BLAST table : Cosmo_00100

DB	UniProtKB

	accession	alignment	Evalue	Score	Ident.	link	product	gene	organism	ec
1	Q2PZR6_9ACTO (Q2PZR6)		0.0	662	100%	UniProt GenBank	CosF	cosF	Streptomyces olindensis
2	Q8VWA9_9ACTO (Q8VWA9)		1e-102	375	68%	UniProt GenBank	AknF	aknF	Streptomyces galilaeus
3	Q9L547_9ACTO (Q9L547)		1e-100	370	67%	UniProt GenBank	AknF	aknF	Streptomyces galilaeus
4	Q55226_STRSQ (Q55226)		2e-89	334	58%	UniProt GenBank	Acyltransferase	dauA	Streptomyces sp
5	Q3S8Q0_STRRM (Q3S8Q0)		5e-89	332	59%	UniProt GenBank	OxyP	oxyP	Streptomyces rimosus
6	B5G882_9ACTO (B5G882)		3e-87	326	64%	UniProt GenBank	Modular polyketide synthase	SSBG_00490	Streptomyces sp. SPB74
7	Q54817_STRPE (Q54817)		8e-85	318	56%	UniProt GenBank	Daunorubicin-doxorubicin polyketide synthase	dpsD	Streptomyces peucetius
8	E8W967_STRFA (E8W967)		1e-78	298	59%	UniProt GenBank	Acyl transferase	Sfla_5333	Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD)
9	D9UBR5_STRPR (D9UBR5)		2e-75	287	52%	UniProt GenBank	Putative acyltransferase	cpp19	Streptomyces pristinaespiralis	2.3.1.94 niceE keggE
10	B5HIU7_STRPR (B5HIU7)		2e-75	287	52%	UniProt GenBank	Acyl transferase domain-containing protein	SSDG_05084	Streptomyces pristinaespiralis ATCC 25486
11	E2EKJ3_9ACTO (E2EKJ3)		3e-75	286	53%	UniProt GenBank	Acyl-ACP-thioesterase	san2	Streptomyces sp. SANK 61196
12	Q2MGD7_STRGR (Q2MGD7)		2e-74	284	51%	UniProt GenBank	Putative acyl transferase		Streptomyces griseus
13	D2SYY7_MICEC (D2SYY7)		3e-73	280	52%	UniProt GenBank	Acyl transferase		Micromonospora echinospora subsp. challisensis
14	Q67G33_9ACTO (Q67G33)		2e-70	270	52%	UniProt GenBank	Putative acyltransferase		Streptomyces griseoruber
15	A4X727_SALTO (A4X727)		3e-69	266	52%	UniProt GenBank	Acyl transferase domain protein	Strop_2226	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
16	D1A6S4_THECD (D1A6S4)		2e-68	263	50%	UniProt GenBank	Acyl transferase	Tcur_2783	Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
17	Q9F6D9_9ACTO (Q9F6D9)		1e-67	261	53%	UniProt GenBank	Acyl transferase	zhuC	Streptomyces sp. R1128
18	Q9KHK3_9ACTO (Q9KHK3)		8e-59	232	45%	UniProt GenBank	Putative acyl transferase EncL	encL	Streptomyces maritimus
19	D2XDZ7_9PSEU (D2XDZ7)		1e-56	225	46%	UniProt GenBank	AzicK	azicK	Kibdelosporangium sp. MJ126-NF4
20	D6MSU7_9ACTO (D6MSU7)		2e-55	221	49%	UniProt GenBank	SsfV	ssfV	Streptomyces sp. SF2575
21	Q47QK0_THEFY (Q47QK0)		2e-54	217	46%	UniProt GenBank	Modular polyketide synthase	Tfu_1231	Thermobifida fusca (strain YX)
22	O68917_9ACTO (O68917)		1e-51	208	47%	UniProt GenBank	Putative acyltransferase for starter unit	frnK	Streptomyces roseofulvus
23	E5RLL4_9ACTO (E5RLL4)		2e-51	207	49%	UniProt GenBank	Putative acyltransferase	pnxJ	Streptomyces sp. TA-0256
24	D9UKN4_9ACTO (D9UKN4)		3e-51	207	48%	UniProt GenBank	CosF	SSLG_05750	Streptomyces sp. SPB78
25	E6TM66_MYCSR (E6TM66)		3e-50	204	41%	UniProt GenBank	Polyketide synthase family protein	Mspyr1_27210	Mycobacterium sp. (strain Spyr1)
26	A1T9S5_MYCVP (A1T9S5)		6e-50	202	44%	UniProt GenBank	Beta-ketoacyl synthase	Mvan_3123	Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
27	A4TAA3_MYCGI (A4TAA3)		2e-49	201	41%	UniProt GenBank	Beta-ketoacyl synthase	Mflv_3390	Mycobacterium gilvum (strain PYR-GCK) Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)
28	B2IXJ8_NOSP7 (B2IXJ8)		4e-49	199	35%	UniProt GenBank	Beta-ketoacyl synthase	Npun_R3024	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	2.3.1.94 niceE keggE
