Substance Data


Safety information on chemicals is from the results of the existing chemicals survey program conducted by the Japanese Government (Ministry of Health, Labour and Welfare, 
Ministry of Economy, Trade and Industry, and Ministry of the Environment).

User should check the details with the original report(in Jpanenese) for confirmation. 

Data may not be evaluated or assessed by expert and confirmation of test results is needed if these data are used for assessment.

Some of Year in DATA SOURCE means tested year (financial year).



Endpoints

#32: Bioaccumulation: aquatic/sediment


Administrative data
         Purpose flag :
         Data waiving :
         Justification for data waiving :
         Study result type :
         Study period :2001-11-09 - 2002-03-29
         Reliability :1 (reliable without restriction)
         Rationale for reliability incl. deficiencies :
DATA SOURCE
       Reference
         Testing laboratory:Mitsubishi Chemical Safety Institute Ltd.
MATERIALS AND METHODS
       Test guideline
         Qualifier:according to
         Guideline:other guideline:
         Guideline:"The Notice on the Test Method Concerning New Chemical Substances"
         GLP compliance:yes (incl. certificate)
   Test materials
       Test material identity
         Identifier:common name
         Identity:Poly(oxyethylene) octylphenyl ether n=7-11(average number of polymerization is 9)
         Details on test material:- Purity: 98.93 % (n=3 - 18) (by HPLC) - Water solubility: >= 100 g/L
         Details on analytical methods:- Recovery ratio : Test water : peak A (n=11) 100 %, peak B (n=10) 100 %, peak C (n=9) 100 %, peak D (n=8) 100 %, peak E (n=7) 100 % Fish : peak A (n=11) 82.4 %, peak B (n=10) 81.1 %, peak C (n=9) 80.8 %, peak D (n=8) 83.5 %, peak E (n=7) 83.3 % - Limit of quantitation : Test water : 1st concentration area : peak A (n=11) 10 microg/L, peak B (n=10) 20 microg/L, peak C (n=9) 20 microg/L, peak D (n=8) 10 microg/L, peak E (n=7) 10 microg/L 2nd concentration area : peak A (n=11) 1 microg/L, peak B (n=10) 2 microg/L, peak C (n=9) 2 microg/L, peak D (n=8) 1 microg/L, peak E (n=7) 1 microg/L Fish: peak A (n=11) 700 ng/g, peak B (n=10) 700 ng/g, peak C (n=9) 700 ng/g, peak D (n=8) 700 ng/g, peak E (n=7) 700 ng/g
   Test organisms
         Test organisms (species):Cyprinus carpio
   Study design
         Exposure / uptake duration:28
         Unit:d
   Test conditions
         Nominal and measured concentrations:- Nominal concentrations  1st Concentration area: 0.2 mg/L  2nd Concentration area: 0.02 mg/L 
         Details on test conditions:RANGE-FINDING / PRELIMINARY STUDY - Test concentrations: LC50(96hr) 28 mg/L - Fish species: Rice fish (Oryzias latipes)
RESULTS AND DISCUSSION
       Lipid content of test organisms
         Lipid content:3.9
         Unit of lipid content:%
         Time point:start of exposure
         Lipid content:4.7
         Unit of lipid content:%
         Time point:end of exposure
       Bioaccumulation factor
         Concentration in environment / dose level:0.2 mg/L peak A (n=11)
         Type of bioaccumulation factor:BCF
         Bioaccumulation value:<
         Bioaccumulation value:3
         Unit:L/kg
         Calculation basis:steady state
         Concentration in environment / dose level:0.2 mg/L peak B (n=10)
         Type of bioaccumulation factor:BCF
         Bioaccumulation value:<
         Bioaccumulation value:3
         Unit:L/kg
         Calculation basis:steady state
         Concentration in environment / dose level:0.2 mg/L peak C (n=9)
         Type of bioaccumulation factor:BCF
         Bioaccumulation value:<
         Bioaccumulation value:3
         Unit:L/kg
         Calculation basis:steady state
         Concentration in environment / dose level:0.2 mg/L peak D (n=8)
         Type of bioaccumulation factor:BCF
         Bioaccumulation value:<
         Bioaccumulation value:3
         Unit:L/kg
         Calculation basis:steady state
         Concentration in environment / dose level:0.2 mg/L peak E (n=7)
         Type of bioaccumulation factor:BCF
         Bioaccumulation value:<
         Bioaccumulation value:3
         Unit:L/kg
         Calculation basis:steady state
         Concentration in environment / dose level:0.02 mg/L peak A (n=11)
         Type of bioaccumulation factor:BCF
         Bioaccumulation value:<
         Bioaccumulation value:30
         Unit:L/kg
         Calculation basis:steady state
         Concentration in environment / dose level:0.02 mg/L peak B (n=10)
         Type of bioaccumulation factor:BCF
         Bioaccumulation value:<
         Bioaccumulation value:30
         Unit:L/kg
         Calculation basis:steady state
         Concentration in environment / dose level:0.02 mg/L peak C (n=9)
         Type of bioaccumulation factor:BCF
         Bioaccumulation value:<
         Bioaccumulation value:31
         Unit:L/kg
         Calculation basis:steady state
         Concentration in environment / dose level:0.02 mg/L peak D (n=8)
         Type of bioaccumulation factor:BCF
         Bioaccumulation value:<
         Bioaccumulation value:30
         Unit:L/kg
         Calculation basis:steady state
         Concentration in environment / dose level:0.02 mg/L peak E (n=7)
         Type of bioaccumulation factor:BCF
         Bioaccumulation value:<
         Bioaccumulation value:31
         Unit:L/kg
         Calculation basis:steady state
       Depuration
         Any other information on results incl. tables:

