BLAST table : Aver_00030

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	Q9S0N6_STRAW (Q9S0N6)	1e-161	571	100%	UniProt GenBank	C5-O-methyltransferase	aveD SAV937 SAV_937	Streptomyces avermitilis
2	A8J700_9ACTO (A8J700)	5e-88	328	61%	UniProt GenBank	C5-O-methyltransferase	nemD	Streptomyces cyaneogriseus subsp. noncyanogenus
3	Q6TKG5_9ACTO (Q6TKG5)	2e-76	290	60%	UniProt GenBank	C5-O-methyltransferase	milD	Streptomyces griseochromogenes
4	B8YGC2_9ACTO (B8YGC2)	5e-76	288	59%	UniProt GenBank	C5-O-methyltransferase	binD	Streptomyces bingchenggensis
5	D7C489_STRBB (D7C489)	6e-76	288	58%	UniProt GenBank	C5-O-methyltransferase	milD SBI_00790	Streptomyces bingchenggensis (strain BCW-1)
6	D6C4C6_9ACTO (D6C4C6)	2e-75	287	59%	UniProt GenBank	C5-O-methyltransferase	meiD	Streptomyces nanchangensis
7	Q9X5Q9_STRLA (Q9X5Q9)	7e-48	195	42%	UniProt GenBank	MitM	mitM	Streptomyces lavendulae
8	A7NH02_ROSCS (A7NH02)	5e-47	192	42%	UniProt GenBank	Methyltransferase type 11	Rcas_0623	Roseiflexus castenholzii (strain DSM 13941 / HLO8)
9	A5UZ15_ROSS1 (A5UZ15)	1e-46	191	42%	UniProt GenBank	Methyltransferase type 11	RoseRS_3510	Roseiflexus sp. (strain RS-1)
10	E0D208_9ACTO (E0D208)	3e-46	189	41%	UniProt GenBank	Methyltransferase	gfsG	Streptomyces graminofaciens
11	D0U2E8_STRPT (D0U2E8)	3e-46	189	42%	UniProt GenBank	O-methyl transferase		Streptomyces platensis subsp. rosaceus
12	D8HZB5_AMYMU (D8HZB5)	3e-46	189	41%	UniProt GenBank	Methyltransferase type 11	AMED_0650	Amycolatopsis mediterranei (strain U-32)
13	O52570_AMYMD (O52570)	4e-46	189	41%	UniProt GenBank	C-27 O-methyltransferase		Amycolatopsis mediterranei Nocardia mediterranei
14	Q0H2W9_9ACTO (Q0H2W9)	7e-46	188	42%	UniProt GenBank	D-glucose O-methyltransferase	atM	Actinomadura melliaura
15	A8LFZ5_FRASN (A8LFZ5)	4e-45	186	43%	UniProt GenBank	Methyltransferase type 11	Franean1_4832	Frankia sp. (strain EAN1pec)
16	E9KTL3_9ACTO (E9KTL3)	1e-44	184	39%	UniProt GenBank	SnogM	Tcs_55098_015	Streptomyces sp. ATCC 55098
17	D5SJT8_STRCL (D5SJT8)	1e-43	181	43%	UniProt GenBank	Methyltransferase	SCLAV_p0694	Streptomyces clavuligerus ATCC 27064
18	B5GND8_STRCL (B5GND8)	1e-43	181	43%	UniProt GenBank	NigE	SSCG_00862	Streptomyces clavuligerus ATCC 27064
19	Q27W70_STRVO (Q27W70)	2e-43	181	40%	UniProt GenBank	NigE		Streptomyces violaceoniger
20	Q83X76_STRRO (Q83X76)	4e-43	179	44%	UniProt GenBank	Putative NDP-hexose 3-O-methyltransferase	lkmG	Streptomyces rochei Streptomyces parvullus
21	Q8KZ94_NOCAE (Q8KZ94)	4e-43	179	42%	UniProt GenBank	Putative D-glucose O-methyltransferase	rebM	Lechevalieria aerocolonigenes Nocardia aerocolonigenes Saccharothrix aerocolonigenes
22	Q8KI52_NOCAE (Q8KI52)	6e-43	179	42%	UniProt GenBank	Methyltransferase Putative methyltransferase RebM	rbmF rebM	Lechevalieria aerocolonigenes Nocardia aerocolonigenes Saccharothrix aerocolonigenes
23	E0KNC0_STRVO (E0KNC0)	7e-43	178	39%	UniProt GenBank	Methyltransferase type 11	StrviDRAFT_4147	Streptomyces violaceusniger Tu 4113
24	D9WWU0_9ACTO (D9WWU0)	2e-42	177	40%	UniProt GenBank	C5-O-methyltransferase	SSOG_08430	Streptomyces himastatinicus ATCC 53653
25	E9KTK3_9ACTO (E9KTK3)	1e-41	174	41%	UniProt GenBank	Putative D-glucose O-methyltransferase	Tcs_55098_005	Streptomyces sp. ATCC 55098
26	A8M6Z4_SALAI (A8M6Z4)	5e-41	172	38%	UniProt GenBank	Methyltransferase type 11	Sare_1271	Salinispora arenicola (strain CNS-205)
27	A8M274_SALAI (A8M274)	2e-40	171	38%	UniProt GenBank	Methyltransferase type 11	Sare_2332	Salinispora arenicola (strain CNS-205)
