BLAST table : Tauto_00230

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism
1	C0SMX6_9ACTO (C0SMX6)	0.0	696	100%	UniProt GenBank	Predicted transcriptional regulator protein	ttmQ	Streptomyces spiroverticillatus
2	Q8GI86_STRKA (Q8GI86)	1e-54	218	43%	UniProt GenBank	Transcriptional regulator protein	kasT	Streptomyces kasugaensis
3	E9L1J6_9ZZZZ (E9L1J6)	1e-54	218	47%	UniProt GenBank	Putative uncharacterized protein	CA37-52	uncultured organism CA37
4	A7VMW2_STRKA (A7VMW2)	1e-54	218	43%	UniProt GenBank	Putative transcriptional regulator	kasT	Streptomyces kasugaensis
5	D6A435_9ACTO (D6A435)	5e-54	216	40%	UniProt GenBank	Str/sts-gene cluster transcriptional regulator StrR	SSFG_06826	Streptomyces ghanaensis ATCC 14672
6	E9L1J5_9ZZZZ (E9L1J5)	5e-54	216	46%	UniProt GenBank	Putative uncharacterized protein	CA37-51	uncultured organism CA37
7	D9WU16_9ACTO (D9WU16)	1e-51	208	43%	UniProt GenBank	Putative uncharacterized protein	SSOG_01976	Streptomyces himastatinicus ATCC 53653
8	Q06Z05_9ACTO (Q06Z05)	3e-50	204	43%	UniProt GenBank	Putative uncharacterized protein		Streptomyces fungicidicus
9	Q83XA1_STRRO (Q83XA1)	7e-50	202	42%	UniProt GenBank	StrR-like regulatory protein		Streptomyces rochei Streptomyces parvullus
10	Q93N91_STRLA (Q93N91)	4e-49	200	40%	UniProt GenBank	Transcriptional regulator		Streptomyces lavendulae
11	D8V3N4_ACTLG (D8V3N4)	4e-49	199	42%	UniProt GenBank	Transcriptional regulator		Actinoplanes liguriae
12	F6K0Y3_9BACT (F6K0Y3)	6e-49	199	41%	UniProt GenBank	Streptomycin biosynthesis operon regulator		uncultured bacterium BAC AB649/1850
13	D9W4I4_9ACTO (D9W4I4)	2e-48	197	42%	UniProt GenBank	Streptomycin biosynthesis operon regulator	SSNG_07064	Streptomyces sp. C
14	Q6ZZH8_ACTTI (Q6ZZH8)	3e-48	197	39%	UniProt GenBank	Transcriptional regulator Transcriptional regulator, StrR family	tcp28	Actinoplanes teichomyceticus
15	E9L1T0_9ZZZZ (E9L1T0)	4e-48	196	40%	UniProt GenBank	Putative uncharacterized protein	CA915-38	uncultured organism CA915
16	Q8KLK0_STRTO (Q8KLK0)	4e-48	196	40%	UniProt GenBank	StaQ		Streptomyces toyocaensis
17	D9XNK4_9ACTO (D9XNK4)	4e-48	196	43%	UniProt GenBank	Putative uncharacterized protein	SSRG_00961	Streptomyces griseoflavus Tu4000
18	Q54267_STRGA (Q54267)	6e-48	196	42%	UniProt GenBank	StrR StrR protein	strR	Streptomyces glaucescens
19	D3Y168_STRPT (D3Y168)	6e-48	196	39%	UniProt GenBank	Streptomycin biosynthesis operon regulator	strR	Streptomyces platensis
20	C4NYJ5_9ACTO (C4NYJ5)	1e-47	195	43%	UniProt GenBank	SaqI	saqI	Micromonospora sp. Tu 6368
21	Q27YR9_STRHY (Q27YR9)	1e-46	192	42%	UniProt GenBank	Putative regulatory protein		Streptomyces hygroscopicus
22	B1W378_STRGG (B1W378)	1e-46	191	40%	UniProt GenBank	Streptomycin biosynthesis operon regulator	strR SGR_5931	Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
23	Q53ID1_STRGR (Q53ID1)	1e-46	191	40%	UniProt GenBank	Str/sts-gene cluster transcriptional regulator StrR	strR SG7F10.21	Streptomyces griseus subsp. griseus
24	STRR_STRGR (P08076)	1e-46	191	40%	UniProt GenBank	Streptomycin biosynthesis operon possible regulatory protein	strR	Streptomyces griseus
