BLAST table : Megalo_00120

DBUniProtKB
accessionDBalignmentEvalueScoreIdent.linkproductgeneorganismec
1
 Q9F830_9ACTO
(Q9F830)		 
[query] 1 - 3546 (3546)
[subject] 1 - 3546 (3546)
 0.0 6902   100% Megalomicin 6-deoxyerythronolide B synthase 1 megAI Micromonospora megalomicea subsp. nigra
2
 A4F7N8_SACEN
(A4F7N8)		 
[query] 1 - 3544 (3546)
[subject] 1 - 3543 (3545)
 0.0 4856   74% EryAI Erythromycin polyketide synthase modules 1 and 2 eryAI
SACE_0721		 Saccharopolyspora erythraea (strain NRRL 23338)
3
 Q5UNP6_SACER
(Q5UNP6)		 
[query] 1 - 3544 (3546)
[subject] 1 - 3543 (3545)
 0.0 4856   74% EryAI eryAI Saccharopolyspora erythraea
Streptomyces erythraeus
4
 ERYA1_SACER
(Q03131)		 
[query] 71 - 3544 (3546)
[subject] 19 - 3489 (3491)
(2 hsp)		 0.0 4759   74% Erythronolide synthase, modules 1 and 2
6-deoxyerythronolide B synthase I
DEBS 1
ORF 1		 eryA Saccharopolyspora erythraea
Streptomyces erythraeus		 2.3.1.94
5
 Q83X69_STRRO
(Q83X69)		 
[query] 21 - 3543 (3546)
[subject] 21 - 3641 (3651)
(3 hsp)		 0.0 3545   60% Lankamycin synthase LkmAI lkmAI Streptomyces rochei
Streptomyces parvullus
6
 Q5Y9G4_9ACTO
(Q5Y9G4)		 
[query] 50 - 3511 (3546)
[subject] 3 - 3477 (3528)
(2 hsp)		 0.0 3222   57% Polyketide synthase modules 1 and 2 eryAI Aeromicrobium erythreum
7
 Q9F828_9ACTO
(Q9F828)		 Jump to Megalo_00140 
[query] 552 - 3465 (3546)
[subject] 34 - 2920 (3201)
(4 hsp)		 0.0 2583   57% Megalomicin 6-deoxyerythronolide B synthase 3 megAIII Micromonospora megalomicea subsp. nigra
8
 A4F7P1_SACEN
(A4F7P1)		 
[query] 557 - 3481 (3546)
[subject] 39 - 2906 (3171)
(4 hsp)		 0.0 2581   53% EryAIII Erythromycin polyketide synthase modules 5 and 6 eryAIII
SACE_0724		 Saccharopolyspora erythraea (strain NRRL 23338)
9
 Q5UNP4_SACER
(Q5UNP4)		 
[query] 557 - 3481 (3546)
[subject] 39 - 2906 (3171)
(4 hsp)		 0.0 2581   53% EryAIII eryAIII Saccharopolyspora erythraea
Streptomyces erythraeus
10
 Q9KIV4_STRAT
(Q9KIV4)		 
[query] 21 - 3543 (3546)
[subject] 475 - 4147 (4150)
(3 hsp)		 0.0 2568   47% 8,8a-deoxyoleandolide synthase 1 oleAI Streptomyces antibioticus
11
 E0D202_9ACTO
(E0D202)		 Jump to FD891_00010 
[query] 69 - 3491 (3546)
[subject] 524 - 4087 (7480)
(10 hsp)		 0.0 2495   46% Polyketide synthase gfsA Streptomyces graminofaciens
12
 ERYA3_SACER
(Q03133)		 
[query] 557 - 3481 (3546)
[subject] 39 - 2907 (3172)
(4 hsp)		 0.0 2493   53% Erythronolide synthase, modules 5 and 6
6-deoxyerythronolide B synthase III
DEBS 3
ORF 3		 eryA Saccharopolyspora erythraea
Streptomyces erythraeus		 2.3.1.94
13
 B4VB12_9ACTO
(B4VB12)		 
[query] 552 - 3543 (3546)
[subject] 29 - 3201 (3203)
(4 hsp)		 0.0 2429   49% Polyketide synthase type I SSAG_04922 Streptomyces sp. Mg1
14
 Q68BG5_STRHA
(Q68BG5)		 Jump to Halsto_00010 
[query] 21 - 3543 (3546)
[subject] 449 - 4191 (4194)
(4 hsp)		 0.0 2410   43% Type I polyketide synthase hlsA Streptomyces halstedii
15
 D9WQ82_9ACTO
(D9WQ82)		 
[query] 552 - 3543 (3546)
[subject] 30 - 3197 (3199)
(4 hsp)		 0.0 2409   48% Erythronolide synthase, modules 1 and 2 SSOG_05756 Streptomyces himastatinicus ATCC 53653
16
 B1W487_STRGG
(B1W487)		 
[query] 552 - 3545 (3546)
[subject] 30 - 3187 (3188)
(4 hsp)		 0.0 2389   48% Putative type-I PKS pks1-3
SGR_6075		 Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
17
 Q52V51_9ACTO
(Q52V51)		 
[query] 552 - 3543 (3546)
[subject] 29 - 3225 (3227)
(5 hsp)		 0.0 2382   48% Polyketide synthase type I Streptomyces aizunensis
18
 D1GLV9_9ACTO
(D1GLV9)		 Jump to Strply_00310 
[query] 19 - 3454 (3546)
[subject] 469 - 4158 (6171)
(12 hsp)		 0.0 2349   44% Polyketide synthase type I slgA1 Streptomyces lydicus
19
 D3Y1I3_9ACTO
(D3Y1I3)		 
[query] 21 - 3458 (3546)
[subject] 454 - 3993 (5828)
(9 hsp)		 0.0 2340   44% TamAI Streptomyces sp. 307-9
20
 F1DI31_9ACTO
(F1DI31)		 
[query] 21 - 3458 (3546)
[subject] 454 - 3994 (5829)
(9 hsp)		 0.0 2328   43% TrdAI Streptomyces sp. SCSIO1666
21
 Q83X71_STRRO
(Q83X71)		 
[query] 551 - 3465 (3546)
[subject] 45 - 3014 (3295)
(4 hsp)		 0.0 2319   51% Lankamycin synthase LkmAIII lkmAIII Streptomyces rochei
Streptomyces parvullus
22
 Q93HJ2_STRAW
(Q93HJ2)		 Jump to Oligo_00110 
[query] 465 - 3543 (3546)
[subject] 1470 - 4682 (4685)
(5 hsp)		 0.0 2314   48% Modular polyketide synthase olmA6
SAV2896
SAV_2896		 Streptomyces avermitilis
23
 F1ADL8_9ACTO
(F1ADL8)		 
[query] 19 - 3465 (3546)
[subject] 17 - 3696 (4884)
(7 hsp)		 0.0 2301   44% BafAI Streptomyces lohii
24
 Q3S869_9ACTO
(Q3S869)		 Jump to Conca_00080 
[query] 552 - 3507 (3546)
[subject] 31 - 3222 (5006)
(7 hsp)		 0.0 2266   47% Modular polyketide synthase Streptomyces neyagawaensis
25
 C9YYI3_STRSW
(C9YYI3)		 
[query] 552 - 3507 (3546)
[subject] 31 - 3223 (5001)
(8 hsp)		 0.0 2259   47% Putative type I polyketide synthase SCAB_83921 Streptomyces scabies (strain 87.22)
Streptomyces scabiei
26
 D7BRE1_STRBB
(D7BRE1)		 
[query] 468 - 3465 (3546)
[subject] 1881 - 5043 (5139)
(7 hsp)		 0.0 2255   46% Modular polyketide synthase SBI_01983 Streptomyces bingchenggensis (strain BCW-1)
27
 Q8KPW5_9ACTO
(Q8KPW5)		 
[query] 69 - 2910 (3546)
[subject] 481 - 3378 (4387)
(7 hsp)		 0.0 2253   48% Putative type I polyketide synthase gerSI Streptomyces sp. KCTC 0041BP
28
 B4VAJ6_9ACTO
(B4VAJ6)		 
[query] 69 - 2910 (3546)
[subject] 492 - 3383 (3605)
(5 hsp)		 0.0 2252   49% Polyketide synthase subunit SSAG_04835 Streptomyces sp. Mg1
29
 E4NJF1_KITSK
(E4NJF1)		 
[query] 19 - 3453 (3546)
[subject] 22 - 3680 (4833)
(8 hsp)		 0.0 2246   45% Modular polyketide synthase BFAS1 bfmA1
KSE_73440		 Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054)
Streptomyces setae
30
 Q0ILD1_9ACTO
(Q0ILD1)		 
[query] 465 - 3543 (3546)
[subject] 1452 - 4632 (4635)
(5 hsp)		 0.0 2242   47% NlmA6 nlmA6 Streptomyces nanchangensis
31
 D5ZU01_9ACTO
(D5ZU01)		 
[query] 534 - 3467 (3546)
[subject] 39 - 3011 (4790)
(8 hsp)		 0.0 2241   47% Nodular polyketide synthase SSFG_00090 Streptomyces ghanaensis ATCC 14672
32
 Q5SFB4_STRBI
(Q5SFB4)		 Jump to Chalc_00210 
[query] 69 - 2910 (3546)
[subject] 539 - 3435 (4441)
(7 hsp)		 0.0 2241   49% Polyketide synthase subunit chmGI Streptomyces bikiniensis
33
 Q53840_SORCE
(Q53840)		 Jump to Soraph_00080 
[query] 468 - 3476 (3546)
[subject] 3579 - 6769 (8817)
(15 hsp)		 0.0 2240   46% Soraphen polyketide synthase B sorB Sorangium cellulosum
Polyangium cellulosum
34
 Q0ILD4_9ACTO
(Q0ILD4)		 
[query] 15 - 3471 (3546)
[subject] 441 - 3987 (6148)
(8 hsp)		 0.0 2240   44% NlmA1 nlmA1 Streptomyces nanchangensis
35
 Q3S864_9ACTO
(Q3S864)		 Jump to Conca_00060 
[query] 524 - 3466 (3546)
[subject] 2 - 3107 (4970)
(7 hsp)		 0.0 2234   47% Nodular polyketide synthase Streptomyces neyagawaensis
36
 E0KBI2_STRVO
(E0KBI2)		 
[query] 468 - 3465 (3546)
[subject] 1662 - 4851 (4930)
(8 hsp)		 0.0 2227   45% Mycocerosate synthase., 6-deoxyerythronolide-B synthase StrviDRAFT_0197 Streptomyces violaceusniger Tu 4113 2.3.1.111

