BLAST table : Heda_00060

DBUniProtKB
accessionDBalignmentEvalueScoreIdent.linkproductgeneorganismec
1
 Q67G52_9ACTO
(Q67G52)		 
[query] 1 - 115 (115)
[subject] 1 - 115 (115)
 7e-60 233   100% Anthrone oxygenase Streptomyces griseoruber
2
 B5G887_9ACTO
(B5G887)		 
[query] 9 - 106 (115)
[subject] 13 - 110 (118)
 3e-23 111   56% Antibiotic biosynthesis monooxygenase subfamily SSBG_00495 Streptomyces sp. SPB74
3
 Q8VWB4_9ACTO
(Q8VWB4)		 
[query] 10 - 108 (115)
[subject] 13 - 111 (122)
 4e-23 111   55% AknX aknX Streptomyces galilaeus
4
 Q2PZS0_9ACTO
(Q2PZS0)		 Jump to Cosmo_00060 
[query] 2 - 107 (115)
[subject] 10 - 116 (117)
 5e-22 107   50% CosX cosX Streptomyces olindensis
5
 D9UBN4_STRPR
(D9UBN4)		 
[query] 11 - 98 (115)
[subject] 2 - 89 (97)
 8e-22 107   57% Putative oxygenase c101_13 Streptomyces pristinaespiralis
6
 D6X7X8_STRPR
(D6X7X8)		 
[query] 11 - 98 (115)
[subject] 2 - 89 (97)
 8e-22 107   57% Predicted protein SSDG_07511 Streptomyces pristinaespiralis ATCC 25486
7
 Q9L552_9ACTO
(Q9L552)		 Jump to Acla_00060 
[query] 10 - 108 (115)
[subject] 13 - 111 (122)
 2e-21 106   53% AknX aknX Streptomyces galilaeus
8
 Q2PA06_9ACTO
(Q2PA06)		 Jump to Stref_00090 
[query] 9 - 101 (115)
[subject] 12 - 106 (111)
 1e-20 103   52% Monooxygenase stfOI Streptomyces steffisburgensis
9
 Q55222_STRSQ
(Q55222)		 Jump to Dauno_00150 
[query] 9 - 101 (115)
[subject] 16 - 113 (131)
 2e-20 102   55% Oxygenase dauA Streptomyces sp
10
 Q54813_STRPE
(Q54813)		 Jump to Adria_00260 
[query] 9 - 110 (115)
[subject] 12 - 127 (129)
 2e-20 102   51% Anthraquinol monooxygenase Streptomyces peucetius
11
 O54259_STRNO
(O54259)		 Jump to Nogl_00350 
[query] 11 - 101 (115)
[subject] 14 - 104 (118)
 2e-18 95.5 52% SnoaB SnoaB Streptomyces nogalater
12
 D1A6U1_THECD
(D1A6U1)		 
[query] 9 - 100 (115)
[subject] 169 - 260 (269)
 4e-16 88.2 55% Antibiotic biosynthesis monooxygenase Tcur_2800 Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
13
 Q4R0L6_STRCX
(Q4R0L6)		 Jump to Chart_00160 
[query] 11 - 97 (115)
[subject] 7 - 93 (106)
 8e-16 87   49% ChaH protein chaH Streptomyces chartreusis
14
 E8RWT7_MICSL
(E8RWT7)		 
[query] 7 - 99 (115)
[subject] 9 - 101 (107)
 5e-14 81.3 53% Antibiotic biosynthesis monooxygenase ML5_4426 Micromonospora sp. (strain L5)
15
 D9T292_MICAI
(D9T292)		 
[query] 7 - 99 (115)
[subject] 9 - 101 (107)
 5e-14 81.3 53% Antibiotic biosynthesis monooxygenase Micau_3995 Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
16
 C0JWC9_9ACTO
(C0JWC9)		 Jump to Polk_00340 
[query] 11 - 97 (115)
[subject] 16 - 102 (109)
 2e-10 69.3 40% PokO3 pokO3 Streptomyces diastatochromogenes
17
 Q3S8Q8_STRRM
(Q3S8Q8)		 Jump to Oxtet_00080 
[query] 12 - 98 (115)
[subject] 3 - 89 (95)
 6e-09 64.3 39% OxyG oxyG Streptomyces rimosus
18
 E8W960_STRFA
(E8W960)		 
[query] 11 - 97 (115)
[subject] 521 - 607 (615)
 1e-08 63.5 34% AMP-dependent synthetase and ligase Sfla_5326 Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD)
19
 Q194R0_STRAA
(Q194R0)		 Jump to Mith_00100 
[query] 11 - 108 (115)
[subject] 2 - 99 (99)
