BLAST table : Adria_00160

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism
1	O68500_STRPE (O68500)	1e-155	550	100%	UniProt GenBank	Polyketide cyclase	dpsY	Streptomyces peucetius
2	Q54196_STRGR (Q54196)	1e-126	456	85%	UniProt GenBank	DNA sequence for ORF's 1-6		Streptomyces griseus
3	Q9RN54_STRNO (Q9RN54)	1e-101	372	69%	UniProt GenBank	Putative polyketide cyclase	snoaM	Streptomyces nogalater
4	E8SDG0_MICSL (E8SDG0)	1e-101	371	70%	UniProt GenBank	Cyclase family protein	ML5_4398	Micromonospora sp. (strain L5)
5	D9T2C0_MICAI (D9T2C0)	1e-101	371	70%	UniProt GenBank	Cyclase family protein	Micau_4023	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
6	Q2PA03_9ACTO (Q2PA03)	1e-100	368	69%	UniProt GenBank	Cyclase	stfY	Streptomyces steffisburgensis
7	Q9L4U2_9ACTO (Q9L4U2)	4e-99	365	70%	UniProt GenBank	Putative cyclase	aknW	Streptomyces galilaeus
8	Q194Q6_STRAA (Q194Q6)	5e-95	352	68%	UniProt GenBank	Cyclase	mtmY	Streptomyces argillaceus
9	C0JWC6_9ACTO (C0JWC6)	8e-94	347	67%	UniProt GenBank	PokC2	pokC2	Streptomyces diastatochromogenes
10	B5G897_9ACTO (B5G897)	3e-91	339	70%	UniProt GenBank	Cyclase superfamily protein	SSBG_00505	Streptomyces sp. SPB74
11	Q3S8Q2_STRRM (Q3S8Q2)	6e-89	331	65%	UniProt GenBank	OxyN	oxyN	Streptomyces rimosus
12	Q70J97_STRGR (Q70J97)	6e-88	328	67%	UniProt GenBank	Cyclase	cmmY	Streptomyces griseus subsp. griseus
13	D7BZQ8_STRBB (D7BZQ8)	8e-87	324	68%	UniProt GenBank	Polyketide cyclase	SBI_06843	Streptomyces bingchenggensis (strain BCW-1)
14	A1C180_9ACTO (A1C180)	5e-86	322	66%	UniProt GenBank	Cyclase		Streptomyces echinatus
15	E8W964_STRFA (E8W964)	5e-84	315	59%	UniProt GenBank	Cyclase family protein	Sfla_5330	Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD)
16	Q4R0M8_STRCX (Q4R0M8)	4e-72	275	61%	UniProt GenBank	ChaG protein	chaG	Streptomyces chartreusis
17	Q7MZT2_PHOLL (Q7MZT2)	1e-53	214	41%	UniProt GenBank	Similar to polyketide cyclase	plu4192	Photorhabdus luminescens subsp. laumondii (strain TT01)
18	A5UTI1_ROSS1 (A5UTI1)	2e-49	200	44%	UniProt GenBank	Cyclase family protein	RoseRS_1541	Roseiflexus sp. (strain RS-1)
19	A7NLJ2_ROSCS (A7NLJ2)	4e-49	199	44%	UniProt GenBank	Cyclase family protein	Rcas_2300	Roseiflexus castenholzii (strain DSM 13941 / HLO8)
20	A0QWH8_MYCS2 (A0QWH8)	2e-48	197	48%	UniProt GenBank	Polyketide cyclase	MSMEG_2947	Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
21	E3C7H6_9LACO (E3C7H6)	4e-48	196	39%	UniProt GenBank	Putative cyclase	HMPREF9265_1205	Lactobacillus oris PB013-T2-3
22	B9JI03_AGRRK (B9JI03)	5e-47	192	48%	UniProt GenBank	Cyclase	Arad_8216	Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