29	D1H0J4_9ACTO (D1H0J4)		2e-48	197	46%	UniProt GenBank	Putative acyltransferase	ravQ	Streptomyces sp. C23201NS3
30	B2HIM7_MYCMM (B2HIM7)		2e-48	197	41%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase PpsE	ppsE MMAR_1772	Mycobacterium marinum (strain ATCC BAA-535 / M)
31	D1H0A7_9ACTO (D1H0A7)		2e-48	197	48%	UniProt GenBank	Putative propionyl-CoA carrier protein transacylase	chryQ	Streptomyces albaduncus
32	A9AV05_HERA2 (A9AV05)	(2 hsp)	1e-47	195	40%	UniProt GenBank	Beta-ketoacyl synthase	Haur_3961	Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
33	A0PQ35_MYCUA (A0PQ35)		1e-47	194	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase PpsE	ppsE MUL_2015	Mycobacterium ulcerans (strain Agy99)
34	D8PF63_9BACT (D8PF63)		4e-47	193	39%	UniProt GenBank	Putative Polyketide synthase	NIDE2152	Candidatus Nitrospira defluvii
35	F5YU20_9MYCO (F5YU20)		6e-46	189	42%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase PpsE	ppsE JDM601_2211	Mycobacterium sp. JDM601
36	B9XIK8_9BACT (B9XIK8)		8e-46	189	36%	UniProt GenBank	Beta-ketoacyl synthase	Cflav_PD2967	Pedosphaera parvula Ellin514
37	Q1D6A6_MYXXD (Q1D6A6)		1e-45	188	39%	UniProt GenBank	Polyketide synthase type I	MXAN_3630	Myxococcus xanthus (strain DK 1622)
38	E3FQV3_STIAD (E3FQV3)		1e-45	188	39%	UniProt GenBank	Polyketide synthase type I	STAUR_4204	Stigmatella aurantiaca (strain DW4/3-1)
39	Q08TI6_STIAD (Q08TI6)		2e-45	187	39%	UniProt GenBank	JamP	STIAU_6402	Stigmatella aurantiaca (strain DW4/3-1)
40	Q1D437_MYXXD (Q1D437)		3e-45	187	37%	UniProt GenBank	Non-ribosomal peptide synthetase/polyketide synthase	MXAN_4415	Myxococcus xanthus (strain DK 1622)
41	E2VLB9_MYCTU (E2VLB9)		5e-45	186	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppse	TMIG_02438	Mycobacterium tuberculosis SUMu009
42	E2UPW6_MYCTU (E2UPW6)		5e-45	186	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppse	TMFG_00136	Mycobacterium tuberculosis SUMu006
43	E2UDP5_MYCTU (E2UDP5)		5e-45	186	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppse	TMEG_02204	Mycobacterium tuberculosis SUMu005
44	E2U126_MYCTU (E2U126)		5e-45	186	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppse	TMDG_00132	Mycobacterium tuberculosis SUMu004
45	E2TQE1_MYCTU (E2TQE1)		5e-45	186	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppse	TMCG_02187	Mycobacterium tuberculosis SUMu003
46	E2TD96_MYCTU (E2TD96)		5e-45	186	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppse	TMBG_03085	Mycobacterium tuberculosis SUMu002
47	E2VCA5_MYCTU (E2VCA5)		6e-45	186	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppse	TMHG_02143	Mycobacterium tuberculosis SUMu008
48	E2V133_MYCTU (E2V133)		6e-45	186	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppse	TMGG_02472	Mycobacterium tuberculosis SUMu007
49	B4AI44_BACPU (B4AI44)		7e-45	186	34%	UniProt GenBank	Non-ribosomal peptide synthetase/polyketide synthase	BAT_3453	Bacillus pumilus ATCC 7061
50	A8FAR4_BACP2 (A8FAR4)		9e-45	185	33%	UniProt GenBank	Polyketide synthase subunit	BPUM_0639	Bacillus pumilus (strain SAFR-032)
51	B9XAZ0_9BACT (B9XAZ0)		2e-44	184	35%	UniProt GenBank	Amino acid adenylation domain protein	Cflav_PD5810	Pedosphaera parvula Ellin514
52	D6FPC7_MYCTU (D6FPC7)		3e-44	184	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppsE	TBOG_03485	Mycobacterium tuberculosis K85
