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General Information
- General Information
  - General Information Data Description
    - CHRIP_ID C004-661-86A CAS RN 88-73-3
      
      Chemical Substance Name 1-Chloro-2-nitrobenzene
      
      Molecular Formula C6H4ClNO2
      
      Molecular Weight 158
      
      SMILES O=[N+]([O-])C1=C(Cl)C=CC=C1
      
      Structure
- Synonym
  - Synonym Data Description
    - Synonym 2-Chloronitrobenzene
      
      Benzene, 1-chloro-2-nitro-
      
      Chloronitrobenzenes
      
      o-Chloronitrobenzene
      
      o-Nitrochlorobenzene
- Nikkaji
  - Information of Japan Chemical Substance Dictionary (Nikkaji) Data Description
    - Nikkaji Number
      J3.546G
      Detail to J-GLOBAL

Laws and Regulations in Japan

Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc. (Chemical Substances Control Law ; CSCL)

Japan CSCL: Existing Chemical Substances Data Description Definition of the terms of Section 6 [PDF] Definition of the terms of Section 7 [PDF] Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]

MITI Number	3-442	Category	Section 3
Chemical Substance Name	Monochloro-nitrobenzene
Remarks	-
Details	to J-CHECK
Remarks to Existing Chemical Substances of Industrial Safety and Health Act	Chemicals have been notified in accordance with the provisions of Chemical Substances Control Law by June 29, 1979
Details to Existing Chemical Substances of Industrial Safety and Health Act	to MHLW site (in Japanese)

Japan CSCL: Type II Monitoring Chemical Substances (before amendment) Data Description Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]
- Registration Number
  991
  Date of Designation in the Official Gazette 2010/03/19
  
  MITI Number
  3-442
  
  Chemical Substance Name 2-Chloronitrobenzene
  
  Remarks -
  
  Details to J-CHECK

Japan CSCL: Type III Monitoring Chemical Substances (before amendment) Data Description Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]
- Registration Number
  196
  Date of Designation in the Official Gazette 2010/03/19
  
  MITI Number
  3-442
  
  Chemical Substance Name 2-Chloronitrobenzene
  
  Remarks -
  
  Details to J-CHECK

Japan METI: Biodegradation and Bioconcentration Results Data Description

Chemical Substance Name	o-chloronitrobenzene
Judgement of Biodegradation	Not readily biodegradable	Judgement of Bioconcentration	Low bioconcentration
Test result of Bioconcentration	-	Test result of Partition Coefficient	-
Details	to J-CHECK

Act on Confirmation, etc. of Release Amounts of Specific Chemical Substances in the Environment and Promotion of Improvements to the Management Thereof(PRTR-SDS Law)
- Japan: PRTR-SDS Law (until March 2023) Data Description Outline PRTR Law (METI site) Analysis of PRTR data
  - Classification I Cabinet Order Number
    1-112
    
    Cabinet Order Name 2-Chloronitrobenzene
    
    Remarks -
    
    Basis of selection Hazard Data (in Japanese)
    
    Link Releases Map (in Japanese) -

Industrial Safety and Health Act (ISHA)

Japan ISHA: Chemical Substances Requiring Labeling and Delivery of Documents, etc. Data Description GHS compatible model label creation method (MH LW site : in Japanese) Risk assessment implementation support tool (MHLW site : in Japanese)

Cabinet Order Number	Attached table 9-152-2 of Cabinet order: To be enforced from April 1, 2024
Cabinet Order Name	2-Chloronitrobenzene
Range of Application for Label (weight%)	>=0.1
Range of Application for SDS (weight%)	>=0.1

Japan ISHA: Carcinogenic Substances (Ordinance on Industrial Safety and Health) (subject to 30-year storage of work records, etc.) Data Description Lists of Target Substances (MHLW site : in Japanese)

GHS Classification Substance Name	ortho-Nitrochlorobenzene
Carcinogenicity in GHS classification	Category 1B	Range of Application (weight%)	>=0.1
Implementation	2024/4/1
Details	to the GHS Classification

Japan ISHA: Chemical substances that cause skin disorders, etc. and other chemical substances that must be handled with impermeable protective equipment etc. based on special chemical regulations. Data Description Target substances list(MHLW site: in japanese)
- Substance Name o-Nitrochlorobenzene
  
