Rule : 3-carboxy-cis,cis-muconate cycloisomerase (PCAB)

Rule Description

ID	NRULE_0068
Rule name	PCAB
Created	2012-10-05
Protein name	Protein name Full 3-carboxy-cis,cis-muconate cycloisomerase EC EC 5.5.1.2 Synonym Full 3-carboxymuconate lactonizing enzyme
Gene name	pcaB
Rule Trigger	TIGRFAMs; TIGR02426; hit=1
Cross Reference	Gene Ontology GO GO:0047472, F:3-carboxy-cis,cis-muconate cycloisomerase activity, IEA:EC GO:0042952, P:beta-ketoadipate pathway, IEA:UniProtKB-UniPathway GO:0019619, P:protocatechuate catabolic process, IEA:InterPro Phylogenomic databases eggNOG COG0015, - KO K01857, - Enzyme and pathway databases UniPathway UPA00157, UER00265 Family and domain databases InterPro IPR019468, AdenyloSucc_lyase_C IPR003031, D_crystallin IPR024083, Fumarase/histidase_N IPR000362, Fumarate_lyase IPR020557, Fumarate_lyase_CS IPR022761, Fumarate_lyase_N IPR008948, L-Aspartase-like IPR012789, Protocat_PcaB Pfam PF10397, ADSL_C, 1 PF00206, Lyase_1, 1 PRINTS PR00145, ARGSUCLYASE PR00149, FUMRATELYASE SMART SM00998, ADSL_C, 1 TIGRFAMs TIGR02426, protocat_pcaB, 1 PROSITE PS00163, FUMARATE_LYASES, 1
Feature	Not assigned
General annotation	Function Catalyzes an anti cycloisomerization Catalytic activity 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = cis,cis-butadiene-1,2,4-tricarboxylate Pathway Aromatic compound metabolism; beta-ketoadipate pathway; 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate: step 1/2 Subunit structure Homotetramer Sequence similarities Belongs to the class-II fumarase/aspartase family
Reference	Q59092 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1). 8063101 Contrasting patterns of evolutionary divergence within the Acinetobacter calcoaceticus pca operon. (Gene. 1994) P32427 Pseudomonas putida (Arthrobacter siderocapsulatus). 1390752 3-Carboxy-cis,cis-muconate lactonizing enzyme from Pseudomonas putida is homologous to the class II fumarase family: a new reaction in the evolution of a mechanistic motif. (Biochemistry. 1992) Q0SH25 Rhodococcus jostii (strain RHA1). 25558786 In vitro reconstitution of the catabolic reactions catalyzed by PcaHG, PcaB, and PcaL: the protocatechuate branch of the beta-ketoadipate pathway in Rhodococcus jostii RHA1. (Biosci Biotechnol Biochem. 2015)

Related Function

Function name
Protocatechuate degradation (beta-ketoadipate pathway)

CDS


Scientific name	NBRC No.	CDS	Product name
Acinetobacter sp.	100985	ACT4_036_01080	3-carboxy-cis,cis-muconate cycloisomerase
Actinosynnema mirum	14064	Amir_4654	3-carboxy-cis,cis-muconate cycloisomerase
Azorhizobium caulinodans	14845	AZC_1441	3-carboxy-cis,cis-muconate cycloisomerase
Bradyrhizobium diazoefficiens	14792	bll7942	probable 3-carboxy-cis,cis-muconate cycloisomerase (EC 5.5.1.2)
Bradyrhizobium diazoefficiens	14792	blr5667	3-carboxy-cis,cis-muconate cycloisomerase
Candidatus Solibacter usitatus		Acid_0245	3-carboxy-cis,cis-muconate cycloisomerase
Caulobacter segnis	15250	Cseg_2354	3-carboxy-cis,cis-muconate cycloisomerase
Corynebacterium callunae	15359	H924_10085	3-carboxy-cis,cis-muconate cycloisomerase
Corynebacterium efficiens	100395	CE2299	putative 3-carboxy-cis,cis-muconate cycloisomerase
Corynebacterium glutamicum	12168	Cgl2396	Adenylosuccinate lyase
Cupriavidus metallidurans	102507	Rmet_4015	3-carboxy-cis,cis-muconate cycloisomerase
Enterobacter aerogenes	13534	EAE_18185	putative fumarate lyase
Escherichia fergusonii	102419	EFER_1633	3-carboxy-cis,cis-muconate cycloisomerase (3-carboxymuconate lactonizing enzyme) (CMLE)
Geodermatophilus obscurus	13315	Gobs_2188	3-carboxy-cis,cis-muconate cycloisomerase
Gordonia amarae	15530	GOAMR_52_00030	3-carboxy-cis,cis-muconate cycloisomerase
Kitasatospora setae	14216	KSE_07790	putative 3-carboxy-cis,cis-muconate cycloisomerase
Klebsiella pneumoniae	14438	KPR_2769
Klebsiella pneumoniae subsp. rhinoscleromatis	105682	HMPREF0484_4171	3-carboxy-cis,cis-muconate cycloisomerase
Meiothermus ruber	106122	Mrub_2695	3-carboxy-cis,cis-muconate cycloisomerase
Ochrobactrum anthropi	15819	Oant_3729	3-carboxy-cis,cis-muconate cycloisomerase
Ochrobactrum intermedium	15820	OINT_2000815	3-carboxy-cis,cis-muconate cycloisomerase
Pseudomonas putida	100650	PP_1379	3-carboxy-cis,cis-muconate cycloisomerase
Pseudomonas stutzeri	14165	PSTAB_1165	3-carboxy-cis,cis-muconate cycloisomerase
Rhizobium etli	15573	RHE_PE00055	3-carboxy-cis,cis-muconate cycloisomerase protein
Rhizobium sp.	101917	NGR_b21200	3-carboxy-cis,cis-muconate cycloisomerase protein
Rhizobium tropici	15247	RTCIAT899_PC07365	3-carboxy-cis,cis-muconate cycloisomerase
Rhodococcus erythropolis	100887	RER_52880	3-carboxy-cis,cis-muconate cycloisomerase
Rhodococcus opacus	108011	ROP_10530	3-carboxy-cis,cis-muconate cycloisomerase
Rubrobacter xylanophilus	100952	Rxyl_1579	3-carboxy-cis,cis-muconate cycloisomerase
Saccharomonospora viridis	12207	Svir_13030	3-carboxy-cis,cis-muconate cycloisomerase
Saccharopolyspora erythraea	13426	SACE_3512	3-carboxy-cis,cis-muconate cycloisomerase
Saccharopolyspora spinosa	15153	SspiN1_010100004758	3-carboxy-cis,cis-muconate cycloisomerase
Saccharothrix espanaensis	15066	BN6_61190	3-carboxy-cis,cis-muconate cycloisomerase
Streptomyces avermitilis	14893	SAV1705	putative 3-carboxy-cis,cis-muconate cycloisomerase
Streptomyces cattleya	14057	SCAT_5480	3-carboxy-cis,cis-muconate cycloisomerase
Streptomyces ghanaensis	15414	SSFG_00972	3-carboxymuconate cycloisomerase
Streptomyces purpureus	13925	STRPU_08_00310	Putative 3-carboxy-cis,cis-muconate cycloisomera se
Streptomyces sviceus	13980	SSEG_08941	adenylosuccinate lyase
Streptosporangium roseum	3776	Sros_7931	3-carboxy-cis,cis-muconate cyclo-isomerase
Thermobispora bispora	14880	Tbis_2833	3-carboxy-cis,cis-muconate cycloisomerase