2.3.1.94
37
 E0KBI6_STRVO
(E0KBI6)		 
[query] 552 - 3461 (3546)
[subject] 28 - 3132 (4996)
(9 hsp)		 0.0 2214   46% Acyl transferase StrviDRAFT_0201 Streptomyces violaceusniger Tu 4113
38
 Q9L4W4_9ACTO
(Q9L4W4)		 Jump to Nysta_00140 
[query] 552 - 3458 (3546)
[subject] 37 - 3103 (3192)
(5 hsp)		 0.0 2212   47% NysB nysB Streptomyces noursei
39
 A9YLB2_9ACTO
(A9YLB2)		 
[query] 69 - 2910 (3546)
[subject] 562 - 3391 (4436)
(8 hsp)		 0.0 2203   49% AngAI angAI Streptomyces eurythermus
40
 E0KRC6_STRVO
(E0KRC6)		 
[query] 468 - 3459 (3546)
[subject] 2838 - 5895 (11118)
(18 hsp)		 0.0 2201   47% Beta-ketoacyl synthase StrviDRAFT_5203 Streptomyces violaceusniger Tu 4113
41
 Q1WEK7_9ACTO
(Q1WEK7)		 
[query] 468 - 3459 (3546)
[subject] 2861 - 5917 (7968)
(11 hsp)		 0.0 2197   47% Polyketide synthase merC Streptomyces sp. NRRL 30748
42
 Q5Y9G6_9ACTO
(Q5Y9G6)		 
[query] 553 - 3511 (3546)
[subject] 28 - 2957 (3195)
(4 hsp)		 0.0 2194   50% Polyketide synthase modules 5 and 6 eryAIII Aeromicrobium erythreum
43
 Q93NX9_9ACTO
(Q93NX9)		 Jump to Amph_00040 
[query] 481 - 3467 (3546)
[subject] 1696 - 4836 (9510)
(16 hsp)		 0.0 2184   45% AmphI amphI Streptomyces nodosus
44
 F1CLA9_9ACTO
(F1CLA9)		 
[query] 465 - 3479 (3546)
[subject] 1692 - 4846 (9498)
(17 hsp)		 0.0 2179   46% ScnS2 scnS2 Streptomyces chattanoogensis
45
 F1ADL9_9ACTO
(F1ADL9)		 
[query] 557 - 3468 (3546)
[subject] 34 - 3172 (5145)
(11 hsp)		 0.0 2176   46% BafAII Streptomyces lohii
46
 Q93NW7_9ACTO
(Q93NW7)		 Jump to Amph_00160 
[query] 552 - 3458 (3546)
[subject] 34 - 3099 (3190)
(6 hsp)		 0.0 2174   46% AmphB amphB Streptomyces nodosus
47
 Q9L4X3_9ACTO
(Q9L4X3)		 Jump to Nysta_00050 
[query] 481 - 3465 (3546)
[subject] 1737 - 4879 (9477)
(17 hsp)		 0.0 2164   46% NysI nysI Streptomyces noursei
48
 E0KFI9_STRVO
(E0KFI9)		 
[query] 484 - 3465 (3546)
[subject] 62 - 3211 (8238)
(15 hsp)		 0.0 2160   45% Beta-ketoacyl synthase StrviDRAFT_1372 Streptomyces violaceusniger Tu 4113
49
 Q9ALM4_9PSEU
(Q9ALM4)		 Jump to Spino_00190 
[query] 543 - 3544 (3546)
[subject] 20 - 3168 (3170)
(4 hsp)		 0.0 2157   46% Polyketide synthase extender modules 3-4 spnC Saccharopolyspora spinosa
50
 E0KBI5_STRVO
(E0KBI5)		 
[query] 557 - 3543 (3546)
[subject] 34 - 3202 (3205)
(5 hsp)		 0.0 2153   45% Acyl transferase StrviDRAFT_0200 Streptomyces violaceusniger Tu 4113
51
 Q93H84_STRAW
(Q93H84)		 
[query] 468 - 3465 (3546)
[subject] 1452 - 4556 (6145)
(8 hsp)		 0.0 2151   46% Modular polyketide synthase pteA4
SAV416
SAV_416		 Streptomyces avermitilis
52
 B6ZIR2_STRPT
(B6ZIR2)		 Jump to Pladi_00010 
[query] 4 - 2919 (3546)
[subject] 439 - 3479 (6532)
(12 hsp)		 0.0 2149   46% Polyketide synthase pldAI Streptomyces platensis
53
 E4NJF2_KITSK
(E4NJF2)		 
[query] 557 - 3465 (3546)
[subject] 34 - 3125 (5004)
(8 hsp)		 0.0 2148   47% Modular polyketide synthase BFAS2 bfmA2
KSE_73450		 Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054)
Streptomyces setae
54
 Q6W5P6_9ACTO
(Q6W5P6)		 Jump to FR008_00200 
[query] 468 - 3467 (3546)
[subject] 3252 - 6405 (9550)
(14 hsp)		 0.0 2143   45% FscD fscD Streptomyces sp. FR-008
55
 Q93H83_STRAW
(Q93H83)		 
[query] 546 - 3469 (3546)
[subject] 24 - 3057 (3352)
(4 hsp)		 0.0 2140   46% Modular polyketide synthase pteA5
SAV415
SAV_415		 Streptomyces avermitilis
56
 Q9EWA1_9ACTO
(Q9EWA1)		 Jump to Pimar_00070 
[query] 425 - 3471 (3546)
[subject] 3184 - 6392 (9507)
(16 hsp)		 0.0 2135   44% PimS2 protein pimS2 Streptomyces natalensis
57
 E0KBI3_STRVO
(E0KBI3)		 
[query] 468 - 3543 (3546)
[subject] 1498 - 4749 (4750)
(6 hsp)		 0.0 2130   44% 6-methylsalicylic acid synthase., 6-deoxyerythronolide-B synthase StrviDRAFT_0198 Streptomyces violaceusniger Tu 4113 2.3.1.165

