| accession | DB | alignment | Evalue | Score | Ident. | link | information | pubmed |
1
|
Q8KUF6_ACTPA (Q8KUF6) |
|
|
0.0 |
6315 |
100% |
|
- Product
- Polyketide synthase
- Gene
- asmD
- Organism
- Actinosynnema pretiosum subsp. auranticum
|
1uniprot[Pubmed] 12060743 [Medline] 22056096 The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.(Proc. Natl. Acad. Sci. U.S.A.) [2002] |
|
2
|
C6W870_ACTMD (C6W870) |
|
|
0.0 |
5589 |
92% |
|
- Product
- Acyl transferase
- Gene
- Amir_3180
- Organism
- Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
|
1uniprot Complete genome sequence of Actinosynnema mirum type strain (101).(Stand. Genomic Sci.) [2009] |
|
3
|
F8QPG0_9ACTO (F8QPG0) |
|
(5 hsp) |
0.0 |
2457 |
49% |
|
- Product
- Polyketide synthase
- Gene
- natC
- Organism
- Streptomyces sp. CS
|
1uniprot[Pubmed] 21614382 Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS.(Mol. Biosyst.) [2011] |
|
5
|
Q9EX53_STRCO (Q9EX53) |
|
(3 hsp) |
0.0 |
2341 |
45% |
|
- Product
- Putative type I polyketide synthase
- Gene
- SCO6274
- Organism
- Streptomyces coelicolor
|
1uniprot[Pubmed] 12000953 [Medline] 21996410 Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002] |
|
7
|
A4FCY9_SACEN (A4FCY9) |
|
(8 hsp) |
0.0 |
2193 |
44% |
|
- Product
- Modular polyketide synthase
- Gene
- SACE_2630
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
9
|
Q49BE0_STRHY (Q49BE0) |
|
(5 hsp) |
0.0 |
2167 |
49% |
|
- Product
- HbmAII
- Gene
- hbmAII
- Organism
- Streptomyces hygroscopicus
|
1uniprot[Pubmed] 16085885 Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption.(Appl. Environ. Microbiol.) [2005] |
|
10
|
F1CT52_9ACTO (F1CT52) |
|
(5 hsp) |
0.0 |
2166 |
49% |
|
- Product
- GdmAII
- Gene
- gdmAII
- Organism
- Streptomyces autolyticus
|
1uniprot[Pubmed] 21544574 Streptomyces autolyticus JX-47 Large-Insert Bacterial Artificial Chromosome Library Construction and Identification of Clones Covering Geldanamycin Biosynthesis Gene Cluster.(Curr. Microbiol.) [2011] |
|
11
|
C6ZCS1_9ACTO (C6ZCS1) |
|
(14 hsp) |
0.0 |
2154 |
45% |
|
- Product
- Type I modular polyketide synthase
- Gene
- ttnA
- Organism
- Streptomyces griseochromogenes
|
1uniprot[Pubmed] 19191560 Characterization of the Tautomycetin Biosynthetic Gene Cluster from Streptomyces griseochromogenes Provides New Insight into Dialkylmaleic Anhydride Biosynthesis.(J. Nat. Prod.) [2009] |
|
12
|
Q84G23_STRHY (Q84G23) |
|
(6 hsp) |
0.0 |
2149 |
48% |
|
- Product
- GdmAII
- Gene
- gdmAII
- Organism
- Streptomyces hygroscopicus
|
1uniprot[Pubmed] 12586396 [Medline] 22474162 Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.(FEMS Microbiol. Lett.) [2003] |
|
13
|
Q1L0T1_STRHY (Q1L0T1) |
|
(5 hsp) |
0.0 |
2149 |
49% |
|
- Product
- GelB
- Gene
-
- Organism
- Streptomyces hygroscopicus subsp. duamyceticus
|
1uniprot[Pubmed] 18600054 Characterization of tailoring genes involved in the modification of geldanamycin polyketide in Streptomyces hygroscopicus JCM4427.(J. Microbiol. Biotechnol.) [2008] |
