| accession | DB | alignment | Evalue | Score | Ident. | link | information | pubmed |
1
|
Q9EWC4_STRGR (Q9EWC4) |
|
|
0.0 |
794 |
100% |
|
- Product
- Cytochrome P-450
- Gene
- canC
- Organism
- Streptomyces griseus
|
1uniprot[Pubmed] 11782498 [Medline] 21642576 The candicidin gene cluster from Streptomyces griseus IMRU 3570.(Microbiology) [2002] |
|
2
|
Q6W5Q7_9ACTO (Q6W5Q7) |
|
|
0.0 |
794 |
100% |
|
- Product
- FscP
- Gene
- fscP
- Organism
- Streptomyces sp. FR-008
|
1uniprot[Pubmed] 14652074 Organizational and Mutational Analysis of a Complete FR-008/Candicidin Gene Cluster Encoding a Structurally Related Polyene Complex.(Chem. Biol.) [2003] |
|
4
|
Q6T2C1_STRDI (Q6T2C1) |
|
|
1e-169 |
597 |
73% |
|
- Product
- RimG
- Gene
- rimG
- Organism
- Streptomyces diastaticus
|
1uniprot[Pubmed] 15123265 Starter unit choice determines the production of two tetraene macrolides, rimocidin and CE-108, in Streptomyces diastaticus var. 108.(Chem. Biol.) [2004] |
|
5
|
F1CLB6_9ACTO (F1CLB6) |
|
|
1e-168 |
597 |
73% |
|
- Product
- ScnG
- Gene
- scnG
- Organism
- Streptomyces chattanoogensis
|
1uniprot[Pubmed] 21330439 The pleitropic regulator AdpAch is required for natamycin biosynthesis and morphological differentiation in Streptomyces chattanoogensis.(Microbiology) [2011] |
|
6
|
Q9EW94_9ACTO (Q9EW94) |
|
|
1e-167 |
592 |
73% |
|
- Product
- PimG protein
- Gene
- pimG
- Organism
- Streptomyces natalensis
|
1uniprot[Pubmed] 11094342 [Medline] 20547809 A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis.(Chem. Biol.) [2000] |
|
7
|
Q93NX1_9ACTO (Q93NX1) |
|
|
1e-149 |
533 |
70% |
|
- Product
- AmphN
- Gene
- amphN
- Organism
- Streptomyces nodosus
|
1uniprot[Pubmed] 11451671 [Medline] 21344785 Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes.(Chem. Biol.) [2001] | 2uniprot[Pubmed] 16079135 Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups.(J. Biol. Chem.) [2005] | [pubmed all]
|
8
|
Q9L4W8_9ACTO (Q9L4W8) |
|
|
1e-148 |
529 |
70% |
|
- Product
- NysN
- Gene
- nysN
- Organism
- Streptomyces noursei
|
1uniprot[Pubmed] 10873841 [Medline] 20334850 Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway.(Chem. Biol.) [2000] |
|
9
|
D2CKL9_PSEAH (D2CKL9) |
|
|
1e-142 |
508 |
67% |
|
- Product
- CppN
- Gene
- cppN
- Organism
- Pseudonocardia autotrophica
Amycolata autotrophica Nocardia autotrophica
|
1uniprot[Pubmed] 19697072 Identification of functionally clustered nystatin-like biosynthetic genes in a rare actinomycetes, Pseudonocardia autotrophica.(J. Ind. Microbiol. Biotechnol.) [2009] |
|
11
|
D7C2C0_STRBB (D7C2C0) |
|
|
1e-138 |
495 |
65% |
|
- Product
- Cytochrome P450
- Gene
- cyp11
SBI_00653
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
12
|
C0JWI1_9BACT (C0JWI1) |
|
|
1e-117 |
426 |
100% |
|
- Product
- Candicidin biosynthesis protein FscP
- Gene
- fscP
- Organism
- uncultured bacterium
|
1uniprot Candicidin-producing Streptomyces sp. support leaf-cutting ants to protect their fungus garden against the pathogenic fungus Escovopsis.(Proc. Natl. Acad. Sci. U.S.A.) [2009] |
|
13
|
C0JWI0_9ACTO (C0JWI0) |
|
|
2e-98 |
364 |
98% |
|
- Product
- Candicidin biosynthesis protein FscP
- Gene
- fscP
- Organism
- uncultured Streptomyces sp
|
1uniprot Candicidin-producing Streptomyces sp. support leaf-cutting ants to protect their fungus garden against the pathogenic fungus Escovopsis.(Proc. Natl. Acad. Sci. U.S.A.) [2009] |