25	Q7WZ87_9ACTO (Q7WZ87)	8e-46	189	37%	UniProt GenBank	Putative regulator StrR family	dbv4	Nonomuraea sp. ATCC 39727
26	E2D2E0_9BACT (E2D2E0)	2e-45	187	38%	UniProt GenBank	Transcriptional regulator		uncultured soil bacterium
27	P72440_STRNE (P72440)	2e-45	187	39%	UniProt GenBank	SpcR	spcR	Streptoverticillium netropsis Streptoverticillium flavopersicus
28	Q2JA59_FRASC (Q2JA59)	4e-45	186	37%	UniProt GenBank	ParB-like nuclease	Francci3_2466	Frankia sp. (strain CcI3)
29	B7T1B4_9BACT (B7T1B4)	7e-45	186	37%	UniProt GenBank	Veg1	veg1	uncultured soil bacterium
30	E9L1K6_9ZZZZ (E9L1K6)	8e-45	185	38%	UniProt GenBank	Putative uncharacterized protein	CA878-7	uncultured organism CA878
31	C4RL70_9ACTO (C4RL70)	9e-45	185	43%	UniProt GenBank	Putative uncharacterized protein	MCAG_05311	Micromonospora sp. ATCC 39149
32	Q06Z07_9ACTO (Q06Z07)	1e-44	185	42%	UniProt GenBank	StrR-like regulatory protein		Streptomyces fungicidicus
33	Q8GHC9_9ACTO (Q8GHC9)	2e-44	184	42%	UniProt GenBank	Regulatory protein cloG	cloG	Streptomyces roseochromogenes subsp. oscitans
34	E9L1I5_9ZZZZ (E9L1I5)	3e-44	184	39%	UniProt GenBank	Putative uncharacterized protein	CA37-41	uncultured organism CA37
35	Q9XBC5_AMYOR (Q9XBC5)	3e-44	183	38%	UniProt GenBank	Putative transcriptional regulator	CZA382.26	Amycolatopsis orientalis Nocardia orientalis
36	F8JU13_STRCT (F8JU13)	6e-44	182	40%	UniProt GenBank	Putative Streptomycin biosynthesis operon regulatory protein	strR SCAT_5797	Streptomyces cattleya
37	B0BLP8_9ACTO (B0BLP8)	2e-43	181	39%	UniProt GenBank	Regulatory protein	mdpR1	Actinomadura madurae
38	A4X6Y8_SALTO (A4X6Y8)	3e-43	180	37%	UniProt GenBank	ParB domain protein nuclease	Strop_2187	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
39	E2D2I0_9BACT (E2D2I0)	8e-43	179	39%	UniProt GenBank	Transcriptional regulator		uncultured soil bacterium
40	B1VT26_STRGG (B1VT26)	1e-42	178	39%	UniProt GenBank	Putative StrR-family transcriptional regulator	SGR_901	Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
41	Q799B3_9PSEU (Q799B3)	1e-42	178	37%	UniProt GenBank	StrR family transcriptional regulator	bbr	Amycolatopsis balhimycina
42	D7B8A0_NOCDD (D7B8A0)	2e-42	177	37%	UniProt GenBank	ParB domain protein nuclease	Ndas_5027	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
43	B7T1C6_9BACT (B7T1C6)	2e-42	177	38%	UniProt GenBank	Teg1	teg1	uncultured soil bacterium
44	Q9F8V4_9ACTO (Q9F8V4)	4e-42	176	41%	UniProt GenBank	CouG	couG	Streptomyces rishiriensis
45	D3Y151_STRPT (D3Y151)	4e-42	176	42%	UniProt GenBank	Putative cytoplasmic protein		Streptomyces platensis
46	F2RB72_STRVP (F2RB72)	6e-42	176	41%	UniProt GenBank	Transcriptional regulator protein	SVEN_0913	Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
47	E4N404_KITSK (E4N404)	8e-42	176	43%	UniProt GenBank	Putative regulatory protein	KSE_00840t KSE_75900t	Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054) Streptomyces setae
48	F8STX0_AMYOR (F8STX0)	1e-41	174	36%	UniProt GenBank	StrR family transcriptional regulator	vtrR	Amycolatopsis orientalis Nocardia orientalis