28	Q846Y0_STRCM (Q846Y0)	4e-40	169	37%	UniProt GenBank	Monensin 3-O-methyl transferase	monE	Streptomyces cinnamonensis
29	B5H2M0_STRCL (B5H2M0)	5e-40	169	42%	UniProt GenBank	Methyltransferase	SSCG_05830	Streptomyces clavuligerus ATCC 27064
30	D5SL07_STRCL (D5SL07)	1e-39	168	42%	UniProt GenBank	Staurosporine biosynthesis methyltransferase StaMA	staMA SCLAV_p1114	Streptomyces clavuligerus ATCC 27064
31	Q83WF7_9ACTO (Q83WF7)	1e-39	168	37%	UniProt GenBank	Methyltransferase	staMB	Streptomyces sp. TP-A0274
32	Q9ALM7_9PSEU (Q9ALM7)	3e-39	166	39%	UniProt GenBank	Methyltransferase-like protein	spnF	Saccharopolyspora spinosa
33	Q4JHR3_9PSEU (Q4JHR3)	6e-39	165	37%	UniProt GenBank	BusF	busF	Saccharopolyspora pogona
34	C6W8T2_ACTMD (C6W8T2)	7e-39	165	44%	UniProt GenBank	Methyltransferase type 11	Amir_3275	Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
35	B5A9R7_9PSEU (B5A9R7)	9e-39	165	44%	UniProt GenBank	MbcT	mbcT	Actinosynnema pretiosum subsp. pretiosum
36	Q83WG2_9ACTO (Q83WG2)	5e-38	162	39%	UniProt GenBank	Methyltransferase	staMA	Streptomyces sp. TP-A0274
37	B4UXS3_9ACTO (B4UXS3)	7e-38	162	42%	UniProt GenBank	Methyltransferase	SSAG_00429	Streptomyces sp. Mg1
38	Q9X5Q8_STRLA (Q9X5Q8)	1e-37	161	38%	UniProt GenBank	MitN	mitN	Streptomyces lavendulae
39	B5GZG7_STRCL (B5GZG7)	6e-37	159	38%	UniProt GenBank	Methyltransferase	SCLAV_4762 SSCG_04741	Streptomyces clavuligerus ATCC 27064
40	D5SL02_STRCL (D5SL02)	1e-36	157	43%	UniProt GenBank	Staurosporine biosynthesis methyltransferase StaMB	staMB SCLAV_p1109	Streptomyces clavuligerus ATCC 27064
41	F8K389_STRCT (F8K389)	2e-36	157	38%	UniProt GenBank	D-glucose O-methyltransferase	atM SCAT_1438	Streptomyces cattleya
42	A4X8P9_SALTO (A4X8P9)	4e-36	156	39%	UniProt GenBank	Methyltransferase type 11	Strop_2808	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
43	B5A9R8_9PSEU (B5A9R8)	1e-35	154	41%	UniProt GenBank	MbcU	mbcU	Actinosynnema pretiosum subsp. pretiosum
44	C6W8T1_ACTMD (C6W8T1)	2e-35	153	41%	UniProt GenBank	Methyltransferase type 11	Amir_3274	Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
45	Q9EYI2_STRNO (Q9EYI2)	3e-35	153	36%	UniProt GenBank	SnogM	snogM	Streptomyces nogalater
46	F8JLJ1_STRCT (F8JLJ1)	8e-33	145	35%	UniProt GenBank	D-glucose O-methyltransferase	atM SCAT_p1623	Streptomyces cattleya NRRL 8057
47	D5SKC5_STRCL (D5SKC5)	1e-32	144	34%	UniProt GenBank	Methyltransferase type 11	SCLAV_p0882	Streptomyces clavuligerus ATCC 27064
48	B5GMU2_STRCL (B5GMU2)	1e-32	144	34%	UniProt GenBank	Methyltransferase type 11	SSCG_00666	Streptomyces clavuligerus ATCC 27064
49	D3D2U8_9ACTO (D3D2U8)	1e-32	144	41%	UniProt GenBank	Methyltransferase type 11	FrEUN1fDRAFT_4120	Frankia sp. EUN1f
50	E0KL87_STRVO (E0KL87)	7e-31	139	35%	UniProt GenBank	Methyltransferase type 11	StrviDRAFT_3458	Streptomyces violaceusniger Tu 4113
51	Q3LRL2_9DELT (Q3LRL2)	3e-30	137	36%	UniProt GenBank	MmxM	mmxM	Cystobacter fuscus
52	D6AAA8_9ACTO (D6AAA8)	1e-28	131	35%	UniProt GenBank	Methyltransferase type 11	SSFG_07678	Streptomyces ghanaensis ATCC 14672
53	D6K9D8_9ACTO (D6K9D8)	2e-28	130	36%	UniProt GenBank	C5-O-methyltransferase	SSTG_04591	Streptomyces sp. e14
54	A4X2I4_SALTO (A4X2I4)	5e-28	129	38%	UniProt GenBank	Methyltransferase type 11	Strop_0604	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
55	D2JNW1_9NOSO (D2JNW1)	2e-27	127	29%	UniProt GenBank	O-methyltrasferase		Nostoc sp. 'Peltigera membranacea cyanobiont'
