BLAST table : Vanco_00340

DB	UniProtKB

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	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	O52812_AMYOR (O52812)	0.0	733	85%	UniProt GenBank	PCZA361.8		Amycolatopsis orientalis Nocardia orientalis
2	Q7WZ58_9ACTO (Q7WZ58)	0.0	693	81%	UniProt GenBank	Putative DpgC protein	dbv33	Nonomuraea sp. ATCC 39727
3	Q939X1_9PSEU (Q939X1)	0.0	684	82%	UniProt GenBank	Hydroxyacyl-dehydrogenase	dpgC	Amycolatopsis balhimycina
4	E9L1P1_9ZZZZ (E9L1P1)	0.0	647	85%	UniProt GenBank	Putative uncharacterized protein	CA878-42	uncultured organism CA878
5	B7T1B1_9BACT (B7T1B1)	0.0	646	86%	UniProt GenBank	Veg39	veg39	uncultured soil bacterium
6	F8STZ8_AMYOR (F8STZ8)	0.0	640	75%	UniProt GenBank	Hydroxyacyl-dehydrogenase	vcm25	Amycolatopsis orientalis Nocardia orientalis
7	Q8KLK7_STRTO (Q8KLK7)	1e-160	570	70%	UniProt GenBank	DpgC		Streptomyces toyocaensis
8	E9L1J0_9ZZZZ (E9L1J0)	1e-154	548	67%	UniProt GenBank	Putative uncharacterized protein	CA37-46	uncultured organism CA37
9	E2D2E7_9BACT (E2D2E7)	1e-153	545	69%	UniProt GenBank	Dihydroxyphenylglycine synthase subunit C		uncultured soil bacterium
10	Q2JA69_FRASC (Q2JA69)	1e-151	541	69%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Francci3_2456	Frankia sp. (strain CcI3)
11	Q6ZZH4_ACTTI (Q6ZZH4)	1e-147	526	66%	UniProt GenBank	DpgC protein	tcp32	Actinoplanes teichomyceticus
12	E9L1U1_9ZZZZ (E9L1U1)	1e-146	521	66%	UniProt GenBank	Putative uncharacterized protein	CA915-49	uncultured organism CA915
13	D9UHH7_9ACTO (D9UHH7)	1e-131	471	60%	UniProt GenBank	Hydroxyacyl-dehydrogenase	SSLG_05413	Streptomyces sp. SPB78
14	D7B4X5_NOCDD (D7B4X5)	1e-131	471	60%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Ndas_1737	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
15	F2R790_STRVP (F2R790)	1e-130	469	59%	UniProt GenBank	Enoyl-CoA hydratase or isomerase	SVEN_0495	Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
16	C0Z469_STRVN (C0Z469)	1e-119	432	56%	UniProt GenBank	Dioxygenase	ken4	Streptomyces violaceoruber
17	F3ZDK5_9ACTO (F3ZDK5)	1e-113	413	63%	UniProt GenBank	Putative enoyl-CoA hydratase/isomerase	STTU_1158	Streptomyces sp. Tu6071
18	D2UD62_XANAP (D2UD62)	1e-108	398	52%	UniProt GenBank	Putative enoyl-coa hydratase isomerase protein	XALc_1061	Xanthomonas albilineans (strain GPE PC73 / CFBP 7063)
19	F3NRX6_9ACTO (F3NRX6)	1e-104	383	52%	UniProt GenBank	Putative enoyl-CoA hydratase/isomerase	SGM_5890	Streptomyces griseoaurantiacus M045
20	D6A5M8_9ACTO (D6A5M8)	1e-103	378	52%	UniProt GenBank	DpgC protein	SSFG_06976	Streptomyces ghanaensis ATCC 14672
21	D2PSN9_KRIFD (D2PSN9)	1e-100	371	56%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Kfla_4130	Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)
22	D0RB78_STRPR (D0RB78)	1e-100	369	50%	UniProt GenBank	Hydroxyacyl-dehydrogenase Putative hydroxyacyl-dehydrogenase	pglA	Streptomyces pristinaespiralis
23	B5HJU2_STRPR (B5HJU2)	1e-100	369	50%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	SSDG_05431	Streptomyces pristinaespiralis ATCC 25486
24	Q9RPT2_9BACT (Q9RPT2)	4e-61	240	50%	UniProt GenBank	Putative uncharacterized protein		uncultured bacterium AH6
25	E9LIP8_9ACTO (E9LIP8)	2e-38	165	39%	UniProt GenBank	Putative enoyl-CoA hydratase/isomerase	tiaN	Dactylosporangium aurantiacum subsp. hamdenensis
26	Q1NB15_9SPHN (Q1NB15)	6e-19	100	32%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	SKA58_07548	Sphingomonas sp. SKA58
27	F6INA6_9SPHN (F6INA6)	2e-18	99	31%	UniProt GenBank	Enoyl-CoA hydratase	PP1Y_AT20327	Novosphingobium sp. PP1Y	4.2.1.17 niceE keggE
