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遺伝子 : Aminoglycoside N(3')-acetyltransferase (AAC3)

遺伝子情報

ID NRULE_0149
遺伝子ID AAC3
作成日 2013/03/05
タンパク質名
Protein name
Full
Aminoglycoside N(3')-acetyltransferase
EC
EC 2.3.1.81
Synonym
Full
ACC(3)
Aminocyclitol 3-N-acetyltransferase
Gentamicin-(3)-N-acetyl-transferase
遺伝子名 aacC
遺伝子条件 PFAM; PF02522; hit=1
参照
Gene Ontology
GO
GO:0046353, F:aminoglycoside 3-N-acetyltransferase activity, IEA:EC
GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW
Family and domain databases
InterPro
IPR003679, Amioglycoside_AcTrfase
Pfam
PF02522, Antibiotic_NAT, 1
配列の特徴 該当データなし
注釈
Function
Resistance to antibiotics containing the 2-deoxy- streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin
Catalytic activity
Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic
Sequence similarities
Belongs to the antibiotic N-acetyltransferase family
参考文献
P29809 Streptomyces fradiae (Streptomyces roseoflavus).
2060791
Characterisation of aminoglycoside acetyltransferase-encoding genes of neomycin-producing Micromonospora chalcea and Streptomyces fradiae. (Gene. 1991)
P08988 Salmonella sp.
6318050
Genes for gentamicin-(3)-N-acetyltransferases III and IV: I. Nucleotide sequence of the AAC(3)-IV gene and possible involvement of an IS140 element in its expression. (Mol Gen Genet. 1984)



関与する機能

機能名
Aminoglycoside resistance (by aminoglycoside N-acetyltransferase)
Gentamicin resistance
Kanamycin resistance

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Acaryochloris marina102967AM1_3129aminoglycoside 3-N-acetyltransferase
AM1_3620hypothetical protein
AM1_A0084aminoglycoside N(3')-acetyltransferase III
AM1_B0404aminoglycoside N(3')-acetyltransferase III
Actinoplanes missouriensis102363AMIS_23580putative aminoglycoside 3-N-acetyltransferase
AMIS_27610putative aminoglycoside 3-N-acetyltransferase
Anaerolinea thermophila100420ANT_28680putative aminoglycoside 3-N-acetyltransferase
ANT_29760hypothetical protein
Bacillus cereus15305BC_2919Aminoglycoside N3'-acetyltransferase
Bacillus mycoides101228bmyco0001_26270hypothetical protein
Bacillus pseudomycoides101232bpmyx0001_24800hypothetical protein
Bacillus psychrosaccharolyticus101233WYK_231_00100aminoglycoside N3-acetyltransferase
Bacillus pumilus12092BAT_3776aminoglycoside N3'-acetyltransferase
Bacillus subtilis subsp. subtilis13719BSU21630aminoglycoside N3'-acetyltransferase
Bacillus thuringiensis101235bthur0008_26940hypothetical protein
Beutenbergia cavernae16432Bcav_0391Aminoglycoside N(3')-acetyltransferase
Caldilinea aerophila104270CLDAP_37020putative aminoglycoside 3-N-acetyltransferase
Calditerrivibrio nitroreducens101217Calni_0720hypothetical protein
Catenulispora acidiphila102108Caci_0513Aminoglycoside N(3')-acetyltransferase
Cellulomonas fimi15513Celf_2310Aminoglycoside N(3')-acetyltransferase
Chitinispirillum alkaliphilumCHISP_2208aminoglycoside 3-N-acetyltransferase
Chthonomonas calidiroseaCCALI_00544Aminoglycoside N3'-acetyltransferase
Clostridium acetobutylicum13948CA_C2197Aminoglycoside N3'-acetyltransferase
Cystobacter fuscus100088D187_005428aminoglycoside N(3')-acetyltransferase IV (ACC(3)-IV)
Deinococcus proteolyticus101906Deipr_0852aminoglycoside 3-N-acetyltransferase
Desulfovibrio magneticus104933DMR_p1_00650hypothetical protein
Fluviicola taffensis106335Fluta_3162aminoglycoside 3-N-acetyltransferase
Gloeobacter violaceusgll0484aminoglycoside N3'-acetyltransferase
Gluconobacter frateurii101659GfraN1_010100009217aminoglycoside N3-acetyltransferase
Gordonia soli108243GS4_06_00470putative aminoglycoside 3-N-acetyltransferase
Haloarcula vallismortis14741C437_01055aminoglycoside N3'-acetyltransferase
Halobacillus halophilus102448HBHAL_1026aminoglycoside N3'-acetyltransferase
Haloplasma contractileHLPCO_003136Aminoglycoside N3-acetyltransferase protein
Ignavibacterium album101810IALB_1029Aminoglycoside N3'-acetyltransferase
Kitasatospora setae14216KSE_44730putative aminoglycoside 3-N-acetyltransferase
Ktedonobacter racemiferKrac_8168Aminoglycoside N(3')-acetyltransferase
Lactobacillus helveticus15019HMPREF0518_1464hypothetical protein
Microlunatus phosphovorus101784MLP_08460putative aminoglycoside 3-N-acetyltransferase
Micromonospora aurantiaca16155Micau_4767Aminoglycoside N(3')-acetyltransferase
Micau_5995Aminoglycoside N(3')-acetyltransferase
Nakamurella multipartita105858Namu_0547aminoglycoside 3-N-acetyltransferase
Nocardiopsis dassonvillei14626Ndas_3033Aminoglycoside N(3')-acetyltransferase
Nostoc sp.alr1528aminoglycoside N3'-acetyltransferase
Paenibacillus alvei3343PAV_6c04160putative phage protein
Paenibacillus polymyxa15309PPT_22130aminoglycoside N(3')-acetyltransferase
Rhizobium etli15573RHE_CH01086aminoglycoside N3`-acetyltransferase protein
Saccharomonospora azurea14651SacazDRAFT_03679aminoglycoside N3'-acetyltransferase
Saccharomonospora cyanea14841SaccyDRAFT_0986aminoglycoside N3'-acetyltransferase
Saccharomonospora glauca14831SacglDRAFT_00925aminoglycoside N3'-acetyltransferase
Saccharopolyspora erythraea13426SACE_3603aminoglycoside acetyltransferase
SACE_3604aminoglycoside N3'-acetyltransferase protein
Salinispora arenicola105043Q5S_1771_00010aminoglycoside acetyltransferase
Streptomyces avermitilis14893SAV5714putative aminoglycoside N3-acetyltransferase
SAV6323hypothetical protein
Streptomyces clavuligerus13307SCLAV_0950Aminoglycoside N3-acetyltransferase
Streptomyces ghanaensis15414SSFG_05444aminoglycoside acetyltransferase
Streptomyces pristinaespiralis13074SSDG_01997aminoglycoside N3-acetyltransferase
Streptomyces purpureus13925STRPU_03_03760Aminoglycoside N3-acetyltransferase
Streptomyces sviceus13980SSEG_08760aminoglycoside acetyltransferase
Xylanimonas cellulosilytica107835Xcel_0724Aminoglycoside N(3')-acetyltransferase