53	D5XXT3_MYCTU (D5XXT3)		4e-44	183	39%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppsE	TBDG_01953	Mycobacterium tuberculosis T92
54	F8CAR9_MYXFU (F8CAR9)		4e-44	183	36%	UniProt GenBank	Polyketide synthase type I	LILAB_26145	Myxococcus fulvus
55	E9ZN23_MYCTU (E9ZN23)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppsE	TMMG_03458	Mycobacterium tuberculosis CDC1551A
56	E2W938_MYCTU (E2W938)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppse	TMKG_03370	Mycobacterium tuberculosis SUMu011
57	E2VXY2_MYCTU (E2VXY2)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppse	TMJG_01928	Mycobacterium tuberculosis SUMu010
58	E1HD28_MYCTU (E1HD28)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppse	TMAG_01138	Mycobacterium tuberculosis SUMu001
59	C1AG51_MYCBT (C1AG51)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase	ppsE JTY_2952	Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)
60	A1KMT0_MYCBP (A1KMT0)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppsE	ppsE BCG_2957	Mycobacterium bovis (strain BCG / Pasteur 1173P2)
61	F8M4T4_9MYCO (F8M4T4)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase PPSE	ppsE MAF_29400	Mycobacterium africanum GM041182
62	D6FKH0_MYCTU (D6FKH0)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppsE	TBNG_03596	Mycobacterium tuberculosis CPHL_A
63	D5ZKC7_MYCTU (D5ZKC7)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppsE	TBJG_02544	Mycobacterium tuberculosis T17
64	D5Z7C0_MYCTU (D5Z7C0)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppsE	TBIG_02297	Mycobacterium tuberculosis GM 1503
65	D5YIP5_MYCTU (D5YIP5)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppse	TBGG_02138	Mycobacterium tuberculosis EAS054
66	PPSE_MYCBO (Q7TXL6)		4e-44	183	40%	UniProt GenBank	Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsE Beta-ketoacyl-acyl-carrier-protein synthase I Beta-ketoacyl-acyl-carrier-protein synthase I	ppsE Mb2960	Mycobacterium bovis	2.3.1.41 niceE keggE
67	C6DWB9_MYCTK (C6DWB9)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppsE	TBMG_01037	Mycobacterium tuberculosis (strain KZN 1435 / MDR)
68	A5WRI7_MYCTF (A5WRI7)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppsE	TBFG_12949	Mycobacterium tuberculosis (strain F11)
69	A5U6U2_MYCTA (A5U6U2)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	ppsE MRA_2961	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
70	F7WYM5_MYCTU (F7WYM5)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppsE	CCDC5180_2659	Mycobacterium tuberculosis CCDC5180
71	F7WIY9_MYCTU (F7WIY9)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppsE	CCDC5079_2695	Mycobacterium tuberculosis CCDC5079
72	F2V8Y1_MYCTU (F2V8Y1)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppsE	TBPG_02457	Mycobacterium tuberculosis W-148
73	F2GP62_MYCTU (F2GP62)		4e-44	183	40%	UniProt GenBank	Polyketide synthase	TBSG_01045	Mycobacterium tuberculosis KZN 4207
74	E2WL78_MYCTU (E2WL78)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppse	TMLG_01429	Mycobacterium tuberculosis SUMu012
75	D7EVS7_MYCTU (D7EVS7)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppse	TBAG_01823	Mycobacterium tuberculosis 94_M4241A
76	D5YVL9_MYCTU (D5YVL9)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppse	TBBG_03142	Mycobacterium tuberculosis 02_1987
77	D5Y727_MYCTU (D5Y727)		4e-44	183	40%	UniProt GenBank	Polyketide synthase	TBEG_01719	Mycobacterium tuberculosis T85