 Bioaccumulation test results

Peak A (n=11)

     4 d 7 d 14 d 21 d 28 d
1st Concentration area Test substance concentration (mg/L) 0.201 0.207 0.192 0.196 0.204
Bioconcentration factor (L/kg) < 3 < 3 < 3 < 3 < 3
< 3 < 3 < 3 < 3 < 3
2nd Concentration area  Test substance concentration (mg/L) 0.0216 0.0196 0.0215 0.0210 0.0210
Bioconcentration factor (L/kg) < 18 < 20 < 19 < 30 < 30
< 17 < 19 < 24 < 29 < 30

Peak B (n=10)

     4 d 7 d 14 d 21 d 28 d
1st Concentration area Test substance concentration (mg/L) 0.202 0.210 0.190 0.195 0.200
Bioconcentration factor (L/kg) < 3 < 3 < 3 < 3 < 3
< 3 < 3 < 3 < 3 < 3
2nd Concentration area  Test substanc econcentration (mg/L) 0.0215 0.0199 0.0208 0.0211 0.0208
Bioconcentration factor (L/kg) < 18 < 20 < 19 < 30 < 30
< 18 < 20 < 24 < 30 < 30

Paek C (n=9)

     4 d 7 d 14 d 21 d 28 d
1st Concentration area  Test substance concentration (mg/L) 0.199 0.209 0.194 0.191 0.198
Bioconcentration factor (L/kg) < 3 < 3 < 3 < 3 < 3
< 3 < 3 < 3 < 3 < 3
2nd Concentration area   Test substance concentration (mg/L) 0.0216 0.0196 0.0213 0.0206 0.0206
Bioconcentration factor (L/kg) < 18 < 21 < 19 < 31 < 31
< 18 < 20 < 24 < 30 < 31

Peak D (n=8)

     4 d 7 d 14 d 21 d 28 d
1st Concentration area Test substance concentration (mg/L) 0.199 0.213 0.190 0.189 0.198
Bioconcentration factor (L/kg) < 3 < 3 < 3 < 3 < 3
< 3 < 3 < 3 < 3 < 3
2nd Concentration area    Test substance concentration (mg/L) 0.0215 0.0195 0.0210 0.0201 0.0202
Bioconcentration factor (L/kg) < 18 < 20 < 19 < 30 < 30
< 17 < 19 < 24 < 29 < 30

Peak E (n=7)

     4 d 7 d 14 d 21 d 28 d
1st Concentration area Test substance concentration (mg/L) 0.193 0.207 0.190 0.186 0.204
Bioconcentration factor (L/kg) < 3 < 3 < 3 < 3 < 3
< 3 < 3 < 3 < 3 < 3
2nd Concentration area   Test substance concentration (mg/L) 0.0201 0.0191 0.0209 0.0198 0.0205
Bioconcentration factor (L/kg) < 19 < 21 < 20 < 31 < 31
< 18 < 20 < 24 < 30 < 31
OVERALL REMARKS, ATTACHMENTS
       Attached background material
       Attached full study report
APPLICANT'S SUMMARY AND CONCLUSION

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