56	Q9ALN3_9PSEU (Q9ALN3)	8e-27	125	31%	UniProt GenBank	Methyltransferase-like protein	spnL	Saccharopolyspora spinosa
57	Q4JHQ7_9PSEU (Q4JHQ7)	2e-26	124	31%	UniProt GenBank	BusL	busL	Saccharopolyspora pogona
58	C7Q6F0_CATAD (C7Q6F0)	4e-26	122	37%	UniProt GenBank	Methyltransferase type 11	Caci_3249	Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
59	A9AWD7_HERA2 (A9AWD7)	5e-26	122	31%	UniProt GenBank	Methyltransferase type 11	Haur_2147	Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
60	F0ZN82_DICPU (F0ZN82)	5e-24	116	34%	UniProt GenBank	Putative uncharacterized protein	DICPUDRAFT_79655	Dictyostelium purpureum Slime mold
61	E3RR62_PYRTT (E3RR62)	6e-23	112	34%	UniProt GenBank	Putative uncharacterized protein	PTT_11273	Pyrenophora teres f. teres (strain 0-1) Barley net blotch fungus Drechslera teres f. teres
62	A9NQ25_PICSI (A9NQ25)	8e-23	112	30%	UniProt GenBank	Putative uncharacterized protein		Picea sitchensis Sitka spruce Pinus sitchensis
63	E1ZM43_9CHLO (E1ZM43)	1e-22	111	31%	UniProt GenBank	Putative uncharacterized protein	CHLNCDRAFT_26131	Chlorella variabilis
64	D9UPS0_9ACTO (D9UPS0)	1e-22	111	33%	UniProt GenBank	Methyltransferase type 11	SSLG_02146	Streptomyces sp. SPB78
65	B7K3A6_CYAP8 (B7K3A6)	2e-22	111	31%	UniProt GenBank	Methyltransferase type 11	PCC8801_0328	Cyanothece sp. (strain PCC 8801) Synechococcus sp. (strain PCC 8801 / RF-1)
66	F3ZMJ1_9ACTO (F3ZMJ1)	2e-22	110	33%	UniProt GenBank	Putative methyltransferase type 11	STTU_4299	Streptomyces sp. Tu6071
67	B2WEK3_PYRTR (B2WEK3)	2e-22	110	33%	UniProt GenBank	Sterol 24-C-methyltransferase (Delta(24)-sterol C-methyltransferase)	PTRG_08576	Pyrenophora tritici-repentis (strain Pt-1C-BFP) Wheat tan spot fungus Drechslera tritici-repentis
68	E9ES52_METAR (E9ES52)	3e-22	110	32%	UniProt GenBank	Sterol 24-c-methyltransferase, putative	MAA_02798	Metarhizium robertsii (strain ARSEF 23) Metarhizium anisopliae
69	B6QTV1_PENMQ (B6QTV1)	3e-22	110	34%	UniProt GenBank	Sterol 24-c-methyltransferase, putative	PMAA_006040	Penicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
70	F4PKW4_DICFS (F4PKW4)	4e-22	109	32%	UniProt GenBank	Sterol 24-C-methyltransferase	DFA_05318	Dictyostelium fasciculatum (strain SH3) Slime mold
71	C7QU57_CYAP0 (C7QU57)	4e-22	109	31%	UniProt GenBank	Methyltransferase type 11	Cyan8802_0335	Cyanothece sp. (strain PCC 8802) Synechococcus sp. (strain RF-2)
72	Q553T0_DICDI (Q553T0)	1e-21	108	31%	UniProt GenBank	Putative uncharacterized protein	DDB_0202574 DDB_G0275359	Dictyostelium discoideum Slime mold
73	B0JHF8_MICAN (B0JHF8)	2e-21	107	33%	UniProt GenBank	Tocopherol O-methyltransferase	MAE_24880	Microcystis aeruginosa (strain NIES-843)
74	B8MP25_TALSN (B8MP25)	2e-21	107	33%	UniProt GenBank	Sterol 24-c-methyltransferase, putative	TSTA_104780	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) Penicillium stipitatum	2.1.1.41 niceE keggE
75	A8YA30_MICAE (A8YA30)	3e-21	107	32%	UniProt GenBank	Genome sequencing data, contig C242	IPF_5314	Microcystis aeruginosa PCC 7806
76	Q2JSI4_SYNJA (Q2JSI4)	3e-21	106	30%	UniProt GenBank	Cyclopropane-fatty-acyl-phospholipid synthase family protein	CYA_2254	Synechococcus sp. (strain JA-3-3Ab) Cyanobacteria bacterium Yellowstone A-Prime
77	B7KCD5_CYAP7 (B7KCD5)	4e-21	106	31%	UniProt GenBank	Methyltransferase type 11	PCC7424_1808	Cyanothece sp. (strain PCC 7424) Synechococcus sp. (strain ATCC 29155)
78	B8HNU8_CYAP4 (B8HNU8)	4e-21	106	33%	UniProt GenBank	Methyltransferase type 11	Cyan7425_3207	Cyanothece sp. (strain PCC 7425 / ATCC 29141)
