English site

遺伝子 : 3-carboxy-cis,cis-muconate cycloisomerase (PCAB)

遺伝子情報

ID NRULE_0068
遺伝子ID PCAB
作成日 2012/10/05
タンパク質名
Protein name
Full
3-carboxy-cis,cis-muconate cycloisomerase
EC
EC 5.5.1.2
Synonym
Full
3-carboxymuconate lactonizing enzyme
遺伝子名 pcaB
遺伝子条件 TIGRFAMs; TIGR02426; hit=1
参照
Gene Ontology
GO
GO:0047472, F:3-carboxy-cis,cis-muconate cycloisomerase activity, IEA:EC
GO:0042952, P:beta-ketoadipate pathway, IEA:UniProtKB-UniPathway
GO:0019619, P:protocatechuate catabolic process, IEA:InterPro
Phylogenomic databases
eggNOG
COG0015, -
KO
K01857, -
Enzyme and pathway databases
UniPathway
UPA00157, UER00265
Family and domain databases
InterPro
IPR019468, AdenyloSucc_lyase_C
IPR003031, D_crystallin
IPR024083, Fumarase/histidase_N
IPR000362, Fumarate_lyase
IPR020557, Fumarate_lyase_CS
IPR022761, Fumarate_lyase_N
IPR008948, L-Aspartase-like
IPR012789, Protocat_PcaB
Pfam
PF10397, ADSL_C, 1
PF00206, Lyase_1, 1
PRINTS
PR00145, ARGSUCLYASE
PR00149, FUMRATELYASE
SMART
SM00998, ADSL_C, 1
TIGRFAMs
TIGR02426, protocat_pcaB, 1
PROSITE
PS00163, FUMARATE_LYASES, 1
配列の特徴 該当データなし
注釈
Function
Catalyzes an anti cycloisomerization
Catalytic activity
2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = cis,cis-butadiene-1,2,4-tricarboxylate
Pathway
Aromatic compound metabolism; beta-ketoadipate pathway; 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate: step 1/2
Subunit structure
Homotetramer
Sequence similarities
Belongs to the class-II fumarase/aspartase family
参考文献
Q59092 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1).
8063101
Contrasting patterns of evolutionary divergence within the Acinetobacter calcoaceticus pca operon. (Gene. 1994)
P32427 Pseudomonas putida (Arthrobacter siderocapsulatus).
1390752
3-Carboxy-cis,cis-muconate lactonizing enzyme from Pseudomonas putida is homologous to the class II fumarase family: a new reaction in the evolution of a mechanistic motif. (Biochemistry. 1992)
Q0SH25 Rhodococcus jostii (strain RHA1).
25558786
In vitro reconstitution of the catabolic reactions catalyzed by PcaHG, PcaB, and PcaL: the protocatechuate branch of the beta-ketoadipate pathway in Rhodococcus jostii RHA1. (Biosci Biotechnol Biochem. 2015)



関与する機能

機能名
Protocatechuate degradation (beta-ketoadipate pathway)

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Acinetobacter sp.100985ACT4_036_010803-carboxy-cis,cis-muconate cycloisomerase
Actinosynnema mirum14064Amir_46543-carboxy-cis,cis-muconate cycloisomerase
Azorhizobium caulinodans14845AZC_14413-carboxy-cis,cis-muconate cycloisomerase
Bradyrhizobium diazoefficiens14792bll7942probable 3-carboxy-cis,cis-muconate cycloisomerase (EC 5.5.1.2)
blr56673-carboxy-cis,cis-muconate cycloisomerase
Candidatus Solibacter usitatusAcid_02453-carboxy-cis,cis-muconate cycloisomerase
Caulobacter segnis15250Cseg_23543-carboxy-cis,cis-muconate cycloisomerase
Corynebacterium callunae15359H924_100853-carboxy-cis,cis-muconate cycloisomerase
Corynebacterium efficiens100395CE2299putative 3-carboxy-cis,cis-muconate cycloisomerase
Corynebacterium glutamicum12168Cgl2396Adenylosuccinate lyase
Cupriavidus metallidurans102507Rmet_40153-carboxy-cis,cis-muconate cycloisomerase
Enterobacter aerogenes13534EAE_18185putative fumarate lyase
Escherichia fergusonii102419EFER_16333-carboxy-cis,cis-muconate cycloisomerase (3-carboxymuconate lactonizing enzyme) (CMLE)
Geodermatophilus obscurus13315Gobs_21883-carboxy-cis,cis-muconate cycloisomerase
Gordonia amarae15530GOAMR_52_000303-carboxy-cis,cis-muconate cycloisomerase
Kitasatospora setae14216KSE_07790putative 3-carboxy-cis,cis-muconate cycloisomerase
Klebsiella pneumoniae14438KPR_2769
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_41713-carboxy-cis,cis-muconate cycloisomerase
Meiothermus ruber106122Mrub_26953-carboxy-cis,cis-muconate cycloisomerase
Ochrobactrum anthropi15819Oant_37293-carboxy-cis,cis-muconate cycloisomerase
Ochrobactrum intermedium15820OINT_20008153-carboxy-cis,cis-muconate cycloisomerase
Pseudomonas putida100650PP_13793-carboxy-cis,cis-muconate cycloisomerase
Pseudomonas stutzeri14165PSTAB_11653-carboxy-cis,cis-muconate cycloisomerase
Rhizobium etli15573RHE_PE000553-carboxy-cis,cis-muconate cycloisomerase protein
Rhizobium sp.101917NGR_b212003-carboxy-cis,cis-muconate cycloisomerase protein
Rhizobium tropici15247RTCIAT899_PC073653-carboxy-cis,cis-muconate cycloisomerase
Rhodococcus erythropolis100887RER_528803-carboxy-cis,cis-muconate cycloisomerase
Rhodococcus opacus108011ROP_105303-carboxy-cis,cis-muconate cycloisomerase
Rubrobacter xylanophilus100952Rxyl_15793-carboxy-cis,cis-muconate cycloisomerase
Saccharomonospora viridis12207Svir_130303-carboxy-cis,cis-muconate cycloisomerase
Saccharopolyspora erythraea13426SACE_35123-carboxy-cis,cis-muconate cycloisomerase
Saccharopolyspora spinosa15153SspiN1_0101000047583-carboxy-cis,cis-muconate cycloisomerase
Saccharothrix espanaensis15066BN6_611903-carboxy-cis,cis-muconate cycloisomerase
Streptomyces avermitilis14893SAV1705putative 3-carboxy-cis,cis-muconate cycloisomerase
Streptomyces cattleya14057SCAT_54803-carboxy-cis,cis-muconate cycloisomerase
Streptomyces ghanaensis15414SSFG_009723-carboxymuconate cycloisomerase
Streptomyces purpureus13925STRPU_08_00310Putative 3-carboxy-cis,cis-muconate cycloisomera se
Streptomyces sviceus13980SSEG_08941adenylosuccinate lyase
Streptosporangium roseum3776Sros_79313-carboxy-cis,cis-muconate cyclo-isomerase
Thermobispora bispora14880Tbis_28333-carboxy-cis,cis-muconate cycloisomerase