2.3.1.94
58
 Q93HJ5_STRAW
(Q93HJ5)		 Jump to Oligo_00080 
[query] 456 - 3465 (3546)
[subject] 906 - 3968 (6146)
(11 hsp)		 0.0 2123   47% Modular polyketide synthase olmA1
SAV2899
SAV_2899		 Streptomyces avermitilis
59
 E0KN03_STRVO
(E0KN03)		 
[query] 13 - 2915 (3546)
[subject] 435 - 3339 (3735)
(4 hsp)		 0.0 2120   46% 6-deoxyerythronolide-B synthase., Mycocerosate synthase StrviDRAFT_3962 Streptomyces violaceusniger Tu 4113 2.3.1.111

2.3.1.94
60
 A0FCL3_STRVO
(A0FCL3)		 Jump to Merid_00040 
[query] 468 - 3459 (3546)
[subject] 2857 - 5919 (11604)
(18 hsp)		 0.0 2117   46% MerC merC Streptomyces violaceoniger
61
 D2CKL5_PSEAH
(D2CKL5)		 
[query] 468 - 3474 (3546)
[subject] 1702 - 4868 (9499)
(15 hsp)		 0.0 2114   45% CppI cppI Pseudonocardia autotrophica
Amycolata autotrophica
Nocardia autotrophica
62
 E0KRC7_STRVO
(E0KRC7)		 
[query] 484 - 2919 (3546)
[subject] 118 - 2611 (5559)
(10 hsp)		 0.0 2106   50% Beta-ketoacyl synthase StrviDRAFT_5204 Streptomyces violaceusniger Tu 4113
63
 Q1WEK9_9ACTO
(Q1WEK9)		 
[query] 23 - 2910 (3546)
[subject] 498 - 3377 (5712)
(8 hsp)		 0.0 2106   46% Polyketide synthase merA Streptomyces sp. NRRL 30748
64
 Q1WEK8_9ACTO
(Q1WEK8)		 
[query] 461 - 2919 (3546)
[subject] 1633 - 4150 (7102)
(14 hsp)		 0.0 2098   50% Polyketide synthase merB Streptomyces sp. NRRL 30748
65
 D7P614_CHOCO
(D7P614)		 
[query] 557 - 3467 (3546)
[subject] 17 - 3112 (6610)
(10 hsp)		 0.0 2097   44% TugD tugD Chondromyces crocatus
66
 Q52V46_9ACTO
(Q52V46)		 
[query] 458 - 3543 (3546)
[subject] 4892 - 8144 (8147)
(12 hsp)		 0.0 2096   44% Polyketide synthase type I Streptomyces aizunensis
67
 A0FCL1_STRVO
(A0FCL1)		 Jump to Merid_00020 
[query] 32 - 2910 (3546)
[subject] 503 - 3381 (5721)
(7 hsp)		 0.0 2093   46% MerA merA Streptomyces violaceoniger
68
 Q3S865_9ACTO
(Q3S865)		 Jump to Conca_00050 
[query] 534 - 3474 (3546)
[subject] 35 - 3198 (4825)
(7 hsp)		 0.0 2085   46% Modular polyketide synthase Streptomyces neyagawaensis
69
 E8S0B8_MICSL
(E8S0B8)		 
[query] 557 - 3465 (3546)
[subject] 34 - 3081 (3165)
(6 hsp)		 0.0 2082   46% Beta-ketoacyl synthase ML5_5891 Micromonospora sp. (strain L5)
70
 D5ZU03_9ACTO
(D5ZU03)		 
[query] 484 - 2912 (3546)
[subject] 1404 - 3769 (4652)
(9 hsp)		 0.0 2079   52% Type I modular polyketide synthase SSFG_00092 Streptomyces ghanaensis ATCC 14672
71
 D9T6X1_MICAI
(D9T6X1)		 
[query] 557 - 3465 (3546)
[subject] 34 - 3081 (3165)
(6 hsp)		 0.0 2078   47% Beta-ketoacyl synthase Micau_2471 Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
72
 A0FCL2_STRVO
(A0FCL2)		 Jump to Merid_00030 
[query] 461 - 2919 (3546)
[subject] 1637 - 4197 (7178)
(14 hsp)		 0.0 2077   49% MerB merB Streptomyces violaceoniger
73
 Q9ZGI5_9ACTO
(Q9ZGI5)		 Jump to Pikro_00030 
[query] 69 - 2911 (3546)
[subject] 599 - 3558 (4613)
(9 hsp)		 0.0 2076   46% Type I polyketide synthase PikAI pikAI Streptomyces venezuelae
74
 E0KBI4_STRVO
(E0KBI4)		 
[query] 552 - 3458 (3546)
[subject] 29 - 3108 (8275)
(14 hsp)		 0.0 2076   45% Beta-ketoacyl synthase StrviDRAFT_0199 Streptomyces violaceusniger Tu 4113
75
 B4VBW0_9ACTO
(B4VBW0)		 
[query] 484 - 3465 (3546)
[subject] 107 - 3232 (10873)
(18 hsp)		 0.0 2072   44% Polyketide synthase type I SSAG_05337 Streptomyces sp. Mg1
76
 A0ACI1_STRAM
(A0ACI1)		 
[query] 552 - 3543 (3546)
[subject] 29 - 3154 (3157)
(4 hsp)		 0.0 2063   45% Putative modular polyketide synthase SAMR0475 Streptomyces ambofaciens ATCC 23877
77
 D7C2C3_STRBB
(D7C2C3)		 
[query] 468 - 3356 (3546)
[subject] 1776 - 4847 (4868)
(10 hsp)		 0.0 2061   46% Modular polyketide synthase pks3-4
SBI_00656		 Streptomyces bingchenggensis (strain BCW-1)
78
 Q9ALM3_9PSEU
(Q9ALM3)		 Jump to Spino_00200 
[query] 436 - 3543 (3546)
[subject] 1664 - 4926 (4928)
(7 hsp)		 0.0 2056   44% Polyketide synthase extender modules 5-7 spnD Saccharopolyspora spinosa
79
 D9T6W8_MICAI
(D9T6W8)		 
[query] 480 - 2910 (3546)
[subject] 1471 - 3980 (4710)
(9 hsp)		 0.0 2056   51% Beta-ketoacyl synthase Micau_2468 Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
80
 E8S0C1_MICSL
(E8S0C1)		 
[query] 480 - 2920 (3546)
[subject] 1467 - 3984 (4706)
(9 hsp)		 0.0 2050   51% 6-deoxyerythronolide-B synthase., (Acyl-carrier-protein) S-acetyltransferase ML5_5894 Micromonospora sp. (strain L5) 2.3.1.38