23	D3STQ2_NATMM (D3STQ2)	1e-46	191	40%	UniProt GenBank	Cyclase family protein	Nmag_1493	Natrialba magadii (strain ATCC 43099 / DSM 3394 / NCIMB 2190 / MS3) Natronobacterium magadii
24	Q0SB98_RHOSR (Q0SB98)	2e-46	190	50%	UniProt GenBank	Possible cyclase	RHA1_ro03385	Rhodococcus sp. (strain RHA1)
25	A8MJJ2_ALKOO (A8MJJ2)	2e-46	190	40%	UniProt GenBank	Cyclase family protein	Clos_2442	Alkaliphilus oremlandii (strain OhILAs) Clostridium oremlandii (strain OhILAs)
26	C6JPN0_FUSVA (C6JPN0)	8e-46	188	39%	UniProt GenBank	Cyclase	FVAG_00930	Fusobacterium varium ATCC 27725
27	F8GVF4_CUPNE (F8GVF4)	1e-45	187	41%	UniProt GenBank	Cyclase protein	CNE_BB1p00860	Cupriavidus necator N-1
28	Q1ATU7_RUBXD (Q1ATU7)	1e-45	187	42%	UniProt GenBank	Putative cyclase	Rxyl_2245	Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
29	D2RQE4_HALTV (D2RQE4)	2e-45	187	44%	UniProt GenBank	Cyclase family protein	Htur_3459	Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734) Halococcus turkmenicus
30	D2QNY6_SPILD (D2QNY6)	2e-45	186	42%	UniProt GenBank	Cyclase family protein	Slin_1543	Spirosoma linguale (strain ATCC 33905 / DSM 74 / LMG 10896)
31	F6F1S0_SPHCR (F6F1S0)	4e-45	186	44%	UniProt GenBank	Cyclase family protein	Sphch_3905	Sphingobium chlorophenolicum L-1
32	F3L0C7_9GAMM (F3L0C7)	4e-45	186	45%	UniProt GenBank	Cyclase family protein	IMCC3088_843	gamma proteobacterium IMCC3088
33	C9BE73_ENTFC (C9BE73)	7e-45	185	40%	UniProt GenBank	Cyclase	EFSG_00464	Enterococcus faecium 1,141,733
34	D4VXF1_ENTFC (D4VXF1)	1e-44	184	40%	UniProt GenBank	Putative cyclase	CUO_0236	Enterococcus faecium PC4.1
35	C9AGV4_ENTFC (C9AGV4)	1e-44	184	40%	UniProt GenBank	Cyclase	EFVG_00437	Enterococcus faecium Com12
36	C2HCD4_ENTFC (C2HCD4)	1e-44	184	40%	UniProt GenBank	Cyclase family protein	HMPREF0352_1866	Enterococcus faecium TX1330
37	D9W8F5_9ACTO (D9W8F5)	2e-44	183	43%	UniProt GenBank	Putative cyclase	SSOG_02376	Streptomyces himastatinicus ATCC 53653
38	A0Z2E6_9GAMM (A0Z2E6)	3e-44	183	44%	UniProt GenBank	Putative cyclase	MGP2080_11983	marine gamma proteobacterium HTCC2080
39	F6GAZ3_RALSO (F6GAZ3)	3e-44	182	44%	UniProt GenBank	Cyclase protein	RSPO_m01491	Ralstonia solanacearum Po82
40	Q470M5_CUPPJ (Q470M5)	3e-44	182	45%	UniProt GenBank	Putative cyclase	Reut_A1793	Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) Alcaligenes eutrophus Ralstonia eutropha
41	A1BB13_PARDP (A1BB13)	4e-44	182	48%	UniProt GenBank	Cyclase family protein	Pden_4646	Paracoccus denitrificans (strain Pd 1222)
