, F:4-amino-4-deoxychorismate lyase activity, IDA:EcoCyc GO:0030170, F:pyridoxal phosphate binding, IDA:EcoCyc GO:0046656, P:folic acid biosynthetic process, IEA:UniProtKB-KW GO:0046654, P:tetrahydrofolate biosynthetic process, IEA:UniProtKB-UniPathway Phylogenomic databases eggNOG COG0115, - HOGENOM HOG000276707, - KO K02619, - ProtClustDB PRK06092, - Enzyme and pathway databases BioCyc MetaCyc:ADCLY-MONOMER, - BRENDA 4.1.3.38, 2026 UniPathway UPA00077, UER00150 Family and domain databases InterPro IPR017824, Aminodeoxychorismate_lyase_IV IPR001544, Aminotrans_IV IPR018300, Aminotrans_IV_CS Pfam PF01063, Aminotran_4, 1 TIGRFAMs TIGR03461, pabC_Proteo, 1 PROSITE PS00770, AA_TRANSFER_CLASS_4, 1
Feature	Not assigned
General annotation	Function Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate Catalytic activity 4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate Cofactor Pyridoxal phosphate Pathway Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4- aminobenzoate from chorismate: step 2/2 Subunit structure Homodimer Sequence similarities Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Reference	P28305 Escherichia coli (strain K12). 1644759 Characterization and sequence of Escherichia coli pabC, the gene encoding aminodeoxychorismate lyase, a pyridoxal phosphate-containing enzyme. (J Bacteriol. 1992) 2251281 p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase. (Proc Natl Acad Sci U S A. 1990)

Related Function

Function name
Folate biosynthesis

CDS


Scientific name	NBRC No.	CDS	Product name
Acidithiobacillus ferrooxidans		Lferr_1586	aminodeoxychorismate lyase
Acinetobacter radioresistens	102413	ACRAD_02_00330	4-amino-4-deoxychorismate lyase
Acinetobacter sp.	100985	ACT4_005_00630	putative D-amino acid aminotransferase
Alteromonas macleodii	102226	MASE_07925	4-amino-4-deoxychorismate lyase
Chromobacterium violaceum	12614	CV_3410	4-amino-4-deoxychorismate lyase
Congregibacter litoralis	104960	KT71_15324	aminodeoxychorismate lyase apoprotein
Edwardsiella tarda	105688	ET1_06_00300	aminodeoxychorismate lyase
Enterobacter aerogenes	13534	EAE_16390	4-amino-4-deoxychorismate lyase
Enterobacter cloacae subsp. cloacae	13535	ECL_02540	4-amino-4-deoxychorismate lyase
Enterobacter hormaechei	105718	HMPREF9086_0761	aminodeoxychorismate lyase
Escherichia coli	3972	EcolC_2505	aminodeoxychorismate lyase
Escherichia coli	13500	WFL_05880	4-amino-4-deoxychorismate lyase
Escherichia coli	12713	Y75_1072	4-amino-4-deoxychorismate lyase component of para-aminobenzoate synthase multienzyme complex
Escherichia fergusonii	102419	EFER_1831	Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase) (ADC lyase) (ADCL)
Escherichia hermannii	105704	EH105704_03_02500	aminodeoxychorismate lyase
Frateuria aurantia	3245	Fraau_1400	aminodeoxychorismate lyase
Halomonas elongata	15536	HELO_2001	4-amino-4-deoxychorismate lyase
Klebsiella pneumoniae	14438	KPR_2134
Klebsiella pneumoniae subsp. rhinoscleromatis	105682	HMPREF0484_3359	aminodeoxychorismate lyase
Marinomonas mediterranea	103028	Marme_2294	aminodeoxychorismate lyase
Photobacterium damselae subsp. damselae corrig.	15633	VDA_001689	aminodeoxychorismate lyase
Proteus mirabilis	105697	HMPREF0693_2994	aminodeoxychorismate lyase
Providencia alcalifaciens	105687	PROVALCAL_03905	aminodeoxychorismate lyase
Pseudomonas putida	100650	PP_1917	4-amino-4-deoxychorismate lyase
Pseudomonas stutzeri	14165	PSTAB_2600	4-amino-4-deoxychorismate lyase
Rahnella aquatilis	105701	Rahaq2_2974	aminodeoxychorismate lyase
Serratia odorifera	102598	HMPREF0758_4184	aminodeoxychorismate lyase
Shimwellia blattae	105725	EB105725_05_00410	aminodeoxychorismate lyase
Vibrio alginolyticus	15630	N646_1127	4-amino-4-deoxychorismate lyase
Vibrio ichthyoenteri	15847	VII00023_22004	4-amino-4-deoxychorismate lyase
Vibrio metschnikovii	103153	VIB_001611	aminodeoxychorismate lyase
Vibrio orientalis	15638	VIOR3934_16266	4-amino-4-deoxychorismate lyase
Vibrio tubiashii	15644	VITU9109_01042	4-amino-4-deoxychorismate lyase
Yersinia bercovieri	105717	yberc0001_24420	Aminodeoxychorismate lyase
Yersinia rohdei	105715	yrohd0001_29850	Aminodeoxychorismate lyase