49	Q9L9G1_STRSH (Q9L9G1)	1e-40	171	42%	UniProt GenBank	NovG	novG	Streptomyces spheroides Streptomyces caeruleus
50	F8JQK5_STRCT (F8JQK5)	2e-40	171	38%	UniProt GenBank	Putative Streptomycin biosynthesis operon regulatory protein	strR SCAT_5483	Streptomyces cattleya
51	E2D2L7_9BACT (E2D2L7)	1e-39	168	39%	UniProt GenBank	Transcriptional regulator		uncultured soil bacterium
52	Q6L744_STRKN (Q6L744)	2e-39	167	39%	UniProt GenBank	Putative regulator of gene expression Putative transcriptional regulatory protein Transcriptional regulator	kanR kanL	Streptomyces kanamyceticus
53	B5GVQ0_STRCL (B5GVQ0)	2e-39	167	39%	UniProt GenBank	Putative StrR-family transcriptional regulator StaQ	SCLAV_5334 SSCG_03543	Streptomyces clavuligerus ATCC 27064
54	B5GYS9_STRCL (B5GYS9)	6e-37	159	40%	UniProt GenBank	StrR	SSCG_04680	Streptomyces clavuligerus ATCC 27064
55	D5SLC8_STRCL (D5SLC8)	2e-34	150	39%	UniProt GenBank	Transcriptional regulator	strR SCLAV_p1235	Streptomyces clavuligerus ATCC 27064
56	B4VAS3_9ACTO (B4VAS3)	3e-33	147	34%	UniProt GenBank	StrR	SSAG_04927	Streptomyces sp. Mg1
57	Q84HA6_STRCZ (Q84HA6)	1e-32	145	34%	UniProt GenBank	Transcriptional regulator		Streptomyces carzinostaticus subsp. neocarzinostaticus
58	Q8GME5_STRGL (Q8GME5)	7e-31	139	34%	UniProt GenBank	Regulatory protein		Streptomyces globisporus
59	D6AAD8_9ACTO (D6AAD8)	8e-29	132	35%	UniProt GenBank	Transcriptional regulator	SSFG_07708	Streptomyces ghanaensis ATCC 14672
60	Q54253_STRGR (Q54253)	4e-28	130	50%	UniProt GenBank	SPH and AT genes for streptomycinphosphotransferase and amidinotransferase		Streptomyces griseus
61	D6M4J1_9ACTO (D6M4J1)	3e-27	127	47%	UniProt GenBank	Putative uncharacterized protein	SSBG_05958	Streptomyces sp. SPB74
62	E8QZ66_ISOPI (E8QZ66)	1e-12	79.3	37%	UniProt GenBank	Putative uncharacterized protein	Isop_2638	Isosphaera pallida (strain ATCC 43644 / DSM 9630 / IS1B)
63	A8ZPS3_ACAM1 (A8ZPS3)	9e-08	62.8	33%	UniProt GenBank	Streptomycin biosynthesis operon possible regulatory protein, putative	AM1_F0130	Acaryochloris marina (strain MBIC 11017)
64	A8ZND4_ACAM1 (A8ZND4)	1e-06	58.9	35%	UniProt GenBank	Putative uncharacterized protein	AM1_D0023	Acaryochloris marina (strain MBIC 11017)
65	A8ZK48_ACAM1 (A8ZK48)	1e-06	58.9	29%	UniProt GenBank	Putative uncharacterized protein	AM1_A0039	Acaryochloris marina (strain MBIC 11017)
66	D5ERD1_CORAD (D5ERD1)	2e-06	58.5	33%	UniProt GenBank	Putative uncharacterized protein	Caka_2962	Coraliomargarita akajimensis (strain DSM 45221 / IAM 15411 / JCM 23193 / KCTC 12865)
67	A8ZME0_ACAM1 (A8ZME0)	1e-05	55.8	36%	UniProt GenBank	Putative uncharacterized protein	AM1_C0041	Acaryochloris marina (strain MBIC 11017)
68	B5JG02_9BACT (B5JG02)	0.0001	52.4	31%	UniProt GenBank	ParB-like nuclease domain family	VDG1235_2550	Verrucomicrobiae bacterium DG1235
69	A8ZK47_ACAM1 (A8ZK47)	0.0004	50.8	32%	UniProt GenBank	Putative uncharacterized protein	AM1_A0038	Acaryochloris marina (strain MBIC 11017)
70	A3IZM3_9CHRO (A3IZM3)	0.0005	50.1	27%	UniProt GenBank	Probable streptomycin biosynthesis operon possible regulatory protein	CY0110_31990	Cyanothece sp. CCY0110

