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Rule : Putative molybdate-dependent transcriptional regulator (MODE)

Rule Description

Rule name MODE
Created 2014-08-18
Protein name
Protein name
Putative molybdate-dependent transcriptional regulator
Gene name Not assigned
Rule Trigger PFAM; PF03459; hit=1ANDPFAM; PF00126; hit=1
Cross Reference
Gene Ontology
GO:0003677, F:DNA binding, IEA:UniProtKB-KW
GO:0030151, F:molybdenum ion binding, IEA:InterPro
GO:0003700, F:sequence-specific DNA binding transcription factor activity, IEA:InterPro
GO:0006351, P:transcription, DNA-templated, IEA:UniProtKB-KW
Phylogenomic databases
K02019, -
Family and domain databases
IPR004606, Mo-pterin-bd
IPR008995, Mo/tungstate-bd_C_term_dom
IPR003725, ModE-bd_N
IPR016462, Molybdate-dep_T_reg_ModE
IPR005116, Transp-assoc_OB_typ1
IPR000847, Tscrpt_reg_HTH_LysR
IPR011991, WHTH_DNA-bd_dom
PF00126, HTH_1, 1
PF03459, TOBE, 1
TIGR00637, ModE_repress, 1
TIGR00638, Mop, 1
Feature Not assigned
General annotation
It is putative transcriptional regulator which bind molybdenum (maybe also tungstate). Maybe involved in molybdenum transport system
Contains two major domains: the N-terminal domain I forms a winged helix-turn-helix motif and interacts with DNA. The C-terminal domain II is the putative molybdate-binding component
Sequence similarities
Belongs to the ModE family
P0A9G8 Escherichia coli (strain K12).
Repression of the Escherichia coli modABCD (molybdate transport) operon by ModE. (J Bacteriol. 1996)
Characterisation of the molybdenum-responsive ModE regulatory protein and its binding to the promoter region of the modABCD (molybdenum transport) operon of Escherichia coli. (Eur J Biochem. 1997)
The high-resolution crystal structure of the molybdate-dependent transcriptional regulator (ModE) from Escherichia coli: a novel combination of domain folds. (EMBO J. 1999)
Q08385 Rhodobacter capsulatus (Rhodopseudomonas capsulata).
Characterization of Rhodobacter capsulatus genes encoding a molybdenum transport system and putative molybdenum-pterin-binding proteins. (J Bacteriol. 1993)
Specific interactions between four molybdenum-binding proteins contribute to Mo-dependent gene regulation in Rhodobacter capsulatus. (J Bacteriol. 2009)

Related Function

Function name
Metal-binding protein
Molybdate transport (ABC transporter)


Data Download
Scientific name NBRC No. CDS Product name
Azorhizobium caulinodans14845AZC_1791molybdenum-binding protein
Chlorobaculum tepidum103806CT1543molybdenum transport protein ModE
Chlorobium limicola103803Clim_0673transcriptional regulator, ModE family
Chrysiogenes arsenatisP304_RS0109020ModE family transcriptional regulator
Cupriavidus metallidurans102507Rmet_0567DNA-binding transcriptional dual regulator
Edwardsiella tarda105688ET1_08_00090modABC operon transcriptional regulator ModE
Enterobacter aerogenes13534EAE_14310DNA-binding transcriptional regulator ModE
Enterobacter cloacae subsp. cloacae13535ECL_02976DNA-binding transcriptional regulator ModE
Enterobacter hormaechei105718HMPREF9086_1100transcriptional regulator ModE
Escherichia coli3972EcolC_2901transcriptional regulator, ModE family
Escherichia coli13500WFL_03955DNA-binding transcriptional regulator ModE
Escherichia coli12713Y75_0738DNA-binding transcriptional dual regulator
Escherichia fergusonii102419EFER_2348DNA-binding transcriptional dual regulator
Escherichia hermannii105704EH105704_23_00290modABC operon transcriptional regulator ModE
Haloarcula vallismortis14741C437_18617putative molybdenum-binding protein
Holophaga foetidaHOLFODRAFT_RS0215020ModE family transcriptional regulator
Hylemonella gracilis14920HGR_05896tobe domain-containing protein
Klebsiella pneumoniae14438KPR_3820
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_1413TOBE domain protein
Magnetospirillum gryphiswaldense15271MGR_3405Molybdenum-binding protein, N-terminal:Molybdenum-pterin binding protein
Magnetospirillum magnetotacticum15272Magn03009350COG2005: N-terminal domain of molybdenum-binding protein
Pelobacter carbinolicus103641Pcar_0662molybdate transport regulatory protein ModE
Pelobacter propionicus103807Ppro_1529transcriptional regulator, ModE family
Photobacterium damselae subsp. damselae corrig.15633VDA_000515DNA-binding domain of ModE/molybdate-binding domain of ModE
Proteus mirabilis105697HMPREF0693_1948TOBE domain protein
Providencia alcalifaciens105687PROVALCAL_03270TOBE domain protein
Pseudomonas putida100650PP_0360molybdate transport regulator
Rahnella aquatilis105701Rahaq2_3145ModE molybdate transport repressor domain/molybdenum-pterin binding domain protein
Rhodobacter capsulatus16581RCAP_rcc00560molybdenum transport operon repressor MopB
RCAP_rcc00561molybdenum transport operon repressor MopA
Rhodobacter sphaeroides12203RSP_3874transcriptional repressor, ModE
Serratia odorifera102598HMPREF0758_4811TOBE domain protein
Shimwellia blattae105725EB105725_03_00100modABC operon transcriptional regulator ModE
Thauera linaloolentis102519C666_05875ModE family transcriptional regulator
Yersinia bercovieri105717yberc0001_37720Transcriptional regulator modE
Yersinia rohdei105715yrohd0001_35930Transcriptional regulator modE