| accession | DB | alignment | Evalue | Score | Ident. | link | information | pubmed |
1
|
O87605_9ACTO (O87605) |
|
|
0.0 |
829 |
100% |
|
- Product
- Cytochrome P450 hydroxylase PiKC
Cytochrome P450 monooxygenase
- Gene
- picK
pikC
- Organism
- Streptomyces venezuelae
|
1uniprot[Pubmed] 9831532 [Medline] 99051447 Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae.(Chem. Biol.) [1998] | 2uniprot[Pubmed] 16825192 The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae.(J. Biol. Chem.) [2006] | 3uniprot[Pubmed] 19124459 Analysis of transient and catalytic desosamine-binding pockets in cytochrome P-450 PikC from Streptomyces venezuelae.(J. Biol. Chem.) [2009] | 4uniprot[Pubmed] 19833867 Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase.(Proc. Natl. Acad. Sci. U.S.A.) [2009] | 5uniprot[Pubmed] 9770448 [Medline] 98445333 A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.(Proc. Natl. Acad. Sci. U.S.A.) [1998] | 6uniprot[Pubmed] 9778370 [Medline] 98453342 Characterization of the macrolide P-450 hydroxylase from Streptomyces venezuelae which converts narbomycin to picromycin.(Biochemistry) [1998] | [pubmed all]
|
2
|
F2QB25_STRPT (F2QB25) |
|
|
1e-141 |
507 |
65% |
|
- Product
- Cytochrome P450 monooxygenase
- Gene
- p450
- Organism
- Streptomyces platensis
|
1uniprot A new cytochrome P450 belonging to the 107L subfamily is responsible for the efficient hydroxylation of the drug terfenadine by Streptomyces platensis.(Arch. Biochem. Biophys.) [2011] |
|
4
|
B1VVC3_STRGG (B1VVC3) |
|
|
1e-132 |
477 |
60% |
|
- Product
- Putative cytochrome P450
- Gene
- SGR_1278
- Organism
- Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
|
1uniprot[Pubmed] 18375553 Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008] |
|
8
|
Q595R7_9ACTO (Q595R7) |
|
|
1e-128 |
462 |
61% |
|
- Product
- Cytochrome P450 monooxygenase CYP107L4
- Gene
- cypLC
- Organism
- Streptomyces tubercidicus
|
1uniprot[Pubmed] 16269732 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes.(Appl. Environ. Microbiol.) [2005] | 2uniprot[Pubmed] 16269733 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: heterologous expression of the ema1 cytochrome P450 monooxygenase.(Appl. Environ. Microbiol.) [2005] | [pubmed all]
|
9
|
Q595T3_9ACTO (Q595T3) |
|
|
1e-127 |
461 |
60% |
|
- Product
- Cytochrome P450 monooxygenase CYP107L3
- Gene
- cypLA
- Organism
- Streptomyces tubercidicus
|
1uniprot[Pubmed] 16269732 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes.(Appl. Environ. Microbiol.) [2005] | 2uniprot[Pubmed] 16269733 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: heterologous expression of the ema1 cytochrome P450 monooxygenase.(Appl. Environ. Microbiol.) [2005] | [pubmed all]
|
10
|
Q70AR3_STRPE (Q70AR3) |
|
|
1e-124 |
451 |
60% |
|
- Product
- Putative cytochrome P450
- Gene
- cyp0854
- Organism
- Streptomyces peucetius
|
1uniprot[Pubmed] 15111132 Genome analyses of Streptomyces peucetius ATCC 27952 for the identification and comparison of cytochrome P450 complement with other Streptomyces.(Arch. Biochem. Biophys.) [2004] |
|
17
|
C9ZGI2_STRSW (C9ZGI2) |
|
|
1e-120 |
437 |
58% |
|
- Product
- P450-like protein
- Gene
- SCAB_18241
- Organism
- Streptomyces scabies (strain 87.22)
Streptomyces scabiei
|
1uniprot[Pubmed] 20064060 Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010] |
|
18
|
Q82LM3_STRAW (Q82LM3) |
|
|
1e-120 |
435 |
60% |
|
- Product
- Cytochrome P450 hydroxylase
- Gene
- cyp8
SAV1987 SAV_1987