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

C0SMX6_9ACTO
(C0SMX6)

0.0

696

100%

Product: Predicted transcriptional regulator protein
Gene: ttmQ
Organism: Streptomyces spiroverticillatus

[pubmed all]
1uniprot[Pubmed] 16707708 Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus.(J. Bacteriol.) [2006]
2uniprot[Pubmed] 18708355 Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis.(J. Biol. Chem.) [2008]

Q8GI86_STRKA
(Q8GI86)

1e-54

218

43%

Product: Transcriptional regulator protein
Gene: kasT
Organism: Streptomyces kasugaensis

1uniprot[Pubmed] 12617515 [Medline] 22504381
kasT gene of Streptomyces kasugaensis M338-M1 encodes a DNA-binding protein which binds to intergenic region of kasU-kasJ in the kasugamycin biosynthesis gene cluster.(J. Antibiot.) [2002]

E9L1J6_9ZZZZ
(E9L1J6)

1e-54

218

47%

Product: Putative uncharacterized protein
Gene: CA37-52
Organism: uncultured organism CA37

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

E9L1J5_9ZZZZ
(E9L1J5)

5e-54

216

46%

Product: Putative uncharacterized protein
Gene: CA37-51
Organism: uncultured organism CA37

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

Q06Z05_9ACTO
(Q06Z05)

3e-50

204

43%

Product: Putative uncharacterized protein
Gene
Organism: Streptomyces fungicidicus

1uniprot[Pubmed] 17005978
The enduracidin biosynthetic gene cluster from Streptomyces fungicidicus.(Microbiology) [2006]

Q83XA1_STRRO
(Q83XA1)

7e-50

202

42%

Product: StrR-like regulatory protein
Gene
Organism: Streptomyces rochei
Streptomyces parvullus

[pubmed all]
1uniprot[Pubmed] 12791134 [Medline] 22676866 The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003]
2uniprot[Pubmed] 10954087 [Medline] 20408175 Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000]
3uniprot[Pubmed] 10767533 [Medline] 20231737 Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000]
4uniprot[Pubmed] 9836424 [Medline] 99053144 Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998]

Q93N91_STRLA
(Q93N91)

4e-49

200

40%

Product: Transcriptional regulator
Gene
Organism: Streptomyces lavendulae

1uniprot[Pubmed] 11447274 [Medline] 21353013
Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster.(Proc. Natl. Acad. Sci. U.S.A.) [2001]

Q6ZZH8_ACTTI
(Q6ZZH8)

3e-48

197

39%

Product: Transcriptional regulator
Transcriptional regulator, StrR family
Gene: tcp28
Organism: Actinoplanes teichomyceticus

[pubmed all]
1uniprot[Pubmed] 15113000 Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase.(Chem. Biol.) [2004]
2uniprot[Pubmed] 14702401 Organization of the teicoplanin gene cluster in Actinoplanes teichomyceticus.(Microbiology) [2004]

E9L1T0_9ZZZZ
(E9L1T0)

4e-48

196

40%

Product: Putative uncharacterized protein
Gene: CA915-38
Organism: uncultured organism CA915

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

Q8KLK0_STRTO
(Q8KLK0)

4e-48

196

40%

Product: StaQ
Gene
Organism: Streptomyces toyocaensis

[pubmed all]
1uniprot[Pubmed] 9177243 [Medline] 97322398 D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB.(Proc. Natl. Acad. Sci. U.S.A.) [1997]
2uniprot[Pubmed] 12060705 [Medline] 22080153 Assembling the glycopeptide antibiotic scaffold: the biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009.(Proc. Natl. Acad. Sci. U.S.A.) [2002]

Q54267_STRGA
(Q54267)

6e-48

196

42%

Product: StrR
StrR protein
Gene: strR
Organism: Streptomyces glaucescens

1uniprot[Pubmed] 8628239 [Medline] 96204519
The str gene cluster for the biosynthesis of 5'-hydroxystreptomycin in Streptomyces glaucescens GLA.0 (ETH 22794): new operons and evidence for pathway-specific regulation by StrR.(Mol. Gen. Genet.) [1996]