78	A4KKJ5_MYCTU (A4KKJ5)		4e-44	183	40%	UniProt GenBank	Phenolpthiocerol synthesis type-I polyketide synthase ppsE	TBHG_02865	Mycobacterium tuberculosis str. Haarlem
79	PPSE_MYCTU (P96204)		4e-44	183	40%	UniProt GenBank	Phthiocerol synthesis polyketide synthase type I PpsE Beta-ketoacyl-acyl-carrier-protein synthase I Beta-ketoacyl-acyl-carrier-protein synthase I	ppsE MT3005 Rv2935	Mycobacterium tuberculosis	2.3.1.41 niceE keggE
80	Q5ZPA8_9DELT (Q5ZPA8)		6e-44	182	38%	UniProt GenBank	TubD protein	tubD	Angiococcus disciformis
81	Q1D592_MYXXD (Q1D592)		1e-43	181	41%	UniProt GenBank	Non-ribosomal peptide synthase/polyketide synthase	MXAN_4001	Myxococcus xanthus (strain DK 1622)
82	B8I980_CLOCE (B8I980)		1e-43	181	32%	UniProt GenBank	Beta-ketoacyl synthase	Ccel_0978	Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
83	C6XWU5_PEDHD (C6XWU5)		1e-43	181	35%	UniProt GenBank	Amino acid adenylation domain protein	Phep_2034	Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / NCIB 9290)
84	E1MJP0_9GAMM (E1MJP0)		2e-43	181	36%	UniProt GenBank	Amino acid adenylation domain protein	MettuDRAFT_0907	Methylobacter tundripaludum SV96
85	Q08MR5_STIAD (Q08MR5)		3e-43	180	37%	UniProt GenBank	JamP	STIAU_5215	Stigmatella aurantiaca (strain DW4/3-1)
86	D8I8X6_AMYMU (D8I8X6)		3e-43	180	39%	UniProt GenBank	Non-ribosomal peptide synthetase/polyketide synthase	AMED_3681	Amycolatopsis mediterranei (strain U-32)
87	Q49934_MYCLE (Q49934)		3e-43	180	37%	UniProt GenBank	PksF Polyketide synthase	ML2353	Mycobacterium leprae
88	B8ZT36_MYCLB (B8ZT36)		3e-43	180	37%	UniProt GenBank	Polyketide synthase	MLBr02353	Mycobacterium leprae (strain Br4923)
89	E3FPD0_STIAD (E3FPD0)		3e-43	180	37%	UniProt GenBank	Polyketide synthase subunit	STAUR_4158	Stigmatella aurantiaca (strain DW4/3-1)
90	B1WWV9_CYAA5 (B1WWV9)		4e-43	180	34%	UniProt GenBank	Polyketide synthase type I	cce_3080	Cyanothece sp. (strain ATCC 51142)
91	D6AV95_STRFL (D6AV95)		4e-43	180	39%	UniProt GenBank	Non-ribosomal peptide synthetase/polyketide synthase	SSGG_05710	Streptomyces roseosporus NRRL 15998
92	Q2Y7Z3_NITMU (Q2Y7Z3)		4e-43	179	35%	UniProt GenBank	Beta-ketoacyl synthase	Nmul_A1831	Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849)
93	A0Z9S2_NODSP (A0Z9S2)		5e-43	179	32%	UniProt GenBank	Polyketide synthase type I	N9414_20965	Nodularia spumigena CCY9414
94	A9AV09_HERA2 (A9AV09)	(3 hsp)	6e-43	179	35%	UniProt GenBank	Beta-ketoacyl synthase	Haur_3965	Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
95	B2J103_NOSP7 (B2J103)		7e-43	179	34%	UniProt GenBank	Beta-ketoacyl synthase	Npun_R3445	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	2.3.1.94 niceE keggE 5.1.1.11 niceE keggE
96	E7MB98_9BACL (E7MB98)		1e-42	178	32%	UniProt GenBank	Polyketide synthase-like protein 1	PL1_2113	Paenibacillus larvae subsp. larvae B-3650
97	Q1D6B5_MYXXD (Q1D6B5)		1e-42	178	37%	UniProt GenBank	Polyketide synthase type I	MXAN_3621	Myxococcus xanthus (strain DK 1622)
98	D2B1D6_STRRD (D2B1D6)		1e-42	178	39%	UniProt GenBank	Polyketide/non-ribosomal peptide synthetase	Sros_2423	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
99	D7C2B8_STRBB (D7C2B8)	(4 hsp)	2e-42	177	39%	UniProt GenBank	Type I modular polyketide synthase	pks3-2 SBI_00651	Streptomyces bingchenggensis (strain BCW-1)
100	C8TEQ8_PLARU (C8TEQ8)		3e-42	177	33%	UniProt GenBank	Putative uncharacterized protein		Planktothrix rubescens NIVA-CYA 98

