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Rule : Rrf2 family transcriptional regulator IscR (ISCR)

Rule Description

ID NRULE_0332
Rule name ISCR
Created 2014-10-09
Protein name
Protein name
Full
Rrf2 family transcriptional regulator IscR
Gene name iscR
Rule Trigger HAMAP; MF_01176; hit=1
OR
TIGRFAMs; TIGR02010; hit=1
Cross Reference
Gene Ontology
GO
GO:0051537, F:2 iron, 2 sulfur cluster binding, IEA:UniProtKB-KW
GO:0003690, F:double-stranded DNA binding, IEA:UniProtKB-HAMAP
GO:0005506, F:iron ion binding, IEA:UniProtKB-HAMAP
GO:0003700, F:sequence-specific DNA binding transcription factor activity, IDA:EcoCyc
GO:0006355, P:regulation of transcription, DNA-templated, IDA:EcoCyc
GO:0006950, P:response to stress, IEA:UniProtKB-KW
GO:0006351, P:transcription, DNA-templated, IEA:UniProtKB-KW
Phylogenomic databases
eggNOG
COG1959, -
HOGENOM
HOG000249812, -
KO
K13643, -
Family and domain databases
HAMAP
MF_01176, HTH_type_IscR, 1
InterPro
IPR010242, TF_HTH_IscR
IPR000944, Tscrpt_reg_Rrf2-like
IPR011991, WHTH_DNA-bd_dom
Pfam
PF02082, Rrf2, 1
TIGRFAMs
TIGR02010, IscR, 1
TIGR00738, rrf2_super, 1
PROSITE
PS01332, HTH_RRF2_1, 1
PS51197, HTH_RRF2_2, 1
Feature
P0AGK8 Escherichia coli (strain K12).
METAL92Iron-sulfur (2Fe-2S).
METAL98Iron-sulfur (2Fe-2S).
METAL104Iron-sulfur (2Fe-2S).
General annotation
Function
Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S cluster-containing proteins
Cofactor
Binds 1 2Fe-2S cluster
Domain
Contains 1 HTH rrf2-type DNA-binding domain
Reference
P0AGK8 Escherichia coli (strain K12).
11742080
IscR, an Fe-S cluster-containing transcription factor, represses expression of Escherichia coli genes encoding Fe-S cluster assembly proteins. (Proc Natl Acad Sci U S A. 2001)
16824106
IscR acts as an activator in response to oxidative stress for the suf operon encoding Fe-S assembly proteins. (Mol Microbiol. 2006)
23075318
Regulation of iron-sulphur cluster homeostasis through transcriptional control of the Isc pathway by [2Fe-2S]-IscR in Escherichia coli. (Mol Microbiol. 2013)



Related Function

Function name
Metal-binding protein

CDS

Data Download
Scientific name NBRC No. CDS Product name
Alteromonas macleodii102226MASE_12895BadM/Rrf2 family transcriptional regulator
Chromobacterium violaceum12614CV_1095conserved hypothetical protein
Congregibacter litoralis104960KT71_06764transcriptional regulator, BadM/Rrf2 family
Cupriavidus metallidurans102507Rmet_1024transcriptional regulator of iron sulfur clusterassembly
Edwardsiella tarda105688ET1_12_00130transcriptional regulator IscR
Enterobacter aerogenes13534EAE_00790DNA-binding transcriptional regulator IscR
Enterobacter cloacae subsp. cloacae13535ECL_03880putative FeS cluster assembly transcriptional regulator IscR
Enterobacter hormaechei105718HMPREF9086_3389iron-sulfur cluster assembly transcription regulator IscR
Escherichia coli3972EcolC_1146transcriptional regulator, BadM/Rrf2 family
Escherichia coli13500WFL_13500DNA-binding transcriptional regulator IscR
Escherichia coli12713Y75_2524DNA-binding transcriptional activator
Escherichia fergusonii102419EFER_0641DNA-binding transcriptional repressor
Escherichia hermannii105704EH105704_01_09190HTH-type transcriptional regulator IscR
Hylemonella gracilis14920HGR_00779transcriptional regulator, BadM/Rrf2 family protein
Klebsiella pneumoniae14438KPR_1412
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_0537iron-sulfur cluster assembly transcription factor IscR
Marinomonas mediterranea103028Marme_1209transcriptional regulator, BadM/Rrf2 family
Photobacterium damselae subsp. damselae corrig.15633VDA_002714iron-sulfur cluster regulator IscR
Proteus mirabilis105697HMPREF0693_1507iron-sulfur cluster assembly transcription factor IscR
Providencia alcalifaciens105687PROVALCAL_01699iron-sulfur cluster assembly transcription factor IscR
Pseudomonas putida100650PP_0841rrf2 family protein
Pseudomonas stutzeri14165PSTAB_3090iron-sulfur cluster assembly transcription factor IscR
Rahnella aquatilis105701Rahaq2_1104iron-sulfur cluster assembly transcription factor IscR
Shimwellia blattae105725EB105725_12_01210HTH-type transcriptional regulator IscR
Thauera linaloolentis102519C666_02335Rrf2 family protein
Vibrio alginolyticus15630N646_2753hypothetical protein
Vibrio orientalis15638VIOR3934_18298hypothetical protein
Vibrio tubiashii15644VITU9109_21719hypothetical protein
Vibrio vulnificus15645B736_04775Rrf2 family transcriptional regulator
Yersinia bercovieri105717yberc0001_30610HTH-type transcriptional regulator iscR
Yersinia rohdei105715yrohd0001_20690HTH-type transcriptional regulator iscR