2.3.1.94
81
 Q52V44_9ACTO
(Q52V44)		 
[query] 468 - 3465 (3546)
[subject] 1727 - 4859 (6751)
(13 hsp)		 0.0 2042   44% Polyketide synthase type I Streptomyces aizunensis
82
 C9YYI0_STRSW
(C9YYI0)		 
[query] 534 - 3471 (3546)
[subject] 4 - 3175 (4799)
(7 hsp)		 0.0 2039   45% Putative type I polyketide synthase SCAB_83891 Streptomyces scabies (strain 87.22)
Streptomyces scabiei
83
 Q8GBX6_SORCE
(Q8GBX6)		 
[query] 525 - 3465 (3546)
[subject] 5 - 3127 (5017)
(9 hsp)		 0.0 2026   44% Polyketide synthase spiH Sorangium cellulosum
Polyangium cellulosum
84
 A4F5C7_SORCE
(A4F5C7)		 
[query] 534 - 3465 (3546)
[subject] 1 - 3115 (5005)
(9 hsp)		 0.0 2024   44% Polyketide synthase spiH Sorangium cellulosum
Polyangium cellulosum
85
 D6C474_9ACTO
(D6C474)		 Jump to Meili_00270 
[query] 552 - 3472 (3546)
[subject] 31 - 3079 (5277)
(9 hsp)		 0.0 2022   45% Modular polyketide synthase meiA4 Streptomyces nanchangensis
86
 D9T6W1_MICAI
(D9T6W1)		 
[query] 466 - 3477 (3546)
[subject] 1680 - 4822 (6415)
(10 hsp)		 0.0 2016   44% Beta-ketoacyl synthase Micau_2461 Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
87
 Q6MZ72_MYCUA
(Q6MZ72)		 Jump to MUP_00320 
[query] 490 - 3474 (3546)
[subject] 1750 - 4886 (14130)
(29 hsp)		 0.0 2014   42% Type I modular polyketide synthase mlsB
MUP032c		 Mycobacterium ulcerans (strain Agy99)
88
 D6C473_9ACTO
(D6C473)		 Jump to Meili_00240 
[query] 20 - 3461 (3546)
[subject] 476 - 4047 (5987)
(11 hsp)		 0.0 2014   39% Modular polyketide synthase meiA2 Streptomyces nanchangensis
89
 D3Y1I4_9ACTO
(D3Y1I4)		 
[query] 552 - 2922 (3546)
[subject] 28 - 2464 (3365)
(7 hsp)		 0.0 2008   49% TamAII Streptomyces sp. 307-9
90
 A0ACI0_STRAM
(A0ACI0)		 
[query] 425 - 3536 (3546)
[subject] 2916 - 6118 (6333)
(7 hsp)		 0.0 2006   44% Putative modular polyketide synthase SAMR0474 Streptomyces ambofaciens ATCC 23877
91
 D7C2C2_STRBB
(D7C2C2)		 
[query] 468 - 3465 (3546)
[subject] 59 - 3210 (4821)
(6 hsp)		 0.0 2006   44% Modular polyketide synthase pks3-3
SBI_00655		 Streptomyces bingchenggensis (strain BCW-1)
92
 F1DI32_9ACTO
(F1DI32)		 
[query] 552 - 2922 (3546)
[subject] 41 - 2477 (3378)
(7 hsp)		 0.0 2004   49% TrdAII Streptomyces sp. SCSIO1666
93
 E0KBI1_STRVO
(E0KBI1)		 
[query] 552 - 2912 (3546)
[subject] 29 - 2491 (3456)
(7 hsp)		 0.0 2001   49% Acyl transferase StrviDRAFT_0196 Streptomyces violaceusniger Tu 4113
94
 B6ZIR3_STRPT
(B6ZIR3)		 Jump to Pladi_00020 
[query] 465 - 2912 (3546)
[subject] 3529 - 6107 (7026)
(14 hsp)		 0.0 1995   47% Polyketide synthase pldAII Streptomyces platensis
95
 Q27W58_STRVO
(Q27W58)		 Jump to Niger_00170 
[query] 557 - 3465 (3546)
[subject] 35 - 3145 (4787)
(7 hsp)		 0.0 1995   42% NigAVII Streptomyces violaceoniger
96
 D7C488_STRBB
(D7C488)		 
[query] 21 - 2911 (3546)
[subject] 14 - 3040 (4343)
(8 hsp)		 0.0 1991   43% Type I polyketide synthase milA1
SBI_00789		 Streptomyces bingchenggensis (strain BCW-1)
97
 B6CLY1_9MYCO
(B6CLY1)		 
[query] 490 - 3474 (3546)
[subject] 1742 - 4881 (12352)
(24 hsp)		 0.0 1987   42% Type I modular polyketide synthase, MlsB mlsB
MULP_051		 Mycobacterium liflandii 128FXT
98
 D6C4C5_9ACTO
(D6C4C5)		 Jump to Meili_00790 
[query] 21 - 2911 (3546)
[subject] 5 - 3033 (4330)
(8 hsp)		 0.0 1986   43% Modular polyketide synthase meiA1 Streptomyces nanchangensis
99
 C9YYI1_STRSW
(C9YYI1)		 
[query] 524 - 2913 (3546)
[subject] 2 - 2463 (4970)
(9 hsp)		 0.0 1986   50% Putative type I polyketide synthase SCAB_83901 Streptomyces scabies (strain 87.22)
Streptomyces scabiei
100
 B1W4J2_STRGG
(B1W4J2)		 
[query] 552 - 3465 (3546)
[subject] 29 - 3172 (5343)
(8 hsp)		 0.0 1984   44% Putative type-I PKS pks2-2
SGR_6180		 Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
accessionDBalignmentEvalueScoreIdent.linkinformationpubmed
1
 Q9F830_9ACTO
(Q9F830)		 
[query] 1 - 3546 (3546)
[subject] 1 - 3546 (3546)
 0.0 6902   100%
Product
Megalomicin 6-deoxyerythronolide B synthase 1
Gene
megAI
Organism
Micromonospora megalomicea subsp. nigra
1uniprot[Pubmed] 10972798 [Medline] 20430101
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.(Mol. Microbiol.) [2000]
2
 A4F7N8_SACEN
(A4F7N8)		 
[query] 1 - 3544 (3546)
[subject] 1 - 3543 (3545)
 0.0 4856   74%
Product
EryAI Erythromycin polyketide synthase modules 1 and 2
Gene
eryAI
SACE_0721
Organism
Saccharopolyspora erythraea (strain NRRL 23338)
1uniprot[Pubmed] 17369815
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]
3
 Q5UNP6_SACER
(Q5UNP6)		 
[query] 1 - 3544 (3546)
[subject] 1 - 3543 (3545)
 0.0 4856   74%
Product
EryAI
Gene
eryAI
Organism
Saccharopolyspora erythraea
Streptomyces erythraeus
1uniprot[Pubmed] 15496466
Total synthesis of long DNA sequences: synthesis of a contiguous 32-kb polyketide synthase gene cluster.(Proc. Natl. Acad. Sci. U.S.A.) [2004]
4
 ERYA1_SACER
(Q03131)		 
[query] 71 - 3544 (3546)
[subject] 19 - 3489 (3491)
(2 hsp)		 0.0 4759   74%
Product
Erythronolide synthase, modules 1 and 2
6-deoxyerythronolide B synthase I
DEBS 1
ORF 1
Gene
eryA
Organism
Saccharopolyspora erythraea
Streptomyces erythraeus
1uniprot[Pubmed] 2024119 [Medline] 91220065
Modular organization of genes required for complex polyketide biosynthesis.(Science) [1991]
2uniprot[Pubmed] 8386127 [Medline] 93231529
IS1136, an insertion element in the erythromycin gene cluster of Saccharopolyspora erythraea.(Gene) [1993]
[pubmed all]
5
 Q83X69_STRRO
(Q83X69)		 
[query] 21 - 3543 (3546)
[subject] 21 - 3641 (3651)
(3 hsp)		 0.0 3545   60%
Product
Lankamycin synthase LkmAI
Gene
lkmAI
Organism
Streptomyces rochei
Streptomyces parvullus
1uniprot[Pubmed] 12791134 [Medline] 22676866
The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003]
2uniprot[Pubmed] 10954087 [Medline] 20408175
Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000]
3uniprot[Pubmed] 10767533 [Medline] 20231737
Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000]
4uniprot[Pubmed] 9836424 [Medline] 99053144
Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998]
[pubmed all]
6
 Q5Y9G4_9ACTO
(Q5Y9G4)		 
[query] 50 - 3511 (3546)
[subject] 3 - 3477 (3528)
(2 hsp)		 0.0 3222   57%
Product
Polyketide synthase modules 1 and 2
Gene
eryAI
Organism
Aeromicrobium erythreum
1uniprot[Pubmed] 15257441
The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum.(J. Ind. Microbiol. Biotechnol.) [2004]
7
 Q9F828_9ACTO
(Q9F828)		 Jump to Megalo_00140 
[query] 552 - 3465 (3546)
[subject] 34 - 2920 (3201)
(4 hsp)		 0.0 2583   57%
Product
Megalomicin 6-deoxyerythronolide B synthase 3
Gene
megAIII
Organism
Micromonospora megalomicea subsp. nigra
1uniprot[Pubmed] 10972798 [Medline] 20430101
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.(Mol. Microbiol.) [2000]
8
 A4F7P1_SACEN
(A4F7P1)		 
[query] 557 - 3481 (3546)
[subject] 39 - 2906 (3171)
(4 hsp)		 0.0 2581   53%
Product
EryAIII Erythromycin polyketide synthase modules 5 and 6
Gene
eryAIII
SACE_0724
Organism
Saccharopolyspora erythraea (strain NRRL 23338)
1uniprot[Pubmed] 17369815
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]
9
 Q5UNP4_SACER
(Q5UNP4)		 
[query] 557 - 3481 (3546)
[subject] 39 - 2906 (3171)
(4 hsp)		 0.0 2581   53%
Product
EryAIII
Gene
eryAIII
Organism
Saccharopolyspora erythraea
Streptomyces erythraeus
1uniprot[Pubmed] 15496466
Total synthesis of long DNA sequences: synthesis of a contiguous 32-kb polyketide synthase gene cluster.(Proc. Natl. Acad. Sci. U.S.A.) [2004]
2uniprot[Pubmed] 16844787
The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.(Proc. Natl. Acad. Sci. U.S.A.) [2006]
[pubmed all]
10
 Q9KIV4_STRAT
(Q9KIV4)		 
[query] 21 - 3543 (3546)
[subject] 475 - 4147 (4150)
(3 hsp)		 0.0 2568   47%
Product
8,8a-deoxyoleandolide synthase 1
Gene
oleAI
Organism
Streptomyces antibioticus
1uniprot[Pubmed] 10908114 [Medline] 20363406
Cloning, characterization and heterologous expression of a polyketide synthase and P-450 oxidase involved in the biosynthesis of the antibiotic oleandomycin.(J. Antibiot.) [2000]
11
 E0D202_9ACTO
(E0D202)		 Jump to FD891_00010 
[query] 69 - 3491 (3546)
[subject] 524 - 4087 (7480)
(10 hsp)		 0.0 2495   46%
Product
Polyketide synthase
Gene
gfsA
Organism
Streptomyces graminofaciens
1uniprot[Pubmed] 20589823
Cloning and characterization of the biosynthetic gene cluster of 16-membered macrolide antibiotic FD-891: involvement of a dual functional cytochrome P450 monooxygenase catalyzing epoxidation and hydroxylation.(Chembiochem) [2010]
12
 ERYA3_SACER
(Q03133)		 
[query] 557 - 3481 (3546)
[subject] 39 - 2907 (3172)
(4 hsp)		 0.0 2493   53%
Product
Erythronolide synthase, modules 5 and 6
6-deoxyerythronolide B synthase III
DEBS 3
ORF 3
Gene
eryA
Organism
Saccharopolyspora erythraea
Streptomyces erythraeus
1uniprot[Pubmed] 2234082 [Medline] 91043075
An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea.(Nature) [1990]
2uniprot[Pubmed] 2024119 [Medline] 91220065
Modular organization of genes required for complex polyketide biosynthesis.(Science) [1991]
3uniprot[Pubmed] 1740151 [Medline] 92155230
6-deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme.(Eur. J. Biochem.) [1992]
4uniprot[Pubmed] 1618327
Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea.(FEBS Lett.) [1992]
5uniprot[Pubmed] 11752428
Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel.(Proc. Natl. Acad. Sci. U.S.A.) [2001]
6uniprot[Pubmed] 12379102
Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases.(Biochemistry) [2002]
[pubmed all]
14
 Q68BG5_STRHA
(Q68BG5)		 Jump to Halsto_00010 
[query] 21 - 3543 (3546)
[subject] 449 - 4191 (4194)
(4 hsp)		 0.0 2410   43%
Product
Type I polyketide synthase
Gene
hlsA
Organism
Streptomyces halstedii
1uniprot
Genome-inspired search for new antibiotics; Isolation and structure determination of new 28-membered polyketide macrolactones, halstoctacosanolides A and B, from Streptomyces halstedii HC34.(Tetrahedron) [2004]
16
 B1W487_STRGG
(B1W487)		 
[query] 552 - 3545 (3546)
[subject] 30 - 3187 (3188)
(4 hsp)		 0.0 2389   48%
Product
Putative type-I PKS
Gene
pks1-3
SGR_6075
Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
1uniprot[Pubmed] 18375553
Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008]
17
 Q52V51_9ACTO
(Q52V51)		 
[query] 552 - 3543 (3546)
[subject] 29 - 3225 (3227)
(5 hsp)		 0.0 2382   48%
Product
Polyketide synthase type I
Gene
 
