遺伝子 : Homoprotocatechuate 2,3-dioxygenase (HPAD2)

遺伝子情報

ID	NRULE_0194
遺伝子ID	HPAD2
作成日	2013/01/23
タンパク質名	Protein name Full Homoprotocatechuate 2,3-dioxygenase Short HPC dioxygenase EC EC 1.13.11.15 Synonym Full 3,4-dihydroxyphenylacetate 2,3-dioxygenase
遺伝子名	hpaD, hpcB
遺伝子条件	TIGRFAMs; TIGR02295; hit=1
参照	Gene Ontology GO GO:0046872, F:metal ion binding, IEA:UniProtKB-KW GO:0016702, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, IEA:UniProtKB-KW Enzyme and pathway databases UniPathway UPA00208, UER00417 Family and domain databases InterPro IPR011981, dHPA_dOase IPR004360, Glyas_Fos-R_dOase_dom Pfam PF00903, Glyoxalase, 2 TIGRFAMs TIGR02295, HpaD, 1
配列の特徴	Q45135 Brevibacterium fuscum. METAL 155 Cobalt; via tele nitrogen. METAL 155 Iron; via tele nitrogen. METAL 155 Manganese; via tele nitrogen. METAL 184 Calcium. METAL 185 Calcium. METAL 214 Cobalt; via tele nitrogen. METAL 214 Iron; via tele nitrogen. METAL 214 Manganese; via tele nitrogen. METAL 267 Cobalt. METAL 267 Iron. METAL 267 Manganese. Q44048 Arthrobacter globiformis. METAL 155 Manganese; via tele nitrogen. METAL 214 Manganese; via tele nitrogen. METAL 266 Manganese.
注釈	Catalytic activity 3,4-dihydroxyphenylacetate + O(2) = 5-carboxymethyl-2-hydroxymuconic-semialdehyde Cofactor Metal ion Pathway Aromatic compound metabolism; 4-hydroxyphenylacetate degradation; pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 2/7
参考文献	Q45135 Brevibacterium fuscum. 9179284 Cloning, overexpression, and mutagenesis of the gene for homoprotocatechuate 2,3-dioxygenase from Brevibacterium fuscum. (Protein Expr Purif. 1997) 15028678 Crystallographic comparison of manganese- and iron-dependent homoprotocatechuate 2,3-dioxygenases. (J Bacteriol. 2004) 18492808 Swapping metals in Fe- and Mn-dependent dioxygenases: evidence for oxygen activation without a change in metal redox state. (Proc Natl Acad Sci U S A. 2008) Q44048 Arthrobacter globiformis. 7868595 A manganese-dependent dioxygenase from Arthrobacter globiformis CM-2 belongs to the major extradiol dioxygenase family. (J Bacteriol. 1995)

関与する機能

機能名
4-hydroxyphenylacetate degradation

該当CDS

学名	NBRC番号	CDS	タンパク質名
Acetobacter tropicalis	101654	ATPR_0350	Catechol 2,3-dioxygenase
Alicyclobacillus acidocaldarius subsp. acidocaldarius	15652	Aaci_0340	3,4-dihydroxyphenylacetate 2,3-dioxygenase
Amycolatopsis azurea	14573	C791_5119	Catechol 2,3-dioxygenase
Arthrobacter globiformis	12137	ARGLB_027_02040	3,4-dihydroxyphenylacetate 2,3-dioxygenase
Beutenbergia cavernae	16432	Bcav_0866	3,4-dihydroxyphenylacetate 2,3-dioxygenase
Bradyrhizobium diazoefficiens	14792	bll2967	putative metapyrocatechase (EC 1.13.11.2)
Brevibacterium linens	12170	BlinB_010200012336	3,4-dihydroxyphenylacetate 2,3-dioxygenase
Cellulomonas fimi	15513	Celf_2075	3,4-dihydroxyphenylacetate 2,3-dioxygenase
Corynebacterium ammoniagenes	12612	HMPREF0281_01051	3,4-dihydroxyphenylacetate 2,3-dioxygenase
Corynebacterium striatum	15291	HMPREF0308_2500	3,4-dihydroxyphenylacetate 2,3-dioxygenase
Deinococcus proteolyticus	101906	Deipr_2618	3,4-dihydroxyphenylacetate 2,3-dioxygenase
Gordonia polyisoprenivorans	16320	GOPIP_092_00640	putative 3,4-dihydroxyphenylacetate 2,3-dioxygenase
Gordonia rhizosphera	16068	GORHZ_126_00220	putative 3,4-dihydroxyphenylacetate 2,3-dioxygenase
Halobacillus halophilus	102448	HBHAL_2384	3,4-dihydroxyphenylacetate 2,3-dioxygenase
Kocuria rhizophila	103217	KRH_22020	3,4-dihydroxyphenylacetate 2,3-dioxygenase
Kyrpidia tusciae	15312	Btus_1572	3,4-dihydroxyphenylacetate 2,3-dioxygenase
Labrenzia aggregata	16684	SIAM614_21802	Extradiol ring-cleavage dioxygenase:Glyoxalase/Bleomycin resistance protein/dioxygenase domain:Glyoxalase I
Meiothermus ruber	106122	Mrub_1330	3,4-dihydroxyphenylacetate 2,3-dioxygenase
Meiothermus silvanus	106475	Mesil_2314	3,4-dihydroxyphenylacetate 2,3-dioxygenase
Micrococcus luteus	3333	Mlut_20010	3,4-dihydroxyphenylacetate 2,3-dioxygenase
Phaeobacter gallaeciensis	16654	PGA1_c32210	3,4-dihydroxyphenylacetate 2,3-dioxygenase HpaD
Rhizobium sp.	101917	NGR_b20130	Catechol 2,3-dioxygenase
Rhizobium tropici	15247	RTCIAT899_PC03855	3,4-dihydroxyphenylacetate 2,3-dioxygenase
Sulfolobus tokodaii	100140	STK_07240	putative 3,4-dihydroxyphenylacetate-2,3-dioxygenase
Thermomicrobium roseum		trd_A0935	3,4-dihydroxyphenylacetate 2,3-dioxygenase
Thermus thermophilus	101084	TTHA0962	homoprotocatechuate 2,3-dioxygenase
Thermus thermophilus	101085	TT_C0596	homoprotocatechuate 2,3-dioxygenase
Zimmermannella faecalis	15706	G328_07445	3,4-dihydroxyphenylacetate 2,3-dioxygenase
		G328_07765	hypothetical protein