42	B5S9N2_RALSO (B5S9N2)	4e-44	182	44%	UniProt GenBank	Cyclase protein	RSMK04792	Ralstonia solanacearum Pseudomonas solanacearum
43	F4CY90_9PSEU (F4CY90)	4e-44	182	44%	UniProt GenBank	Cyclase family protein	Psed_2509	Pseudonocardia dioxanivorans CB1190
44	B5SA82_RALSO (B5SA82)	4e-44	182	44%	UniProt GenBank	Putative cyclase protein	RSIPO_04457	Ralstonia solanacearum Pseudomonas solanacearum
45	A3RYM2_RALSO (A3RYM2)	4e-44	182	44%	UniProt GenBank	Predicted metal-dependent hydrolase	RRSL_00918	Ralstonia solanacearum UW551
46	E0I596_9BACL (E0I596)	5e-44	182	39%	UniProt GenBank	Cyclase family protein	PaecuDRAFT_0818	Paenibacillus curdlanolyticus YK9
47	C6CY72_PAESJ (C6CY72)	6e-44	182	38%	UniProt GenBank	Cyclase family protein	Pjdr2_2113	Paenibacillus sp. (strain JDR-2)
48	A8IMQ1_AZOC5 (A8IMQ1)	6e-44	182	47%	UniProt GenBank	Putative cyclase	AZC_0592	Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571)
49	D8P2K4_RALSO (D8P2K4)	7e-44	181	44%	UniProt GenBank	Putative cyclase	RCFBP_mp10352	Ralstonia solanacearum Pseudomonas solanacearum
50	D8J0X1_HERSS (D8J0X1)	1e-43	181	47%	UniProt GenBank	Cyclase protein	Hsero_1009	Herbaspirillum seropedicae (strain SmR1)
51	B9C5M7_9BURK (B9C5M7)	1e-43	181	46%	UniProt GenBank	Polyketide cyclase	BURMUCGD2M_5970	Burkholderia multivorans CGD2M
52	B9BLM3_9BURK (B9BLM3)	1e-43	181	46%	UniProt GenBank	Polyketide cyclase	BURMUCGD2_5981	Burkholderia multivorans CGD2
53	B1YYP0_BURA4 (B1YYP0)	2e-43	180	46%	UniProt GenBank	Cyclase family protein	BamMC406_4826	Burkholderia ambifaria (strain MC40-6)
54	F7V2P6_9CLOT (F7V2P6)	2e-43	180	40%	UniProt GenBank	Uncharacterized ACR protein	CXIVA_10580	Clostridium sp. SY8519
55	Q39M12_BURS3 (Q39M12)	2e-43	180	45%	UniProt GenBank	Putative cyclase	Bcep18194_C7460	Burkholderia sp. (strain 383) Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)
56	B8KHR1_9GAMM (B8KHR1)	2e-43	180	45%	UniProt GenBank	Cyclase family protein	NOR53_1929	gamma proteobacterium NOR5-3
57	A5VBU4_SPHWW (A5VBU4)	6e-43	179	44%	UniProt GenBank	Cyclase family protein	Swit_3414	Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
58	B1FBF4_9BURK (B1FBF4)	7e-43	178	45%	UniProt GenBank	Cyclase family protein	BamIOP4010DRAFT_1363	Burkholderia ambifaria IOP40-10
59	B2AIL0_CUPTR (B2AIL0)	7e-43	178	46%	UniProt GenBank	Putative cyclase	RALTA_B0414	Cupriavidus taiwanensis (strain R1 / LMG 19424) Ralstonia taiwanensis (strain LMG 19424)
60	B9B7K8_9BURK (B9B7K8)	8e-43	178	47%	UniProt GenBank	Polyketide cyclase	BURMUCGD1_4919	Burkholderia multivorans CGD1
61	A4JED9_BURVG (A4JED9)	8e-43	178	46%	UniProt GenBank	Cyclase family protein	Bcep1808_1635	Burkholderia vietnamiensis (strain G4 / LMG 22486) Burkholderia cepacia (strain R1808)