|
14
|
D3PYH2_STANL (D3PYH2) |
|
|
1e-87 |
328 |
46% |
|
- Product
- Cytochrome P450
- Gene
- Snas_1843
- Organism
- Stackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)
|
1uniprot Complete genome sequence of Stackebrandtia nassauensis type strain (LLR-40K-21T).(Stand. Genomic Sci.) [2009] |
|
15
|
Q5ENH9_PSEAH (Q5ENH9) |
|
|
3e-87 |
327 |
46% |
|
- Product
- FadC
- Gene
- fadC
- Organism
- Pseudonocardia autotrophica
Amycolata autotrophica Nocardia autotrophica
|
1uniprot[Pubmed] 15752735 A gene cluster for the fatty acid catabolism from Pseudonocardia autotrophica BCRC12444.(Biochem. Biophys. Res. Commun.) [2005] |
|
16
|
Q8KRU0_PSEAH (Q8KRU0) |
|
|
8e-86 |
322 |
45% |
|
- Product
- PauC
- Gene
- pauC
- Organism
- Pseudonocardia autotrophica
Amycolata autotrophica Nocardia autotrophica
|
1uniprot Molecular cloning and analysis of the gene for P-450 hydroxylase from Pseudonocardia autotrophica IFO12743.(J. Microbiol.) [2002] |
|
18
|
D0U2E9_STRPT (D0U2E9) |
|
|
1e-82 |
311 |
44% |
|
- Product
- Hydroxylase
- Gene
-
- Organism
- Streptomyces platensis subsp. rosaceus
|
1uniprot[Pubmed] 19726666 iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase.(J. Biol. Chem.) [2009] |
|
19
|
D8I294_AMYMU (D8I294) |
|
|
9e-81 |
305 |
45% |
|
- Product
- Cytochrome P450
- Gene
- AMED_0876
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
20
|
Q156A0_AMYOR (Q156A0) |
|
|
2e-80 |
304 |
42% |
|
- Product
- Epothilone b hydroxylase
- Gene
- ebh
- Organism
- Amycolatopsis orientalis
Nocardia orientalis
|
1uniprot[Pubmed] 16972046 Cloning and expression of a cytochrome P450 hydroxylase gene from Amycolatopsis orientalis: hydroxylation of epothilone B for the production of epothilone F.(J. Ind. Microbiol. Biotechnol.) [2007] |
|
23
|
D8I293_AMYMU (D8I293) |
|
|
1e-79 |
301 |
45% |
|
- Product
- Cytochrome P450
- Gene
- AMED_0875
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
24
|
Q595S4_9ACTO (Q595S4) |
|
|
1e-79 |
301 |
45% |
|
- Product
- Cytochrome P450 monooxygenase CYP105D8
- Gene
- cyp233
- Organism
- Streptomyces tubercidicus
|
1uniprot[Pubmed] 16269732 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes.(Appl. Environ. Microbiol.) [2005] | 2uniprot[Pubmed] 16269733 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: heterologous expression of the ema1 cytochrome P450 monooxygenase.(Appl. Environ. Microbiol.) [2005] | [pubmed all]
|
31
|
Q825I8_STRAW (Q825I8) |
|
|
3e-78 |
296 |
45% |
|
- Product
- Cytochrome P450 hydroxylase
- Gene
- cyp28
SAV7469 SAV_7469
- Organism
- Streptomyces avermitilis
|
1uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001] |
|
35
|
C7MXK5_SACVD (C7MXK5) |
|
|
7e-78 |
295 |
44% |
|
- Product
- Cytochrome P450
- Gene
- Svir_22760
- Organism
- Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
|
1uniprot Complete genome sequence of Saccharomonospora viridis type strain (P101T).(Stand. Genomic Sci.) [2009] |
|
37
|
A4FF79_SACEN (A4FF79) |
|
|
4e-77 |
293 |
44% |
|
- Product
- Cytochrome P450 hydroxylase
- Gene
- cyp28
SACE_3429
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
38
|
Q595R1_9ACTO (Q595R1) |
|
|
5e-77 |
293 |
43% |
|
- Product
- Cytochrome P450 monooxygenase CYP105S1
- Gene
- cyp230
- Organism
