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Function : Protocatechuate degradation (beta-ketoadipate pathway)

Function Description

ID NFUNC_0014
Created 2012-11-02
Description Ortho cleavage of protocatechuate (3,4-dihydroxybenzoate) leads to beta-ketoadipate (3-oxoadipate), which is subsequently converted to succinyl-coenzyme A (CoA) and acetyl-CoA.
Comment
Pathway
Aromatic compound metabolism; beta-ketoadipate pathway
Cross Reference UniPathway UPA00157
MetaCyc Protocatechuate degradation II (ortho-cleavage pathway)

Function Constitution

TypePattern Component Gene
Protocatechuate degradation (beta-ketoadipate pathway)(NFUNC_0014)
RequireA
PCAG
(NRULE_0066)
Protocatechuate 3,4-dioxygenase alpha subunit
PCAH
(NRULE_0067)
Protocatechuate 3,4-dioxygenase beta subunit
PCAB
(NRULE_0068)
3-carboxy-cis,cis-muconate cycloisomerase
PCAC
(NRULE_0069)
4-carboxymuconolactone decarboxylase
PCAD
(NRULE_0070)
3-oxoadipate enol-lactonase
PCAI
(NRULE_0072)
3-oxoadipate CoA-transferase subunit A
PCAJ
(NRULE_0073)
3-oxoadipate CoA-transferase subunit B
PCAF
(NRULE_0074)
Beta-ketoadipyl-CoA thiolase
B
PCAG
(NRULE_0066)
Protocatechuate 3,4-dioxygenase alpha subunit
PCAH
(NRULE_0067)
Protocatechuate 3,4-dioxygenase beta subunit
PCAB
(NRULE_0068)
3-carboxy-cis,cis-muconate cycloisomerase
PCAL
(NRULE_0071)
3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase
PCAI
(NRULE_0072)
3-oxoadipate CoA-transferase subunit A
PCAJ
(NRULE_0073)
3-oxoadipate CoA-transferase subunit B
PCAF
(NRULE_0074)
Beta-ketoadipyl-CoA thiolase

Potential Functional Microbe

Scientific nameNBRC No.Scientific nameNBRC No.Scientific nameNBRC No.
Acinetobacter sp.100985Azorhizobium caulinodans14845Corynebacterium callunae15359
Corynebacterium efficiens100395Corynebacterium glutamicum12168Cupriavidus metallidurans102507
Enterobacter aerogenes13534Escherichia fergusonii102419Geodermatophilus obscurus13315
Ochrobactrum anthropi15819Pseudomonas putida100650Rhizobium etli15573
Rhizobium tropici15247Rhodococcus erythropolis100887Rhodococcus opacus108011
Streptomyces avermitilis14893Streptomyces ghanaensis15414Streptomyces sviceus13980