62	E6TNN5_MYCSR (E6TNN5)	8e-43	178	44%	UniProt GenBank	Predicted metal-dependent hydrolase	Mspyr1_51850	Mycobacterium sp. (strain Spyr1)
63	A4T4B4_MYCGI (A4T4B4)	8e-43	178	44%	UniProt GenBank	Cyclase family protein	Mflv_1005	Mycobacterium gilvum (strain PYR-GCK) Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)
64	Q9F6D2_9ACTO (Q9F6D2)	9e-43	178	46%	UniProt GenBank	Cyclase	zhuJ	Streptomyces sp. R1128
65	Q1BIS5_BURCA (Q1BIS5)	1e-42	177	46%	UniProt GenBank	Putative cyclase	Bcen_5611	Burkholderia cenocepacia (strain AU 1054)
66	A0KBZ5_BURCH (A0KBZ5)	1e-42	177	46%	UniProt GenBank	Cyclase family protein	Bcen2424_5975	Burkholderia cenocepacia (strain HI2424)
67	C6A4Y1_THESM (C6A4Y1)	1e-42	177	41%	UniProt GenBank	Cyclase family protein	TSIB_1625	Thermococcus sibiricus (strain MM 739 / DSM 12597)
68	E5WAK5_9BACI (E5WAK5)	1e-42	177	39%	UniProt GenBank	Putative uncharacterized protein	HMPREF1012_03914	Bacillus sp. BT1B_CT2
69	B5WKU7_9BURK (B5WKU7)	1e-42	177	46%	UniProt GenBank	Cyclase family protein	BH160DRAFT_3700	Burkholderia sp. H160
70	Q89HD3_BRAJA (Q89HD3)	3e-42	176	43%	UniProt GenBank	Blr6059 protein	blr6059	Bradyrhizobium japonicum
71	C1FJH1_MICSR (C1FJH1)	4e-42	176	46%	UniProt GenBank	Predicted protein	MICPUN_87321	Micromonas sp. (strain RCC299 / NOUM17) Picoplanktonic green alga
72	Q11L41_MESSB (Q11L41)	5e-42	176	45%	UniProt GenBank	Putative cyclase	Meso_0480	Mesorhizobium sp. (strain BNC1)
73	F7QNH4_9BRAD (F7QNH4)	6e-42	175	43%	UniProt GenBank	Cyclase	CSIRO_3122	Bradyrhizobiaceae bacterium SG-6C
74	A4YZ46_BRASO (A4YZ46)	6e-42	175	44%	UniProt GenBank	Putative cyclase	BRADO5497	Bradyrhizobium sp. (strain ORS278)
75	D5RJK7_9PROT (D5RJK7)	6e-42	175	49%	UniProt GenBank	Probable cyclase	HMPREF0731_1267	Roseomonas cervicalis ATCC 49957
76	D9VFF4_9ACTO (D9VFF4)	6e-42	175	47%	UniProt GenBank	Cyclase	SSMG_03758	Streptomyces sp. AA4
77	Q65N24_BACLD (Q65N24)	7e-42	175	39%	UniProt GenBank	Putative uncharacterized protein	BL02015 BLi00591	Bacillus licheniformis (strain DSM 13 / ATCC 14580)
78	D3P4T9_AZOS1 (D3P4T9)	8e-42	175	47%	UniProt GenBank	Protein	AZL_c03750	Azospirillum sp. (strain B510)
79	B0T5J6_CAUSK (B0T5J6)	1e-41	174	45%	UniProt GenBank	Cyclase family protein	Caul_0417	Caulobacter sp. (strain K31)
80	D9QIT6_BRESC (D9QIT6)	1e-41	174	46%	UniProt GenBank	Cyclase family protein	Bresu_2109	Brevundimonas subvibrioides (strain ATCC 15264 / DSM 4735 / LMG 14903 / NBRC 16000 / CB 81) Caulobacter subvibrioides