- Streptomyces tubercidicus
|
1uniprot[Pubmed] 16269732 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes.(Appl. Environ. Microbiol.) [2005] | 2uniprot[Pubmed] 16269733 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: heterologous expression of the ema1 cytochrome P450 monooxygenase.(Appl. Environ. Microbiol.) [2005] | [pubmed all]
|
40
|
D2B913_STRRD (D2B913) |
|
|
9e-77 |
291 |
41% |
|
- Product
- Putative cytochrome P450
- Gene
- Sros_7070
- Organism
- Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
|
1uniprot Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010] |
|
44
|
Q5SFA8_STRBI (Q5SFA8) |
|
|
4e-76 |
290 |
44% |
|
- Product
- P450
- Gene
- chmHI
- Organism
- Streptomyces bikiniensis
|
1uniprot[Pubmed] 15561847 Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae.(Antimicrob. Agents Chemother.) [2004] |
|
45
|
Q331Q9_9ACTO (Q331Q9) |
|
|
5e-76 |
289 |
44% |
|
- Product
- Cytochrome P-450
- Gene
- gerPIII
- Organism
- Streptomyces sp. KCTC 0041BP
|
1uniprot[Pubmed] 17053005 Biosynthesis of dTDP-6-deoxy-beta-D-allose, biochemical characterization of dTDP-4-keto-6-deoxyglucose reductase (GerKI) from Streptomyces sp. KCTC 0041BP.(Glycobiology) [2007] | 2uniprot Cloning and characterization of a gene cluster for the production of the polyketide macrolide antibiotic dihydrochalcomycin in Streptomyces sp. KCTC 0041BP.(J. Microbiol. Biotechnol.) [2006] |
|
47
|
Q2L6S8_9ACTO (Q2L6S8) |
|
|
7e-76 |
289 |
45% |
|
- Product
- Cytochrome P450 type compactin 3'',4''-hydroxylase
- Gene
- moxA
- Organism
- Nonomuraea recticatena
|
1uniprot[Pubmed] 16428858 Hydroxylation of testosterone by bacterial cytochromes P450 using the Escherichia coli expression system.(Biosci. Biotechnol. Biochem.) [2006] | 2uniprot[Pubmed] 17679139 Crystal structure of cytochrome P450 MoxA from Nonomuraea recticatena (CYP105).(Biochem. Biophys. Res. Commun.) [2007] | [pubmed all]
|
48
|
A4FDJ6_SACEN (A4FDJ6) |
|
|
1e-75 |
288 |
42% |
|
- Product
- Cytochrome P450 hydroxylase
- Gene
- cyp7
SACE_2842
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
49
|
Q9EWS4_STRCO (Q9EWS4) |
|
|
1e-75 |
288 |
43% |
|
- Product
- Putative cytochrome P450
- Gene
- SCO0774
- Organism
- Streptomyces coelicolor
|
1uniprot[Pubmed] 12000953 [Medline] 21996410 Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002] |
|
50
|
O85697_STRLI (O85697) |
|
|
1e-75 |
288 |
43% |
|
- Product
- Putative cytochrome P450 oxidoreductase
- Gene
-
- Organism
- Streptomyces lividans
|
1uniprot[Pubmed] 10627032 [Medline] 20090458 AUD4, a new amplifiable element from Streptomyces lividans.(Microbiology) [1999] |
|
52
|
C6WQG7_ACTMD (C6WQG7) |
|
|
1e-75 |
288 |
42% |
|
- Product
- Cytochrome P450
- Gene
- Amir_2894
- Organism
- Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
|
1uniprot Complete genome sequence of Actinosynnema mirum type strain (101).(Stand. Genomic Sci.) [2009] |
|
54
|
Q73Z21_MYCPA (Q73Z21) |
|
|
2e-75 |
288 |
43% |
|
- Product
- Putative uncharacterized protein
- Gene
- MAP_1782c
- Organism
- Mycobacterium paratuberculosis
|
1uniprot[Pubmed] 16116077 The complete genome sequence of Mycobacterium avium subspecies paratuberculosis.(Proc. Natl. Acad. Sci. U.S.A.) [2005] |
|
56
|
CPXE_STRGO (P18326) |
|
|
2e-75 |
287 |
44% |
|
- Product
- Cytochrome P450-SU1
CYP105A1 Cytochrome P450-CVA1