28	D4Z2S5_SPHJU (D4Z2S5)	4e-18	97.4	31%	UniProt GenBank	Enoyl-CoA hydratase	paaG SJA_C1-20730	Sphingobium japonicum (strain NBRC 101211 / UT26S)	4.2.1.17 niceE keggE
29	F6EUP7_SPHCR (F6EUP7)	4e-18	97.4	32%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Sphch_1075	Sphingobium chlorophenolicum L-1
30	A5PAX2_9SPHN (A5PAX2)	5e-18	97.1	31%	UniProt GenBank	Enoyl-CoA hydratase/isomerase family protein	ED21_21894	Erythrobacter sp. SD-21
31	F8I8I9_9FIRM (F8I8I9)	2e-17	95.1	33%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	paaG TPY_0690	Sulfobacillus acidophilus TPY
32	E8WNW0_GEOS8 (E8WNW0)	2e-17	95.1	31%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	GM18_1287	Geobacter sp. (strain M18)
33	D8F324_9DELT (D8F324)	3e-17	94.4	29%	UniProt GenBank	Enoyl-CoA hydratase/isomerase family protein	NPH_7275	delta proteobacterium NaphS2
34	E7DDH9_ALCFA (E7DDH9)	4e-17	94	32%	UniProt GenBank	Enoyl-CoA hydratase family	acuK	Alcaligenes faecalis
35	C0QFR9_DESAH (C0QFR9)	5e-17	94	31%	UniProt GenBank	CrtA2	crtA2 HRM2_23920	Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)	4.2.1.55 niceE keggE
36	F4A6J9_CLOBO (F4A6J9)	5e-17	94	31%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	CbC4_2221	Clostridium botulinum BKT015925	4.2.1.55 niceE keggE
37	C5VNX5_CLOBO (C5VNX5)	6e-17	93.6	31%	UniProt GenBank	3-hydroxybutyryl-CoA dehydratase	CLG_B0355	Clostridium botulinum D str. 1873	4.2.1.55 niceE keggE
38	F7MNE5_CLOBO (F7MNE5)	7e-17	93.6	31%	UniProt GenBank	3-hydroxybutyryl-CoA dehydratase	CBCST_10366	Clostridium botulinum C str. Stockholm	4.2.1.55 niceE keggE
39	Q939X0_9PSEU (Q939X0)	2e-16	92	35%	UniProt GenBank	Putative enoyl-CoA-isomerase	dpgD	Amycolatopsis balhimycina
40	Q2NDF3_ERYLH (Q2NDF3)	2e-16	91.7	33%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	ELI_00980	Erythrobacter litoralis (strain HTCC2594)
41	Q2N892_ERYLH (Q2N892)	3e-16	91.7	30%	UniProt GenBank	Enoyl-CoA hydratase/isomerase family protein	ELI_10035	Erythrobacter litoralis (strain HTCC2594)
42	A8N3H3_COPC7 (A8N3H3)	3e-16	91.3	33%	UniProt GenBank	Enoyl-CoA hydratase/carnithine racemase	CC1G_00729	Coprinopsis cinerea (strain Okayama-7 / 130 / FGSC 9003) Inky cap fungus Hormographiella aspergillata
43	Q1GNL3_SPHAL (Q1GNL3)	3e-16	91.3	32%	UniProt GenBank	Short chain enoyl-CoA hydratase	Sala_3055	Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) Sphingomonas alaskensis	4.2.1.17 niceE keggE
44	D9T059_MICAI (D9T059)	4e-16	90.9	34%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Micau_3771	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
45	Q1LK46_RALME (Q1LK46)	4e-16	90.9	33%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	paaG1 Rmet_2603	Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)	4.2.1.17 niceE keggE
46	E8RDP9_9DELT (E8RDP9)	5e-16	90.5	32%	UniProt GenBank	Short chain enoyl-CoA hydratase	Despr_0732	Desulfobulbus propionicus DSM 2032	4.2.1.17 niceE keggE
47	Q5YVK2_NOCFA (Q5YVK2)	6e-16	90.5	31%	UniProt GenBank	Putative enoyl-CoA hydratase/isomerase family protein	echA13 NFA_29420	Nocardia farcinica
48	E1IGB5_9CHLR (E1IGB5)	6e-16	90.1	33%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	OSCT_2366	Oscillochloris trichoides DG-6
49	E7C8P6_9GAMM (E7C8P6)	8e-16	89.7	32%	UniProt GenBank	Enoyl-CoA hydratase/carnithine racemase		uncultured gamma proteobacterium HF4000_47G05
50	Q0S9N9_RHOSR (Q0S9N9)	1e-15	89.4	34%	UniProt GenBank	Possible enoyl-CoA hydratase	RHA1_ro03950	Rhodococcus sp. (strain RHA1)
51	A3MVR3_PYRCJ (A3MVR3)	1e-15	89.4	31%	UniProt GenBank	Short chain enoyl-CoA hydratase	Pcal_1306	Pyrobaculum calidifontis (strain JCM 11548 / VA1)	4.2.1.17 niceE keggE