Organism
Streptomyces aizunensis
1uniprot[Pubmed] 15844935
Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.(J. Nat. Prod.) [2005]
18
 D1GLV9_9ACTO
(D1GLV9)		 Jump to Strply_00310 
[query] 19 - 3454 (3546)
[subject] 469 - 4158 (6171)
(12 hsp)		 0.0 2349   44%
Product
Polyketide synthase type I
Gene
slgA1
Organism
Streptomyces lydicus
1uniprot
Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.(Chem. Biol.) [2009]
19
 D3Y1I3_9ACTO
(D3Y1I3)		 
[query] 21 - 3458 (3546)
[subject] 454 - 3993 (5828)
(9 hsp)		 0.0 2340   44%
Product
TamAI
Gene
 
Organism
Streptomyces sp. 307-9
1uniprot[Pubmed] 20127927
Identification of the tirandamycin biosynthetic gene cluster from Streptomyces sp. 307-9.(Chembiochem) [2010]
20
 F1DI31_9ACTO
(F1DI31)		 
[query] 21 - 3458 (3546)
[subject] 454 - 3994 (5829)
(9 hsp)		 0.0 2328   43%
Product
TrdAI
Gene
 
Organism
Streptomyces sp. SCSIO1666
1uniprot[Pubmed] 21329667
Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomyces sp. SCSIO1666.(Biochem. Biophys. Res. Commun.) [2011]
21
 Q83X71_STRRO
(Q83X71)		 
[query] 551 - 3465 (3546)
[subject] 45 - 3014 (3295)
(4 hsp)		 0.0 2319   51%
Product
Lankamycin synthase LkmAIII
Gene
lkmAIII
Organism
Streptomyces rochei
Streptomyces parvullus
1uniprot[Pubmed] 12791134 [Medline] 22676866
The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003]
2uniprot[Pubmed] 10954087 [Medline] 20408175
Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000]
3uniprot[Pubmed] 10767533 [Medline] 20231737
Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000]
4uniprot[Pubmed] 9836424 [Medline] 99053144
Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998]
[pubmed all]
22
 Q93HJ2_STRAW
(Q93HJ2)		 Jump to Oligo_00110 
[query] 465 - 3543 (3546)
[subject] 1470 - 4682 (4685)
(5 hsp)		 0.0 2314   48%
Product
Modular polyketide synthase
Gene
olmA6
SAV2896
SAV_2896
Organism
Streptomyces avermitilis
1uniprot[Pubmed] 11572948 [Medline] 21477403
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001]
2uniprot[Pubmed] 12692562 [Medline] 22608306
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003]
[pubmed all]
24
 Q3S869_9ACTO
(Q3S869)		 Jump to Conca_00080 
[query] 552 - 3507 (3546)
[subject] 31 - 3222 (5006)
(7 hsp)		 0.0 2266   47%
Product
Modular polyketide synthase
Gene
 