|
15
|
D7BRE0_STRBB (D7BRE0) |
|
(5 hsp) |
0.0 |
2122 |
48% |
|
- Product
- Modular polyketide synthase
- Gene
- SBI_01982
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
16
|
Q93NW6_9ACTO (Q93NW6) |
|
(14 hsp) |
0.0 |
2085 |
46% |
|
- Product
- AmphC
- Gene
- amphC
- Organism
- Streptomyces nodosus
|
1uniprot[Pubmed] 11451671 [Medline] 21344785 Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes.(Chem. Biol.) [2001] | 2uniprot[Pubmed] 16079135 Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups.(J. Biol. Chem.) [2005] | [pubmed all]
|
17
|
Q93HE5_STRAW (Q93HE5) |
|
(7 hsp) |
0.0 |
2073 |
47% |
|
- Product
- Modular polyketide synthase
Putative modular polyketide synthase
- Gene
- pks5
SAV2368 SAV_2368
- Organism
- Streptomyces avermitilis
|
1uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001] | 2uniprot[Pubmed] 12692562 [Medline] 22608306 Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003] | [pubmed all]
|
20
|
A4FH85_SACEN (A4FH85) |
|
(11 hsp) |
0.0 |
2050 |
57% |
|
- Product
- Type I modular polyketide synthase
- Gene
- SACE_4141
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
21
|
Q5VKQ3_SACER (Q5VKQ3) |
|
(11 hsp) |
0.0 |
2050 |
57% |
|
- Product
- Type I PKS
- Gene
- pkeAI
- Organism
- Saccharopolyspora erythraea
Streptomyces erythraeus
|
1uniprot[Pubmed] 15925898 A new modular polyketide synthase in the erythromycin producer Saccharopolyspora erythraea.(J. Mol. Microbiol. Biotechnol.) [2004] |
|
22
|
C9YYI2_STRSW (C9YYI2) |
|
(6 hsp) |
0.0 |
2048 |
56% |
|
- Product
- Putative type I polyketide synthase
- Gene
- SCAB_83911
- Organism
- Streptomyces scabies (strain 87.22)
Streptomyces scabiei
|
1uniprot[Pubmed] 20064060 Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010] |
|
23
|
C6WNW1_ACTMD (C6WNW1) |
|
(7 hsp) |
0.0 |
2040 |
57% |
|
- Product
- Short-chain dehydrogenase/reductase SDR
- Gene
- Amir_2695
- Organism
- Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
|
1uniprot Complete genome sequence of Actinosynnema mirum type strain (101).(Stand. Genomic Sci.) [2009] |
|
24
|
Q3S863_9ACTO (Q3S863) |
|
(9 hsp) |
0.0 |
2037 |
56% |
|
- Product
- Modular polyketide synthase
- Gene
-
- Organism
- Streptomyces neyagawaensis
|
1uniprot[Pubmed] 16207901 Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.(Microbiology) [2005] |
|
27
|
Q9ALM3_9PSEU (Q9ALM3) |
|
(9 hsp) |
0.0 |
2024 |
49% |
|
- Product
- Polyketide synthase extender modules 5-7
- Gene
- spnD
- Organism
- Saccharopolyspora spinosa
|
1uniprot[Pubmed] 11358695 [Medline] 21257765 Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001] |
|
28
|
Q9L4W3_9ACTO (Q9L4W3) |
|
(16 hsp) |
0.0 |
2020 |
47% |
|
- Product
- NysC
- Gene
- nysC
- Organism
- Streptomyces noursei
|
1uniprot[Pubmed] 10873841 [Medline] 20334850 Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway.(Chem. Biol.) [2000] |
|
30
|
E0D206_9ACTO (E0D206) |
|
(4 hsp) |
0.0 |
2016 |
55% |
|
- Product
- Polyketide synthase
- Gene
- gfsE
- Organism