52	Q1GC54_SILST (Q1GC54)	2e-15	89	29%	UniProt GenBank	Short chain enoyl-CoA hydratase	TM1040_3030	Silicibacter sp. (strain TM1040)	4.2.1.17 niceE keggE
53	Q582Q0_9TRYP (Q582Q0)	2e-15	88.6	32%	UniProt GenBank	Enoyl-CoA hydratase, mitochondrial, putative	Tb927.3.4850	Trypanosoma brucei	4.2.1.17 niceE keggE
54	D6XE41_TRYB2 (D6XE41)	2e-15	88.6	32%	UniProt GenBank	Enoyl-CoA hydratase, mitochondrial, putative	Tb927.3.4850	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	4.2.1.17 niceE keggE
55	C9ZLJ2_TRYB9 (C9ZLJ2)	2e-15	88.6	32%	UniProt GenBank	Enoyl-CoA hydratase, mitochondrial,putative	TbgDal_III5430	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	4.2.1.17 niceE keggE
56	E4KRB8_9LACT (E4KRB8)	2e-15	88.6	31%	UniProt GenBank	3-hydroxybutyryl-CoA dehydratase	crt HMPREF9257_0418	Eremococcus coleocola ACS-139-V-Col8	4.2.1.55 niceE keggE
57	A5Z9I6_9FIRM (A5Z9I6)	3e-15	88.2	31%	UniProt GenBank	Putative uncharacterized protein	EUBVEN_02382	Eubacterium ventriosum ATCC 27560
58	F0QSR3_VULM7 (F0QSR3)	3e-15	87.8	30%	UniProt GenBank	3-hydroxyacyl-CoA dehydrogenase, NAD-binding protein	VMUT_1375	Vulcanisaeta moutnovskia (strain 768-28)
59	C1B644_RHOOB (C1B644)	3e-15	87.8	33%	UniProt GenBank	Enoyl-CoA hydratase	echA ROP_72080	Rhodococcus opacus (strain B4)	4.2.1.17 niceE keggE
60	C9CYQ9_9RHOB (C9CYQ9)	3e-15	87.8	29%	UniProt GenBank	Enoyl-coa hydratase	SCH4B_3361	Silicibacter sp. TrichCH4B	4.2.1.17 niceE keggE
61	F6D0X2_9GAMM (F6D0X2)	4e-15	87.8	32%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Mar181_0638	Marinomonas posidonica IVIA-Po-181
62	O84978_PSEPU (O84978)	4e-15	87.4	33%	UniProt GenBank	PaaA	paaA	Pseudomonas putida Arthrobacter siderocapsulatus
63	E7C4A8_9ACTN (E7C4A8)	4e-15	87.4	30%	UniProt GenBank	Enoyl-CoA hydratase/carnithine racemase		uncultured actinobacterium HF0200_46I24
64	E7C432_9GAMM (E7C432)	4e-15	87.4	30%	UniProt GenBank	Enoyl-CoA hydratase/carnithine racemase		uncultured gamma proteobacterium HF0200_34B07
65	Q8FSR0_COREF (Q8FSR0)	4e-15	87.4	32%	UniProt GenBank	Putative 3-hydroxybutyryl-CoA dehydratase	CE0322	Corynebacterium efficiens
66	A5G5Z5_GEOUR (A5G5Z5)	4e-15	87.4	30%	UniProt GenBank	Short chain enoyl-CoA hydratase	Gura_3041	Geobacter uraniireducens (strain Rf4) Geobacter uraniumreducens	4.2.1.17 niceE keggE
67	C8NKF6_COREF (C8NKF6)	4e-15	87.4	32%	UniProt GenBank	3-hydroxybutyryl-CoA dehydratase	crt3 HMPREF0290_0481	Corynebacterium efficiens YS-314	4.2.1.55 niceE keggE
68	E0TEI9_PARBH (E0TEI9)	4e-15	87.4	34%	UniProt GenBank	Enoyl CoA hydratase	PB2503_12094	Parvularcula bermudensis (strain ATCC BAA-594 / HTCC2503 / KCTC 12087)
69	C8YX87_9GAMM (C8YX87)	4e-15	87.4	32%	UniProt GenBank	AcuK	acuK	Halomonas sp. HTNK1
70	Q82Q04_STRAW (Q82Q04)	5e-15	87.4	38%	UniProt GenBank	Putative enoyl-CoA hydratase	echA3 SAV717 SAV_717	Streptomyces avermitilis
71	D3D8V1_9ACTO (D3D8V1)	5e-15	87.4	31%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	FrEUN1fDRAFT_6223	Frankia sp. EUN1f
72	B5E7U4_GEOBB (B5E7U4)	5e-15	87.4	30%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Gbem_1462	Geobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
73	B9CYZ5_WOLRE (B9CYZ5)	5e-15	87	34%	UniProt GenBank	3-hydroxybutyryl-CoA dehydratase (Crotonase)	CAMRE0001_1568	Campylobacter rectus RM3267	4.2.1.55 niceE keggE
74	E9L1P2_9ZZZZ (E9L1P2)	6e-15	87	33%	UniProt GenBank	Putative uncharacterized protein	CA878-43	uncultured organism CA878
75	B8FC62_DESAA (B8FC62)	6e-15	87	35%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Dalk_3794	Desulfatibacillum alkenivorans (strain AK-01)	4.2.1.18 niceE keggE