 2e-08 62.8 37% Oxygenase mtmOIII Streptomyces argillaceus
20
 D9UBK9_STRPR
(D9UBK9)		 
[query] 11 - 97 (115)
[subject] 2 - 88 (103)
 2e-08 62.4 39% Putative oxygenase c104_05c Streptomyces pristinaespiralis
21
 B5HJX8_STRPR
(B5HJX8)		 
[query] 11 - 97 (115)
[subject] 2 - 88 (103)
 2e-08 62.4 39% Oxygenase SSDG_05475 Streptomyces pristinaespiralis ATCC 25486
22
 B5WK68_9BURK
(B5WK68)		 
[query] 11 - 81 (115)
[subject] 24 - 95 (122)
 8e-06 53.9 40% Antibiotic biosynthesis monooxygenase BH160DRAFT_3471 Burkholderia sp. H160
23
 Q1MEI2_RHIL3
(Q1MEI2)		 
[query] 9 - 81 (115)
[subject] 22 - 95 (122)
 9e-06 53.9 38% Putative monooxygenase RL3157 Rhizobium leguminosarum bv. viciae (strain 3841)
24
 A2W3S6_9BURK
(A2W3S6)		 
[query] 11 - 81 (115)
[subject] 24 - 95 (122)
 9e-06 53.9 39% Putative uncharacterized protein BCPG_05014 Burkholderia cenocepacia PC184
25
 B4EFW0_BURCJ
(B4EFW0)		 
[query] 11 - 81 (115)
[subject] 24 - 95 (122)
 1e-05 53.5 39% Putative monooxygenase BceJ2315_56000
BCAM2163		 Burkholderia cepacia (strain J2315 / LMG 16656)
Burkholderia cenocepacia (strain J2315)
26
 D7BZS2_STRBB
(D7BZS2)		 
[query] 3 - 79 (115)
[subject] 5 - 83 (214)
 2e-05 53.1 40% Putative uncharacterized protein SBI_06857 Streptomyces bingchenggensis (strain BCW-1)
27
 Q1BPX1_BURCA
(Q1BPX1)		 
[query] 11 - 81 (115)
[subject] 24 - 95 (122)
 3e-05 52.4 38% Antibiotic biosynthesis monooxygenase Bcen_3440 Burkholderia cenocepacia (strain AU 1054)
28
 A0B1Y5_BURCH
(A0B1Y5)		 
[query] 11 - 81 (115)
[subject] 24 - 95 (122)
 3e-05 52.4 38% Antibiotic biosynthesis monooxygenase Bcen2424_4927 Burkholderia cenocepacia (strain HI2424)
29
 D7BZR9_STRBB
(D7BZR9)		 
[query] 7 - 95 (115)
[subject] 563 - 653 (766)
 3e-05 52.4 34% Acyl-CoA ligase SBI_06854 Streptomyces bingchenggensis (strain BCW-1)
30
 B1YZ27_BURA4
(B1YZ27)		 
[query] 11 - 81 (115)
[subject] 24 - 95 (122)
 5e-05 51.2 38% Antibiotic biosynthesis monooxygenase BamMC406_4876 Burkholderia ambifaria (strain MC40-6)
31
 Q0B7G2_BURCM
(Q0B7G2)		 
[query] 11 - 81 (115)
[subject] 24 - 95 (122)
 6e-05 51.2 38% Antibiotic biosynthesis monooxygenase Bamb_4359 Burkholderia ambifaria (strain ATCC BAA-244 / AMMD)
Burkholderia cepacia (strain AMMD)
32
 B1FL90_9BURK
(B1FL90)		 
[query] 11 - 81 (115)
[subject] 24 - 95 (122)
 6e-05 51.2 38% Antibiotic biosynthesis monooxygenase BamIOP4010DRAFT_4801 Burkholderia ambifaria IOP40-10
33
 D5QF00_GLUHA
(D5QF00)		 
[query] 11 - 79 (115)
[subject] 24 - 93 (122)
 6e-05 51.2 39% Antibiotic biosynthesis monooxygenase GXY_08579 Gluconacetobacter hansenii ATCC 23769
34
 Q399I3_BURS3
(Q399I3)		 
[query] 11 - 81 (115)
[subject] 24 - 95 (122)
 9e-05 50.4 36% Antibiotic biosynthesis monooxygenase Bcep18194_B0764 Burkholderia sp. (strain 383)
Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)
35
 B1K833_BURCC
(B1K833)		 
[query] 11 - 81 (115)
[subject] 24 - 95 (122)
 0.0001 50.1 36% Antibiotic biosynthesis monooxygenase Bcenmc03_5360 Burkholderia cenocepacia (strain MC0-3)
36
 F6EZ78_SPHCR
(F6EZ78)		 
[query] 11 - 82 (115)
[subject] 27 - 99 (125)