81	A5EP24_BRASB (A5EP24)	1e-41	174	44%	UniProt GenBank	Putative cyclase	BBta_5979	Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
82	Q6N497_RHOPA (Q6N497)	1e-41	174	43%	UniProt GenBank	Putative cyclase	RPA3442	Rhodopseudomonas palustris
83	D2THH3_CITRI (D2THH3)	2e-41	174	40%	UniProt GenBank	Putative uncharacterized protein	ROD_14041	Citrobacter rodentium (strain ICC168) Citrobacter freundii biotype 4280
84	B7X2X0_COMTE (B7X2X0)	2e-41	174	45%	UniProt GenBank	Cyclase family protein	CtesDRAFT_PD3470	Comamonas testosteroni KF-1
85	F4L2P9_HALH1 (F4L2P9)	2e-41	174	41%	UniProt GenBank	Cyclase family protein	Halhy_0705	Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O)
86	B8FAE3_DESAA (B8FAE3)	3e-41	173	41%	UniProt GenBank	Cyclase family protein	Dalk_1541	Desulfatibacillum alkenivorans (strain AK-01)
87	Q1GTT2_SPHAL (Q1GTT2)	3e-41	172	44%	UniProt GenBank	Putative cyclase	Sala_1225	Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) Sphingomonas alaskensis
88	Q5YUM7_NOCFA (Q5YUM7)	5e-41	172	46%	UniProt GenBank	Putative cyclase	NFA_32670	Nocardia farcinica
89	Q2N7W3_ERYLH (Q2N7W3)	6e-41	172	40%	UniProt GenBank	Putative cyclase	ELI_10680	Erythrobacter litoralis (strain HTCC2594)
90	Q3INL7_NATPD (Q3INL7)	6e-41	172	40%	UniProt GenBank	Putative uncharacterized protein	NP4388A	Natronomonas pharaonis (strain DSM 2160 / ATCC 35678)
91	A4A9M0_9GAMM (A4A9M0)	6e-41	172	41%	UniProt GenBank	Putative cyclase	KT71_07404	Congregibacter litoralis KT71
92	F8EG38_9BACT (F8EG38)	7e-41	172	40%	UniProt GenBank	Cyclase family protein	Runsl_0473	Runella slithyformis DSM 19594
93	Q5NTM8_9BACT (Q5NTM8)	8e-41	171	40%	UniProt GenBank	Cyclase	bzo71-4	uncultured bacterium
94	C5CW66_VARPS (C5CW66)	8e-41	171	44%	UniProt GenBank	Cyclase family protein	Vapar_0101	Variovorax paradoxus (strain S110)
95	A6W029_MARMS (A6W029)	9e-41	171	44%	UniProt GenBank	Cyclase family protein	Mmwyl1_3149	Marinomonas sp. (strain MWYL1)
96	B8KND8_9GAMM (B8KND8)	9e-41	171	40%	UniProt GenBank	Cyclase family protein	NOR53_2638	gamma proteobacterium NOR5-3
97	E1QDZ4_DESB2 (E1QDZ4)	1e-40	171	42%	UniProt GenBank	Cyclase family protein	Deba_0405	Desulfarculus baarsii (strain ATCC 33931 / DSM 2075 / VKM B-1802 / 2st14)
98	A0YCA5_9GAMM (A0YCA5)	2e-40	170	43%	UniProt GenBank	Putative cyclase	GP2143_07739	marine gamma proteobacterium HTCC2143
99	Q5LV67_SILPO (Q5LV67)	3e-40	169	38%	UniProt GenBank	Cyclase, putative	SPO0835	Silicibacter pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)
100	C0ZIS6_BREBN (C0ZIS6)	5e-40	169	40%	UniProt GenBank	Putative uncharacterized protein	BBR47_03170	Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