- Gene
- CYP105A1
suaC
- Organism
- Streptomyces griseolus
|
1uniprot[Pubmed] 2345149 [Medline] 90264332 Genes for two herbicide-inducible cytochromes P-450 from Streptomyces griseolus.(J. Bacteriol.) [1990] |
|
66
|
A8KXU3_FRASN (A8KXU3) |
|
|
3e-74 |
283 |
44% |
|
- Product
- Cytochrome P450
- Gene
- Franean1_3475
- Organism
- Frankia sp. (strain EAN1pec)
|
1uniprot[Pubmed] 17151343 Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007] |
|
67
|
Q9EWP1_STRCO (Q9EWP1) |
|
|
4e-74 |
283 |
41% |
|
- Product
- Putative cytochrome P450
- Gene
- SCO7686
- Organism
- Streptomyces coelicolor
|
1uniprot[Pubmed] 12000953 [Medline] 21996410 Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002] |
|
68
|
D2B704_STRRD (D2B704) |
|
|
7e-74 |
282 |
44% |
|
- Product
- Putative cytochrome P450
- Gene
- Sros_4934
- Organism
- Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
|
1uniprot Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010] |
|
69
|
B3XWK3_9ACTO (B3XWK3) |
|
|
9e-74 |
282 |
41% |
|
- Product
- Cytochrome P450 monooxygenase
- Gene
- psmA
- Organism
- Streptomyces sp. A-1544
|
1uniprot[Pubmed] 18640605 Increase in pladienolide D production rate using a Streptomyces strain overexpressing a cytochrome P450 gene.(J. Biosci. Bioeng.) [2008] |
|
71
|
CPXH_STRGR (P26911) |
|
|
1e-73 |
281 |
43% |
|
- Product
- Cytochrome P450-SOY
- Gene
- CYP105D1
soyC
- Organism
- Streptomyces griseus
|
1uniprot[Pubmed] 1406253 [Medline] 93023839 Cloning, nucleotide sequence determination and expression of the genes encoding cytochrome P-450soy (soyC) and ferredoxinsoy (soyB) from Streptomyces griseus.(Mol. Microbiol.) [1992] |
|
72
|
Q8KNC8_MICEC (Q8KNC8) |
|
|
2e-73 |
280 |
41% |
|
- Product
- CalE10
- Gene
- calE10
- Organism
- Micromonospora echinospora
Micromonospora purpurea
|
1uniprot[Pubmed] 12183629 [Medline] 22171414 The calicheamicin gene cluster and its iterative type I enediyne PKS.(Science) [2002] |
|
74
|
D8I768_AMYMU (D8I768) |
|
|
3e-73 |
280 |
41% |
|
- Product
- Cytochrome P450
- Gene
- AMED_3473
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
78
|
D2AYJ7_STRRD (D2AYJ7) |
|
|
1e-72 |
278 |
42% |
|
- Product
- Putative cytochrome P450
- Gene
- Sros_6255
- Organism
- Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
|
1uniprot Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010] |
|
79
|
E4N5M4_KITSK (E4N5M4) |
|
|
1e-72 |
278 |
42% |
|
- Product
- Putative cytochrome P450
- Gene
- KSE_06650
- Organism
- Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054)
Streptomyces setae
|
1uniprot[Pubmed] 21059706 Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.(DNA Res.) [2010] |
|
80
|
C7QED3_CATAD (C7QED3) |
|
|
1e-72 |
278 |
41% |
|
- Product
- Cytochrome P450
- Gene
- Caci_1904
- Organism
- Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
|
1uniprot Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009] |
|
83
|
CPXF_STRGO (P18327) |
|
|
3e-72 |
277 |
42% |
|
- Product
- Cytochrome P450-SU2
CYP105B1 Cytochrome P450-CVB1
- Gene
- CYP105B1
subC
- Organism
- Streptomyces griseolus
|
1uniprot[Pubmed] 2345149 [Medline] 90264332 Genes for two herbicide-inducible cytochromes P-450 from Streptomyces griseolus.(J. Bacteriol.) [1990] |
|
85
|
B1VNS0_STRGG (B1VNS0) |
|
|
4e-72 |
276 |
43% |
|
- Product
- Putative cytochrome P450