79	B0BZ72_ACAM1 (B0BZ72)	4e-21	106	36%	UniProt GenBank	Cyclopropane-fatty-acyl-phospholipid synthase	AM1_4540	Acaryochloris marina (strain MBIC 11017)
80	B1WZZ6_CYAA5 (B1WZZ6)	6e-21	105	30%	UniProt GenBank	Cyclopropane-fatty-acyl-phospholipid synthase	cce_3547	Cyanothece sp. (strain ATCC 51142)
81	Q5MP01_9BACT (Q5MP01)	8e-21	105	28%	UniProt GenBank	OnnH	onnH	symbiont bacterium of Theonella swinhoei
82	B5W857_SPIMA (B5W857)	9e-21	105	31%	UniProt GenBank	Methyltransferase type 11	AmaxDRAFT_4957	Arthrospira maxima CS-328
83	A6SD04_BOTFB (A6SD04)	1e-20	105	33%	UniProt GenBank	Putative uncharacterized protein	BC1G_10646	Botryotinia fuckeliana (strain B05.10) Noble rot fungus Botrytis cinerea
84	F2L8L4_BURGA (F2L8L4)	1e-20	104	34%	UniProt GenBank	Putative methyltransferase	bgla_1g21560	Burkholderia gladioli BSR3
85	Q0UIH1_PHANO (Q0UIH1)	1e-20	104	37%	UniProt GenBank	Putative uncharacterized protein	SNOG_08443	Phaeosphaeria nodorum (strain SN15 / FGSC 10173) Glume blotch fungus Septoria nodorum
86	D3B2B8_POLPA (D3B2B8)	2e-20	104	31%	UniProt GenBank	Sterol 24-C-methyltransferase	PPL_02527	Polysphondylium pallidum Cellular slime mold
87	Q7NC89_GLOVI (Q7NC89)	2e-20	104	33%	UniProt GenBank	Gamma-tocopherol methyltransferase	glr3090	Gloeobacter violaceus
88	Q2U0V6_ASPOR (Q2U0V6)	2e-20	103	31%	UniProt GenBank	SAM-dependent methyltransferases	AO090011000289	Aspergillus oryzae (strain ATCC 42149 / RIB 40)
89	B8NCE8_ASPFN (B8NCE8)	2e-20	103	31%	UniProt GenBank	Sterol 24-c-methyltransferase, putative	AFLA_041230	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
90	E4ZIQ5_LEPMJ (E4ZIQ5)	2e-20	103	37%	UniProt GenBank	Similar to sterol 24-c-methyltransferase	Lema_P061100.1	Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) Blackleg fungus Phoma lingam
91	D8R439_SELML (D8R439)	4e-20	103	29%	UniProt GenBank	Putative uncharacterized protein	SELMODRAFT_167817	Selaginella moellendorffii Spikemoss
92	B8N7F5_ASPFN (B8N7F5)	5e-20	102	36%	UniProt GenBank	Tocopherol O-methyltransferase, putative	AFLA_021770	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
93	Q2HF89_CHAGB (Q2HF89)	6e-20	102	40%	UniProt GenBank	Putative uncharacterized protein	CHGG_01115	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) Soil fungus
94	Q2UBN2_ASPOR (Q2UBN2)	7e-20	102	36%	UniProt GenBank	SAM-dependent methyltransferases	AO090012000932	Aspergillus oryzae (strain ATCC 42149 / RIB 40)
95	C7Z6E0_NECH7 (C7Z6E0)	7e-20	102	30%	UniProt GenBank	Predicted protein	NECHADRAFT_33136	Nectria haematococca (strain 77-13-4 / FGSC 9596 / MPVI) Fusarium solani subsp. pisi
96	A3IQT5_9CHRO (A3IQT5)	8e-20	102	29%	UniProt GenBank	Cyclopropane-fatty-acyl-phospholipid synthase	CY0110_12772	Cyanothece sp. CCY0110
97	A4S821_OSTLU (A4S821)	8e-20	102	32%	UniProt GenBank	Predicted protein	OSTLU_40586	Ostreococcus lucimarinus (strain CCE9901)
98	B7S0E6_9GAMM (B7S0E6)	9e-20	102	29%	UniProt GenBank	Cyclopropane-fatty-acyl-phospholipid synthase superfamily protein	GPB2148_1046	marine gamma proteobacterium HTCC2148	2.1.1.79 niceE keggE
99	C9SVI5_VERA1 (C9SVI5)	1e-19	102	38%	UniProt GenBank	Sterol 24-C-methyltransferase	VDBG_08910	Verticillium albo-atrum (strain VaMs.102) Verticillium wilt
100	F0XBV8_GROCL (F0XBV8)	1e-19	102	37%	UniProt GenBank	Sterol 24-c-methyltransferase	CMQ_5152	Grosmannia clavigera (strain kw1407 / UAMH 11150) Blue stain fungus Graphiocladiella clavigera