O68500_STRPE
(O68500)

1e-155

550

100%

Product: Polyketide cyclase
Gene: dpsY
Organism: Streptomyces peucetius

1uniprot[Pubmed] 9573189 [Medline] 98233733
The Streptomyces peucetius dpsY and dnrX genes govern early and late steps of daunorubicin and doxorubicin biosynthesis.(J. Bacteriol.) [1998]

Q54196_STRGR
(Q54196)

1e-126

456

85%

Product: DNA sequence for ORF's 1-6
Gene
Organism: Streptomyces griseus

1uniprot[Pubmed] 8232204 [Medline] 94049680
Nucleotide sequence analysis of five putative Streptomyces griseus genes, one of which complements an early function in daunorubicin biosynthesis that is linked to a putative gene cluster involved in TDP-daunosamine formation.(Mol. Gen. Genet.) [1993]

Q9RN54_STRNO
(Q9RN54)

1e-101

372

69%

Product: Putative polyketide cyclase
Gene: snoaM
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
2uniprot[Pubmed] 10639368 [Medline] 20106987 Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.(Antimicrob. Agents Chemother.) [2000]

Q2PA03_9ACTO
(Q2PA03)

1e-100

368

69%

Product: Cyclase
Gene: stfY
Organism: Streptomyces steffisburgensis

1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006]

Q9L4U2_9ACTO
(Q9L4U2)

4e-99

365

70%

Product: Putative cyclase
Gene: aknW
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 11016846 [Medline] 20469061
A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.(Mol. Gen. Genet.) [2000]

Q194Q6_STRAA
(Q194Q6)

5e-95

352

68%

Product: Cyclase
Gene: mtmY
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

C0JWC6_9ACTO
(C0JWC6)

8e-94

347

67%

Product: PokC2
Gene: pokC2
Organism: Streptomyces diastatochromogenes

1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]

Q3S8Q2_STRRM
(Q3S8Q2)

6e-89

331

65%

Product: OxyN
Gene: oxyN
Organism: Streptomyces rimosus

1uniprot[Pubmed] 16597959
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006]

D7BZQ8_STRBB
(D7BZQ8)

8e-87

324

68%

Product: Polyketide cyclase
Gene: SBI_06843
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

Q4R0M8_STRCX
(Q4R0M8)

4e-72

275

61%

Product: ChaG protein
Gene: chaG
Organism: Streptomyces chartreusis

1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]

Q7MZT2_PHOLL
(Q7MZT2)

1e-53

214

41%

Product: Similar to polyketide cyclase
Gene: plu4192
Organism: Photorhabdus luminescens subsp. laumondii (strain TT01)

1uniprot[Pubmed] 14528314 [Medline] 22957627
The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens.(Nat. Biotechnol.) [2003]

B9JI03_AGRRK
(B9JI03)

5e-47

192

48%

Product: Cyclase
Gene: Arad_8216
Organism: Agrobacterium radiobacter (strain K84 / ATCC BAA-868)

1uniprot[Pubmed] 19251847
Genome sequences of three Agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria.(J. Bacteriol.) [2009]

Q0SB98_RHOSR
(Q0SB98)

2e-46

190

50%

Product: Possible cyclase
Gene: RHA1_ro03385
Organism: Rhodococcus sp. (strain RHA1)

1uniprot[Pubmed] 17030794
The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

D2RQE4_HALTV
(D2RQE4)

2e-45

187

44%

Product: Cyclase family protein
Gene: Htur_3459
Organism: Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734)
Halococcus turkmenicus

1uniprot[Pubmed] 21304683
Complete genome sequence of Haloterrigena turkmenica type strain (4k).(Stand. Genomic Sci.) [2009]

F3L0C7_9GAMM
(F3L0C7)

4e-45

186

45%

Product: Cyclase family protein
Gene: IMCC3088_843
Organism: gamma proteobacterium IMCC3088

1uniprot[Pubmed] 21551310
Genome Sequence of Strain IMCC3088, a Proteorhodopsin-Containing Marine Bacterium Belonging to the OM60/NOR5 Clade.(J. Bacteriol.) [2011]

A0Z2E6_9GAMM
(A0Z2E6)

3e-44

183

44%

Product: Putative cyclase
Gene: MGP2080_11983
Organism: marine gamma proteobacterium HTCC2080

1uniprot[Pubmed] 20472793
Genome sequences of strains HTCC2148 and HTCC2080, belonging to the OM60/NOR5 clade of the Gammaproteobacteria.(J. Bacteriol.) [2010]

A3RYM2_RALSO
(A3RYM2)

4e-44

182

44%

Product: Predicted metal-dependent hydrolase
Gene: RRSL_00918
Organism: Ralstonia solanacearum UW551

1uniprot[Pubmed] 16404955
Identification of open reading frames unique to a select agent: Ralstonia solanacearum race 3 biovar 2.(Mol. Plant Microbe Interact.) [2006]

D8P2K4_RALSO
(D8P2K4)

7e-44

181

44%

Product: Putative cyclase
Gene: RCFBP_mp10352
Organism: Ralstonia solanacearum
Pseudomonas solanacearum