- Organism
- Streptomyces avermitilis
|
1uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001] |
|
20
|
B1VVC4_STRGG (B1VVC4) |
|
|
1e-119 |
433 |
61% |
|
- Product
- Putative cytochrome P450
- Gene
- SGR_1279
- Organism
- Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
|
1uniprot[Pubmed] 18375553 Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008] |
|
21
|
E2PZM4_STRCL (E2PZM4) |
|
|
1e-119 |
432 |
56% |
|
- Product
- Cytochrome P450 monooxygenase
- Gene
- SCLAV_1254
- Organism
- Streptomyces clavuligerus ATCC 27064
|
1uniprot[Pubmed] 20624727 The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010] |
|
26
|
A8R0I4_9ACTO (A8R0I4) |
|
|
1e-111 |
408 |
56% |
|
- Product
- Cytochrome P450 monooxygenase
Putative cytochrome P450 monooxygenase
- Gene
- pctA
ptmY
- Organism
- Streptomyces pactum
|
1uniprot[Pubmed] 17827660 Cloning of the pactamycin biosynthetic gene cluster and characterization of a crucial glycosyltransferase prior to a unique cyclopentane ring formation.(J. Antibiot.) [2007] |
|
27
|
F2RCF4_STRVP (F2RCF4) |
|
|
1e-110 |
402 |
55% |
|
- Product
- Putative cytochrome P450 hydroxylase
- Gene
- SVEN_6119
- Organism
- Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
|
1uniprot[Pubmed] 21463507 Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011] |
|
28
|
Q6V1M0_9ACTO (Q6V1M0) |
|
|
1e-107 |
394 |
54% |
|
- Product
- PlmS2
- Gene
- plmS2
- Organism
- Streptomyces sp. HK803
|
1uniprot[Pubmed] 12819191 [Medline] 22841069 Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster.(J. Biol. Chem.) [2003] |
|
29
|
B5GRQ0_STRCL (B5GRQ0) |
|
|
1e-106 |
388 |
54% |
|
- Product
- Cytochrome P450 monooxygenase
Putative cytochrome P450
- Gene
- SCLAV_5015
SSCG_02024
- Organism
- Streptomyces clavuligerus ATCC 27064
|
1uniprot[Pubmed] 20624727 The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010] |
|
32
|
A4FLS3_SACEN (A4FLS3) |
|
|
7e-97 |
358 |
51% |
|
- Product
- Cytochrome P450-like enzyme
- Gene
- cypA
SACE_5814
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
33
|
CPXK_SACEN (P33271) |
|
|
7e-97 |
358 |
51% |
|
- Product
- Cytochrome P450 107B1
Cytochrome P450CVIIB1
- Gene
- CYP107B1
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 1732208 [Medline] 92121109 Characterization of Saccharopolyspora erythraea cytochrome P-450 genes and enzymes, including 6-deoxyerythronolide B hydroxylase.(J. Bacteriol.) [1992] |
|
34
|
E2PYN1_STRCL (E2PYN1) |
|
|
9e-96 |
355 |
50% |
|
- Product
- Cytochrome P450 hydroxylase
- Gene
- SCLAV_1175
- Organism
- Streptomyces clavuligerus ATCC 27064
|
1uniprot[Pubmed] 20624727 The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010] |
|
36
|
D7C4A9_STRBB (D7C4A9) |
|
|
2e-95 |
354 |
51% |
|
- Product
- Cytochrome P450 hydroxylase
- Gene
- cyp14
SBI_00810
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
39
|
D8HTB4_AMYMU (D8HTB4) |
|
|
6e-95 |
352 |
52% |
|
- Product
- Cytochrome P450
- Gene
- AMED_2213
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
42
|
D1GLU0_9ACTO (D1GLU0) |
|
|
5e-94 |
349 |
49% |
|
- Product
- Cytochrome P450
- Gene
- slgO2
- Organism
- Streptomyces lydicus
|
1uniprot Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.(Chem. Biol.) [2009] |
|
43
|
Q9F2L1_STRCO (Q9F2L1) |
|
|
2e-93 |
347 |
52% |
|
- Product
- Putative cytochrome P450 oxidoreductase
- Gene
- SCO3770
- Organism
- Streptomyces coelicolor
|
1uniprot[Pubmed] 12000953 [Medline] 21996410 Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002] |