76	Q2GA18_NOVAD (Q2GA18)	6e-15	87	31%	UniProt GenBank	Short chain enoyl-CoA hydratase	Saro_0860	Novosphingobium aromaticivorans (strain DSM 12444)	4.2.1.17 niceE keggE
77	D6TH89_9CHLR (D6TH89)	7e-15	87	32%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Krac_12472	Ktedonobacter racemifer DSM 44963
78	F1Z4G9_9SPHN (F1Z4G9)	7e-15	86.7	30%	UniProt GenBank	Short chain enoyl-CoA hydratase	Y88_2869	Novosphingobium nitrogenifigens DSM 19370
79	C0Z573_BREBN (C0Z573)	8e-15	86.7	31%	UniProt GenBank	Probable enoyl-CoA hydratase	paaF BBR47_50020	Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)	4.2.1.17 niceE keggE
80	D3CZ81_9ACTO (D3CZ81)	9e-15	86.7	32%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	FrEUN1fDRAFT_2852	Frankia sp. EUN1f
81	D9V2U9_9ACTO (D9V2U9)	9e-15	86.3	33%	UniProt GenBank	2-ketocyclohexanecarboxyl-CoA hydrolase	SSMG_04764	Streptomyces sp. AA4
82	F2LY45_HIPMA (F2LY45)	1e-14	86.3	29%	UniProt GenBank	Enoyl-CoA hydratase	Hipma_1412	Hippea maritima (strain ATCC 700847 / DSM 10411 / MH2)	4.2.1.17 niceE keggE 4.2.1.55 niceE keggE
83	A5V769_SPHWW (A5V769)	1e-14	86.3	32%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Swit_1773	Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
84	D5ZW09_9ACTO (D5ZW09)	1e-14	86.3	36%	UniProt GenBank	Enoyl-CoA hydratase	SSFG_02231	Streptomyces ghanaensis ATCC 14672
85	A0QFV0_MYCA1 (A0QFV0)	1e-14	85.9	32%	UniProt GenBank	Carnitinyl-CoA dehydratase	MAV_2597	Mycobacterium avium (strain 104)	4.2.1.- niceE keggE
86	F4DZ62_PSEMN (F4DZ62)	1e-14	85.9	33%	UniProt GenBank	Enoyl-CoA hydratase-isomerase	MDS_2861	Pseudomonas mendocina (strain NK-01)
87	F1ZD15_9SPHN (F1ZD15)	1e-14	85.9	33%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Y88_3808	Novosphingobium nitrogenifigens DSM 19370
88	Q64BG5_9ARCH (Q64BG5)	1e-14	85.9	28%	UniProt GenBank	Enoyl-CoA hydratase/carnithine racemase	GZ27B6_24	uncultured archaeon GZfos27B6
89	B5JZC2_9RHOB (B5JZC2)	1e-14	85.9	31%	UniProt GenBank	Enoyl-CoA hydratase	OA238_1996	Octadecabacter antarcticus 238	4.2.1.17 niceE keggE
90	Q485U2_COLP3 (Q485U2)	1e-14	85.9	31%	UniProt GenBank	Enoyl-CoA hydratase/isomerase family protein	CPS_1430	Colwellia psychrerythraea (strain 34H / ATCC BAA-681) Vibrio psychroerythus
91	F8E8W7_FLESI (F8E8W7)	1e-14	85.9	30%	UniProt GenBank	3-hydroxybutyryl-CoA dehydratase	Flexsi_0403	Flexistipes sinusarabici	4.2.1.55 niceE keggE
92	F0K423_CLOAE (F0K423)	1e-14	85.9	30%	UniProt GenBank	3-hydroxybutyryl-CoA dehydratase	crt CEA_G2720	Clostridium acetobutylicum (strain EA 2018)
93	F7ZT50_CLOAB (F7ZT50)	1e-14	85.9	30%	UniProt GenBank	3-hydroxybutyryl-CoA dehydratase	crt SMB_G2747	Clostridium acetobutylicum DSM 1731
94	CRT_CLOAB (P52046)	1e-14	85.9	30%	UniProt GenBank	3-hydroxybutyryl-CoA dehydratase Crotonase	crt CA_C2712	Clostridium acetobutylicum	4.2.1.55 niceE keggE
95	F8CXT0_BACTR (F8CXT0)	1e-14	85.5	30%	UniProt GenBank	Methylglutaconyl-CoA hydratase	Geoth_1586	Geobacillus thermoglucosidasius C56-YS93	4.2.1.18 niceE keggE
96	E3IAH6_GEOS0 (E3IAH6)	2e-14	85.5	30%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	GY4MC1_1494	Geobacillus sp. (strain Y4.1MC1)
97	C2FS94_9SPHI (C2FS94)	2e-14	85.5	28%	UniProt GenBank	3-hydroxybutyryl-CoA dehydratase	crt HMPREF0765_0200	Sphingobacterium spiritivorum ATCC 33300	4.2.1.55 niceE keggE
98	Q67P31_SYMTH (Q67P31)	2e-14	85.5	34%	UniProt GenBank	Enoyl-CoA hydratase/isomerase family protein	STH1577	Symbiobacterium thermophilum
99	A3WEF3_9SPHN (A3WEF3)	2e-14	85.5	30%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	NAP1_10393	Erythrobacter sp. NAP1
100	E4MGK6_9FIRM (E4MGK6)	2e-14	85.5	30%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	EubceDRAFT_0302	Eubacterium cellulosolvens 6