 0.0006 47.8 38% Antibiotic biosynthesis monooxygenase Sphch_2520 Sphingobium chlorophenolicum L-1
37
 D9V1J8_9ACTO
(D9V1J8)		 
[query] 9 - 95 (115)
[subject] 22 - 102 (116)
 0.0007 47.4 36% Predicted protein SSMG_06788 Streptomyces sp. AA4
accessionDBalignmentEvalueScoreIdent.linkinformationpubmed
1
 Q67G52_9ACTO
(Q67G52)		 
[query] 1 - 115 (115)
[subject] 1 - 115 (115)
 7e-60 233   100%
Product
Anthrone oxygenase
Gene
 
Organism
Streptomyces griseoruber
1uniprot[Pubmed] 15271354
The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004]
3
 Q8VWB4_9ACTO
(Q8VWB4)		 
[query] 10 - 108 (115)
[subject] 13 - 111 (122)
 4e-23 111   55%
Product
AknX
Gene
aknX
Organism
Streptomyces galilaeus
1uniprot[Pubmed] 12399480 [Medline] 22286521
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002]
4
 Q2PZS0_9ACTO
(Q2PZS0)		 Jump to Cosmo_00060 
[query] 2 - 107 (115)
[subject] 10 - 116 (117)
 5e-22 107   50%
Product
CosX
Gene
cosX
Organism
Streptomyces olindensis
1uniprot[Pubmed] 16810496
Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes.(Appl. Microbiol. Biotechnol.) [2006]
5
 D9UBN4_STRPR
(D9UBN4)		 
[query] 11 - 98 (115)
[subject] 2 - 89 (97)
 8e-22 107   57%
Product
Putative oxygenase
Gene
c101_13
Organism
Streptomyces pristinaespiralis
1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]
7
 Q9L552_9ACTO
(Q9L552)		 Jump to Acla_00060 
[query] 10 - 108 (115)
[subject] 13 - 111 (122)
 2e-21 106   53%
Product
AknX
Gene
aknX
Organism
Streptomyces galilaeus
1uniprot[Pubmed] 12137949 [Medline] 22133312
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002]
8
 Q2PA06_9ACTO
(Q2PA06)		 Jump to Stref_00090 
[query] 9 - 101 (115)
[subject] 12 - 106 (111)
 1e-20 103   52%
Product
Monooxygenase
Gene
stfOI
Organism
Streptomyces steffisburgensis
1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006]
9
 Q55222_STRSQ
(Q55222)		 Jump to Dauno_00150 
[query] 9 - 101 (115)
[subject] 16 - 113 (131)
 2e-20 102   55%
Product
Oxygenase
Gene
dauA
Organism
Streptomyces sp
1uniprot[Pubmed] 7928998 [Medline] 95014072
Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5.(J. Bacteriol.) [1994]
10
 Q54813_STRPE
(Q54813)		 Jump to Adria_00260 
[query] 9 - 110 (115)
[subject] 12 - 127 (129)
 2e-20 102   51%
Product
Anthraquinol monooxygenase
Gene
 
Organism
Streptomyces peucetius
1uniprot[Pubmed] 7828855 [Medline] 95129838
Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase.(Gene) [1994]
11
 O54259_STRNO
(O54259)		 Jump to Nogl_00350 
[query] 11 - 101 (115)
[subject] 14 - 104 (118)
 2e-18 95.5 52%
Product
SnoaB
Gene
SnoaB
Organism
Streptomyces nogalater
1uniprot[Pubmed] 8668120 [Medline] 96242142
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996]
2uniprot[Pubmed] 9349712 [Medline] 98007868
Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
3uniprot[Pubmed] 8760909 [Medline] 96349102
Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996]
4uniprot[Pubmed] 20052967
Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism.(Biochemistry) [2010]
[pubmed all]
12
 D1A6U1_THECD
(D1A6U1)		 
[query] 9 - 100 (115)
[subject] 169 - 260 (269)
 4e-16 88.2 55%
Product