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q2PZR6_9ACTO
(Q2PZR6)

0.0

662

100%

Product: CosF
Gene: cosF
Organism: Streptomyces olindensis

1uniprot[Pubmed] 16810496
Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes.(Appl. Microbiol. Biotechnol.) [2006]

Q8VWA9_9ACTO
(Q8VWA9)

1e-102

375

68%

Product: AknF
Gene: aknF
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 12399480 [Medline] 22286521
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002]

Q9L547_9ACTO
(Q9L547)

1e-100

370

67%

Product: AknF
Gene: aknF
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 12137949 [Medline] 22133312
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002]

Q55226_STRSQ
(Q55226)

2e-89

334

58%

Product: Acyltransferase
Gene: dauA
Organism: Streptomyces sp

1uniprot[Pubmed] 7928998 [Medline] 95014072
Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5.(J. Bacteriol.) [1994]

Q3S8Q0_STRRM
(Q3S8Q0)

5e-89

332

59%

Product: OxyP
Gene: oxyP
Organism: Streptomyces rimosus

1uniprot[Pubmed] 16597959
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006]

Q54817_STRPE
(Q54817)

8e-85

318

56%

Product: Daunorubicin-doxorubicin polyketide synthase
Gene: dpsD
Organism: Streptomyces peucetius

1uniprot[Pubmed] 7828855 [Medline] 95129838
Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase.(Gene) [1994]

D9UBR5_STRPR
(D9UBR5)

2e-75

287

52%

Product: Putative acyltransferase
Gene: cpp19
Organism: Streptomyces pristinaespiralis

1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]

E2EKJ3_9ACTO
(E2EKJ3)

