BLAST table : Adria_00260

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism
1	Q54813_STRPE (Q54813)	5e-68	260	100%	UniProt GenBank	Anthraquinol monooxygenase		Streptomyces peucetius
2	Q55222_STRSQ (Q55222)	3e-56	221	89%	UniProt GenBank	Oxygenase	dauA	Streptomyces sp
3	Q67G52_9ACTO (Q67G52)	2e-20	102	51%	UniProt GenBank	Anthrone oxygenase		Streptomyces griseoruber
4	Q8VWB4_9ACTO (Q8VWB4)	2e-19	99.4	49%	UniProt GenBank	AknX	aknX	Streptomyces galilaeus
5	Q9L552_9ACTO (Q9L552)	3e-18	95.5	48%	UniProt GenBank	AknX	aknX	Streptomyces galilaeus
6	O54259_STRNO (O54259)	5e-18	94.7	46%	UniProt GenBank	SnoaB	SnoaB	Streptomyces nogalater
7	B5G887_9ACTO (B5G887)	5e-18	94.7	50%	UniProt GenBank	Antibiotic biosynthesis monooxygenase subfamily	SSBG_00495	Streptomyces sp. SPB74
8	D9UBN4_STRPR (D9UBN4)	1e-17	92.8	54%	UniProt GenBank	Putative oxygenase	c101_13	Streptomyces pristinaespiralis
9	D6X7X8_STRPR (D6X7X8)	1e-17	92.8	54%	UniProt GenBank	Predicted protein	SSDG_07511	Streptomyces pristinaespiralis ATCC 25486
10	Q2PA06_9ACTO (Q2PA06)	3e-17	92	44%	UniProt GenBank	Monooxygenase	stfOI	Streptomyces steffisburgensis
11	Q2PZS0_9ACTO (Q2PZS0)	1e-15	86.7	48%	UniProt GenBank	CosX	cosX	Streptomyces olindensis
12	D1A6U1_THECD (D1A6U1)	4e-14	81.6	50%	UniProt GenBank	Antibiotic biosynthesis monooxygenase	Tcur_2800	Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
13	Q4R0L6_STRCX (Q4R0L6)	1e-11	73.2	46%	UniProt GenBank	ChaH protein	chaH	Streptomyces chartreusis
14	E8RWT7_MICSL (E8RWT7)	4e-11	71.6	49%	UniProt GenBank	Antibiotic biosynthesis monooxygenase	ML5_4426	Micromonospora sp. (strain L5)
15	D9T292_MICAI (D9T292)	4e-11	71.6	49%	UniProt GenBank	Antibiotic biosynthesis monooxygenase	Micau_3995	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
16	Q194R0_STRAA (Q194R0)	8e-08	60.5	36%	UniProt GenBank	Oxygenase	mtmOIII	Streptomyces argillaceus
17	Q399I3_BURS3 (Q399I3)	4e-07	58.2	36%	UniProt GenBank	Antibiotic biosynthesis monooxygenase	Bcep18194_B0764	Burkholderia sp. (strain 383) Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)
18	A2W3S6_9BURK (A2W3S6)	6e-07	57.8	34%	UniProt GenBank	Putative uncharacterized protein	BCPG_05014	Burkholderia cenocepacia PC184
19	Q3S8Q8_STRRM (Q3S8Q8)	6e-07	57.8	37%	UniProt GenBank	OxyG	oxyG	Streptomyces rimosus
20	B4EFW0_BURCJ (B4EFW0)	1e-06	56.6	34%	UniProt GenBank	Putative monooxygenase	BceJ2315_56000 BCAM2163	Burkholderia cepacia (strain J2315 / LMG 16656) Burkholderia cenocepacia (strain J2315)
21	Q1BPX1_BURCA (Q1BPX1)	1e-06	56.6	33%	UniProt GenBank	Antibiotic biosynthesis monooxygenase	Bcen_3440	Burkholderia cenocepacia (strain AU 1054)
22	A0B1Y5_BURCH (A0B1Y5)	1e-06	56.6	33%	UniProt GenBank	Antibiotic biosynthesis monooxygenase	Bcen2424_4927	Burkholderia cenocepacia (strain HI2424)
23	B1K833_BURCC (B1K833)	2e-06	56.2	33%	UniProt GenBank	Antibiotic biosynthesis monooxygenase	Bcenmc03_5360	Burkholderia cenocepacia (strain MC0-3)
24	Q0B7G2_BURCM (Q0B7G2)	5e-06	54.7	36%	UniProt GenBank	Antibiotic biosynthesis monooxygenase	Bamb_4359	Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) Burkholderia cepacia (strain AMMD)
25	B1FL90_9BURK (B1FL90)	5e-06	54.7	36%	UniProt GenBank	Antibiotic biosynthesis monooxygenase	BamIOP4010DRAFT_4801	Burkholderia ambifaria IOP40-10
26	B1YZ27_BURA4 (B1YZ27)	5e-06	54.7	36%	UniProt GenBank	Antibiotic biosynthesis monooxygenase	BamMC406_4876	Burkholderia ambifaria (strain MC40-6)
27	E8W960_STRFA (E8W960)	5e-06	54.7	32%	UniProt GenBank	AMP-dependent synthetase and ligase	Sfla_5326	Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD)
28	B5WK68_9BURK (B5WK68)	1e-05	53.1	36%	UniProt GenBank	Antibiotic biosynthesis monooxygenase	BH160DRAFT_3471	Burkholderia sp. H160
29	D9UBK9_STRPR (D9UBK9)	2e-05	52.8	36%	UniProt GenBank	Putative oxygenase	c104_05c	Streptomyces pristinaespiralis
30	B5HJX8_STRPR (B5HJX8)	2e-05	52.8	36%	UniProt GenBank	Oxygenase	SSDG_05475	Streptomyces pristinaespiralis ATCC 25486
31	Q1MEI2_RHIL3 (Q1MEI2)	3e-05	52	33%	UniProt GenBank	Putative monooxygenase	RL3157	Rhizobium leguminosarum bv. viciae (strain 3841)
32	D5QF00_GLUHA (D5QF00)	5e-05	51.2	32%	UniProt GenBank	Antibiotic biosynthesis monooxygenase	GXY_08579	Gluconacetobacter hansenii ATCC 23769
33	Q8XYB2_RALSO (Q8XYB2)	8e-05	50.8	34%	UniProt GenBank	Hypothetical transmembrane protein	RSc1850	Ralstonia solanacearum Pseudomonas solanacearum
34	C0JWC9_9ACTO (C0JWC9)	0.0001	50.1	30%	UniProt GenBank	PokO3	pokO3	Streptomyces diastatochromogenes
35	F8GXJ6_CUPNE (F8GXJ6)	0.0005	48.1	32%	UniProt GenBank	Monooxygenase	CNE_BB1p06460	Cupriavidus necator N-1