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q9S0N6_STRAW
(Q9S0N6)

1e-161

571

100%

Product: C5-O-methyltransferase
Gene: aveD
SAV937
SAV_937
Organism: Streptomyces avermitilis

[pubmed all]
1uniprot[Pubmed] 10449723 [Medline] 99380548 Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.(Proc. Natl. Acad. Sci. U.S.A.) [1999]
2uniprot[Pubmed] 9469930 [Medline] 98137789 Cloning of the gene encoding avermectin B 5-O-methyltransferase in avermectin-producing Streptomyces avermitilis.(Gene) [1998]
3uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001]
4uniprot[Pubmed] 12692562 [Medline] 22608306 Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003]

Q6TKG5_9ACTO
(Q6TKG5)

2e-76

290

60%

Product: C5-O-methyltransferase
Gene: milD
Organism: Streptomyces griseochromogenes

1uniprot
Sceening of the gene cluster for milbemycin biosynthesis from Streptomyces griseochromogenes.(Shenyang Yao Ke Da Xue Xue Bao) [2001]

D7C489_STRBB
(D7C489)

6e-76

288

58%

Product: C5-O-methyltransferase
Gene: milD
SBI_00790
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

D6C4C6_9ACTO
(D6C4C6)

2e-75

287

59%

Product: C5-O-methyltransferase
Gene: meiD
Organism: Streptomyces nanchangensis

[pubmed all]
1uniprot[Pubmed] 12811466 [Medline] 22777186 Identification of a gene cluster encoding meilingmycin biosynthesis among multiple polyketide synthase contigs isolated from Streptomyces nanchangensis NS3226.(Arch. Microbiol.) [2003]
2uniprot[Pubmed] 20348291 Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification.(Appl. Environ. Microbiol.) [2010]

Q9X5Q9_STRLA
(Q9X5Q9)

7e-48

195

42%

Product: MitM
Gene: mitM
Organism: Streptomyces lavendulae

1uniprot[Pubmed] 10099135 [Medline] 99201491
Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564.(Chem. Biol.) [1999]

E0D208_9ACTO
(E0D208)

3e-46

189

41%

Product: Methyltransferase
Gene: gfsG
Organism: Streptomyces graminofaciens

1uniprot[Pubmed] 20589823
Cloning and characterization of the biosynthetic gene cluster of 16-membered macrolide antibiotic FD-891: involvement of a dual functional cytochrome P450 monooxygenase catalyzing epoxidation and hydroxylation.(Chembiochem) [2010]

D0U2E8_STRPT
(D0U2E8)

3e-46

189

42%

Product: O-methyl transferase
Gene
Organism: Streptomyces platensis subsp. rosaceus

1uniprot[Pubmed] 19726666
iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase.(J. Biol. Chem.) [2009]

D8HZB5_AMYMU
(D8HZB5)

3e-46

189

41%

Product: Methyltransferase type 11
Gene: AMED_0650
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

O52570_AMYMD
(O52570)

4e-46

189

41%

Product: C-27 O-methyltransferase
Gene
Organism: Amycolatopsis mediterranei
Nocardia mediterranei

[pubmed all]
1uniprot[Pubmed] 9512878 [Medline] 98174059 Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.(Chem. Biol.) [1998]
2uniprot[Pubmed] 9497318 [Medline] 98165773 3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.(J. Biol. Chem.) [1998]
3uniprot[Pubmed] 11278540 [Medline] 21201076 Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699.(J. Biol. Chem.) [2001]

Q0H2W9_9ACTO
(Q0H2W9)

7e-46

188

42%

Product: D-glucose O-methyltransferase
Gene: atM
Organism: Actinomadura melliaura

1uniprot[Pubmed] 16873021
Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.(Chem. Biol.) [2006]

A8LFZ5_FRASN
(A8LFZ5)

4e-45

186

43%

Product: Methyltransferase type 11
Gene: Franean1_4832
Organism: Frankia sp. (strain EAN1pec)

1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]

E9KTL3_9ACTO
(E9KTL3)

1e-44

184

39%

Product: SnogM
Gene: Tcs_55098_015
Organism: Streptomyces sp. ATCC 55098

1uniprot[Pubmed] 21175203
Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.(J. Am. Chem. Soc.) [2011]

D5SJT8_STRCL
(D5SJT8)

1e-43

181

43%

Product: Methyltransferase
Gene: SCLAV_p0694
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot
The sequence of a 1.8 Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

Q27W70_STRVO
(Q27W70)

2e-43

181

40%

Product: NigE
Gene
Organism: Streptomyces violaceoniger

1uniprot[Pubmed] 17584617
Insights into Polyether Biosynthesis from Analysis of the Nigericin Biosynthetic Gene Cluster in Streptomyces sp. DSM4137.(Chem. Biol.) [2007]

Q83X76_STRRO
(Q83X76)

4e-43

179

44%

Product: Putative NDP-hexose 3-O-methyltransferase
Gene: lkmG
Organism: Streptomyces rochei
Streptomyces parvullus

[pubmed all]
1uniprot[Pubmed] 12791134 [Medline] 22676866 The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003]
2uniprot[Pubmed] 10954087 [Medline] 20408175 Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000]
3uniprot[Pubmed] 10767533 [Medline] 20231737 Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000]
4uniprot[Pubmed] 9836424 [Medline] 99053144 Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998]

Q8KZ94_NOCAE
(Q8KZ94)

4e-43

179

42%

Product: Putative D-glucose O-methyltransferase
Gene: rebM
Organism: Lechevalieria aerocolonigenes
Nocardia aerocolonigenes
Saccharothrix aerocolonigenes

[pubmed all]
1uniprot[Pubmed] 15743957 Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243.(J. Bacteriol.) [2005]
2uniprot[Pubmed] 18502766 Structure and mechanism of the rebeccamycin sugar 4'-O-methyltransferase RebM.(J. Biol. Chem.) [2008]

Q8KI52_NOCAE
(Q8KI52)

