遺伝子 : Erythronate-4-phosphate dehydrogenase (PDXB)

遺伝子情報

ID	NRULE_0209
遺伝子ID	PDXB
作成日	2013/05/09
タンパク質名	Protein name Full Erythronate-4-phosphate dehydrogenase EC EC 1.1.1.290
遺伝子名	pdxB
遺伝子条件	HAMAP; MF_01825; hit=1
参照	Gene Ontology GO GO:0005737, C:cytoplasm, IEA:UniProtKB-SubCell GO:0033711, F:4-phosphoerythronate dehydrogenase activity, IDA:EcoCyc GO:0051287, F:NAD binding, IDA:EcoCyc GO:0042823, P:pyridoxal phosphate biosynthetic process, IDA:EcoCyc GO:0008615, P:pyridoxine biosynthetic process, IDA:EcoCyc Phylogenomic databases eggNOG COG0111, - HOGENOM HOG000234432, - KO K03473, - ProtClustDB PRK15438, - Enzyme and pathway databases BioCyc MetaCyc:ERYTHRON4PDEHYDROG-MONOMER, - BRENDA 1.1.1.290, 2026 UniPathway UPA00244, UER00310 Family and domain databases HAMAP MF_01825, PdxB, 1, - InterPro IPR006139, D-isomer_2_OHA_DH_cat_dom IPR006140, D-isomer_2_OHA_DH_NAD-bd IPR020921, Erythronate-4-P_DHase IPR024531, Erythronate-4-P_DHase_dimer Pfam PF00389, 2-Hacid_dh, 1 PF02826, 2-Hacid_dh_C, 1 PF11890, DUF3410, 1 PROSITE PS00065, D_2_HYDROXYACID_DH_1, 1 PS00670, D_2_HYDROXYACID_DH_2, FALSE_NEG PS00671, D_2_HYDROXYACID_DH_3, 1
配列の特徴	P05459 Escherichia coli (strain K12). ACT_SITE 208 By similarity. ACT_SITE 237 By similarity. ACT_SITE 254 Proton donor (By similarity). BINDING 45 Substrate (By similarity). BINDING 66 Substrate (By similarity). BINDING 146 NAD (By similarity). BINDING 175 NAD; via carbonyl oxygen (By similarity). BINDING 232 NAD (By similarity). BINDING 257 NAD; via amide nitrogen (By similarity). BINDING 258 Substrate (By similarity).
注釈	Function Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) Catalytic activity 4-phospho-D-erythronate + NAD(+) = (3R)-3- hydroxy-2-oxo-4-phosphonooxybutanoate + NADH Pathway Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4- phosphate: step 2/5 Subunit structure Homodimer (By similarity) Subcellular location Cytoplasm (Potential) Sequence similarities Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily
参考文献	P05459 Escherichia coli (strain K12). 2681152 Divergent transcription of pdxB and homology between the pdxB and serA gene products in Escherichia coli K-12. (J Bacteriol. 1989) 9205837 Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features. (DNA Res. 1997) 9278503 The complete genome sequence of Escherichia coli K-12. (Science. 1997) 16738553 Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. (Mol Syst Biol. 2006) 2991861 Structural features of the hisT operon of Escherichia coli K-12. (Nucleic Acids Res. 1985) 3029016 Structural analysis of the Escherichia coli K-12 hisT operon by using a kanamycin resistance cassette. (J Bacteriol. 1987) 8595869 4-Phospho-hydroxy-L-threonine is an obligatory intermediate in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12. (FEMS Microbiol Lett. 1996) 9696782 Involvement of the gapA- and epd (gapB)-encoded dehydrogenases in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12. (J Bacteriol. 1998)

関与する機能

機能名
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)