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

O52812_AMYOR
(O52812)

0.0

733

85%

Product: PCZA361.8
Gene
Organism: Amycolatopsis orientalis
Nocardia orientalis

1uniprot[Pubmed] 9545426 [Medline] 98212597
Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic.(Chem. Biol.) [1998]

Q7WZ58_9ACTO
(Q7WZ58)

0.0

693

81%

Product: Putative DpgC protein
Gene: dbv33
Organism: Nonomuraea sp. ATCC 39727

1uniprot[Pubmed] 12837387 [Medline] 22721464
The gene cluster for the biosynthesis of the glycopeptide antibiotic A40926 by nonomuraea species.(Chem. Biol.) [2003]

Q939X1_9PSEU
(Q939X1)

0.0

684

82%

Product: Hydroxyacyl-dehydrogenase
Gene: dpgC
Organism: Amycolatopsis balhimycina

[pubmed all]
1uniprot[Pubmed] 10390204 [Medline] 99318579 Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908.(Antimicrob. Agents Chemother.) [1999]
2uniprot[Pubmed] 11932455 [Medline] 21930292 Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules.(Microbiology) [2002]
3uniprot[Pubmed] 11495926 [Medline] 21486455 A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine.(J. Biol. Chem.) [2001]
4uniprot[Pubmed] 12404385 The biosynthesis of vancomycin-type glycopeptide antibiotics - the order of cyclization steps.(Angew. Chem. Int. Ed. Engl.) [2001]
5uniprot[Pubmed] 11880037 [Medline] 21869276 Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908: function of a halogenase and a haloperoxidase/perhydrolase.(Chem. Biol.) [2002]
6uniprot Precursor-directed biosynthesis for the generation of novel glycopetides.(Ernst Schering Res. Found. Workshop) [2005]

E9L1P1_9ZZZZ
(E9L1P1)

0.0

647

85%

Product: Putative uncharacterized protein
Gene: CA878-42
Organism: uncultured organism CA878

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

B7T1B1_9BACT
(B7T1B1)

0.0

646

86%

Product: Veg39
Gene: veg39
Organism: uncultured soil bacterium

1uniprot[Pubmed] 18987322
Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary.(Proc. Natl. Acad. Sci. U.S.A.) [2008]

Q8KLK7_STRTO
(Q8KLK7)

1e-160

570

70%

Product: DpgC
Gene
Organism: Streptomyces toyocaensis

[pubmed all]
1uniprot[Pubmed] 9177243 [Medline] 97322398 D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB.(Proc. Natl. Acad. Sci. U.S.A.) [1997]
2uniprot[Pubmed] 12060705 [Medline] 22080153 Assembling the glycopeptide antibiotic scaffold: the biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009.(Proc. Natl. Acad. Sci. U.S.A.) [2002]
3uniprot[Pubmed] 17507985 Structural basis for cofactor-independent dioxygenation in vancomycin biosynthesis.(Nature) [2007]
4uniprot[Pubmed] 18004875 Substrate recognition and catalysis by the cofactor-independent dioxygenase DpgC.(Biochemistry) [2007]

E9L1J0_9ZZZZ
(E9L1J0)

1e-154

548

67%

Product: Putative uncharacterized protein
Gene: CA37-46
Organism: uncultured organism CA37

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

E2D2E7_9BACT
(E2D2E7)

1e-153

545

69%

Product: Dihydroxyphenylglycine synthase subunit C
Gene
Organism: uncultured soil bacterium

1uniprot[Pubmed] 20577994
Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR.(Biopolymers) [2010]