6e-43

179

42%

Product: Methyltransferase
Putative methyltransferase
RebM
Gene: rbmF
rebM
Organism: Lechevalieria aerocolonigenes
Nocardia aerocolonigenes
Saccharothrix aerocolonigenes

[pubmed all]
1uniprot[Pubmed] 11983340 [Medline] 21979046 The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives.(Chem. Biol.) [2002]
2uniprot[Pubmed] 12619684 [Medline] 22506660 Characterization of the biosynthetic gene cluster of rebeccamycin from Lechevalieria aerocolonigenes ATCC 39243.(Biosci. Biotechnol. Biochem.) [2003]
3uniprot[Pubmed] 14763561 pTOYAMAcos, pTYM18, and pTYM19, actinomycete-Escherichia coli integrating vectors for heterologous gene expression.(J. Antibiot.) [2003]
4uniprot[Pubmed] 12617516 [Medline] 22504382 Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.(J. Antibiot.) [2002]
5uniprot Direct formation of chromopyrrolic acid from indole-3-pyruvic acid by StaD, a novel hemoprotein in indolocarbazole biosynthesis.(Tetrahedron Lett.) [2006]
6uniprot Biosynthesis of heterocyclic antibiotics in actinomycetes and an approach to synthesize the natural compounds.(Nihon Hosenkin Gakkaishi) [2006]

E9KTK3_9ACTO
(E9KTK3)

1e-41

174

41%

Product: Putative D-glucose O-methyltransferase
Gene: Tcs_55098_005
Organism: Streptomyces sp. ATCC 55098

Q846Y0_STRCM
(Q846Y0)

4e-40

169

37%

Product: Monensin 3-O-methyl transferase
Gene: monE
Organism: Streptomyces cinnamonensis

1uniprot[Pubmed] 12940979 [Medline] 22823264
Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization.(Mol. Microbiol.) [2003]

2uniprot
The gene cluster for monensin biosynthesis. [1999]

D5SL07_STRCL
(D5SL07)

1e-39

168

42%

Product: Staurosporine biosynthesis methyltransferase StaMA
Gene: staMA
SCLAV_p1114
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot
The sequence of a 1.8 Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

Q83WF7_9ACTO
(Q83WF7)

1e-39

168

37%

Product: Methyltransferase
Gene: staMB
Organism: Streptomyces sp. TP-A0274

[pubmed all]
1uniprot Direct formation of chromopyrrolic acid from indole-3-pyruvic acid by StaD, a novel hemoprotein in indolocarbazole biosynthesis.(Tetrahedron Lett.) [2006]
2uniprot Biosynthesis of heterocyclic antibiotics in actinomycetes and an approach to synthesize the natural compounds.(Nihon Hosenkin Gakkaishi) [2006]
3uniprot[Pubmed] 12617516 [Medline] 22504382 Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.(J. Antibiot.) [2002]
4uniprot Characterization of the biosynthetic gene cluster of rebecamycin from Lechevalieria aerocolonigenes ATCC 39243.(Biosci. Biotechnol. Biochem.) [2003]
5uniprot[Pubmed] 16195595 Cytochrome P450 homolog is responsible for C-N bond formation between aglycone and deoxysugar in the staurosporine biosynthesis of Streptomyces sp. TP-A0274.(Biosci. Biotechnol. Biochem.) [2005]

Q9ALM7_9PSEU
(Q9ALM7)

3e-39

166

39%

Product: Methyltransferase-like protein
Gene: spnF
Organism: Saccharopolyspora spinosa

1uniprot[Pubmed] 11358695 [Medline] 21257765
Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001]

Q4JHR3_9PSEU
(Q4JHR3)

6e-39

165

37%

Product: BusF
Gene: busF
Organism: Saccharopolyspora pogona

1uniprot[Pubmed] 16179985
Butenyl-spinosyns, a natural example of genetic engineering of antibiotic biosynthetic genes.(J. Ind. Microbiol. Biotechnol.) [2006]

C6W8T2_ACTMD
(C6W8T2)

7e-39

165

44%

Product: Methyltransferase type 11
Gene: Amir_3275
Organism: Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)

1uniprot
Complete genome sequence of Actinosynnema mirum type strain (101).(Stand. Genomic Sci.) [2009]

Q83WG2_9ACTO
(Q83WG2)

5e-38

162

39%

Product: Methyltransferase
Gene: staMA
Organism: Streptomyces sp. TP-A0274

[pubmed all]
1uniprot Direct formation of chromopyrrolic acid from indole-3-pyruvic acid by StaD, a novel hemoprotein in indolocarbazole biosynthesis.(Tetrahedron Lett.) [2006]
2uniprot Biosynthesis of heterocyclic antibiotics in actinomycetes and an approach to synthesize the natural compounds.(Nihon Hosenkin Gakkaishi) [2006]
3uniprot[Pubmed] 12617516 [Medline] 22504382 Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.(J. Antibiot.) [2002]
4uniprot Characterization of the biosynthetic gene cluster of rebecamycin from Lechevalieria aerocolonigenes ATCC 39243.(Biosci. Biotechnol. Biochem.) [2003]
5uniprot[Pubmed] 16195595 Cytochrome P450 homolog is responsible for C-N bond formation between aglycone and deoxysugar in the staurosporine biosynthesis of Streptomyces sp. TP-A0274.(Biosci. Biotechnol. Biochem.) [2005]