  Classification of Target Substances Skin Absorbing Hazardous Substances Cutoff value(weight %) 0.1
  
  Implementation 2024/4/1
  
  Details to the GHS Classification

Japan ISHA: Guidelines for Carcinogenic Substances Data Description
- Name 1-Chloro-2-nitrobenzene
  
  Details to MHLW site (in Japanese)

Japan ISHA: Strong Mutagenic Chemical Substances Data Description Related information (MHLW site : in Japanese)
- Classification Existing Chemical Substances
  
  Name 2-Chloronitrobenzene
  
  Date of Notification 2001/03/30 Appendix2(3)

Poisonous and Deleterious Substances Control Act
- Japan Poisonous and Deleterious Substances Control Act Data Description Link to the Act (MOJ site)
  - Classification Deleterious Substances(Cabinet order) Law or Cabinet Order Number
    Article 2-1-28-10 of Cabinet order
    
    Law or Cabinet Order Name 2-Chloronitrobenzene and preparations containing it

Fire Service Act

Fire Service Act : Substances that inhibit firefighting activities Data Description

Number of cabinet order etc.	HM Ordinance Article 1-10 (6) Attached Table 2(18), MIC Ordinance Article 2(25)
Substances	2-chloronitrobenzene and preparations containing it
Stipulated quantity	200kg
Sources	MHLW Website; Sample SDS

Laws and Regulations in Other countries

Recommendations on the transport of dangerous goods
- Dangerous Goods List (UN Number and Hazard class) Data Description
  - UN Number
    1578
    Class or Division 6.1
    
    Name and Description CHLORONITROBENZENES, SOLID
    
    UN packing group II
    
    UN Number
    3409
    Class or Division 6.1
    
    Name and Description CHLORONITROBENZENES, LIQUID
    
    UN packing group II

Association of South-East Asian Nations(ASEAN)
- The ASEAN-Japan Chemical Safety Database (AJCSD).: Laws and Regulations Data Description
  - Detail to AJCSD

European Union (EU)
- EC Inventory Data Description
  - EC Number
    201-854-9
    
    EC Name 1-chloro-2-nitrobenzene
    
    Description -
    
    Substance Infocard Infocard
    
    ECHA Name -

US: Toxic Substances Control Act (TSCA)
- TSCA Inventory Data Description
  - TSCA Chemical Substance Name Benzene, 1-chloro-2-nitro-
    
    DEF -
    
    UVCB -
    
    FLAG -
    
    ACTIVITY ACTIVE

China
- China: Catalog of Hazardous Chemicals 2015 Data Description
  - Number
    1544
    
    Name 2-Chloronitrobenzene
    
    Other Name o-Chloronitrobenzene
    
    Remarks -

Korea

Korea: ARECs (K-REACH) / CCA; Hazardous Substance(s), Priority Control Substances Data Description
- Number
  99-1-491
  
  Category Toxic Substance(s)
  
  Chemical Substance Name 1-Chloro-2-nitrobenzene
  
  Range of Application (%)
  >=25

Korea: ARECs (K-REACH); Existing Chemical Substances Data Description

KE Number	KE-05779
Category	Existing Chemical Substances (Domestically distributed commercial purpose before February 2, 1991.)
Chemical Substance Name	1-Chloro-2-nitrobenzene
Remarks	In the case of being hydrated, the resulting hydrate is also applicable.

Taiwan
- Taiwan: TCCSCA/OSHA; Existing Chemical Substances Data Description
  - English Name 1-chloro-2-nitrobenzene
    
    Chinese Name -

Chemical Hazard and Risk Information

GHS Classification Results

NITE Japan-GHS Data Description
- Edition version_2
  
  Chemical Substance Name o-Nitrochlorobenzene
  
  Classification Result To the resut webpage To the Excel flie

GHS Classification Results by the Japanese Government Data Description GHS Information

Year of implementation /renewal	2006	ID	1184_H18_new
Chemical Substance Name	Benzene, 1-chloro-2-nitro-
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2009	ID	21B3200
Chemical Substance Name	o-Phenylenediamine
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2018	ID	H30-C-003-MHLW
Chemical Substance Name	o-Nitrochlorobenzene
Classification Result	To the resut webpage To the Excel flie
Remarks	The reclassification result of only some hazard classes. As for the other classes, please see the result in FY2009.