Organism
Streptomyces neyagawaensis
1uniprot[Pubmed] 16207901
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.(Microbiology) [2005]
25
 C9YYI3_STRSW
(C9YYI3)		 
[query] 552 - 3507 (3546)
[subject] 31 - 3223 (5001)
(8 hsp)		 0.0 2259   47%
Product
Putative type I polyketide synthase
Gene
SCAB_83921
Organism
Streptomyces scabies (strain 87.22)
Streptomyces scabiei
1uniprot[Pubmed] 20064060
Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010]
26
 D7BRE1_STRBB
(D7BRE1)		 
[query] 468 - 3465 (3546)
[subject] 1881 - 5043 (5139)
(7 hsp)		 0.0 2255   46%
Product
Modular polyketide synthase
Gene
SBI_01983
Organism
Streptomyces bingchenggensis (strain BCW-1)
1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
27
 Q8KPW5_9ACTO
(Q8KPW5)		 
[query] 69 - 2910 (3546)
[subject] 481 - 3378 (4387)
(7 hsp)		 0.0 2253   48%
Product
Putative type I polyketide synthase
Gene
gerSI
Organism
Streptomyces sp. KCTC 0041BP
1uniprot[Pubmed] 17053005
Biosynthesis of dTDP-6-deoxy-beta-D-allose, biochemical characterization of dTDP-4-keto-6-deoxyglucose reductase (GerKI) from Streptomyces sp. KCTC 0041BP.(Glycobiology) [2007]
2uniprot
Cloning and characterization of a gene cluster for the production of the polyketide macrolide antibiotic dihydrochalcomycin in Streptomyces sp. KCTC 0041BP.(J. Microbiol. Biotechnol.) [2006]
29
 E4NJF1_KITSK
(E4NJF1)		 
[query] 19 - 3453 (3546)
[subject] 22 - 3680 (4833)
(8 hsp)		 0.0 2246   45%
Product
Modular polyketide synthase BFAS1
Gene
bfmA1
KSE_73440
Organism
Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054)
Streptomyces setae
1uniprot[Pubmed] 21059706
Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.(DNA Res.) [2010]
32
 Q5SFB4_STRBI
(Q5SFB4)		 Jump to Chalc_00210 
[query] 69 - 2910 (3546)
[subject] 539 - 3435 (4441)
(7 hsp)		 0.0 2241   49%
Product
Polyketide synthase subunit
Gene
chmGI
Organism
Streptomyces bikiniensis
1uniprot[Pubmed] 15561847
Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae.(Antimicrob. Agents Chemother.) [2004]
33
 Q53840_SORCE
(Q53840)		 Jump to Soraph_00080 
[query] 468 - 3476 (3546)
[subject] 3579 - 6769 (8817)
(15 hsp)		 0.0 2240   46%
Product
Soraphen polyketide synthase B
Gene
sorB
Organism
Sorangium cellulosum
Polyangium cellulosum
1uniprot[Pubmed] 7601830 [Medline] 95325306
A Sorangium cellulosum (myxobacterium) gene cluster for the biosynthesis of the macrolide antibiotic soraphen A: cloning, characterization, and homology to polyketide synthase genes from actinomycetes.(J. Bacteriol.) [1995]
2uniprot[Pubmed] 12039053 [Medline] 22035375
Characterization of the biosynthetic gene cluster for the antifungal polyketide soraphen A from Sorangium cellulosum So ce26.(Gene) [2002]
[pubmed all]
35
 Q3S864_9ACTO
(Q3S864)		 Jump to Conca_00060 
[query] 524 - 3466 (3546)
[subject] 2 - 3107 (4970)
(7 hsp)		 0.0 2234   47%
Product
Nodular polyketide synthase
Gene
 