- Streptomyces graminofaciens
|
1uniprot[Pubmed] 20589823 Cloning and characterization of the biosynthetic gene cluster of 16-membered macrolide antibiotic FD-891: involvement of a dual functional cytochrome P450 monooxygenase catalyzing epoxidation and hydroxylation.(Chembiochem) [2010] |
|
32
|
A0FCL2_STRVO (A0FCL2) |
|
(11 hsp) |
0.0 |
2004 |
49% |
|
- Product
- MerB
- Gene
- merB
- Organism
- Streptomyces violaceoniger
|
1uniprot[Pubmed] 17159202 Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin.(Microbiology) [2006] |
|
33
|
E4NJF3_KITSK (E4NJF3) |
|
(6 hsp) |
0.0 |
1999 |
55% |
|
- Product
- Modular polyketide synthase BFAS3
- Gene
- bfmA3
KSE_73460
- Organism
- Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054)
Streptomyces setae
|
1uniprot[Pubmed] 21059706 Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.(DNA Res.) [2010] |
|
36
|
D8HZ83_AMYMU (D8HZ83) |
|
(6 hsp) |
0.0 |
1986 |
55% |
|
- Product
- Rifamycin polyketide synthase
- Gene
- rifB
AMED_0618
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
37
|
O52545_AMYMD (O52545) |
|
(6 hsp) |
0.0 |
1986 |
55% |
|
- Product
- RifB
- Gene
- rifB
- Organism
- Amycolatopsis mediterranei
Nocardia mediterranei
|
1uniprot[Pubmed] 9512878 [Medline] 98174059 Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.(Chem. Biol.) [1998] | 2uniprot[Pubmed] 9497318 [Medline] 98165773 3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.(J. Biol. Chem.) [1998] | 3uniprot[Pubmed] 11278540 [Medline] 21201076 Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699.(J. Biol. Chem.) [2001] | [pubmed all]
|
40
|
E9KTB4_STRKN (E9KTB4) |
|
(5 hsp) |
0.0 |
1978 |
48% |
|
- Product
- Polyketide synthase
- Gene
- fkbC
Tcs_SK_030
- Organism
- Streptomyces kanamyceticus
|
1uniprot[Pubmed] 21175203 Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.(J. Am. Chem. Soc.) [2011] |
|
41
|
F8QPF9_9ACTO (F8QPF9) |
|
(6 hsp) |
0.0 |
1972 |
54% |
|
- Product
- Polyketide synthase
- Gene
- natB
- Organism
- Streptomyces sp. CS
|
1uniprot[Pubmed] 21614382 Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS.(Mol. Biosyst.) [2011] |
|
42
|
Q9ALM2_9PSEU (Q9ALM2) |
|
(7 hsp) |
0.0 |
1969 |
53% |
|
- Product
- Polyketide synthase extender modules 8-10
- Gene
- spnE
- Organism
- Saccharopolyspora spinosa
|
1uniprot[Pubmed] 11358695 [Medline] 21257765 Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001] |
|
43
|
Q68BG4_STRHA (Q68BG4) |
|
(15 hsp) |
0.0 |
1969 |
54% |
|
- Product
- Type I polyketide synthase
- Gene
- hlsB
- Organism
- Streptomyces halstedii
|
1uniprot Genome-inspired search for new antibiotics; Isolation and structure determination of new 28-membered polyketide macrolactones, halstoctacosanolides A and B, from Streptomyces halstedii HC34.(Tetrahedron) [2004] |
|
48
|
C6ZCS0_9ACTO (C6ZCS0) |
|
(11 hsp) |
0.0 |
1952 |
49% |
|
- Product
- Type I modular polyketide synthase
- Gene
- ttnB
- Organism
- Streptomyces griseochromogenes
|