Year of implementation /renewal	2021	ID	R03-C-001-MHLW
Chemical Substance Name	o-Nitrochlorobenzene
Classification Result	To the resut webpage To the Excel flie
Remarks	The reclassification result of only some hazard classes. As for the other classes, please see the result in FY2009.

MHLW:GHS Aligned Sample Label and SDS
- GHS Aligned Sample Label and SDS Data Description Information on GHS Aligned Sample Label and SDS (Workplace Safety Site)
  - Chemical Substance Name o-Nitrochlorobenzene
    
    Sample Label to MHLW Website (in Japanese Only)
    
    Sample SDS to MHLW Website (in Japanese Only)

AIST: Relational Information System for Chemical Accidents Database(RISCAD)
- Relational Information System for Chemical Accidents Database(RISCAD) Data Description RISCAD (in Japanese)
  - Material ID 1533
    
    Name 2-chloronitrobenzene
    
    Material Information to RISCAD
    
    Accident Information to RISCAD

Hazard and Risk Assessment Reports etc. in Japan
- ISHA: Risk Assessment Report Data Description to MHLW site (in Japanese)
  - Name 2-Chloronitrobenzene
    
    Initial Risk Assessment Report text/cover (in Japanese)
- ISHA: Examples of Occupational Accidents Caused by Chemical Substances Data Description
  - Name o-Chloronitrobenzene (synonym: 2-Chloronitrobenzene)
    
    Examples of Occupational Accidents to MHLW site (in Japanese)
- Hazard Data Sheet for Chemical Substances Data Description
  - Book Number
    98-21
    Date of publication/ renewal 1999/08
    
    Assessed Chemical Substance Name o-Chloronitrobenzene
    
    Details Hazard Data Sheet (in Japanese)
- CSCL: The Japan HPV Challenge Program Data Description
  - Chemical Substance Name 1-chloro-2-nitrobenzene
    
    Details to J-CHECK

Hazard and Risk Assessment Reports etc. in Other Countries
- OECD: High Production Volume (HPV) Chemicals Data Description
  - Chemical Name Benzene, 1-chloro-2-nitro-
    
    Details to OECD Existing Chemicals Database
- International Chemical Safety Cards (ICSC) Data Description
  - ICSC Number
    28
    
    ICSC Title 2-Chloro-1-nitrobenzene
    
    Details to ILO site
- Advisory Committee on Existing Chemicals (BUA) Reports by the German Chemical Society Data Description
  - BUA Number
    2, 259
    
    Substance Name o-Chloronitrobenzene
    
    Related information to BUA site

Japan Society for Occupational Health (JSOH) Recommendation of Occupational Exposure Limits
- JSOH: Occupational Carcinogens Data Description
  - Substance Name o-Nitrochlorobenzene
    
    Carcinogenicity classification 2B
    
    Details -
    
    Year of proposal 2019
    
    Remarks -

Carcinogenicity Assessment

IARC: Carcinogenicity Assessment Data Description to IARC site

Volume	65, 123	Volume publication year	2020 online
Agent Name	2-Chloronitrobenzene
Group	2B
Details	Vol.65 Vol.123 - - -

Volume	-	Volume publication year	-
Agent Name	Chloronitrobenzenes (see 2-Chloronitrobenzene, 3-Chloronitrobenzene, 4-Chloronitrobenzene)
Group	-
Details	- - - - -

Test Data and Reports

Japan METI: Biodegradation and Bioconcentration Results Data Description

Chemical Substance Name	o-chloronitrobenzene
Judgement of Biodegradation	Not readily biodegradable	Judgement of Bioconcentration	Low bioconcentration
Test result of Bioconcentration	-	Test result of Partition Coefficient	-
Details	to J-CHECK

ISHA: Carcinogenicity Test Results for Chemical Substances Data Description to MHLW site (in Japanese)
- Chemical Name o-Chloronitrobenzene (synonym: 1-Chloro-2-nitrobenzene)
  
  Summary Oral test results (in Japanese)

ISHA: Mutagenicity Test Results for Chemical Substances Data Description to MHLW site (in Japanese)
- Chemical Name 2-Chloronitrobenzene
  