Q9X5Q8_STRLA
(Q9X5Q8)

1e-37

161

38%

Product: MitN
Gene: mitN
Organism: Streptomyces lavendulae

B5GZG7_STRCL
(B5GZG7)

6e-37

159

38%

Product: Methyltransferase
Gene: SCLAV_4762
SSCG_04741
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot[Pubmed] 20624727
The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

D5SL02_STRCL
(D5SL02)

1e-36

157

43%

Product: Staurosporine biosynthesis methyltransferase StaMB
Gene: staMB
SCLAV_p1109
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot
The sequence of a 1.8 Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

C6W8T1_ACTMD
(C6W8T1)

2e-35

153

41%

Product: Methyltransferase type 11
Gene: Amir_3274
Organism: Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)

1uniprot
Complete genome sequence of Actinosynnema mirum type strain (101).(Stand. Genomic Sci.) [2009]

D5SKC5_STRCL
(D5SKC5)

1e-32

144

34%

Product: Methyltransferase type 11
Gene: SCLAV_p0882
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot
The sequence of a 1.8 Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

Q3LRL2_9DELT
(Q3LRL2)

3e-30

137

36%

Product: MmxM
Gene: mmxM
Organism: Cystobacter fuscus

1uniprot[Pubmed] 16556988
Biosynthesis of 2'-O-methylmyxalamide D in the myxobacterium Cystobacter fuscus: a polyketide synthase-nonribosomal peptide synthetase system for the myxalamide D skeleton and a methyltransferase for the final O-methylation.(Biosci. Biotechnol. Biochem.) [2006]

Q9ALN3_9PSEU
(Q9ALN3)

8e-27

125

31%

Product: Methyltransferase-like protein
Gene: spnL
Organism: Saccharopolyspora spinosa

1uniprot[Pubmed] 11358695 [Medline] 21257765
Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001]

Q4JHQ7_9PSEU
(Q4JHQ7)

2e-26

124

31%

Product: BusL
Gene: busL
Organism: Saccharopolyspora pogona

1uniprot[Pubmed] 16179985
Butenyl-spinosyns, a natural example of genetic engineering of antibiotic biosynthetic genes.(J. Ind. Microbiol. Biotechnol.) [2006]

C7Q6F0_CATAD
(C7Q6F0)

4e-26

122

37%

Product: Methyltransferase type 11
Gene: Caci_3249
Organism: Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)

1uniprot
Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009]

F0ZN82_DICPU
(F0ZN82)

5e-24

116

34%

Product: Putative uncharacterized protein
Gene: DICPUDRAFT_79655
Organism: Dictyostelium purpureum
Slime mold

1uniprot[Pubmed] 21356102
Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum.(Genome Biol.) [2011]

E3RR62_PYRTT
(E3RR62)

6e-23

112

34%

Product: Putative uncharacterized protein
Gene: PTT_11273
Organism: Pyrenophora teres f. teres (strain 0-1)
Barley net blotch fungus
Drechslera teres f. teres

1uniprot[Pubmed] 21067574
A first genome assembly of the barley fungal pathogen Pyrenophora teres f. teres.(Genome Biol.) [2010]

A9NQ25_PICSI
(A9NQ25)

8e-23

112

30%

Product: Putative uncharacterized protein
Gene
Organism: Picea sitchensis
Sitka spruce
Pinus sitchensis

1uniprot[Pubmed] 18854048
A conifer genomics resource of 200,000 spruce (Picea spp.) ESTs and 6,464 high-quality, sequence-finished full-length cDNAs for Sitka spruce (Picea sitchensis).(BMC Genomics) [2008]

E1ZM43_9CHLO
(E1ZM43)

1e-22

111

31%

Product: Putative uncharacterized protein
Gene: CHLNCDRAFT_26131
Organism: Chlorella variabilis

1uniprot[Pubmed] 20852019
The Chlorella variabilis NC64A genome reveals adaptation to photosymbiosis, coevolution with viruses, and cryptic sex.(Plant Cell) [2010]

E9ES52_METAR
(E9ES52)

3e-22

110

32%

Product: Sterol 24-c-methyltransferase, putative
Gene: MAA_02798
Organism: Metarhizium robertsii (strain ARSEF 23)
Metarhizium anisopliae

1uniprot[Pubmed] 21253567
Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum.(PLoS Genet.) [2011]

Q553T0_DICDI
(Q553T0)

1e-21

108

31%

Product: Putative uncharacterized protein
Gene: DDB_0202574
DDB_G0275359
Organism: Dictyostelium discoideum
Slime mold

[pubmed all]
1uniprot[Pubmed] 15875012 The genome of the social amoeba Dictyostelium discoideum.(Nature) [2005]
2uniprot[Pubmed] 12097910 [Medline] 22092622 Sequence and analysis of chromosome 2 of Dictyostelium discoideum.(Nature) [2002]

B0JHF8_MICAN
(B0JHF8)

2e-21

107

33%

Product: Tocopherol O-methyltransferase
Gene: MAE_24880
Organism: Microcystis aeruginosa (strain NIES-843)

1uniprot[Pubmed] 18192279
Complete genomic structure of the bloom-forming toxic cyanobacterium Microcystis aeruginosa NIES-843.(DNA Res.) [2007]