1uniprot
Genomes of three tomato pathogens within the Ralstonia solanacearum species complex reveal significant evolutionary divergence.(BMC Genomics) [2010]

B2AIL0_CUPTR
(B2AIL0)

7e-43

178

46%

Product: Putative cyclase
Gene: RALTA_B0414
Organism: Cupriavidus taiwanensis (strain R1 / LMG 19424)
Ralstonia taiwanensis (strain LMG 19424)

1uniprot[Pubmed] 18490699
Genome sequence of the beta-rhizobium Cupriavidus taiwanensis and comparative genomics of rhizobia.(Genome Res.) [2008]

Q9F6D2_9ACTO
(Q9F6D2)

9e-43

178

46%

Product: Cyclase
Gene: zhuJ
Organism: Streptomyces sp. R1128

1uniprot[Pubmed] 10931852 [Medline] 20517899
Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism.(J. Biol. Chem.) [2000]

C6A4Y1_THESM
(C6A4Y1)

1e-42

177

41%

Product: Cyclase family protein
Gene: TSIB_1625
Organism: Thermococcus sibiricus (strain MM 739 / DSM 12597)

1uniprot[Pubmed] 19447963
Metabolic versatility and indigenous origin of the archaeon Thermococcus sibiricus, isolated from a siberian oil reservoir, as revealed by genome analysis.(Appl. Environ. Microbiol.) [2009]

Q89HD3_BRAJA
(Q89HD3)

3e-42

176

43%

Product: Blr6059 protein
Gene: blr6059
Organism: Bradyrhizobium japonicum

1uniprot[Pubmed] 12597275 [Medline] 22484998
Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110.(DNA Res.) [2002]

C1FJH1_MICSR
(C1FJH1)

4e-42

176

46%

Product: Predicted protein
Gene: MICPUN_87321
Organism: Micromonas sp. (strain RCC299 / NOUM17)
Picoplanktonic green alga

1uniprot[Pubmed] 19359590
Green evolution and dynamic adaptations revealed by genomes of the marine picoeukaryotes Micromonas.(Science) [2009]

A4YZ46_BRASO
(A4YZ46)

6e-42

175

44%

Product: Putative cyclase
Gene: BRADO5497
Organism: Bradyrhizobium sp. (strain ORS278)

1uniprot[Pubmed] 17540897
Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.(Science) [2007]

Q65N24_BACLD
(Q65N24)

7e-42

175

39%

Product: Putative uncharacterized protein
Gene: BL02015
BLi00591
Organism: Bacillus licheniformis (strain DSM 13 / ATCC 14580)

[pubmed all]
1uniprot[Pubmed] 15383718 The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential.(J. Mol. Microbiol. Biotechnol.) [2004]
2uniprot[Pubmed] 15461803 Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species.(Genome Biol.) [2004]

D3P4T9_AZOS1
(D3P4T9)

8e-42

175

47%

Product: Protein
Gene: AZL_c03750
Organism: Azospirillum sp. (strain B510)

1uniprot[Pubmed] 20047946
Complete genomic structure of the cultivated rice endophyte Azospirillum sp. B510.(DNA Res.) [2010]

A5EP24_BRASB
(A5EP24)

1e-41

174

44%

Product: Putative cyclase
Gene: BBta_5979
Organism: Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)

1uniprot[Pubmed] 17540897
Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.(Science) [2007]

Q6N497_RHOPA
(Q6N497)

1e-41

174

43%

Product: Putative cyclase
Gene: RPA3442
Organism: Rhodopseudomonas palustris

1uniprot[Pubmed] 14704707
Complete genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris.(Nat. Biotechnol.) [2004]

D2THH3_CITRI
(D2THH3)

2e-41

174

40%

Product: Putative uncharacterized protein
Gene: ROD_14041
Organism: Citrobacter rodentium (strain ICC168)
Citrobacter freundii biotype 4280

1uniprot[Pubmed] 19897651
The Citrobacter rodentium genome sequence reveals convergent evolution with human pathogenic Escherichia coli.(J. Bacteriol.) [2010]

B7X2X0_COMTE
(B7X2X0)