  Bacterial Test Negative/Positive
  
  CHL/IU Test Positive

CHRIP_ID	C004-661-86A	CAS RN	88-73-3
Chemical Substance Name	1-Chloro-2-nitrobenzene
Molecular Formula	C6H4ClNO2
Molecular Weight	158
SMILES	O=[N+]([O-])C1=C(Cl)C=CC=C1
Structure

Synonym	2-Chloronitrobenzene
	Benzene, 1-chloro-2-nitro-
	Chloronitrobenzenes
	o-Chloronitrobenzene
	o-Nitrochlorobenzene

Registration Number	991	Date of Designation in the Official Gazette	2010/03/19
MITI Number	3-442
Chemical Substance Name	2-Chloronitrobenzene
Remarks	-
Details	to J-CHECK

Classification	I	Cabinet Order Number	1-112
Cabinet Order Name	2-Chloronitrobenzene
Remarks	-
Basis of selection	Hazard Data (in Japanese)
Link	Releases Map (in Japanese) -

Substance Name	o-Nitrochlorobenzene
Classification of Target Substances	Skin Absorbing Hazardous Substances	Cutoff value(weight %)	0.1
Implementation	2024/4/1
Details	to the GHS Classification

Name	1-Chloro-2-nitrobenzene
Details	to MHLW site (in Japanese)

Classification	Existing Chemical Substances
Name	2-Chloronitrobenzene
Date of Notification	2001/03/30 Appendix2(3)

Classification	Deleterious Substances(Cabinet order)	Law or Cabinet Order Number	Article 2-1-28-10 of Cabinet order
Law or Cabinet Order Name	2-Chloronitrobenzene and preparations containing it

UN Number	1578	Class or Division	6.1
Name and Description	CHLORONITROBENZENES, SOLID
UN packing group	II

UN Number	3409	Class or Division	6.1
Name and Description	CHLORONITROBENZENES, LIQUID
UN packing group	II

EC Number	201-854-9
EC Name	1-chloro-2-nitrobenzene
Description	-
Substance Infocard	Infocard
ECHA Name	-

TSCA Chemical Substance Name	Benzene, 1-chloro-2-nitro-
DEF	-
UVCB	-
FLAG	-
ACTIVITY	ACTIVE

English Name	1-chloro-2-nitrobenzene
Chinese Name	-

Material ID	1533
Name	2-chloronitrobenzene
Material Information	to RISCAD
Accident Information	to RISCAD

Number	1544
Name	2-Chloronitrobenzene
Other Name	o-Chloronitrobenzene
Remarks	-

Number	99-1-491
Category	Toxic Substance(s)
Chemical Substance Name	1-Chloro-2-nitrobenzene
Range of Application (%)	>=25

Edition	version_2
Chemical Substance Name	o-Nitrochlorobenzene
Classification Result	To the resut webpage To the Excel flie

Chemical Substance Name	o-Nitrochlorobenzene
Sample Label	to MHLW Website (in Japanese Only)
Sample SDS	to MHLW Website (in Japanese Only)

Name	2-Chloronitrobenzene
Initial Risk Assessment Report	text/cover (in Japanese)

Name	o-Chloronitrobenzene (synonym: 2-Chloronitrobenzene)
Examples of Occupational Accidents	to MHLW site (in Japanese)

Book Number	98-21	Date of publication/ renewal	1999/08
Assessed Chemical Substance Name	o-Chloronitrobenzene
Details	Hazard Data Sheet (in Japanese)

Chemical Name	Benzene, 1-chloro-2-nitro-
Details	to OECD Existing Chemicals Database

ICSC Number	28
ICSC Title	2-Chloro-1-nitrobenzene
Details	to ILO site

BUA Number	2, 259
Substance Name	o-Chloronitrobenzene
Related information	to BUA site

Substance Name	o-Nitrochlorobenzene
Carcinogenicity classification	2B
Details	-
Year of proposal	2019
Remarks	-

Chemical Name	o-Chloronitrobenzene (synonym: 1-Chloro-2-nitrobenzene)
Summary	Oral test results (in Japanese)

Chemical Name	2-Chloronitrobenzene
Bacterial Test	Negative/Positive
CHL/IU Test	Positive