Organism
Streptomyces neyagawaensis
1uniprot[Pubmed] 16207901
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.(Microbiology) [2005]
38
 Q9L4W4_9ACTO
(Q9L4W4)		 Jump to Nysta_00140 
[query] 552 - 3458 (3546)
[subject] 37 - 3103 (3192)
(5 hsp)		 0.0 2212   47%
Product
NysB
Gene
nysB
Organism
Streptomyces noursei
1uniprot[Pubmed] 10873841 [Medline] 20334850
Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway.(Chem. Biol.) [2000]
41
 Q1WEK7_9ACTO
(Q1WEK7)		 
[query] 468 - 3459 (3546)
[subject] 2861 - 5917 (7968)
(11 hsp)		 0.0 2197   47%
Product
Polyketide synthase
Gene
merC
Organism
Streptomyces sp. NRRL 30748
1uniprot[Pubmed] 16806745
Isolation and characterization of meridamycin biosynthetic gene cluster from Streptomyces sp. NRRL 30748.(Gene) [2006]
42
 Q5Y9G6_9ACTO
(Q5Y9G6)		 
[query] 553 - 3511 (3546)
[subject] 28 - 2957 (3195)
(4 hsp)		 0.0 2194   50%
Product
Polyketide synthase modules 5 and 6
Gene
eryAIII
Organism
Aeromicrobium erythreum
1uniprot[Pubmed] 15257441
The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum.(J. Ind. Microbiol. Biotechnol.) [2004]
43
 Q93NX9_9ACTO
(Q93NX9)		 Jump to Amph_00040 
[query] 481 - 3467 (3546)
[subject] 1696 - 4836 (9510)
(16 hsp)		 0.0 2184   45%
Product
AmphI
Gene
amphI
Organism
Streptomyces nodosus
1uniprot[Pubmed] 11451671 [Medline] 21344785
Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes.(Chem. Biol.) [2001]
2uniprot[Pubmed] 16079135
Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups.(J. Biol. Chem.) [2005]
[pubmed all]
44
 F1CLA9_9ACTO
(F1CLA9)		 
[query] 465 - 3479 (3546)
[subject] 1692 - 4846 (9498)
(17 hsp)		 0.0 2179   46%
Product
ScnS2
Gene
scnS2
Organism
Streptomyces chattanoogensis
1uniprot[Pubmed] 21330439
The pleitropic regulator AdpAch is required for natamycin biosynthesis and morphological differentiation in Streptomyces chattanoogensis.(Microbiology) [2011]
46
 Q93NW7_9ACTO
(Q93NW7)		 Jump to Amph_00160 
[query] 552 - 3458 (3546)
[subject] 34 - 3099 (3190)
(6 hsp)		 0.0 2174   46%
Product
AmphB
Gene
amphB
Organism
Streptomyces nodosus
1uniprot[Pubmed] 11451671 [Medline] 21344785
Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes.(Chem. Biol.) [2001]
2uniprot[Pubmed] 16079135
Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups.(J. Biol. Chem.) [2005]
3uniprot[Pubmed] 20696392
Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase.(Structure) [2010]
[pubmed all]
47
 Q9L4X3_9ACTO
(Q9L4X3)		 Jump to Nysta_00050 
[query] 481 - 3465 (3546)
[subject] 1737 - 4879 (9477)
(17 hsp)		 0.0 2164   46%
Product
NysI
Gene
nysI
Organism
Streptomyces noursei
1uniprot[Pubmed] 10873841 [Medline] 20334850
Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway.(Chem. Biol.) [2000]
49
 Q9ALM4_9PSEU
(Q9ALM4)		 Jump to Spino_00190 
[query] 543 - 3544 (3546)
[subject] 20 - 3168 (3170)
(4 hsp)		 0.0 2157   46%
Product
Polyketide synthase extender modules 3-4
Gene
spnC
Organism
Saccharopolyspora spinosa
1uniprot[Pubmed] 11358695 [Medline] 21257765
Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001]
51
 Q93H84_STRAW
(Q93H84)		 
[query] 468 - 3465 (3546)
[subject] 1452 - 4556 (6145)
(8 hsp)		 0.0 2151   46%
Product
Modular polyketide synthase
Gene
pteA4
SAV416
SAV_416
Organism
Streptomyces avermitilis
1uniprot[Pubmed] 11572948 [Medline] 21477403
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001]
2uniprot[Pubmed] 12692562 [Medline] 22608306
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003]
[pubmed all]
52
 B6ZIR2_STRPT
(B6ZIR2)		 Jump to Pladi_00010 
[query] 4 - 2919 (3546)
[subject] 439 - 3479 (6532)
(12 hsp)		 0.0 2149   46%
Product
Polyketide synthase
Gene
pldAI
Organism
Streptomyces platensis
1uniprot[Pubmed] 18997414
Organization of the biosynthetic gene cluster for the polyketide antitumor macrolide, pladienolide, in Streptomyces platensis Mer-11107.(Biosci. Biotechnol. Biochem.) [2008]
53
 E4NJF2_KITSK
(E4NJF2)		 
[query] 557 - 3465 (3546)
[subject] 34 - 3125 (5004)
(8 hsp)		 0.0 2148   47%
Product
Modular polyketide synthase BFAS2
Gene
bfmA2
KSE_73450
Organism
Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054)
Streptomyces setae
1uniprot[Pubmed] 21059706
Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.(DNA Res.) [2010]
54
 Q6W5P6_9ACTO
(Q6W5P6)		 Jump to FR008_00200 
[query] 468 - 3467 (3546)
[subject] 3252 - 6405 (9550)
(14 hsp)		 0.0 2143   45%
Product
FscD
Gene
fscD
Organism
Streptomyces sp. FR-008
1uniprot[Pubmed] 14652074
Organizational and Mutational Analysis of a Complete FR-008/Candicidin Gene Cluster Encoding a Structurally Related Polyene Complex.(Chem. Biol.) [2003]
55
 Q93H83_STRAW
(Q93H83)		 
[query] 546 - 3469 (3546)
[subject] 24 - 3057 (3352)
(4 hsp)		 0.0 2140   46%
Product
Modular polyketide synthase
Gene
pteA5
SAV415
SAV_415
Organism
Streptomyces avermitilis
1uniprot[Pubmed] 11572948 [Medline] 21477403
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001]
2uniprot[Pubmed] 12692562 [Medline] 22608306
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003]
[pubmed all]
56
 Q9EWA1_9ACTO
(Q9EWA1)		 Jump to Pimar_00070 
[query] 425 - 3471 (3546)
[subject] 3184 - 6392 (9507)
(16 hsp)		 0.0 2135   44%
Product
PimS2 protein
Gene
pimS2
Organism
Streptomyces natalensis
1uniprot[Pubmed] 11094342 [Medline] 20547809
A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis.(Chem. Biol.) [2000]
58
 Q93HJ5_STRAW
(Q93HJ5)		 Jump to Oligo_00080 
[query] 456 - 3465 (3546)
[subject] 906 - 3968 (6146)
(11 hsp)		 0.0 2123   47%
Product
Modular polyketide synthase
Gene
olmA1
SAV2899
SAV_2899
Organism
Streptomyces avermitilis
1uniprot[Pubmed] 11572948 [Medline] 21477403
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001]
2uniprot[Pubmed] 12692562 [Medline] 22608306
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003]
[pubmed all]
60
 A0FCL3_STRVO
(A0FCL3)		 Jump to Merid_00040 
[query] 468 - 3459 (3546)
[subject] 2857 - 5919 (11604)
(18 hsp)		 0.0 2117   46%
Product
MerC
Gene
merC
Organism
Streptomyces violaceoniger
1uniprot[Pubmed] 17159202
Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin.(Microbiology) [2006]
61
 D2CKL5_PSEAH
(D2CKL5)		 
[query] 468 - 3474 (3546)
[subject] 1702 - 4868 (9499)
(15 hsp)		 0.0 2114   45%
Product
CppI
Gene
cppI
Organism
Pseudonocardia autotrophica
Amycolata autotrophica
Nocardia autotrophica
1uniprot[Pubmed] 19697072
Identification of functionally clustered nystatin-like biosynthetic genes in a rare actinomycetes, Pseudonocardia autotrophica.(J. Ind. Microbiol. Biotechnol.) [2009]
63
 Q1WEK9_9ACTO
(Q1WEK9)		 
[query] 23 - 2910 (3546)
[subject] 498 - 3377 (5712)
(8 hsp)		 0.0 2106   46%
Product
Polyketide synthase
Gene
merA
Organism
Streptomyces sp. NRRL 30748
1uniprot[Pubmed] 16806745
Isolation and characterization of meridamycin biosynthetic gene cluster from Streptomyces sp. NRRL 30748.(Gene) [2006]
64
 Q1WEK8_9ACTO
(Q1WEK8)		 
[query] 461 - 2919 (3546)
[subject] 1633 - 4150 (7102)
(14 hsp)		 0.0 2098   50%
Product
Polyketide synthase
Gene
merB
Organism
Streptomyces sp. NRRL 30748
1uniprot[Pubmed] 16806745
Isolation and characterization of meridamycin biosynthetic gene cluster from Streptomyces sp. NRRL 30748.(Gene) [2006]
65
 D7P614_CHOCO
(D7P614)		 
[query] 557 - 3467 (3546)
[subject] 17 - 3112 (6610)
(10 hsp)		 0.0 2097   44%
Product
TugD
Gene
tugD
Organism
Chondromyces crocatus
1uniprot[Pubmed] 20416506
Biosynthesis of thuggacins in myxobacteria: comparative cluster analysis reveals basis for natural product structural diversity.(Chem. Biol.) [2010]
66
 Q52V46_9ACTO
(Q52V46)		 
[query] 458 - 3543 (3546)
[subject] 4892 - 8144 (8147)
(12 hsp)		 0.0 2096   44%
Product
Polyketide synthase type I
Gene
 
Organism
Streptomyces aizunensis
1uniprot[Pubmed] 15844935
Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.(J. Nat. Prod.) [2005]
67
 A0FCL1_STRVO
(A0FCL1)		 Jump to Merid_00020 
[query] 32 - 2910 (3546)
[subject] 503 - 3381 (5721)
(7 hsp)		 0.0 2093   46%
Product
MerA
Gene
merA
Organism
Streptomyces violaceoniger
1uniprot[Pubmed] 17159202
Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin.(Microbiology) [2006]
68
 Q3S865_9ACTO
(Q3S865)		 Jump to Conca_00050 
[query] 534 - 3474 (3546)
[subject] 35 - 3198 (4825)
(7 hsp)		 0.0 2085   46%
Product
Modular polyketide synthase
Gene
 
Organism
Streptomyces neyagawaensis
1uniprot[Pubmed] 16207901
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.(Microbiology) [2005]
72
 A0FCL2_STRVO
(A0FCL2)		 Jump to Merid_00030 
[query] 461 - 2919 (3546)
[subject] 1637 - 4197 (7178)
(14 hsp)		 0.0 2077   49%
Product
MerB
Gene
merB
Organism
Streptomyces violaceoniger
1uniprot[Pubmed] 17159202
Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin.(Microbiology) [2006]
73
 Q9ZGI5_9ACTO
(Q9ZGI5)		 Jump to Pikro_00030 
[query] 69 - 2911 (3546)
[subject] 599 - 3558 (4613)
(9 hsp)		 0.0 2076   46%
Product
Type I polyketide synthase PikAI
Gene
pikAI
Organism
Streptomyces venezuelae
1uniprot[Pubmed] 9770448 [Medline] 98445333
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.(Proc. Natl. Acad. Sci. U.S.A.) [1998]
76
 A0ACI1_STRAM
(A0ACI1)		 
[query] 552 - 3543 (3546)
[subject] 29 - 3154 (3157)
(4 hsp)		 0.0 2063   45%
Product
Putative modular polyketide synthase
Gene
SAMR0475
Organism
Streptomyces ambofaciens ATCC 23877
1uniprot[Pubmed] 16956972
Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006]
2uniprot
Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006]
77
 D7C2C3_STRBB
(D7C2C3)		 
[query] 468 - 3356 (3546)
[subject] 1776 - 4847 (4868)
(10 hsp)		 0.0 2061   46%
Product
Modular polyketide synthase
Gene
pks3-4
SBI_00656
Organism
Streptomyces bingchenggensis (strain BCW-1)
1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
78
 Q9ALM3_9PSEU
(Q9ALM3)		 Jump to Spino_00200 
[query] 436 - 3543 (3546)
[subject] 1664 - 4926 (4928)
(7 hsp)		 0.0 2056   44%
Product
Polyketide synthase extender modules 5-7
Gene
spnD
Organism
Saccharopolyspora spinosa
1uniprot[Pubmed] 11358695 [Medline] 21257765
Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001]
81
 Q52V44_9ACTO
(Q52V44)		 
[query] 468 - 3465 (3546)
[subject] 1727 - 4859 (6751)
(13 hsp)		 0.0 2042   44%
Product
Polyketide synthase type I
Gene
 