2uniprot
Streptomycin Production in Streptomycetes: a Progress Report.(INDUSTRIAL MICROORGANISMS. BASIC AND APPLIED MOLECULAR GENETICS) [1993]

D3Y168_STRPT
(D3Y168)

6e-48

196

39%

Product: Streptomycin biosynthesis operon regulator
Gene: strR
Organism: Streptomyces platensis

1uniprot[Pubmed] 20067498
Coevolution of antibiotic production and counter-resistance in soil bacteria.(Environ. Microbiol.) [2010]

C4NYJ5_9ACTO
(C4NYJ5)

1e-47

195

43%

Product: SaqI
Gene: saqI
Organism: Micromonospora sp. Tu 6368

[pubmed all]
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]

Q27YR9_STRHY
(Q27YR9)

1e-46

192

42%

Product: Putative regulatory protein
Gene
Organism: Streptomyces hygroscopicus

1uniprot[Pubmed] 16873023
Production of hygromycin A analogs in Streptomyces hygroscopicus NRRL 2388 through identification and manipulation of the biosynthetic gene cluster.(Chem. Biol.) [2006]

B1W378_STRGG
(B1W378)

1e-46

191

40%

Product: Streptomycin biosynthesis operon regulator
Gene: strR
SGR_5931
Organism: Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)

1uniprot[Pubmed] 18375553
Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008]

STRR_STRGR
(P08076)

1e-46

191

40%

Product: Streptomycin biosynthesis operon possible regulatory protein
Gene: strR
Organism: Streptomyces griseus

1uniprot[Pubmed] 3118332 [Medline] 88040426
Gene cluster for streptomycin biosynthesis in Streptomyces griseus: nucleotide sequence of three genes and analysis of transcriptional activity.(Nucleic Acids Res.) [1987]

Q7WZ87_9ACTO
(Q7WZ87)

8e-46

189

37%

Product: Putative regulator StrR family
Gene: dbv4
Organism: Nonomuraea sp. ATCC 39727

1uniprot[Pubmed] 12837387 [Medline] 22721464
The gene cluster for the biosynthesis of the glycopeptide antibiotic A40926 by nonomuraea species.(Chem. Biol.) [2003]

E2D2E0_9BACT
(E2D2E0)

2e-45

187

38%

Product: Transcriptional regulator
Gene
Organism: uncultured soil bacterium

1uniprot[Pubmed] 20577994
Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR.(Biopolymers) [2010]

P72440_STRNE
(P72440)

2e-45

187

39%

Product: SpcR
Gene: spcR
Organism: Streptoverticillium netropsis
Streptoverticillium flavopersicus

1uniprot[Pubmed] 9245803 [Medline] 97388569
A spectinomycin resistance determinant from the spectinomycin producer Streptomyces flavopersicus.(Microbiology)

Q2JA59_FRASC
(Q2JA59)

4e-45

186

37%

Product: ParB-like nuclease
Gene: Francci3_2466
Organism: Frankia sp. (strain CcI3)

1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]

B7T1B4_9BACT
(B7T1B4)

7e-45

186

37%

Product: Veg1
Gene: veg1
Organism: uncultured soil bacterium

1uniprot[Pubmed] 18987322
Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary.(Proc. Natl. Acad. Sci. U.S.A.) [2008]

E9L1K6_9ZZZZ
(E9L1K6)

8e-45

185

38%

Product: Putative uncharacterized protein
Gene: CA878-7
Organism: uncultured organism CA878

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

Q06Z07_9ACTO
(Q06Z07)

1e-44

185

42%

Product: StrR-like regulatory protein
Gene
Organism: Streptomyces fungicidicus

1uniprot[Pubmed] 17005978
The enduracidin biosynthetic gene cluster from Streptomyces fungicidicus.(Microbiology) [2006]

Q8GHC9_9ACTO
(Q8GHC9)

2e-44

184

42%

Product: Regulatory protein cloG
Gene: cloG
Organism: Streptomyces roseochromogenes subsp. oscitans

1uniprot[Pubmed] 12480894 [Medline] 22368916
Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics.(Microbiology) [2002]

E9L1I5_9ZZZZ
(E9L1I5)

3e-44

184

39%

Product: Putative uncharacterized protein
Gene: CA37-41
Organism: uncultured organism CA37

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

B0BLP8_9ACTO
(B0BLP8)

