芳香環開裂
概要
芳香族炭化水素の好気的分解は、まず芳香環が水酸化され (upper pathway) 、ジヒドロキシ化合物の芳香環の開裂が起こり、さらに数段階の反応を経て (lower pathway)、最終的にTCA回路の中間体となり経路に組み込まれる。環開裂は、ジオキシゲナーゼによる酸化的開裂で、メタとオルト開裂がある。
環開裂反応
- メタ開裂 (meta- [extradiol] cleavage) ： 隣接する2つの水酸基の隣で開裂が起こる
- オルト開裂 (ortho- [intradiol] cleavage) ： 隣接する2つの水酸基の間で開裂が起こる
参考文献
MiFuPへのリンク
オルト開裂経路
- NFUNC_0013 Catechol degradation (beta-ketoadipate pathway)
NRULE_0052 Catechol 1,2-dioxygenase
NRULE_0053 (Chloro)muconate cycloisomerase
NRULE_0054 Muconolactone isomerase
NRULE_0070 3-oxoadipate enol-lactonase
NRULE_0071 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase
NRULE_0072 3-oxoadipate CoA-transferase subunit A
NRULE_0073 3-oxoadipate CoA-transferase subunit B
NRULE_0074 Beta-ketoadipyl-CoA thiolase
NRULE_0386 Muconate cycloisomerase - NFUNC_0014 Protocatechuate degradation (beta-ketoadipate pathway)
NRULE_0066 Protocatechuate 3,4-dioxygenase alpha subunit
NRULE_0067 Protocatechuate 3,4-dioxygenase beta subunit
NRULE_0068 3-carboxy-cis,cis-muconate cycloisomerase
NRULE_0069 4-carboxymuconolactone decarboxylase
NRULE_0070 3-oxoadipate enol-lactonase
NRULE_0071 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase
NRULE_0072 3-oxoadipate CoA-transferase subunit A
NRULE_0073 3-oxoadipate CoA-transferase subunit B
NRULE_0074 Beta-ketoadipyl-CoA thiolase - NFUNC_0104 Chlorocatechol degradation (beta-ketoadipate pathway)
NRULE_0053 (Chloro)muconate cycloisomerase
NRULE_0072 3-oxoadipate CoA-transferase subunit A
NRULE_0073 3-oxoadipate CoA-transferase subunit B
NRULE_0074 Beta-ketoadipyl-CoA thiolase
NRULE_0382 Chlorocatechol 1,2-dioxygenase
NRULE_0383 Dienelactone hydrolase
NRULE_0384 Maleylacetate reductase
NRULE_0385 Chloromuconolactone dehalogenase
NRULE_0387 Chloromuconate cycloisomerase
メタ開裂経路
- NFUNC_0011 Dihydroxy aromatic compounds degradation (via meta-cleavage pathway)
NRULE_0058 extradiol dioxygenase
NRULE_0059 meta-cleavage compound hydrolase
NRULE_0060 2-hydroxymuconic semialdehyde dehydrogenase
NRULE_0061 4-oxalocrotonate tautomerase
NRULE_0062 4-oxalocrotonate decarboxylase
NRULE_0063 2-hydroxypent-2,4-dienoate hydratase
NRULE_0064 4-hydroxy-2-oxovalerate aldolase
NRULE_0065 Acetaldehyde dehydrogenase
（更新日 2015/07/22）