|
50
|
F3N9Q4_9ACTO (F3N9Q4) |
|
|
6e-91 |
339 |
51% |
|
- Product
- Putative cytochrome P450
- Gene
- SGM_0088
- Organism
- Streptomyces griseoaurantiacus M045
|
1uniprot[Pubmed] 21551298 Draft Genome Sequence of the Marine Bacterium Streptomyces griseoaurantiacus M045, Which Produces Novel Manumycin-Type Antibiotics with a pABA Core Component.(J. Bacteriol.) [2011] |
|
51
|
A4F8W1_SACEN (A4F8W1) |
|
|
1e-90 |
338 |
50% |
|
- Product
- Putative cytochrome P450
- Gene
- cyp23
SACE_1158
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
52
|
Q70AS2_STRPE (Q70AS2) |
|
|
3e-90 |
337 |
48% |
|
- Product
- Putative cytochrome P450
- Gene
- cyp0819
- Organism
- Streptomyces peucetius
|
1uniprot[Pubmed] 15111132 Genome analyses of Streptomyces peucetius ATCC 27952 for the identification and comparison of cytochrome P450 complement with other Streptomyces.(Arch. Biochem. Biophys.) [2004] |
|
53
|
Q9F2Q0_STRCO (Q9F2Q0) |
|
|
5e-90 |
336 |
47% |
|
- Product
- Cytochrome P450
Putative cytochrome P450 hydroxylase
- Gene
- IT6-107MNPR-12
SCO3099
- Organism
- Streptomyces coelicolor
|
1uniprot[Pubmed] 12000953 [Medline] 21996410 Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002] |
|
57
|
F1DI41_9ACTO (F1DI41) |
|
|
1e-89 |
335 |
47% |
|
- Product
- TrdI
- Gene
-
- Organism
- Streptomyces sp. SCSIO1666
|
1uniprot[Pubmed] 21329667 Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomyces sp. SCSIO1666.(Biochem. Biophys. Res. Commun.) [2011] |
|
58
|
D3Y1J3_9ACTO (D3Y1J3) |
|
|
1e-89 |
335 |
47% |
|
- Product
- TamI
- Gene
-
- Organism
- Streptomyces sp. 307-9
|
1uniprot[Pubmed] 20127927 Identification of the tirandamycin biosynthetic gene cluster from Streptomyces sp. 307-9.(Chembiochem) [2010] |
|
62
|
CPVDH_PSEAH (C4B644) |
|
|
3e-89 |
333 |
48% |
|
- Product
- Vitamin D(3) 25-hydroxylase
Cytochrome P450
- Gene
- vdh
- Organism
- Pseudonocardia autotrophica
Amycolata autotrophica Nocardia autotrophica
|
1uniprot[Pubmed] 19450562 Purification, characterization, and directed evolution study of a vitamin D3 hydroxylase from Pseudonocardia autotrophica.(Biochem. Biophys. Res. Commun.) [2009] |
|
63
|
F2R6D7_STRVP (F2R6D7) |
|
|
3e-89 |
333 |
48% |
|
- Product
- Putative cytochrome P450 hydroxylase
- Gene
- SVEN_2902
- Organism
- Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
|
1uniprot[Pubmed] 21463507 Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011] |
|
71
|
F3NS09_9ACTO (F3NS09) |
|
|
2e-88 |
330 |
48% |
|
- Product
- Cytochrome P450 hydroxylase
- Gene
- SGM_5923
- Organism
- Streptomyces griseoaurantiacus M045
|
1uniprot[Pubmed] 21551298 Draft Genome Sequence of the Marine Bacterium Streptomyces griseoaurantiacus M045, Which Produces Novel Manumycin-Type Antibiotics with a pABA Core Component.(J. Bacteriol.) [2011] |
|
72
|
D2AWQ3_STRRD (D2AWQ3) |
|
|
3e-88 |
330 |
50% |
|
- Product
- Putative uncharacterized protein
- Gene
- Sros_6100
- Organism
- Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
|
1uniprot Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010] |
|
73
|
D1GLV3_9ACTO (D1GLV3) |
|
|
4e-88 |
330 |
49% |
|
- Product
- Cytochrome P450
- Gene
- slgO1
- Organism
- Streptomyces lydicus
|
1uniprot Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.(Chem. Biol.) [2009] |
|
76
|
C9YY34_STRSW (C9YY34) |
|
|
1e-87 |
328 |
48% |
|
- Product
- Putative monooxygenase
- Gene
- SCAB_54411
- Organism
- Streptomyces scabies (strain 87.22)
Streptomyces scabiei
|
