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遺伝子 : Diaminobutyrate--2-oxoglutarate transaminase (ECTB)

遺伝子情報

ID NRULE_0186
遺伝子ID ECTB
作成日 2013/04/09
タンパク質名
Protein name
Full
Diaminobutyrate--2-oxoglutarate transaminase
EC
EC 2.6.1.76
Synonym
Full
DABA aminotransferase
Diaminobutyrate--2-oxoglutarate aminotransferase
L-2,4-diaminobutyric acid transaminase
遺伝子名 ectB
遺伝子条件 TIGRFAMs; TIGR02407; hit=1
参照
Gene Ontology
GO
GO:0045303, F:diaminobutyrate-2-oxoglutarate transaminase activity, IEA:EC
GO:0047307, F:diaminobutyrate-pyruvate transaminase activity, IEA:InterPro
GO:0030170, F:pyridoxal phosphate binding, IEA:InterPro
GO:0019491, P:ectoine biosynthetic process, IEA:UniProtKB-UniPathway
Phylogenomic databases
HOGENOM
HOG000020206, -
KO
K00836, -
Enzyme and pathway databases
UniPathway
UPA00067, UER00121
Family and domain databases
InterPro
IPR005814, Aminotrans_3
IPR004637, Dat
IPR012773, Ectoine_EctB
Pfam
PF00202, Aminotran_3, 1
TIGRFAMs
TIGR00709, dat, 1
TIGR02407, ectoine_ectB, 1
PROSITE
PS00600, AA_TRANSFER_CLASS_3, 1
配列の特徴
O52250 Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9).
MOD_RES267N6-(pyridoxal phosphate)lysine (Potential).
注釈
Function
Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate. Seems to use L-glutamate specifically as the amino group donor to ASA, as it is not active with L-alanine, L-glutamine, L-aspartate and L-lysine, and is only poorly active with L-homoserine. In the reverse reaction, gamma- aminobutyric acid (GABA) and L-ornithine can also be used as amino group donors to 2-oxoglutarate, but with a reduced activity compared to that with DABA
Catalytic activity
L-2,4-diaminobutanoate + 2-oxoglutarate = L- aspartate 4-semialdehyde + L-glutamate
Cofactor
Pyridoxal phosphate
Pathway
Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 1/3
Subunit structure
Homohexamer (Probable)
Sequence similarities
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
参考文献
O52250 Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9).
9864317
Characterization of biosynthetic enzymes for ectoine as a compatible solute in a moderately halophilic eubacterium, Halomonas elongata. (J Bacteriol. 1999)