該当CDS

学名	NBRC番号	CDS	タンパク質名
Acinetobacter radioresistens	102413	ACRAD_02_01070	erythronate-4-phosphate dehydrogenase
Acinetobacter sp.	100985	ACT4_023_01680	erythronate-4-phosphate dehydrogenase
Alteromonas macleodii	102226	MASE_11690	erythronate-4-phosphate dehydrogenase
Bacteroides vulgatus	14291	BVU_1060	erythronate-4-phosphate dehydrogenase
Chitinispirillum alkaliphilum		CHISP_0661	Erythronate-4-phosphate dehydrogenase
Chitinivibrio alkaliphilus		CALK_0890	erythronate-4-phosphate dehydrogenase
Edwardsiella tarda	105688	ET1_09_00070	erythronate-4-phosphate dehydrogenase
Enterobacter aerogenes	13534	EAE_24600	erythronate-4-phosphate dehydrogenase PdxB
Enterobacter cloacae subsp. cloacae	13535	ECL_03669	erythronate-4-phosphate dehydrogenase
Enterobacter hormaechei	105718	HMPREF9086_3236	4-phosphoerythronate dehydrogenase
Escherichia coli	3972	EcolC_1332	D-isomer specific 2-hydroxyacid dehydrogenase catalytic region
Escherichia coli	13500	WFL_12285	erythronate-4-phosphate dehydrogenase PdxB
Escherichia coli	12713	Y75_2326	erythronate-4-phosphate dehydrogenase
Escherichia fergusonii	102419	EFER_0843	erythronate-4-phosphate dehydrogenase
Escherichia hermannii	105704	EH105704_01_07640	erythronate-4-phosphate dehydrogenase
Halomonas elongata	15536	HELO_2011	erythronate-4-phosphate dehydrogenase
Ignavibacterium album	101810	IALB_2961	Erythronate-4-phosphate dehydrogenase
Klebsiella pneumoniae	14438	KPR_1996
Klebsiella pneumoniae subsp. rhinoscleromatis	105682	HMPREF0484_3513	4-phosphoerythronate dehydrogenase
Lentisphaera araneosa		LNTAR_23439	erythronate-4-phosphate dehydrogenase
Marinomonas mediterranea	103028	Marme_2180	Erythronate-4-phosphate dehydrogenase
Mariprofundus ferrooxydans		SPV1_08988	erythronate-4-phosphate dehydrogenase
Photobacterium damselae subsp. damselae corrig.	15633	VDA_001532	erythronate-4-phosphate dehydrogenase
Proteus mirabilis	105697	HMPREF0693_1434	4-phosphoerythronate dehydrogenase
Providencia alcalifaciens	105687	PROVALCAL_03334	4-phosphoerythronate dehydrogenase
Pseudomonas putida	100650	PP_2117	erythronate-4-phosphate dehydrogenase
Pseudomonas stutzeri	14165	PSTAB_1716	erythronate-4-phosphate dehydrogenase
Rahnella aquatilis	105701	Rahaq2_1300	phosphoglycerate dehydrogenase-like oxidoreductase
Salinibacter ruber		SRU_2082	erythronate-4-phosphate dehydrogenase
Serratia odorifera	102598	HMPREF0758_2754	4-phosphoerythronate dehydrogenase
Shimwellia blattae	105725	EB105725_04_00250	erythronate-4-phosphate dehydrogenase
Vibrio alginolyticus	15630	N646_1296	erythronate-4-phosphate dehydrogenase
Vibrio ichthyoenteri	15847	VII00023_13402	erythronate-4-phosphate dehydrogenase
Vibrio metschnikovii	103153	VIB_000791	erythronate-4-phosphate dehydrogenase
Vibrio orientalis	15638	VIOR3934_10145	erythronate-4-phosphate dehydrogenase
Vibrio tubiashii	15644	VITU9109_12633	erythronate-4-phosphate dehydrogenase
Vibrio vulnificus	15645	B736_04415	erythronate-4-phosphate dehydrogenase
Yersinia bercovieri	105717	yberc0001_27410	Erythronate-4-phosphate dehydrogenase
Yersinia rohdei	105715	yrohd0001_24920	Erythronate-4-phosphate dehydrogenase