Q2JA69_FRASC
(Q2JA69)

1e-151

541

69%

Product: Enoyl-CoA hydratase/isomerase
Gene: Francci3_2456
Organism: Frankia sp. (strain CcI3)

1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]

Q6ZZH4_ACTTI
(Q6ZZH4)

1e-147

526

66%

Product: DpgC protein
Gene: tcp32
Organism: Actinoplanes teichomyceticus

[pubmed all]
1uniprot[Pubmed] 15113000 Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase.(Chem. Biol.) [2004]
2uniprot[Pubmed] 14702401 Organization of the teicoplanin gene cluster in Actinoplanes teichomyceticus.(Microbiology) [2004]

E9L1U1_9ZZZZ
(E9L1U1)

1e-146

521

66%

Product: Putative uncharacterized protein
Gene: CA915-49
Organism: uncultured organism CA915

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

D7B4X5_NOCDD
(D7B4X5)

1e-131

471

60%

Product: Enoyl-CoA hydratase/isomerase
Gene: Ndas_1737
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

F2R790_STRVP
(F2R790)

1e-130

469

59%

Product: Enoyl-CoA hydratase or isomerase
Gene: SVEN_0495
Organism: Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)

1uniprot[Pubmed] 21463507
Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011]

D2UD62_XANAP
(D2UD62)

1e-108

398

52%

Product: Putative enoyl-coa hydratase isomerase protein
Gene: XALc_1061
Organism: Xanthomonas albilineans (strain GPE PC73 / CFBP 7063)

1uniprot
The complete genome sequence of Xanthomonas albilineans provides new insights into the reductive genome evolution of the xylem-limited Xanthomonadaceae.(BMC Genomics) [2009]

F3NRX6_9ACTO
(F3NRX6)

1e-104

383

52%

Product: Putative enoyl-CoA hydratase/isomerase
Gene: SGM_5890
Organism: Streptomyces griseoaurantiacus M045

1uniprot[Pubmed] 21551298
Draft Genome Sequence of the Marine Bacterium Streptomyces griseoaurantiacus M045, Which Produces Novel Manumycin-Type Antibiotics with a pABA Core Component.(J. Bacteriol.) [2011]

D0RB78_STRPR
(D0RB78)

1e-100

369

50%

Product: Hydroxyacyl-dehydrogenase
Putative hydroxyacyl-dehydrogenase
Gene: pglA
Organism: Streptomyces pristinaespiralis

1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]

Q9RPT2_9BACT
(Q9RPT2)

4e-61

240

50%

Product: Putative uncharacterized protein
Gene
Organism: uncultured bacterium AH6

1uniprot[Pubmed] 10473393 [Medline] 99402727
Construction of environmental DNA libraries in Escherichia coli and screening for the presence of genes conferring utilization of 4-hydroxybutyrate.(Appl. Environ. Microbiol.) [1999]

E9LIP8_9ACTO
(E9LIP8)

2e-38

165

39%

Product: Putative enoyl-CoA hydratase/isomerase
Gene: tiaN
Organism: Dactylosporangium aurantiacum subsp. hamdenensis

1uniprot[Pubmed] 21186805
Characterization of tiacumicin B biosynthetic gene cluster affording diversified tiacumicin analogues and revealing a tailoring dihalogenase.(J. Am. Chem. Soc.) [2011]

D8F324_9DELT
(D8F324)

3e-17

94.4

29%

Product: Enoyl-CoA hydratase/isomerase family protein
Gene: NPH_7275
Organism: delta proteobacterium NaphS2

1uniprot[Pubmed] 21124915
Genome Sequence of the Deltaproteobacterial Strain NaphS2 and Analysis of Differential Gene Expression during Anaerobic Growth on Naphthalene.(PLoS ONE) [2010]

E7DDH9_ALCFA
(E7DDH9)

4e-17

32%

Product: Enoyl-CoA hydratase family
Gene: acuK
Organism: Alcaligenes faecalis

1uniprot[Pubmed] 21248856
DddY, a periplasmic dimethylsulfoniopropionate lyase found in taxonomically diverse species of Proteobacteria.(ISME J.) [2011]

C0QFR9_DESAH
(C0QFR9)

5e-17

31%

Product: CrtA2
Gene: crtA2
HRM2_23920
Organism: Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)

1uniprot[Pubmed] 19187283
Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate reducer oxidizing organic carbon completely to carbon dioxide.(Environ. Microbiol.) [2009]

F4A6J9_CLOBO
(F4A6J9)

5e-17

31%

Product: Enoyl-CoA hydratase/isomerase
Gene: CbC4_2221
Organism: Clostridium botulinum BKT015925

1uniprot[Pubmed] 21486474
Clostridium botulinum group III: a group with dual identity shaped by plasmids, phages and mobile elements.(BMC Genomics) [2011]

F7MNE5_CLOBO
(F7MNE5)