- Gene
- SGR_264
- Organism
- Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
|
1uniprot[Pubmed] 18375553 Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008] |
|
91
|
D7B189_NOCDD (D7B189) |
|
|
1e-71 |
275 |
41% |
|
- Product
- Cytochrome P450
- Gene
- Ndas_1037
- Organism
- Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei
|
1uniprot Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010] |
|
92
|
F3NBT5_9ACTO (F3NBT5) |
|
|
1e-71 |
275 |
41% |
|
- Product
- Putative cytochrome P450 hydroxylase
- Gene
- SGM_6624
- Organism
- Streptomyces griseoaurantiacus M045
|
1uniprot[Pubmed] 21551298 Draft Genome Sequence of the Marine Bacterium Streptomyces griseoaurantiacus M045, Which Produces Novel Manumycin-Type Antibiotics with a pABA Core Component.(J. Bacteriol.) [2011] |
|
93
|
C6W8T3_ACTMD (C6W8T3) |
|
|
1e-71 |
275 |
39% |
|
- Product
- Cytochrome P450
- Gene
- Amir_3276
- Organism
- Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
|
1uniprot Complete genome sequence of Actinosynnema mirum type strain (101).(Stand. Genomic Sci.) [2009] |
|
95
|
Q595S0_9ACTO (Q595S0) |
|
|
1e-71 |
275 |
40% |
|
- Product
- Cytochrome P450 monooxygenase CYP105S2
- Gene
- cyp234
- Organism
- Streptomyces tubercidicus
|
1uniprot[Pubmed] 16269732 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes.(Appl. Environ. Microbiol.) [2005] | 2uniprot[Pubmed] 16269733 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: heterologous expression of the ema1 cytochrome P450 monooxygenase.(Appl. Environ. Microbiol.) [2005] | [pubmed all]
|
98
|
CPS2_STRCC (Q59831) |
|
|
3e-71 |
273 |
42% |
|
- Product
- Cytochrome P450 105A3
Cytochrome P450 sca-2 Cytochrome P450 sca-2
- Gene
- CYP105A3
- Organism
- Streptomyces carbophilus
|
1uniprot[Pubmed] 7557483 [Medline] 96001248 Cloning, characterization and expression of the gene encoding cytochrome P-450sca-2 from Streptomyces carbophilus involved in production of pravastatin, a specific HMG-CoA reductase inhibitor.(Gene) [1995] | 2uniprot[Pubmed] 2509201 [Medline] 90032660 Purification and characterization of cytochrome P-450sca from Streptomyces carbophilus. ML-236B (compactin) induces a cytochrome P-450sca in Streptomyces carbophilus that hydroxylates ML-236B to pravastatin sodium (CS-514), a tissue-selective inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase.(Eur. J. Biochem.) [1989] | 3uniprot[Pubmed] 10329788 [Medline] 99263338 Crystallization and preliminary X-ray diffraction analysis of cytochrome P450sca-2 from Streptomyces carbophilus involved in production of pravastatin sodium, a tissue-selective inhibitor of HMG-CoA reductase.(Acta Crystallogr. D) [1999] | [pubmed all]
|
99
|
F3NRX8_9ACTO (F3NRX8) |
|
|
3e-71 |
273 |
42% |
|
- Product
- Cytochrome P450 hydroxylase
- Gene
- SGM_5892
- Organism
- Streptomyces griseoaurantiacus M045
|
1uniprot[Pubmed] 21551298 Draft Genome Sequence of the Marine Bacterium Streptomyces griseoaurantiacus M045, Which Produces Novel Manumycin-Type Antibiotics with a pABA Core Component.(J. Bacteriol.) [2011] |
|
100
|
D2BBN4_STRRD (D2BBN4) |
|
|
5e-71 |
273 |
40% |
|
- Product
- Putative cytochrome P450
- Gene
- Sros_3157
- Organism
- Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
|
1uniprot Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010] |
|