1uniprot[Pubmed] 19191560 Characterization of the Tautomycetin Biosynthetic Gene Cluster from Streptomyces griseochromogenes Provides New Insight into Dialkylmaleic Anhydride Biosynthesis.(J. Nat. Prod.) [2009] |
|
49
|
Q1WEK8_9ACTO (Q1WEK8) |
|
(13 hsp) |
0.0 |
1942 |
54% |
|
- Product
- Polyketide synthase
- Gene
- merB
- Organism
- Streptomyces sp. NRRL 30748
|
1uniprot[Pubmed] 16806745 Isolation and characterization of meridamycin biosynthetic gene cluster from Streptomyces sp. NRRL 30748.(Gene) [2006] |
|
50
|
C3VLW9_9ACTO (C3VLW9) |
|
(4 hsp) |
0.0 |
1941 |
53% |
|
- Product
- Polyketide synthase type I
- Gene
- becF
- Organism
- Streptomyces sp. DSM 21069
|
1uniprot[Pubmed] 19875084 Biosynthesis of macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit.(Chem. Biol.) [2009] |
|
51
|
A1YAN0_AMYOR (A1YAN0) |
|
(7 hsp) |
0.0 |
1937 |
55% |
|
- Product
- Polyketide synthase type I
- Gene
-
- Organism
- Amycolatopsis orientalis
Nocardia orientalis
|
1uniprot[Pubmed] 17136886 Genomic analyses lead to novel secondary metabolites. Part 3. ECO-0501, a novel antibacterial of a new class.(J. Antibiot.) [2006] |
|
52
|
B1W485_STRGG (B1W485) |
|
(10 hsp) |
0.0 |
1933 |
55% |
|
- Product
- Putative type-I PKS
- Gene
- pks1-1
SGR_6073
- Organism
- Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
|
1uniprot[Pubmed] 18375553 Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008] |
|
53
|
Q6JHN6_9PSEU (Q6JHN6) |
|
(11 hsp) |
0.0 |
1932 |
55% |
|
- Product
- ObsC
- Gene
-
- Organism
- Saccharopolyspora spinosa
|
1uniprot[Pubmed] 15346767 Analysis of a 108-kb region of the Saccharopolyspora spinosa genome covering the obscurin polyketide synthase locus.(DNA Seq.) [2004] |
|
54
|
D7CC08_STRBB (D7CC08) |
|
(10 hsp) |
0.0 |
1930 |
54% |
|
- Product
- Putative type I polyketide synthase
- Gene
- pks5-2
SBI_01382
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
55
|
A4KCE5_9ACTO (A4KCE5) |
|
(12 hsp) |
0.0 |
1927 |
48% |
|
- Product
- Tautomycetin biosynthetic PKS
- Gene
-
- Organism
- Streptomyces sp. CK4412
|
1uniprot[Pubmed] 17379718 Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412.(Microbiology) [2007] | 2uniprot[Pubmed] 20623733 Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase.(Angew. Chem. Int. Ed.) [2010] | [pubmed all]
|
56
|
Q0QMN7_9ACTO (Q0QMN7) |
|
(9 hsp) |
0.0 |
1926 |
57% |
|
- Product
- Polyketide synthase type I
- Gene
-
- Organism
- Streptomyces sp. Eco86
|
1uniprot[Pubmed] 16724457 Isolation and identification of three new 5-alkenyl-3,3(2H)-furanones from two streptomyces species using a genomic screening approach.(J. Antibiot.) [2006] |
|
57
|
D7P611_CHOCO (D7P611) |
|
(12 hsp) |
0.0 |
1926 |
53% |
|
- Product
- TugA
- Gene
- tugA
- Organism
- Chondromyces crocatus
|
1uniprot[Pubmed] 20416506 Biosynthesis of thuggacins in myxobacteria: comparative cluster analysis reveals basis for natural product structural diversity.(Chem. Biol.) [2010] |
|
58
|
F8QPG1_9ACTO (F8QPG1) |
|
(4 hsp) |
0.0 |
1918 |
54% |
|
- Product
- Polyketide synthase
- Gene
- natD