Organism
Streptomyces aizunensis
1uniprot[Pubmed] 15844935
Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.(J. Nat. Prod.) [2005]
82
 C9YYI0_STRSW
(C9YYI0)		 
[query] 534 - 3471 (3546)
[subject] 4 - 3175 (4799)
(7 hsp)		 0.0 2039   45%
Product
Putative type I polyketide synthase
Gene
SCAB_83891
Organism
Streptomyces scabies (strain 87.22)
Streptomyces scabiei
1uniprot[Pubmed] 20064060
Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010]
84
 A4F5C7_SORCE
(A4F5C7)		 
[query] 534 - 3465 (3546)
[subject] 1 - 3115 (5005)
(9 hsp)		 0.0 2024   44%
Product
Polyketide synthase
Gene
spiH
Organism
Sorangium cellulosum
Polyangium cellulosum
1uniprot[Pubmed] 17317575
Spiroketal polyketide formation in Sorangium: Identification of the biosynthetic gene cluster for the highly cytotoxic spirangienes.(Chem. Biol.) [2007]
85
 D6C474_9ACTO
(D6C474)		 Jump to Meili_00270 
[query] 552 - 3472 (3546)
[subject] 31 - 3079 (5277)
(9 hsp)		 0.0 2022   45%
Product
Modular polyketide synthase
Gene
meiA4
Organism
Streptomyces nanchangensis
1uniprot[Pubmed] 12811466 [Medline] 22777186
Identification of a gene cluster encoding meilingmycin biosynthesis among multiple polyketide synthase contigs isolated from Streptomyces nanchangensis NS3226.(Arch. Microbiol.) [2003]
2uniprot[Pubmed] 20348291
Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification.(Appl. Environ. Microbiol.) [2010]
[pubmed all]
87
 Q6MZ72_MYCUA
(Q6MZ72)		 Jump to MUP_00320 
[query] 490 - 3474 (3546)
[subject] 1750 - 4886 (14130)
(29 hsp)		 0.0 2014   42%
Product
Type I modular polyketide synthase
Gene
mlsB
MUP032c
Organism
Mycobacterium ulcerans (strain Agy99)
1uniprot[Pubmed] 14736915
Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.(Proc. Natl. Acad. Sci. U.S.A.) [2004]
2uniprot[Pubmed] 15758215
Functional analysis and annotation of the virulence plasmid pMUM001 from Mycobacterium ulcerans.(Microbiology) [2005]
[pubmed all]
88
 D6C473_9ACTO
(D6C473)		 Jump to Meili_00240 
[query] 20 - 3461 (3546)
[subject] 476 - 4047 (5987)
(11 hsp)		 0.0 2014   39%
Product
Modular polyketide synthase
Gene
meiA2
Organism
Streptomyces nanchangensis
1uniprot[Pubmed] 12811466 [Medline] 22777186
Identification of a gene cluster encoding meilingmycin biosynthesis among multiple polyketide synthase contigs isolated from Streptomyces nanchangensis NS3226.(Arch. Microbiol.) [2003]
2uniprot[Pubmed] 20348291
Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification.(Appl. Environ. Microbiol.) [2010]
[pubmed all]
89
 D3Y1I4_9ACTO
(D3Y1I4)		 
[query] 552 - 2922 (3546)
[subject] 28 - 2464 (3365)
(7 hsp)		 0.0 2008   49%
Product
TamAII
Gene
 
Organism
Streptomyces sp. 307-9
1uniprot[Pubmed] 20127927
Identification of the tirandamycin biosynthetic gene cluster from Streptomyces sp. 307-9.(Chembiochem) [2010]
90
 A0ACI0_STRAM
(A0ACI0)		 
[query] 425 - 3536 (3546)
[subject] 2916 - 6118 (6333)
(7 hsp)		 0.0 2006   44%
Product
Putative modular polyketide synthase
Gene
SAMR0474
Organism
Streptomyces ambofaciens ATCC 23877
1uniprot[Pubmed] 16956972
Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006]
2uniprot
Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006]
91
 D7C2C2_STRBB
(D7C2C2)		 
[query] 468 - 3465 (3546)
[subject] 59 - 3210 (4821)
(6 hsp)		 0.0 2006   44%
Product
Modular polyketide synthase
Gene
pks3-3
SBI_00655
Organism
Streptomyces bingchenggensis (strain BCW-1)
1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
92
 F1DI32_9ACTO
(F1DI32)		 
[query] 552 - 2922 (3546)
[subject] 41 - 2477 (3378)
(7 hsp)		 0.0 2004   49%
Product
TrdAII
Gene
 
Organism
Streptomyces sp. SCSIO1666
1uniprot[Pubmed] 21329667
Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomyces sp. SCSIO1666.(Biochem. Biophys. Res. Commun.) [2011]
94
 B6ZIR3_STRPT
(B6ZIR3)		 Jump to Pladi_00020 
[query] 465 - 2912 (3546)
[subject] 3529 - 6107 (7026)
(14 hsp)		 0.0 1995   47%
Product
Polyketide synthase
Gene
pldAII
Organism
Streptomyces platensis
1uniprot[Pubmed] 18997414
Organization of the biosynthetic gene cluster for the polyketide antitumor macrolide, pladienolide, in Streptomyces platensis Mer-11107.(Biosci. Biotechnol. Biochem.) [2008]
95
 Q27W58_STRVO
(Q27W58)		 Jump to Niger_00170 
[query] 557 - 3465 (3546)
[subject] 35 - 3145 (4787)
(7 hsp)		 0.0 1995   42%
Product
NigAVII
Gene
 
Organism
Streptomyces violaceoniger
1uniprot[Pubmed] 17584617
Insights into Polyether Biosynthesis from Analysis of the Nigericin Biosynthetic Gene Cluster in Streptomyces sp. DSM4137.(Chem. Biol.) [2007]
96
 D7C488_STRBB
(D7C488)		 
[query] 21 - 2911 (3546)
[subject] 14 - 3040 (4343)
(8 hsp)		 0.0 1991   43%
Product
Type I polyketide synthase
Gene
milA1
SBI_00789
Organism
Streptomyces bingchenggensis (strain BCW-1)
1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
97
 B6CLY1_9MYCO
(B6CLY1)		 
[query] 490 - 3474 (3546)
[subject] 1742 - 4881 (12352)
(24 hsp)		 0.0 1987   42%
Product
Type I modular polyketide synthase, MlsB
Gene
mlsB
MULP_051
Organism
Mycobacterium liflandii 128FXT
1uniprot[Pubmed] 18840298
Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones.(BMC Genomics) [2008]
98
 D6C4C5_9ACTO
(D6C4C5)		 Jump to Meili_00790 
[query] 21 - 2911 (3546)
[subject] 5 - 3033 (4330)
(8 hsp)		 0.0 1986   43%
Product
Modular polyketide synthase
Gene
meiA1
Organism
Streptomyces nanchangensis
1uniprot[Pubmed] 12811466 [Medline] 22777186
Identification of a gene cluster encoding meilingmycin biosynthesis among multiple polyketide synthase contigs isolated from Streptomyces nanchangensis NS3226.(Arch. Microbiol.) [2003]
2uniprot[Pubmed] 20348291
Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification.(Appl. Environ. Microbiol.) [2010]
[pubmed all]
99
 C9YYI1_STRSW
(C9YYI1)		 
[query] 524 - 2913 (3546)
[subject] 2 - 2463 (4970)
(9 hsp)		 0.0 1986   50%
Product
Putative type I polyketide synthase
Gene
SCAB_83901
Organism
Streptomyces scabies (strain 87.22)
Streptomyces scabiei
1uniprot[Pubmed] 20064060
Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010]
100
 B1W4J2_STRGG
(B1W4J2)		 
[query] 552 - 3465 (3546)
[subject] 29 - 3172 (5343)
(8 hsp)		 0.0 1984   44%
Product
Putative type-I PKS
Gene
pks2-2
SGR_6180
Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
1uniprot[Pubmed] 18375553
Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008]