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q54813_STRPE
(Q54813)

5e-68

260

100%

Product: Anthraquinol monooxygenase
Gene
Organism: Streptomyces peucetius

1uniprot[Pubmed] 7828855 [Medline] 95129838
Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase.(Gene) [1994]

Q55222_STRSQ
(Q55222)

3e-56

221

89%

Product: Oxygenase
Gene: dauA
Organism: Streptomyces sp

1uniprot[Pubmed] 7928998 [Medline] 95014072
Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5.(J. Bacteriol.) [1994]

Q67G52_9ACTO
(Q67G52)

2e-20

102

51%

Product: Anthrone oxygenase
Gene
Organism: Streptomyces griseoruber

1uniprot[Pubmed] 15271354
The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004]

Q8VWB4_9ACTO
(Q8VWB4)

2e-19

99.4

49%

Product: AknX
Gene: aknX
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 12399480 [Medline] 22286521
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002]

Q9L552_9ACTO
(Q9L552)

3e-18

95.5

48%

Product: AknX
Gene: aknX
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 12137949 [Medline] 22133312
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002]

O54259_STRNO
(O54259)

5e-18

94.7

46%

Product: SnoaB
Gene: SnoaB
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 8668120 [Medline] 96242142 A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996]
2uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
3uniprot[Pubmed] 8760909 [Medline] 96349102 Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996]
4uniprot[Pubmed] 20052967 Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism.(Biochemistry) [2010]

D9UBN4_STRPR
(D9UBN4)

1e-17

92.8

54%

Product: Putative oxygenase
Gene: c101_13
Organism: Streptomyces pristinaespiralis

1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]

Q2PA06_9ACTO
(Q2PA06)

3e-17

44%

Product: Monooxygenase
Gene: stfOI
Organism: Streptomyces steffisburgensis

1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006]

Q2PZS0_9ACTO
(Q2PZS0)

1e-15

86.7

48%

Product: CosX
Gene: cosX
Organism: Streptomyces olindensis

1uniprot[Pubmed] 16810496
Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes.(Appl. Microbiol. Biotechnol.) [2006]

D1A6U1_THECD
(D1A6U1)

4e-14

81.6

50%

Product: Antibiotic biosynthesis monooxygenase
Gene: Tcur_2800
Organism: Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)

1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]

Q4R0L6_STRCX
(Q4R0L6)

1e-11

73.2

46%

Product: ChaH protein
Gene: chaH
Organism: Streptomyces chartreusis

1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]

Q194R0_STRAA
(Q194R0)

8e-08

60.5

36%

Product: Oxygenase
Gene: mtmOIII
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

Q3S8Q8_STRRM
(Q3S8Q8)

6e-07

57.8

37%

Product: OxyG
Gene: oxyG
Organism: Streptomyces rimosus

1uniprot[Pubmed] 16597959
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006]

D9UBK9_STRPR
(D9UBK9)

2e-05

52.8

36%

Product: Putative oxygenase
Gene: c104_05c
Organism: Streptomyces pristinaespiralis

1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]

Q1MEI2_RHIL3
(Q1MEI2)

3e-05

33%

Product: Putative monooxygenase
Gene: RL3157
Organism: Rhizobium leguminosarum bv. viciae (strain 3841)

1uniprot[Pubmed] 16640791
The genome of Rhizobium leguminosarum has recognizable core and accessory components.(Genome Biol.) [2006]

D5QF00_GLUHA
(D5QF00)

5e-05

51.2

32%

Product: Antibiotic biosynthesis monooxygenase
Gene: GXY_08579
Organism: Gluconacetobacter hansenii ATCC 23769

1uniprot[Pubmed] 20543071
Genome sequence of a cellulose-producing bacterium, Gluconacetobacter hansenii ATCC 23769.(J. Bacteriol.) [2010]

Q8XYB2_RALSO
(Q8XYB2)

8e-05

50.8

34%

Product: Hypothetical transmembrane protein
Gene: RSc1850
Organism: Ralstonia solanacearum
Pseudomonas solanacearum

1uniprot[Pubmed] 11823852 [Medline] 21681879
Genome sequence of the plant pathogen Ralstonia solanacearum.(Nature) [2002]

C0JWC9_9ACTO
(C0JWC9)

0.0001

50.1

30%

Product: PokO3
Gene: pokO3
Organism: Streptomyces diastatochromogenes

1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]