| accession | DB | alignment | Evalue | Score | Ident. | link | information | pubmed |
|---|
1
|
Q194R0_STRAA
(Q194R0) |
|
|
1e-50 |
202 |
100% |
|
- Product
- Oxygenase
- Gene
- mtmOIII
- Organism
- Streptomyces argillaceus
|
1uniprot[Pubmed] 8654997 [Medline] 96257259
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996] | 2uniprot[Pubmed] 8757400 [Medline] 96335144
An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996] | 3uniprot[Pubmed] 9150235 [Medline] 97294479
Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997] | 4uniprot[Pubmed] 9733697 [Medline] 98406047
Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998] | 5uniprot[Pubmed] 10102355 [Medline] 99200478
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999] | 6uniprot[Pubmed] 9889148 [Medline] 99111236
Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999] | 7uniprot[Pubmed] 10660060 [Medline] 20123456
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000] | 8uniprot[Pubmed] 11254130 [Medline] 21148776
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001] | 9uniprot[Pubmed] 12733914 [Medline] 22619809
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003] | 10uniprot[Pubmed] 9917296 [Medline] 99115752
The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999] | 11uniprot[Pubmed] 11853433 [Medline] 21843297
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002] | 12uniprot[Pubmed] 10652287 [Medline] 20119254
Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000] | 13uniprot[Pubmed] 10779713 [Medline] 20243461
Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000] | 14uniprot[Pubmed] 12022840 [Medline] 22017994
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002] | 15uniprot[Pubmed] 12813091 [Medline] 22697398
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003] | 16uniprot[Pubmed] 8807845 [Medline] 97113238
Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996] | 17uniprot[Pubmed] 14660589
MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004] | 18uniprot[Pubmed] 9375253 [Medline] 98042823
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997] | 19uniprot[Pubmed] 15712316
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005] | 20uniprot[Pubmed] 10760873
The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000] | [pubmed all]
|
2
|
D9UBK9_STRPR
(D9UBK9) |
|
|
4e-19 |
98.2 |
51% |
|
- Product
- Putative oxygenase
- Gene
- c104_05c
- Organism
- Streptomyces pristinaespiralis
|
1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011] |
|
4
|
C0JWC9_9ACTO
(C0JWC9) |
 |
|
3e-18 |
95.1 |
45% |
|
- Product
- PokO3
- Gene
- pokO3
- Organism
- Streptomyces diastatochromogenes
|
1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009] |
|
5
|
Q3S8Q8_STRRM
(Q3S8Q8) |
|
|
1e-15 |
87 |
48% |
|
- Product
- OxyG
- Gene
- oxyG
- Organism
- Streptomyces rimosus
|
1uniprot[Pubmed] 16597959
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006] |
|
6
|
Q8VWB4_9ACTO
(Q8VWB4) |
|
|
8e-10 |
67.4 |
40% |
|
- Product
- AknX
- Gene
- aknX
- Organism
- Streptomyces galilaeus
|
1uniprot[Pubmed] 12399480 [Medline] 22286521
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002] |
|
8
|
Q9L552_9ACTO
(Q9L552) |
|
|
2e-09 |
66.2 |
40% |
|
- Product
- AknX
- Gene
- aknX
- Organism
- Streptomyces galilaeus
|
1uniprot[Pubmed] 12137949 [Medline] 22133312
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002] |
|
9
|
D9UBN4_STRPR
(D9UBN4) |
|
|
1e-08 |
63.2 |
33% |
|
- Product
- Putative oxygenase
- Gene
- c101_13
- Organism
- Streptomyces pristinaespiralis
|
1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011] |
|
11
|
Q67G52_9ACTO
(Q67G52) |
|
|
2e-08 |
62.8 |
37% |
|
- Product
- Anthrone oxygenase
- Gene
-
- Organism
- Streptomyces griseoruber
|
1uniprot[Pubmed] 15271354
The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004] |
|
13
|
Q55222_STRSQ
(Q55222) |
|
|
4e-08 |
61.6 |
38% |
|
- Product
- Oxygenase
- Gene
- dauA
- Organism
- Streptomyces sp
|
1uniprot[Pubmed] 7928998 [Medline] 95014072
Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5.(J. Bacteriol.) [1994] |
|
14
|
Q54813_STRPE
(Q54813) |
|
|
8e-08 |
60.5 |
36% |
|
- Product
- Anthraquinol monooxygenase
- Gene
-
- Organism
- Streptomyces peucetius
|
1uniprot[Pubmed] 7828855 [Medline] 95129838
Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase.(Gene) [1994] |
|
15
|
Q2PZS0_9ACTO
(Q2PZS0) |
|
|
1e-07 |
59.7 |
34% |
|
- Product
- CosX
- Gene
- cosX
- Organism
- Streptomyces olindensis
|
1uniprot[Pubmed] 16810496
Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes.(Appl. Microbiol. Biotechnol.) [2006] |
|
16
|
D1A6U1_THECD
(D1A6U1) |
|
|
2e-07 |
59.7 |
34% |
|
- Product
- Antibiotic biosynthesis monooxygenase
- Gene
- Tcur_2800
- Organism
- Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
|
1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011] |
|
17
|
Q4R0L6_STRCX
(Q4R0L6) |
|
|
1e-06 |
56.6 |
31% |
|
- Product
- ChaH protein
- Gene
- chaH
- Organism
- Streptomyces chartreusis
|
1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005] |
|
18
|
Q2PA06_9ACTO
(Q2PA06) |
|
|
1e-06 |
56.6 |
40% |
|
- Product
- Monooxygenase
- Gene
- stfOI
- Organism
- Streptomyces steffisburgensis
|
1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006] |
|
21
|
O54259_STRNO
(O54259) |
|
|
2e-05 |
52.8 |
31% |
|
- Product
- SnoaB
- Gene
- SnoaB
- Organism
- Streptomyces nogalater
|
1uniprot[Pubmed] 8668120 [Medline] 96242142
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996] | 2uniprot[Pubmed] 9349712 [Medline] 98007868
Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997] | 3uniprot[Pubmed] 8760909 [Medline] 96349102
Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996] | 4uniprot[Pubmed] 20052967
Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism.(Biochemistry) [2010] | [pubmed all]
|
22
|
O68922_9ACTO
(O68922) |
|
|
0.0001 |
50.4 |
33% |
|
- Product
- Quinone-forming monooxygenase
- Gene
- frnU
- Organism
- Streptomyces roseofulvus
|
1uniprot[Pubmed] 8181754 [Medline] 94237486
Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.(Gene) [1994] |
|
25
|
Q1MEI2_RHIL3
(Q1MEI2) |
|
|
0.0002 |
49.3 |
27% |
|
- Product
- Putative monooxygenase
- Gene
- RL3157
- Organism
- Rhizobium leguminosarum bv. viciae (strain 3841)
|
1uniprot[Pubmed] 16640791
The genome of Rhizobium leguminosarum has recognizable core and accessory components.(Genome Biol.) [2006] |
|
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