Q2JSI4_SYNJA
(Q2JSI4)

3e-21

106

30%

Product: Cyclopropane-fatty-acyl-phospholipid synthase family protein
Gene: CYA_2254
Organism: Synechococcus sp. (strain JA-3-3Ab)
Cyanobacteria bacterium Yellowstone A-Prime

[pubmed all]
1uniprot[Pubmed] 18059494 Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses.(ISME J.) [2007]
2uniprot[Pubmed] 16467157 In situ analysis of nitrogen fixation and metabolic switching in unicellular thermophilic cyanobacteria inhabiting hot spring microbial mats.(Proc. Natl. Acad. Sci. U.S.A.) [2006]
3uniprot[Pubmed] 16391090 Effect of temperature and light on growth of and photosynthesis by Synechococcus isolates typical of those predominating in the Octopus Spring microbial mat community of Yellowstone National Park.(Appl. Environ. Microbiol.) [2006]

B0BZ72_ACAM1
(B0BZ72)

4e-21

106

36%

Product: Cyclopropane-fatty-acyl-phospholipid synthase
Gene: AM1_4540
Organism: Acaryochloris marina (strain MBIC 11017)

1uniprot[Pubmed] 18252824
Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina.(Proc. Natl. Acad. Sci. U.S.A.) [2008]

B1WZZ6_CYAA5
(B1WZZ6)

6e-21

105

30%

Product: Cyclopropane-fatty-acyl-phospholipid synthase
Gene: cce_3547
Organism: Cyanothece sp. (strain ATCC 51142)

1uniprot[Pubmed] 18812508
The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium important in the marine nitrogen cycle.(Proc. Natl. Acad. Sci. U.S.A.) [2008]

Q5MP01_9BACT
(Q5MP01)

8e-21

105

28%

Product: OnnH
Gene: onnH
Organism: symbiont bacterium of Theonella swinhoei

1uniprot[Pubmed] 15520376
Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei.(Proc. Natl. Acad. Sci. U.S.A.) [2004]

F2L8L4_BURGA
(F2L8L4)

1e-20

104

34%

Product: Putative methyltransferase
Gene: bgla_1g21560
Organism: Burkholderia gladioli BSR3

1uniprot[Pubmed] 21478339
Complete Genome Sequence of Burkholderia gladioli BSR3.(J. Bacteriol.) [2011]

Q0UIH1_PHANO
(Q0UIH1)

1e-20

104

37%

Product: Putative uncharacterized protein
Gene: SNOG_08443
Organism: Phaeosphaeria nodorum (strain SN15 / FGSC 10173)
Glume blotch fungus
Septoria nodorum

1uniprot[Pubmed] 18024570
Dothideomycete-plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum.(Plant Cell) [2007]

Q7NC89_GLOVI
(Q7NC89)

2e-20

104

33%

Product: Gamma-tocopherol methyltransferase
Gene: glr3090
Organism: Gloeobacter violaceus

1uniprot[Pubmed] 14621292 [Medline] 22977040
Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids.(DNA Res.) [2003]

Q2U0V6_ASPOR
(Q2U0V6)

2e-20

103

31%

Product: SAM-dependent methyltransferases
Gene: AO090011000289
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40)

1uniprot[Pubmed] 16372010
Genome sequencing and analysis of Aspergillus oryzae.(Nature) [2005]

D8R439_SELML
(D8R439)

4e-20

103

29%

Product: Putative uncharacterized protein
Gene: SELMODRAFT_167817
Organism: Selaginella moellendorffii
Spikemoss

1uniprot[Pubmed] 21551031
The Selaginella genome identifies genetic changes associated with the evolution of vascular plants.(Science) [2011]

Q2UBN2_ASPOR
(Q2UBN2)

7e-20

102

36%

Product: SAM-dependent methyltransferases
Gene: AO090012000932
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40)

1uniprot[Pubmed] 16372010
Genome sequencing and analysis of Aspergillus oryzae.(Nature) [2005]

C7Z6E0_NECH7
(C7Z6E0)

7e-20

102

30%

Product: Predicted protein
Gene: NECHADRAFT_33136
Organism: Nectria haematococca (strain 77-13-4 / FGSC 9596 / MPVI)
Fusarium solani subsp. pisi

1uniprot[Pubmed] 19714214
The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion.(PLoS Genet.) [2009]

A4S821_OSTLU
(A4S821)

8e-20

102

32%

Product: Predicted protein
Gene: OSTLU_40586
Organism: Ostreococcus lucimarinus (strain CCE9901)

1uniprot[Pubmed] 17460045
The tiny eukaryote Ostreococcus provides genomic insights into the paradox of plankton speciation.(Proc. Natl. Acad. Sci. U.S.A.) [2007]

100

F0XBV8_GROCL
(F0XBV8)

1e-19

102

37%

Product: Sterol 24-c-methyltransferase
Gene: CMQ_5152
Organism: Grosmannia clavigera (strain kw1407 / UAMH 11150)
Blue stain fungus
Graphiocladiella clavigera

1uniprot[Pubmed] 21262841
Genome and transcriptome analyses of the mountain pine beetle-fungal symbiont Grosmannia clavigera, a lodgepole pine pathogen.(Proc. Natl. Acad. Sci. U.S.A.) [2011]