March 2024

[HESS]

• 1.Repeated dose toxicity study data of Japanese CSCL were added to the database (67 chemicals, 67 studies).

March 2023

[HESS]

• 1.Repeated dose toxicity study data of Japanese CSCL were added to the database (56 chemicals, 56 studies).
• 2.RDT Data: HESS repeated dose toxicity: Some data were corrected.

[HESS DB]

• 1.The system has been updated to support Windows 11 and PostgreSQL14.

June 2022

[HESS]

• 1.BUGFIX: Resolved problems with the function for adding user-owned data (in-house data).

March 2022

[HESS]

• 1.Repeated dose toxicity study data of Japanese CSCL were added to the database (110 chemicals, 110 studies)
• 2.New toxicological categories developed mostly in collaboration with KAO corporation (8 categories)

March 2021

[HESS]

• 1.Repeated dose toxicity study data of Japanese CSCL were added to the database. (53 chemicals, 60 studies)
• 2.Repeated dose toxicity study data were added to the database.
  • * MHLW RDT data (20 chemicals, 20 studies total)
• 3.New toxicological categories developed mostly in collaboration with KAO corporation. (19 categories)

March 2020

[HESS]

• 1.Repeated dose toxicity study data were added to the database. (40 chemicals, 40 studies)
• 2.With the cooperation of AI-SHIPS (Mizuho Information & Research Institute, Inc.), we conducted QA in SMILES notation for test substances (identification of　steric structure, clarification of mixture, etc.)

[HESS DB]

• 1.Toxicity mechanism information (5 chemicals, 12 references) and summary of toxicity mechanism (4 chemicals) were added.

April 2019

[HESS]

• 1.Repeated dose toxicity study data were added to the database. (55 chemicals, 55 studies)

[HESS DB]

• 1.Repeated dose toxicity study data were added to the database. (55 chemicals, 55 studies)
• 2.Toxicity mechanism information (27 chemicals, 37 references) were added.

September 2018

[HESS]

• 1. Repeated dose toxicity study data were added to the database. New chemical substance data under CSCL (50 chemicals, 50 studies)

March 2018

[HESS]

• 1. Repeated dose toxicity study data were added to the database. New chemical substance data under CSCL (35 chemicals, 35 studies)
• 2. New toxicological alerts developed in collaboration with KAO corporation (92 alerts for nephrotoxicity) were added.
• 3. New function for identifying tautomer was implemented.

August 2017

[HESS]

• 1. Repeated dose Inhalation study data were added to the new sub-database(HESS RDT DB(Inhalation)).
  • * HPV
  • * New chemical substance data under CSCL
• 2.New toxicological categories developed mostly in collaboration with KAO corporation (2 categories).

February 2017

[HESS]

• 1.Repeated dose toxicity study data were added to the database.
  • New chemical substance data under CSCL (38 chemicals, 38 studies total)
• 2.New toxicological alert developed mostly in collaboration with KAO corporation (75 alerts).

October 2016

[HESS]

• 1.Repeated dose toxicity study data of Japanese CSCL were added to the database.(46 chemicals, 46 studies total)

[HESS DB]

• 1.Repeated dose toxicity study data of Japanese CSCL were added to the database.(46 chemicals, 46 studies total)
• 2.Toxicity mechanism information (3 chemicals, 3 references) were added.

January 2016

[HESS]

• 1.Repeated dose toxicity study data were added to the database.
  • * MHLW RDT data (24 chemicals, 24 studies total)

[HESS DB]

• 1.Repeated dose toxicity study data were added to the database.
  • * MHLW RDT data (24 chemicals, 24 studies total)
• 2.ADME information were added (247 chemicals, 380 references).
• 3.Toxicity mechanism information (11 chemicals, 25 references) and summary of toxicity mechanism (2 chemicals) were added.

July 2015

[HESS]

• 1.The following repeated dose toxicity RDT test data were added.
  • * Tox-Omics RDT data (31 chemicals, 32 studies in total)
  • * TGP (Toxicogenomics) RDT data (124 chemicals, 124 studies in total)
  • * OECD HPV RDT data (130 chemicals, 150 studies total)
• 2.Metabolic maps were added (150 chemicals, 159 maps in total)
• 3.Nine categories of HPV chemicals were added.

[HESS DB]

• 1.Tox-Omics repeated dose toxicity data (31 chemicals, 32 studies total) were added.