2e-43

181

39%

Product: Regulatory protein
Gene: mdpR1
Organism: Actinomadura madurae

[pubmed all]
1uniprot[Pubmed] 14528002 [Medline] 22922109 Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model.(Proc. Natl. Acad. Sci. U.S.A.) [2003]
2uniprot[Pubmed] 17918933 Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.(J. Am. Chem. Soc.) [2007]

E2D2I0_9BACT
(E2D2I0)

8e-43

179

39%

Product: Transcriptional regulator
Gene
Organism: uncultured soil bacterium

1uniprot[Pubmed] 20577994
Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR.(Biopolymers) [2010]

B1VT26_STRGG
(B1VT26)

1e-42

178

39%

Product: Putative StrR-family transcriptional regulator
Gene: SGR_901
Organism: Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)

1uniprot[Pubmed] 18375553
Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008]

Q799B3_9PSEU
(Q799B3)

1e-42

178

37%

Product: StrR family transcriptional regulator
Gene: bbr
Organism: Amycolatopsis balhimycina

[pubmed all]
1uniprot[Pubmed] 10390204 [Medline] 99318579 Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908.(Antimicrob. Agents Chemother.) [1999]
2uniprot[Pubmed] 11932455 [Medline] 21930292 Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules.(Microbiology) [2002]
3uniprot[Pubmed] 11495926 [Medline] 21486455 A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine.(J. Biol. Chem.) [2001]
4uniprot[Pubmed] 12404385 The biosynthesis of vancomycin-type glycopeptide antibiotics - the order of cyclization steps.(Angew. Chem. Int. Ed. Engl.) [2001]
5uniprot[Pubmed] 11880037 [Medline] 21869276 Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908: function of a halogenase and a haloperoxidase/perhydrolase.(Chem. Biol.) [2002]
6uniprot Precursor-directed biosynthesis for the generation of novel glycopetides.(Ernst Schering Res. Found. Workshop) [2005]

D7B8A0_NOCDD
(D7B8A0)

2e-42

177

37%

Product: ParB domain protein nuclease
Gene: Ndas_5027
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

B7T1C6_9BACT
(B7T1C6)

2e-42

177

38%

Product: Teg1
Gene: teg1
Organism: uncultured soil bacterium

1uniprot[Pubmed] 18987322
Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary.(Proc. Natl. Acad. Sci. U.S.A.) [2008]

Q9F8V4_9ACTO
(Q9F8V4)

4e-42

176

41%

Product: CouG
Gene: couG
Organism: Streptomyces rishiriensis

1uniprot[Pubmed] 11036020 [Medline] 20493109
Identification of the coumermycin A(1) biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489.(Antimicrob. Agents Chemother.) [2000]

D3Y151_STRPT
(D3Y151)

4e-42

176

42%

Product: Putative cytoplasmic protein
Gene
Organism: Streptomyces platensis

1uniprot[Pubmed] 20067498
Coevolution of antibiotic production and counter-resistance in soil bacteria.(Environ. Microbiol.) [2010]

F2RB72_STRVP
(F2RB72)

6e-42

176

41%

Product: Transcriptional regulator protein
Gene: SVEN_0913
Organism: Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)

1uniprot[Pubmed] 21463507
Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011]

E4N404_KITSK
(E4N404)

8e-42

176

43%

Product: Putative regulatory protein
Gene: KSE_00840t
KSE_75900t
Organism: Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054)
Streptomyces setae

1uniprot[Pubmed] 21059706
Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.(DNA Res.) [2010]

Q9L9G1_STRSH
(Q9L9G1)

1e-40

171

42%

Product: NovG
Gene: novG
Organism: Streptomyces spheroides
Streptomyces caeruleus

1uniprot[Pubmed] 10770754 [Medline] 20233587
Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.(Antimicrob. Agents Chemother.) [2000]

E2D2L7_9BACT
(E2D2L7)

1e-39

168

39%

Product: Transcriptional regulator
Gene
Organism: uncultured soil bacterium

1uniprot[Pubmed] 20577994
Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR.(Biopolymers) [2010]

Q6L744_STRKN
(Q6L744)

2e-39

167

39%

Product: Putative regulator of gene expression
Putative transcriptional regulatory protein
Transcriptional regulator
Gene: kanR
kanL
Organism: Streptomyces kanamyceticus