2e-41

174

45%

Product: Cyclase family protein
Gene: CtesDRAFT_PD3470
Organism: Comamonas testosteroni KF-1

1uniprot[Pubmed] 15240283
Mineralization of individual congeners of linear alkylbenzenesulfonate by defined pairs of heterotrophic bacteria.(Appl. Environ. Microbiol.) [2004]

F4L2P9_HALH1
(F4L2P9)

2e-41

174

41%

Product: Cyclase family protein
Gene: Halhy_0705
Organism: Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O)

1uniprot
Complete genome sequence of Haliscomenobacter hydrossis type strain (O).(Stand. Genomic Sci.) [2011]

Q5YUM7_NOCFA
(Q5YUM7)

5e-41

172

46%

Product: Putative cyclase
Gene: NFA_32670
Organism: Nocardia farcinica

1uniprot[Pubmed] 15466710
The complete genomic sequence of Nocardia farcinica IFM 10152.(Proc. Natl. Acad. Sci. U.S.A.) [2004]

Q2N7W3_ERYLH
(Q2N7W3)

6e-41

172

40%

Product: Putative cyclase
Gene: ELI_10680
Organism: Erythrobacter litoralis (strain HTCC2594)

1uniprot[Pubmed] 19168610
Complete genome sequence of Erythrobacter litoralis HTCC2594.(J. Bacteriol.) [2009]

Q3INL7_NATPD
(Q3INL7)

6e-41

172

40%

Product: Putative uncharacterized protein
Gene: NP4388A
Organism: Natronomonas pharaonis (strain DSM 2160 / ATCC 35678)

1uniprot[Pubmed] 16169924
Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis.(Genome Res.) [2005]

A4A9M0_9GAMM
(A4A9M0)

6e-41

172

41%

Product: Putative cyclase
Gene: KT71_07404
Organism: Congregibacter litoralis KT71

[pubmed all]
1uniprot[Pubmed] 19287491 The photosynthetic apparatus and its regulation in the aerobic gammaproteobacterium Congregibacter litoralis gen. nov., sp. nov.(PLoS ONE) [2009]
2uniprot[Pubmed] 17299055 Characterization of a marine gammaproteobacterium capable of aerobic anoxygenic photosynthesis.(Proc. Natl. Acad. Sci. U.S.A.) [2007]

Q5NTM8_9BACT
(Q5NTM8)

8e-41

171

40%

Product: Cyclase
Gene: bzo71-4
Organism: uncultured bacterium

1uniprot[Pubmed] 15608629
Substrate-induced gene-expression screening of environmental metagenome libraries for isolation of catabolic genes.(Nat. Biotechnol.) [2005]

C5CW66_VARPS
(C5CW66)

8e-41

171

44%

Product: Cyclase family protein
Gene: Vapar_0101
Organism: Variovorax paradoxus (strain S110)

1uniprot[Pubmed] 21183664
Complete genome sequence of the metabolically versatile plant growth-promoting endophyte, Variovorax paradoxus S110.(J. Bacteriol.) [2011]

E1QDZ4_DESB2
(E1QDZ4)

1e-40

171

42%

Product: Cyclase family protein
Gene: Deba_0405
Organism: Desulfarculus baarsii (strain ATCC 33931 / DSM 2075 / VKM B-1802 / 2st14)

1uniprot
Complete genome sequence of Desulfarculus baarsii type strain (2st14).(Stand. Genomic Sci.) [2010]

A0YCA5_9GAMM
(A0YCA5)

2e-40

170

43%

Product: Putative cyclase
Gene: GP2143_07739
Organism: marine gamma proteobacterium HTCC2143

1uniprot[Pubmed] 20601481
Genome sequence of the oligotrophic marine Gammaproteobacterium HTCC2143, isolated from the Oregon Coast.(J. Bacteriol.) [2010]

Q5LV67_SILPO
(Q5LV67)

3e-40

169

38%

Product: Cyclase, putative
Gene: SPO0835
Organism: Silicibacter pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)

1uniprot[Pubmed] 15602564
Genome sequence of Silicibacter pomeroyi reveals adaptations to the marine environment.(Nature) [2004]