- Organism
- Streptomyces sp. CS
|
1uniprot[Pubmed] 21614382 Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS.(Mol. Biosyst.) [2011] |
|
59
|
C3VLZ7_9ACTO (C3VLZ7) |
|
(5 hsp) |
0.0 |
1917 |
53% |
|
- Product
- Polyketide synthase type I
- Gene
- mlaF
- Organism
- Streptomyces sp. MP39-85
|
1uniprot[Pubmed] 19854930 Insights into the Evolution of Macrolactam Biosynthesis through Cloning and Comparative Analysis of the Biosynthetic Gene Cluster for a Novel Macrocyclic Lactam, ML-449.(Appl. Environ. Microbiol.) [2010] |
|
61
|
Q6JHN8_9PSEU (Q6JHN8) |
|
(11 hsp) |
0.0 |
1915 |
54% |
|
- Product
- ObsA
- Gene
-
- Organism
- Saccharopolyspora spinosa
|
1uniprot[Pubmed] 15346767 Analysis of a 108-kb region of the Saccharopolyspora spinosa genome covering the obscurin polyketide synthase locus.(DNA Seq.) [2004] |
|
62
|
Q0R4M8_STRAT (Q0R4M8) |
|
(9 hsp) |
0.0 |
1906 |
53% |
|
- Product
- ChlA1
- Gene
-
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 16793515 Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006] |
|
64
|
C5HV16_STRAT (C5HV16) |
|
(11 hsp) |
0.0 |
1903 |
54% |
|
- Product
- Polyketide synthase
- Gene
- idmN
- Organism
- Streptomyces antibioticus
|
1uniprot Analysis of the indanomycin biosynthetic gene cluster from Streptomyces antibioticus NRRL 8167.(Chembiochem) [2009] |
|
65
|
B3TMQ8_9ACTO (B3TMQ8) |
|
(12 hsp) |
0.0 |
1899 |
55% |
|
- Product
- Polyketide synthase
- Gene
- KijS1
- Organism
- Actinomadura kijaniata
|
1uniprot[Pubmed] 17985890 Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007] |
|
67
|
Q6JHN7_9PSEU (Q6JHN7) |
|
(6 hsp) |
0.0 |
1894 |
54% |
|
- Product
- ObsB
- Gene
-
- Organism
- Saccharopolyspora spinosa
|
1uniprot[Pubmed] 15346767 Analysis of a 108-kb region of the Saccharopolyspora spinosa genome covering the obscurin polyketide synthase locus.(DNA Seq.) [2004] |
|
68
|
A4KCE4_9ACTO (A4KCE4) |
|
(16 hsp) |
0.0 |
1894 |
49% |
|
- Product
- Tautomycetin biosynthetic PKS
- Gene
-
- Organism
- Streptomyces sp. CK4412
|
1uniprot[Pubmed] 17379718 Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412.(Microbiology) [2007] |
|
69
|
Q52V53_9ACTO (Q52V53) |
|
(11 hsp) |
0.0 |
1893 |
52% |
|
- Product
- Polyketide synthase type I
- Gene
-
- Organism
- Streptomyces aizunensis
|
1uniprot[Pubmed] 15844935 Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.(J. Nat. Prod.) [2005] |
|
70
|
Q52V49_9ACTO (Q52V49) |
|
(4 hsp) |
0.0 |
1893 |
52% |
|
- Product
- Polyketide synthase type I
- Gene
-
- Organism
- Streptomyces aizunensis
|
1uniprot[Pubmed] 15844935 Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.(J. Nat. Prod.) [2005] |
|
71
|
A0FCL1_STRVO (A0FCL1) |
|
(13 hsp) |
0.0 |
1890 |
54% |
|
- Product
- MerA
- Gene
- merA
- Organism
- Streptomyces violaceoniger
|
1uniprot[Pubmed] 17159202 Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin.(Microbiology) [2006] |
|
73
|
B6ZK64_STRLS (B6ZK64) |
|
(12 hsp) |
0.0 |
1888 |
52% |
|
- Product
- Putative polyketide synthase
- Gene
- lsd11
