English site

遺伝子 : Haloalkane dehalogenase (DHAA)

遺伝子情報

ID NRULE_0050
遺伝子ID DHAA
作成日 2012/09/28
タンパク質名
Protein name
Full
Haloalkane dehalogenase
EC
EC 3.8.1.5
遺伝子名 該当データなし
遺伝子条件 HAMAP; MF_01230; hit=1
OR
HAMAP; MF_01231; hit=1
参照
Gene Ontology
GO
GO:0018786, F:haloalkane dehalogenase activity, IEA:EC
GO:0019260, P:1,2-dichloroethane catabolic process, IEA:UniProtKB-UniPathway
GO:0009636, P:response to toxin, IEA:UniProtKB-KW
Enzyme and pathway databases
UniPathway
UPA00265, UER00387
Family and domain databases
InterPro
IPR000073, AB_hydrolase_1
IPR000639, Epox_hydrolase-like
IPR023489, Haloalkane_dehalogenase_1
Pfam
PF00561, Abhydrolase_1, 1
PRINTS
PR00111, ABHYDROLASE
PR00412, EPOXHYDRLASE
配列の特徴
P22643 Xanthobacter autotrophicus.
ACT_SITE124Nucleophile.
ACT_SITE260Proton donor.
ACT_SITE289Proton acceptor.
BINDING125Halide.
BINDING175Halide.
注釈
Function
Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. Has a broad substrate specificity, which includes terminally mono- and di- chlorinated and brominated alkanes (up to C4 only)
Catalytic activity
1-haloalkane + H(2)O = a primary alcohol + halide
Pathway
Xenobiotic degradation; 1,2-dichloroethane degradation; glycolate from 1,2-dichloroethane: step 1/4
Subunit structure
Monomer
参考文献
P22643 Xanthobacter autotrophicus.
2687254
Cloning of 1,2-dichloroethane degradation genes of Xanthobacter autotrophicus GJ10 and expression and sequencing of the dhlA gene. (J Bacteriol. 1989)
P51698 Sphingomonas paucimobilis (Pseudomonas paucimobilis).
9293022
Purification and characterization of a haloalkane dehalogenase of a new substrate class from a gamma-hexachlorocyclohexane-degrading bacterium, Sphingomonas paucimobilis UT26. (Appl Environ Microbiol. 1997)



関与する機能

機能名
1,3-dichloropropene degradation
Haloalkane degradation (conversion into hydroxyacid)

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Bradyrhizobium diazoefficiens14792blr1087haloalkane dehalogenase
Caulobacter segnis15250Cseg_2706alpha/beta hydrolase fold protein
Chthoniobacter flavusCfE428DRAFT_6046alpha/beta hydrolase fold protein
Gordonia rhizosphera16068GORHZ_205_00240haloalkane dehalogenase
Ktedonobacter racemiferKrac_6512alpha/beta hydrolase fold protein
Krac_7198alpha/beta hydrolase fold protein
Sphingobium japonicum101211SJA_C1-195901,3,4,6-tetrachloro-1,4-cyclohexadiene hydrolase LinB
Sphingomonas echinoides15742SechA1_010100008112haloalkane dehalogenase