関与する機能

機能名
Ectoine biosynthesis
Hydroxyectoine biosynthesis

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Acaryochloris marina102967AM1_A0234diaminobutyrate--2-oxoglutarate aminotransferase, putative
Acidiphilium multivorum100883ACMV_33530diaminobutyrate--2-oxoglutarate transaminase
Acinetobacter sp.100985ACT4_006_00920diaminobutyrate--2-oxoglutarate transaminase
Actinoalloteichus cyanogriseus14455G443_01_06860diaminobutyrate--2-oxoglutarate aminotransferase
Actinoalloteichus spitiensis102582ACTIDRAF_18920diadenosine tetraphosphatase
Actinomadura atramentaria14695G339_08370hypothetical protein
Actinopolyspora iraqiensis103187ACTIR_206_00080diaminobutyrate--2-oxoglutarate aminotransferase
Actinosynnema mirum14064Amir_2022diaminobutyrate/2-oxoglutarate aminotransferase
Amir_4204diaminobutyrate/2-oxoglutarate aminotransferase
Amycolatopsis azurea14573C791_7093Diaminobutyrate-pyruvate aminotransferase
Amycolatopsis mediterranei13415RAM_44120diaminobutyrate--2-oxoglutarate aminotransferase
Brevibacterium linens12170BlinB_010200009577diaminobutyrate--2-oxoglutarate aminotransferase
Candidatus Nitrosopumilus sp.NSED_02000diaminobutyrate--2-oxoglutarate aminotransferase
Chitinivibrio alkaliphilusCALK_1395L-2,4-diaminobutyric acid transaminase
Chrysiogenes arsenatisP304_RS0104510diaminobutyrate--2-oxoglutarate aminotransferase
Fischerella sp.PCC9339_RS0102745diadenosine tetraphosphatase
PCC9339_RS0107750diadenosine tetraphosphatase
Gordonia aichiensis108223GOACH_17_00380diaminobutyrate--2-oxoglutarate transaminase
Gordonia alkanivorans16433GOALK_040_00390diaminobutyrate--2-oxoglutarate transaminase
Gordonia amarae15530GOAMR_67_00010diaminobutyrate--2-oxoglutarate transaminase
Gordonia amicalis100051GOAMI_27_00950diaminobutyrate--2-oxoglutarate transaminase
Gordonia araii100433GOARA_043_00300diaminobutyrate--2-oxoglutarate transaminase
Gordonia bronchialis16047Gbro_2065diaminobutyrate/2-oxoglutarate aminotransferase
Gordonia effusa100432GOEFS_046_00430diaminobutyrate--2-oxoglutarate transaminase
Gordonia hirsuta16056GOHSU_54_00090diaminobutyrate--2-oxoglutarate transaminase
Gordonia namibiensis108229GONAM_16_00910diaminobutyrate--2-oxoglutarate transaminase
Gordonia otitidis100426GOOTI_217_00420diaminobutyrate--2-oxoglutarate transaminase
Gordonia polyisoprenivorans16320GOPIP_070_00710diaminobutyrate--2-oxoglutarate transaminase
Gordonia rhizosphera16068GORHZ_032_00140diaminobutyrate--2-oxoglutarate transaminase
Gordonia rubripertincta101908GORBP_068_01420diaminobutyrate--2-oxoglutarate transaminase
Gordonia sihwensis108236GSI01S_15_01220diaminobutyrate--2-oxoglutarate transaminase
Gordonia soli108243GS4_20_00920diaminobutyrate--2-oxoglutarate transaminase
Gordonia sputi100414GOSPT_051_00830diaminobutyrate--2-oxoglutarate transaminase
Gordonia terrae100016GOTRE_026_01220diaminobutyrate--2-oxoglutarate transaminase
Halobacillus halophilus102448HBHAL_1519diaminobutyrate--2-oxoglutarate aminotransferase
Halomonas elongata15536HELO_2589diaminobutyrate--2-oxoglutarateaminotransferase
Herpetosiphon aurantiacusHaur_2088diaminobutyrate--2-oxoglutarate aminotransferase
Hyphomonas neptunium14232HNE_1640diaminobutyrate-2-oxoglutarate transaminase
Kytococcus sedentarius15357Ksed_19650diaminobutyrate aminotransferase
Marinomonas mediterranea103028Marme_1546diaminobutyrate/2-oxoglutarate aminotransferase
Mariprofundus ferrooxydansSPV1_00155diaminobutyrate--2-oxoglutarate aminotransferase
Nitriliruptor alkaliphilusNitalDRAFT_4158diaminobutyrate-2-oxoglutarate transaminase
Nocardiopsis dassonvillei14626Ndas_52132,4-diaminobutyrate 4-transaminase
Paenibacillus peoriae15541PpeoK3_010100000905diaminobutyrate--2-oxoglutarate aminotransferase
Paenibacillus polymyxa15309PPT_12215diadenosine tetraphosphatase
Planctomyces brasiliensis103401Plabr_3301diaminobutyrate aminotransferase apoenzyme
Pseudomonas stutzeri14165PSTAB_0245transaminase
Rhizobium sp.101917NGR_a01910diaminobutyrate--2-oxoglutarate transaminase BxrG
Rhizobium tropici15247RTCIAT899_PB01645diaminobutyrate-pyruvate aminotransferase
Rhodococcus erythropolis100887RER_37860probable diaminobutyrate--2-oxoglutarate transaminase
Rhodococcus opacus108011ROP_10280diaminobutyrate--2-oxoglutarate transaminase
Saccharomonospora azurea14651SacazDRAFT_02245diaminobutyrate--2-oxoglutarate aminotransferase
Saccharomonospora cyanea14841SaccyDRAFT_4583diaminobutyrate--2-oxoglutarate aminotransferase
Saccharomonospora glauca14831SacglDRAFT_03856diaminobutyrate--2-oxoglutarate aminotransferase
Saccharomonospora viridis12207Svir_34800diaminobutyrate aminotransferase
Saccharopolyspora erythraea13426SACE_0484diaminobutyrate--pyruvate aminotransferase
Saccharopolyspora spinosa15153SspiN1_010100021358diadenosine tetraphosphatase
Salinispora arenicola105043Q5S_232_00030diaminobutyrate-2-oxoglutarate aminotransferase
Sphingobium sp.103272SLG_08050diaminobutyrate-2-oxoglutarate transaminase
Stackebrandtia nassauensis102104Snas_5812diaminobutyrate/2-oxoglutarate aminotransferase
Streptomyces avermitilis14893SAV6397putative aminotransferase
Streptomyces cattleya14057SCAT_1065Diaminobutyrate--2-oxoglutarate transaminase
Streptomyces clavuligerus13307SCLAV_1076Diaminobutyrate--2-oxoglutarate transaminase
SCLAV_3449Diaminobutyrate--2-oxoglutarate transaminase
Streptomyces ghanaensis15414SSFG_05505diaminobutyrate-2-oxoglutarate transaminase
Streptomyces pristinaespiralis13074SSDG_07154diaminobutyrate-2-oxoglutarate transaminase
Streptomyces purpureus13925STRPU_04_00020Diaminobutyrate/2-oxoglutarate aminotransferase
Streptomyces sviceus13980SSEG_08021diaminobutyrate-2-oxoglutarate aminotransferase
Streptomyces venezuelae13096SVEN_0227Diaminobutyrate-pyruvate aminotransferase
Thauera linaloolentis102519C666_07550diaminobutyrate--2-oxoglutarate aminotransferase
Tsukamurella paurometabola16120Tpau_1556diaminobutyrate/2-oxoglutarate aminotransferase
Vibrio alginolyticus15630N646_0443Diaminobutyrate--2-oxoglutarate transaminase
Vibrio ichthyoenteri15847VII00023_05507diaminobutyrate--2-oxoglutarate aminotransferase
Vibrio metschnikovii103153VIB_002763diaminobutyrate--2-oxoglutarate aminotransferase
Vibrio orientalis15638VIOR3934_21261diaminobutyrate--2-oxoglutarate aminotransferase
Vibrio tubiashii15644VITU9109_24625diaminobutyrate--2-oxoglutarate aminotransferase
Xenococcus sp.Xen7305DRAFT_00002040diaminobutyrate--2-oxoglutarate aminotransferase
Zimmermannella faecalis15706G328_12865hypothetical protein