[pubmed all]
1uniprot[Pubmed] 15303497 The kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus.(J. Antibiot.) [2004]
2uniprot[Pubmed] 15313224 A gene cluster for biosynthesis of kanamycin from Streptomyces kanamyceticus: comparison with gentamicin biosynthetic gene cluster.(Arch. Biochem. Biophys.) [2004]

B5GVQ0_STRCL
(B5GVQ0)

2e-39

167

39%

Product: Putative StrR-family transcriptional regulator
StaQ
Gene: SCLAV_5334
SSCG_03543
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot[Pubmed] 20624727
The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

D5SLC8_STRCL
(D5SLC8)

2e-34

150

39%

Product: Transcriptional regulator
Gene: strR
SCLAV_p1235
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot
The sequence of a 1.8 Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

Q84HA6_STRCZ
(Q84HA6)

1e-32

145

34%

Product: Transcriptional regulator
Gene
Organism: Streptomyces carzinostaticus subsp. neocarzinostaticus

1uniprot[Pubmed] 15797213
The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.(Chem. Biol.) [2005]

Q8GME5_STRGL
(Q8GME5)

7e-31

139

34%

Product: Regulatory protein
Gene
Organism: Streptomyces globisporus

1uniprot[Pubmed] 12183628 [Medline] 22171413
Biosynthesis of the enediyne antitumor antibiotic C-1027.(Science) [2002]

Q54253_STRGR
(Q54253)

4e-28

130

50%

Product: SPH and AT genes for streptomycinphosphotransferase and amidinotransferase
Gene
Organism: Streptomyces griseus

1uniprot[Pubmed] 3029728 [Medline] 87146497
Nucleotide sequence of the streptomycinphosphotransferase and amidinotransferase genes from Streptomyces griseus.(Nucleic Acids Res.) [1987]

E8QZ66_ISOPI
(E8QZ66)

1e-12

79.3

37%

Product: Putative uncharacterized protein
Gene: Isop_2638
Organism: Isosphaera pallida (strain ATCC 43644 / DSM 9630 / IS1B)

1uniprot
Complete genome sequence of Isosphaera pallida type strain (IS1B).(Stand. Genomic Sci.) [2011]

A8ZPS3_ACAM1
(A8ZPS3)

9e-08

62.8

33%

Product: Streptomycin biosynthesis operon possible regulatory protein, putative
Gene: AM1_F0130
Organism: Acaryochloris marina (strain MBIC 11017)

1uniprot[Pubmed] 18252824
Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina.(Proc. Natl. Acad. Sci. U.S.A.) [2008]

A8ZND4_ACAM1
(A8ZND4)

1e-06

58.9

35%

Product: Putative uncharacterized protein
Gene: AM1_D0023
Organism: Acaryochloris marina (strain MBIC 11017)

1uniprot[Pubmed] 18252824
Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina.(Proc. Natl. Acad. Sci. U.S.A.) [2008]

A8ZK48_ACAM1
(A8ZK48)

1e-06

58.9

29%

Product: Putative uncharacterized protein
Gene: AM1_A0039
Organism: Acaryochloris marina (strain MBIC 11017)

1uniprot[Pubmed] 18252824
Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina.(Proc. Natl. Acad. Sci. U.S.A.) [2008]

D5ERD1_CORAD
(D5ERD1)

2e-06

58.5

33%

Product: Putative uncharacterized protein
Gene: Caka_2962
Organism: Coraliomargarita akajimensis (strain DSM 45221 / IAM 15411 / JCM 23193 / KCTC 12865)

1uniprot
Complete genome sequence of Coraliomargarita akajimensis type strain (04OKA010-24).(Stand. Genomic Sci.) [2010]

A8ZME0_ACAM1
(A8ZME0)

1e-05

55.8

36%

Product: Putative uncharacterized protein
Gene: AM1_C0041
Organism: Acaryochloris marina (strain MBIC 11017)

1uniprot[Pubmed] 18252824
Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina.(Proc. Natl. Acad. Sci. U.S.A.) [2008]

A8ZK47_ACAM1
(A8ZK47)

0.0004

50.8

32%

Product: Putative uncharacterized protein
Gene: AM1_A0038
Organism: Acaryochloris marina (strain MBIC 11017)

1uniprot[Pubmed] 18252824
Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina.(Proc. Natl. Acad. Sci. U.S.A.) [2008]