Antibiotic biosynthesis monooxygenase
Gene
Tcur_2800
Organism
Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]
13
 Q4R0L6_STRCX
(Q4R0L6)		 Jump to Chart_00160 
[query] 11 - 97 (115)
[subject] 7 - 93 (106)
 8e-16 87   49%
Product
ChaH protein
Gene
chaH
Organism
Streptomyces chartreusis
1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]
16
 C0JWC9_9ACTO
(C0JWC9)		 Jump to Polk_00340 
[query] 11 - 97 (115)
[subject] 16 - 102 (109)
 2e-10 69.3 40%
Product
PokO3
Gene
pokO3
Organism
Streptomyces diastatochromogenes
1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]
17
 Q3S8Q8_STRRM
(Q3S8Q8)		 Jump to Oxtet_00080 
[query] 12 - 98 (115)
[subject] 3 - 89 (95)
 6e-09 64.3 39%
Product
OxyG
Gene
oxyG
Organism
Streptomyces rimosus
1uniprot[Pubmed] 16597959
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006]
19
 Q194R0_STRAA
(Q194R0)		 Jump to Mith_00100 
[query] 11 - 108 (115)
[subject] 2 - 99 (99)
 2e-08 62.8 37%
Product
Oxygenase
Gene
mtmOIII
Organism
Streptomyces argillaceus
1uniprot[Pubmed] 8654997 [Medline] 96257259
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144
An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479
Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047
Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236
Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752
The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254
Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461
Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238
Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589
MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873
The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]
[pubmed all]
20
 D9UBK9_STRPR
(D9UBK9)		 
[query] 11 - 97 (115)
[subject] 2 - 88 (103)
 2e-08 62.4 39%
Product
Putative oxygenase
Gene
c104_05c
Organism
Streptomyces pristinaespiralis
1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]
23
 Q1MEI2_RHIL3
(Q1MEI2)		 
[query] 9 - 81 (115)
[subject] 22 - 95 (122)
 9e-06 53.9 38%
Product
Putative monooxygenase
Gene
RL3157
Organism
Rhizobium leguminosarum bv. viciae (strain 3841)
1uniprot[Pubmed] 16640791
The genome of Rhizobium leguminosarum has recognizable core and accessory components.(Genome Biol.) [2006]
26
 D7BZS2_STRBB
(D7BZS2)		 
[query] 3 - 79 (115)
[subject] 5 - 83 (214)
 2e-05 53.1 40%
Product
Putative uncharacterized protein
Gene
SBI_06857
Organism
Streptomyces bingchenggensis (strain BCW-1)
1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
29
 D7BZR9_STRBB
(D7BZR9)		 
[query] 7 - 95 (115)
[subject] 563 - 653 (766)
 3e-05 52.4 34%
Product
Acyl-CoA ligase
Gene
SBI_06854
Organism
Streptomyces bingchenggensis (strain BCW-1)
1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
33
 D5QF00_GLUHA
(D5QF00)		 
[query] 11 - 79 (115)
[subject] 24 - 93 (122)
 6e-05 51.2 39%
Product
Antibiotic biosynthesis monooxygenase
Gene
GXY_08579
Organism
Gluconacetobacter hansenii ATCC 23769
1uniprot[Pubmed] 20543071
Genome sequence of a cellulose-producing bacterium, Gluconacetobacter hansenii ATCC 23769.(J. Bacteriol.) [2010]