1uniprot[Pubmed] 20064060 Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010] |
|
81
|
Q82A10_STRAW (Q82A10) |
|
|
3e-86 |
323 |
48% |
|
- Product
- Cytochrome P450 hydroxylase
- Gene
- cyp23
SAV6249 SAV_6249
- Organism
- Streptomyces avermitilis
|
1uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001] |
|
82
|
Q93HA3_STRAW (Q93HA3) |
|
|
3e-86 |
323 |
50% |
|
- Product
- Cytochrome P450
Putative cytochrome P450
- Gene
- cyp10
SAV2377 SAV_2377
- Organism
- Streptomyces avermitilis
|
1uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001] | 2uniprot[Pubmed] 12692562 [Medline] 22608306 Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003] | [pubmed all]
|
84
|
B5GZN3_STRCL (B5GZN3) |
|
|
6e-86 |
322 |
47% |
|
- Product
- Cytochrome P450 hydroxylase
- Gene
- SCLAV_2218
SSCG_04850
- Organism
- Streptomyces clavuligerus ATCC 27064
|
1uniprot[Pubmed] 20624727 The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010] |
|
89
|
CPXJ_SACEN (Q00441) |
|
|
4e-85 |
320 |
46% |
|
- Product
- 6-deoxyerythronolide B hydroxylase
CYPCVIIA1 Cytochrome P450 107A1 Cytochrome P450eryF Erythomycin A biosynthesis hydrolase
- Gene
- eryF
CYP107A1 SACE_0730
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 1840640 [Medline] 92079886 Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases.(Mol. Gen. Genet.) [1991] | 2uniprot[Pubmed] 2011746 [Medline] 91188269 An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea.(Science) [1991] | 3uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] | 4uniprot[Pubmed] 7749919 [Medline] 95269057 Structure of cytochrome P450eryF involved in erythromycin biosynthesis.(Nat. Struct. Biol.) [1995] | 5uniprot[Pubmed] 10716705 [Medline] 20202586 Crystal structures of ligand complexes of P450eryF exhibiting homotropic cooperativity.(Proc. Natl. Acad. Sci. U.S.A.) [2000] | 6uniprot[Pubmed] 11469860 [Medline] 21363699 Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF.(J. Mol. Biol.) [2001] | [pubmed all]
|
90
|
E4NG24_KITSK (E4NG24) |
|
|
9e-85 |
318 |
47% |
|
- Product
- Putative cytochrome P450
- Gene
- KSE_46730
- Organism
- Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054)
Streptomyces setae
|
1uniprot[Pubmed] 21059706 Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.(DNA Res.) [2010] |
|
92
|
B6ZIR6_STRPT (B6ZIR6) |
|
|
1e-84 |
318 |
46% |
|
- Product
- Cytochrome P450
- Gene
- pldB
- Organism
- Streptomyces platensis
|
1uniprot[Pubmed] 18997414 Organization of the biosynthetic gene cluster for the polyketide antitumor macrolide, pladienolide, in Streptomyces platensis Mer-11107.(Biosci. Biotechnol. Biochem.) [2008] |
|
94
|
Q83X78_STRRO (Q83X78) |
|
|
7e-84 |
315 |
46% |
|
- Product
- P450 hydroxylase LkmF
- Gene
- lkmF
- Organism
- Streptomyces rochei
Streptomyces parvullus
|
1uniprot[Pubmed] 12791134 [Medline] 22676866 The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003] | 2uniprot[Pubmed] 10954087 [Medline] 20408175 Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000] | 3uniprot[Pubmed] 10767533 [Medline] 20231737 Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000] | 4uniprot[Pubmed] 9836424 [Medline] 99053144 Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998] | [pubmed all]
|
97
|
C9ZED8_STRSW (C9ZED8) |
|
|
2e-83 |
314 |
45% |
|
- Product
- Putative monooxygenase
- Gene
- SCAB_79691
- Organism
- Streptomyces scabies (strain 87.22)
Streptomyces scabiei
|
1uniprot[Pubmed] 20064060 Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010] |
|