7e-17

93.6

31%

Product: 3-hydroxybutyryl-CoA dehydratase
Gene: CBCST_10366
Organism: Clostridium botulinum C str. Stockholm

1uniprot[Pubmed] 21486474
Clostridium botulinum group III: a group with dual identity shaped by plasmids, phages and mobile elements.(BMC Genomics) [2011]

Q939X0_9PSEU
(Q939X0)

2e-16

35%

Product: Putative enoyl-CoA-isomerase
Gene: dpgD
Organism: Amycolatopsis balhimycina

[pubmed all]
1uniprot[Pubmed] 10390204 [Medline] 99318579 Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908.(Antimicrob. Agents Chemother.) [1999]
2uniprot[Pubmed] 11932455 [Medline] 21930292 Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules.(Microbiology) [2002]
3uniprot[Pubmed] 11495926 [Medline] 21486455 A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine.(J. Biol. Chem.) [2001]
4uniprot[Pubmed] 12404385 The biosynthesis of vancomycin-type glycopeptide antibiotics - the order of cyclization steps.(Angew. Chem. Int. Ed. Engl.) [2001]
5uniprot[Pubmed] 11880037 [Medline] 21869276 Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908: function of a halogenase and a haloperoxidase/perhydrolase.(Chem. Biol.) [2002]
6uniprot Precursor-directed biosynthesis for the generation of novel glycopetides.(Ernst Schering Res. Found. Workshop) [2005]

Q2NDF3_ERYLH
(Q2NDF3)

2e-16

91.7

33%

Product: Enoyl-CoA hydratase/isomerase
Gene: ELI_00980
Organism: Erythrobacter litoralis (strain HTCC2594)

1uniprot[Pubmed] 19168610
Complete genome sequence of Erythrobacter litoralis HTCC2594.(J. Bacteriol.) [2009]

Q2N892_ERYLH
(Q2N892)

3e-16

91.7

30%

Product: Enoyl-CoA hydratase/isomerase family protein
Gene: ELI_10035
Organism: Erythrobacter litoralis (strain HTCC2594)

1uniprot[Pubmed] 19168610
Complete genome sequence of Erythrobacter litoralis HTCC2594.(J. Bacteriol.) [2009]

A8N3H3_COPC7
(A8N3H3)

3e-16

91.3

33%

Product: Enoyl-CoA hydratase/carnithine racemase
Gene: CC1G_00729
Organism: Coprinopsis cinerea (strain Okayama-7 / 130 / FGSC 9003)
Inky cap fungus
Hormographiella aspergillata

1uniprot[Pubmed] 20547848
Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).(Proc. Natl. Acad. Sci. U.S.A.) [2010]

E8RDP9_9DELT
(E8RDP9)

5e-16

90.5

32%

Product: Short chain enoyl-CoA hydratase
Gene: Despr_0732
Organism: Desulfobulbus propionicus DSM 2032

1uniprot[Pubmed] 21475592
Complete genome sequence of Desulfobulbus propionicus type strain (1pr3).(Stand. Genomic Sci.) [2011]

Q5YVK2_NOCFA
(Q5YVK2)

6e-16

90.5

31%

Product: Putative enoyl-CoA hydratase/isomerase family protein
Gene: echA13
NFA_29420
Organism: Nocardia farcinica

1uniprot[Pubmed] 15466710
The complete genomic sequence of Nocardia farcinica IFM 10152.(Proc. Natl. Acad. Sci. U.S.A.) [2004]

E1IGB5_9CHLR
(E1IGB5)

6e-16

90.1

33%

Product: Enoyl-CoA hydratase/isomerase
Gene: OSCT_2366
Organism: Oscillochloris trichoides DG-6

1uniprot[Pubmed] 21037015
Draft genome sequence of the anoxygenic filamentous phototrophic bacterium Oscillochloris trichoides subsp. DG-6.(J. Bacteriol.) [2011]

Q0S9N9_RHOSR
(Q0S9N9)

1e-15

89.4

34%

Product: Possible enoyl-CoA hydratase
Gene: RHA1_ro03950
Organism: Rhodococcus sp. (strain RHA1)

1uniprot[Pubmed] 17030794
The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

D6XE41_TRYB2
(D6XE41)

2e-15

88.6

32%

Product: Enoyl-CoA hydratase, mitochondrial, putative
Gene: Tb927.3.4850
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)

[pubmed all]
1uniprot[Pubmed] 16020724 Comparative genomics of trypanosomatid parasitic protozoa.(Science) [2005]
2uniprot[Pubmed] 16020726 The genome of the African trypanosome Trypanosoma brucei.(Science) [2005]

C9ZLJ2_TRYB9
(C9ZLJ2)

2e-15

88.6

32%

Product: Enoyl-CoA hydratase, mitochondrial,putative
Gene: TbgDal_III5430
Organism: Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)

1uniprot[Pubmed] 20404998
The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic human african trypanosomiasis.(PLoS Negl. Trop. Dis.) [2010]