January 2015

[HESS]

• 1.Repeated dose toxicity study data of Japanese CSCL, NTP and OECD HPV chemicals (64 chemicals, 77 studies total) were added to the database.
• 2.Profiler: Repeated dose (HESS): OECD HPV long chain alcohol category were added. Seven categories were updated in terms of data set chemicals.

[HESS DB]

• 1.Dose response data of repeated dose toxicity study of Japanese CSCL and NTP chemicals (31 chemicals, 32 studies total) were added to the database.
• 2.Reference information on toxicity mechanism (14 chemicals, 22 references) and 1 AOP were added to the database.

July 2014

[HESS/HESS DB]

The following data were added to the databases:

• 1.Repeated dose toxicity studies of 14 chemicals recently released under Japanese CSCL.
• 2.Repeated dose toxicity studies of 50 drugs published in journals prior to registration in Japan.

March 2014

[HESS/HESS DB]

• 1.Repeated dose toxicity test data for existing chemicals under Japanese Chemical Substances Control Law (63 chemicals).

[HESS]

New features of HESS

• 1.Function of profiling metabolites was equipped.
• 2.Undo function was equipped.

Updated data

• 1.Repeated dose toxicity test data kindly provided from COSMOS project (852 chemicals).
• 2.Repeated dose toxicity test data kindly provided from ToxCast project (493 chemicals).
• 3.New toxicological categories developed mostly in collaboration with KAO corporation (28 categories).

[HESS DB]

New features of HESS DB

• 1.Compatible with 64 bit Windows 7/8.
• 2.Improvement of data input by equipped "copy" & "paste" function.

Updated data

• 1.Reference information on toxicity mechanism (32 chemicals, 60 refs, 8 AOP summaries)

July 2013

[HESS/HESS DB]

Updated data

• 1.Repeated dose toxicity test data for 16 existing chemicals under Japanese Chemical Substances Control Law (Chem No. 340, 524-538).

[HESS]

• 1.Profiler: Repeated dose (HESS): Descriptions of some categories were updated.
• 2.Profiler: Custom: A bug related to similarity boundaries setting was fixed.
• 3.RDT Data: HESS repeated dose toxicity: A part of the endpoint tree was modified.
• 4.RDT Data: HESS repeated dose toxicity: Some data were corrected.

[HESS DB]

• 1.ADME information: Results of in silico P450 metabolism prediction were added to the database for 51 chemicals.
• 2.Toxicity mechanism information: Nineteen references for 8 chemicals and 6 toxicity mechanism summary reports were added to the database.
• 3.Link to original: The following links were updated.
  • * Toxicity data on the "Study_View" screen to the original toxicity test report
  • * Reference information on "ADME_View" screen to PubMed
  • * Reference information on "Mechanism_View" screen to PubMed

January 2013

[HESS/HESS DB]

Updated data

• 1.Repeated dose toxicity test data for 14 existing chemicals under Japanese Chemical Substances Control Law (Chem No. 354, 374, 512-523).

[HESS]

• 1.Input: Added Study No. to input methods.
• 2.Input: Added CAS querying when adding a post target.
• 3.Input: Changed the way stereo is handled during input in order to match database chemicals.
• 4.Profiler: Updated dendroid profiler visualization.
• 5.Profiler: Updated some of the profilers.
• 6.Profiler: Updated HESS profiler: updated training set chemicals in some of the categories.
• 7.Profiler: Updated HESS profiler: changed is Counter profile - "Not categorized" instead of N/A.
• 8.Categories: Fixed problem with filter.
• 9.Reports: Updated.

[HESS DB]

• 1.ADME information: Results of in silico P450 metabolism prediction were added to the database for 60 chemicals.
• 2.Toxicity mechanism information: Information on 33 references for 12 chemicals were added to the database.

July 2012

[HESS/HESS DB]

Updated data

• 1.Repeated dose toxicity test data for 2 existing chemicals under Japanese Chemical Substances Control Law (Chem No. 510, 511).

[HESS]

• 1.Profiling: Corrected a wrong table in the description of azobenzenes (Hemolytic anemia with methemoglobinemia) category in repeated dose (HESS) profiler.
• 2.BUGFIX: Fixed a bug where RDT data for a post target chemical could not be gathered.
• 3.BUGFIX: Fixed a bug where a name of saved filter could not be displayed.

[HESS DB]

• 1.ADME information: Results of in silico P450 metabolism prediction were added to the database for about 50 chemicals.