- Organism
- Streptomyces lasaliensis
|
1uniprot[Pubmed] 19129623 Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis.(Biosci. Biotechnol. Biochem.) [2009] | 2uniprot[Pubmed] 18710235 Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis.(J. Am. Chem. Soc.) [2008] | [pubmed all]
|
74
|
D3U9Y8_9ACTO (D3U9Y8) |
|
(13 hsp) |
0.0 |
1887 |
57% |
|
- Product
- Type I polyketide synthase
- Gene
- sfaH
- Organism
- Streptomyces flaveolus
|
1uniprot Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor.(Mol. Biosyst.) [2010] |
|
75
|
F4F8H8_VERMA (F4F8H8) |
|
(4 hsp) |
0.0 |
1885 |
48% |
|
- Product
- Modular polyketide synthase
- Gene
- VAB18032_17095
- Organism
- Verrucosispora maris (strain AB-18-032)
|
1uniprot[Pubmed] 21551311 Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.(J. Bacteriol.) [2011] |
|
77
|
B1W4J1_STRGG (B1W4J1) |
|
(9 hsp) |
0.0 |
1884 |
53% |
|
- Product
- Putative type-I PKS
- Gene
- pks2-1
SGR_6179
- Organism
- Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
|
1uniprot[Pubmed] 18375553 Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008] |
|
78
|
Q52V50_9ACTO (Q52V50) |
|
(13 hsp) |
0.0 |
1881 |
52% |
|
- Product
- Polyketide synthase type I
- Gene
-
- Organism
- Streptomyces aizunensis
|
1uniprot[Pubmed] 15844935 Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.(J. Nat. Prod.) [2005] |
|
80
|
D7CC07_STRBB (D7CC07) |
|
(11 hsp) |
0.0 |
1878 |
54% |
|
- Product
- Putative type I polyketide synthase
- Gene
- pks5-1
SBI_01381
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
82
|
D8HZ82_AMYMU (D8HZ82) |
|
(13 hsp) |
0.0 |
1877 |
55% |
|
- Product
- Rifamycin polyketide synthase
- Gene
- rifA
AMED_0617
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
83
|
O54666_AMYMD (O54666) |
|
(13 hsp) |
0.0 |
1877 |
55% |
|
- Product
- RifA
Rifamycin polyketide synthase, type 1
- Gene
- rifA
- Organism
- Amycolatopsis mediterranei
Nocardia mediterranei
|
1uniprot[Pubmed] 9512878 [Medline] 98174059 Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.(Chem. Biol.) [1998] | 2uniprot[Pubmed] 9497318 [Medline] 98165773 3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.(J. Biol. Chem.) [1998] | 3uniprot[Pubmed] 11278540 [Medline] 21201076 Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699.(J. Biol. Chem.) [2001] | [pubmed all]
|
84
|
Q0S8W4_RHOSR (Q0S8W4) |
|
(4 hsp) |
0.0 |
1876 |
51% |
|
- Product
- Type I polyketide synthase
- Gene
- RHA1_ro04231
- Organism
- Rhodococcus sp. (strain RHA1)
|
1uniprot[Pubmed] 17030794 The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse.(Proc. Natl. Acad. Sci. U.S.A.) [2006] |
|
85
|
Q6MZ72_MYCUA (Q6MZ72) |
|
(21 hsp) |
0.0 |
1875 |
43% |
|
- Product
- Type I modular polyketide synthase
- Gene
- mlsB
MUP032c
- Organism
- Mycobacterium ulcerans (strain Agy99)
|
1uniprot[Pubmed] 14736915 Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.(Proc. Natl. Acad. Sci. U.S.A.) [2004] | 2uniprot[Pubmed] 15758215 Functional analysis and annotation of the virulence plasmid pMUM001 from Mycobacterium ulcerans.(Microbiology) [2005] | [pubmed all]