F0QSR3_VULM7
(F0QSR3)

3e-15

87.8

30%

Product: 3-hydroxyacyl-CoA dehydrogenase, NAD-binding protein
Gene: VMUT_1375
Organism: Vulcanisaeta moutnovskia (strain 768-28)

1uniprot[Pubmed] 21398550
Complete genome sequence of "Vulcanisaeta moutnovskia" strain 768-28, a novel member of the hyperthermophilic crenarchaeal genus vulcanisaeta.(J. Bacteriol.) [2011]

O84978_PSEPU
(O84978)

4e-15

87.4

33%

Product: PaaA
Gene: paaA
Organism: Pseudomonas putida
Arthrobacter siderocapsulatus

1uniprot[Pubmed] 9600981 [Medline] 98263372
Molecular characterization of the phenylacetic acid catabolic pathway in Pseudomonas putida U: the phenylacetyl-CoA catabolon.(Proc. Natl. Acad. Sci. U.S.A.) [1998]

Q8FSR0_COREF
(Q8FSR0)

4e-15

87.4

32%

Product: Putative 3-hydroxybutyryl-CoA dehydratase
Gene: CE0322
Organism: Corynebacterium efficiens

1uniprot[Pubmed] 12840036 [Medline] 22723752
Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens.(Genome Res.) [2003]

C8YX87_9GAMM
(C8YX87)

4e-15

87.4

32%

Product: AcuK
Gene: acuK
Organism: Halomonas sp. HTNK1

1uniprot[Pubmed] 19807777
Molecular dissection of bacterial acrylate catabolism - unexpected links with dimethylsulfoniopropionate catabolism and dimethyl sulfide production.(Environ. Microbiol.) [2009]

Q82Q04_STRAW
(Q82Q04)

5e-15

87.4

38%

Product: Putative enoyl-CoA hydratase
Gene: echA3
SAV717
SAV_717
Organism: Streptomyces avermitilis

1uniprot[Pubmed] 11572948 [Medline] 21477403
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001]

E9L1P2_9ZZZZ
(E9L1P2)

6e-15

33%

Product: Putative uncharacterized protein
Gene: CA878-43
Organism: uncultured organism CA878

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

F4DZ62_PSEMN
(F4DZ62)

1e-14

85.9

33%

Product: Enoyl-CoA hydratase-isomerase
Gene: MDS_2861
Organism: Pseudomonas mendocina (strain NK-01)

1uniprot[Pubmed] 21551299
Complete Genome of Pseudomonas mendocina NK-01, Which Synthesizes Medium-Chain-Length Polyhydroxyalkanoates and Alginate Oligosaccharides.(J. Bacteriol.) [2011]

Q64BG5_9ARCH
(Q64BG5)

1e-14

85.9

28%

Product: Enoyl-CoA hydratase/carnithine racemase
Gene: GZ27B6_24
Organism: uncultured archaeon GZfos27B6

1uniprot[Pubmed] 15353801
Reverse methanogenesis: testing the hypothesis with environmental genomics.(Science) [2004]

Q485U2_COLP3
(Q485U2)

1e-14

85.9

31%

Product: Enoyl-CoA hydratase/isomerase family protein
Gene: CPS_1430
Organism: Colwellia psychrerythraea (strain 34H / ATCC BAA-681)
Vibrio psychroerythus

1uniprot[Pubmed] 16043709
The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses.(Proc. Natl. Acad. Sci. U.S.A.) [2005]

F0K423_CLOAE
(F0K423)

1e-14

85.9

30%

Product: 3-hydroxybutyryl-CoA dehydratase
Gene: crt
CEA_G2720
Organism: Clostridium acetobutylicum (strain EA 2018)

1uniprot[Pubmed] 21284892
Comparative genomic and transcriptomic analysis revealed genetic characteristics related to solvent formation and xylose utilization in Clostridium acetobutylicum EA 2018.(BMC Genomics) [2011]

CRT_CLOAB
(P52046)

1e-14

85.9

30%

Product: 3-hydroxybutyryl-CoA dehydratase
Crotonase
Gene: crt
CA_C2712
Organism: Clostridium acetobutylicum

[pubmed all]
1uniprot[Pubmed] 8655474 [Medline] 96236011 Cloning, sequencing, and expression of clustered genes encoding beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase, crotonase, and butyryl-CoA dehydrogenase from Clostridium acetobutylicum ATCC 824.(J. Bacteriol.) [1996]
2uniprot[Pubmed] 11466286 [Medline] 21359325 Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum.(J. Bacteriol.) [2001]

Q67P31_SYMTH
(Q67P31)

2e-14

85.5

34%

Product: Enoyl-CoA hydratase/isomerase family protein
Gene: STH1577
Organism: Symbiobacterium thermophilum

1uniprot[Pubmed] 15383646
Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism.(Nucleic Acids Res.) [2004]