遺伝子 : Beta-lactamase class C (BLAC)

遺伝子情報

ID	NRULE_0124
遺伝子ID	BLAC
作成日	2013/01/28
タンパク質名	Protein name Full Beta-lactamase class C EC EC 3.5.2.6
遺伝子名	ampC
遺伝子条件	PROSITE; PS00336; hit=1
参照	Gene Ontology GO GO:0030288, C:outer membrane-bounded periplasmic space, IEA:InterPro GO:0008800, F:beta-lactamase activity, IEA:EC GO:0017001, P:antibiotic catabolic process, IEA:InterPro GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW Phylogenomic databases eggNOG COG1680, - HOGENOM HOG000267102, - KO K01467, - Family and domain databases InterPro IPR001466, Beta-lactam-related IPR001586, Beta-lactam_class-C_AS Pfam PF00144, Beta-lactamase, 1 PROSITE PS00336, BETA_LACTAMASE_C, 1
配列の特徴	P00811 Escherichia coli (strain K12). ACT_SITE 80 Acyl-ester intermediate. ACT_SITE 166 Proton acceptor.
注釈	Catalytic activity A beta-lactam + H(2)O = a substituted beta- amino acid Sequence similarities Belongs to the class-C beta-lactamase family
参考文献	P00811 Escherichia coli (strain K12). 6795623 ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type. (Proc Natl Acad Sci U S A. 1981) P24735 Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228). 2125210 Cloning, sequencing and analysis of the structural gene and regulatory region of the Pseudomonas aeruginosa chromosomal ampC beta-lactamase. (Biochem J. 1990)

関与する機能

機能名
Beta-lactam antibiotic resistance
Cephalosporin resistance

該当CDS

学名	NBRC番号	CDS	タンパク質名
Acinetobacter sp.	100985	ACT4_020_00170	hypothetical protein
Arthrobacter globiformis	12137	ARGLB_083_00580	putative S12 family peptidase
Candidatus Solibacter usitatus		Acid_5605	beta-lactamase
		Acid_7087	beta-lactamase
Chromobacterium violaceum	12614	CV_1310	beta-lactamase
Cupriavidus metallidurans	102507	Rmet_1776	beta-lactamase/D-alanine carboxypeptidase
Cystobacter fuscus	100088	D187_001949	beta-lactamase
Edwardsiella tarda	105688	ET1_15_00010	beta-lactamase
Enterobacter aerogenes	13534	EAE_12120	beta-lactamase/D-alanine carboxypeptidase
Enterobacter cloacae subsp. cloacae	13535	ECL_00553	class C beta-lactamase
Enterobacter hormaechei	105718	HMPREF9086_2076	beta-lactamase
Escherichia coli	3972	EcolC_3860	Beta-lactamase
Escherichia coli	13500	WFL_21965	beta-lactamase/D-alanine carboxypeptidase
Escherichia coli	12713	Y75_4084	beta-lactamase/D-alanine carboxypeptidase
Escherichia fergusonii	102419	EFER_4204	beta-lactamase/D-alanine carboxypeptidase
Kitasatospora setae	14216	KSE_08360	putative peptidase S12 family protein
Kribbella flavida	14399	Kfla_0870	beta-lactamase
Ktedonobacter racemifer		Krac_1224	beta-lactamase
Methylobacterium radiotolerans	15690	Mrad2831_5292	beta-lactamase
Nocardiopsis dassonvillei	14626	Ndas_1136	beta-lactamase
Ochrobactrum anthropi	15819	Oant_2585	beta-lactamase
Providencia alcalifaciens	105687	PROVALCAL_02707	beta-lactamase
Pseudomonas putida	100650	PP_2876	beta-lactamase
Rhizobium etli	15573	RHE_CH03194	beta-lactamase protein
Rhizobium sp.	101917	NGR_c32650	beta-lactamase, class C
Rhizobium tropici	15247	RTCIAT899_PC04360	beta-lactamase family protein
Rhodobacter sphaeroides	12203	RSP_3749	putative beta-lactamase precursor
Saccharothrix espanaensis	15066	BN6_49090	beta-lactamase
Serratia odorifera	102598	HMPREF0758_3355	beta-lactamase
Shimwellia blattae	105725	EB105725_04_01180	beta-lactamase
Sphingobacterium spiritivorum	14948	HMPREF0766_12891	beta-lactamase
Sporichthya polymorpha	12702	Spopo_31_10720	Beta-lactamase
Starkeya novella	14993	Snov_4480	Beta-lactamase
Tsukamurella paurometabola	16120	Tpau_0388	Beta-lactamase
Vibrio alginolyticus	15630	N646_3968	putative exported beta-lactamase protein
Yersinia bercovieri	105717	yberc0001_3030	Beta-lactamase
Yersinia rohdei	105715	yrohd0001_13780	Beta-lactamase