|
88
|
Q54296_STRHY (Q54296) |
|
(14 hsp) |
0.0 |
1874 |
53% |
|
- Product
- Polyketide synthase
- Gene
- rapB
- Organism
- Streptomyces hygroscopicus
|
1uniprot[Pubmed] 7644502 [Medline] 95372374 The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.(Proc. Natl. Acad. Sci. U.S.A.) [1995] | 2uniprot[Pubmed] 8635730 [Medline] 96186895 Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase.(Gene) [1996] | 3uniprot[Pubmed] 8635756 [Medline] 96186896 Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase.(Gene) [1996] | [pubmed all]
|
91
|
Q30CS0_STRAU (Q30CS0) |
|
(4 hsp) |
0.0 |
1867 |
51% |
|
- Product
- LipPks3
- Gene
- lipPks3
- Organism
- Streptomyces aureofaciens
|
1uniprot[Pubmed] 16723573 Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin.(Antimicrob. Agents Chemother.) [2006] |
|
92
|
Q6TEI0_STRDI (Q6TEI0) |
|
(7 hsp) |
0.0 |
1865 |
55% |
|
- Product
- Type I polyketide synthase
- Gene
- mnp2
- Organism
- Streptomyces diastaticus
|
1uniprot[Pubmed] 15123265 Starter unit choice determines the production of two tetraene macrolides, rimocidin and CE-108, in Streptomyces diastaticus var. 108.(Chem. Biol.) [2004] |
|
94
|
Q1WEK9_9ACTO (Q1WEK9) |
|
(13 hsp) |
0.0 |
1864 |
54% |
|
- Product
- Polyketide synthase
- Gene
- merA
- Organism
- Streptomyces sp. NRRL 30748
|
1uniprot[Pubmed] 16806745 Isolation and characterization of meridamycin biosynthetic gene cluster from Streptomyces sp. NRRL 30748.(Gene) [2006] |
|
95
|
B1W4J3_STRGG (B1W4J3) |
|
(4 hsp) |
0.0 |
1863 |
46% |
|
- Product
- Putative type-I PKS
- Gene
- pks2-3
SGR_6181
- Organism
- Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
|
1uniprot[Pubmed] 18375553 Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008] |
|
97
|
Q2PC52_STRAH (Q2PC52) |
|
(6 hsp) |
0.0 |
1859 |
52% |
|
- Product
- Putative polyketide synthase
- Gene
- rubB
- Organism
- Streptomyces achromogenes subsp. rubradiris
|
1uniprot[Pubmed] 9387157 [Medline] 98048398 Identification of a gene cluster of biosynthetic genes of rubradirin substructures in S. achromogenes var. rubradiris NRRL3061.(Mol. Cells) [1997] | 2uniprot[Pubmed] 12889805 [Medline] 22771458 Functional identification of rub52 gene involved in the biosynthesis of rubradirin.(Biotechnol. Lett.) [2003] | [pubmed all]
|
98
|
Q82QT5_STRAW (Q82QT5) |
|
(4 hsp) |
0.0 |
1857 |
52% |
|
- Product
- Modular polyketide synthase
- Gene
- pteA2
SAV418 SAV_418
- Organism
- Streptomyces avermitilis
|
1uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001] |
|
99
|
C0SMW2_9ACTO (C0SMW2) |
|
(6 hsp) |
0.0 |
1857 |
43% |
|
- Product
- Type I modular polyketide synthase
- Gene
- ttmH
- Organism
- Streptomyces spiroverticillatus
|
1uniprot[Pubmed] 16707708 Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus.(J. Bacteriol.) [2006] | 2uniprot[Pubmed] 18708355 Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis.(J. Biol. Chem.) [2008] | [pubmed all]
|