3e-75

286

53%

Product: Acyl-ACP-thioesterase
Gene: san2
Organism: Streptomyces sp. SANK 61196

1uniprot[Pubmed] 20550125
Cloning, sequencing, heterologous expression, and mechanistic analysis of A-74528 biosynthesis.(J. Am. Chem. Soc.) [2010]

Q2MGD7_STRGR
(Q2MGD7)

2e-74

284

51%

Product: Putative acyl transferase
Gene
Organism: Streptomyces griseus

1uniprot[Pubmed] 16305230
Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus.(J. Am. Chem. Soc.) [2005]

D2SYY7_MICEC
(D2SYY7)

3e-73

280

52%

Product: Acyl transferase
Gene
Organism: Micromonospora echinospora subsp. challisensis

1uniprot[Pubmed] 19680283
TLN-05220, TLN-05223, new Echinosporamicin-type antibiotics, and proposed revision of the structure of bravomicins(*).(J. Antibiot.) [2009]

Q67G33_9ACTO
(Q67G33)

2e-70

270

52%

Product: Putative acyltransferase
Gene
Organism: Streptomyces griseoruber

1uniprot[Pubmed] 15271354
The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004]

D1A6S4_THECD
(D1A6S4)

2e-68

263

50%

Product: Acyl transferase
Gene: Tcur_2783
Organism: Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)

1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]

Q9F6D9_9ACTO
(Q9F6D9)

1e-67

261

53%

Product: Acyl transferase
Gene: zhuC
Organism: Streptomyces sp. R1128

1uniprot[Pubmed] 10931852 [Medline] 20517899
Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism.(J. Biol. Chem.) [2000]

Q9KHK3_9ACTO
(Q9KHK3)

8e-59

232

45%

Product: Putative acyl transferase EncL
Gene: encL
Organism: Streptomyces maritimus

[pubmed all]
1uniprot Natural Metabolic Diversity Encoded by the Enterocin Biosynthesis Gene Cluster.(J. Am. Chem. Soc.) [2000]
2uniprot[Pubmed] 11137817 [Medline] 20579517 Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase.(Chem. Biol.) [2000]
3uniprot[Pubmed] 11948863 [Medline] 21942282 A mechanism of benzoic acid biosynthesis in plants and bacteria that mirrors fatty acid beta-oxidation.(Chembiochem) [2001]

D2XDZ7_9PSEU
(D2XDZ7)

1e-56

225

46%

Product: AzicK
Gene: azicK
Organism: Kibdelosporangium sp. MJ126-NF4

1uniprot[Pubmed] 19928906
Biosynthetic studies of aziridine formation in azicemicins.(J. Am. Chem. Soc.) [2009]

D6MSU7_9ACTO
(D6MSU7)

2e-55

221

49%

Product: SsfV
Gene: ssfV
Organism: Streptomyces sp. SF2575

1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]

Q47QK0_THEFY
(Q47QK0)

2e-54

217

46%

Product: Modular polyketide synthase
Gene: Tfu_1231
Organism: Thermobifida fusca (strain YX)

1uniprot[Pubmed] 17209016
Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX.(J. Bacteriol.) [2007]

O68917_9ACTO
(O68917)

1e-51

208

47%

Product: Putative acyltransferase for starter unit
Gene: frnK
Organism: Streptomyces roseofulvus

1uniprot[Pubmed] 8181754 [Medline] 94237486
Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.(Gene) [1994]

B2HIM7_MYCMM
(B2HIM7)

2e-48

197

41%

Product: Phenolpthiocerol synthesis type-I polyketide synthase PpsE
Gene: ppsE
MMAR_1772
Organism: Mycobacterium marinum (strain ATCC BAA-535 / M)

1uniprot[Pubmed] 18403782
Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.(Genome Res.) [2008]

A0PQ35_MYCUA
(A0PQ35)

1e-47

194

40%

Product: Phenolpthiocerol synthesis type-I polyketide synthase PpsE
Gene: ppsE
MUL_2015
Organism: Mycobacterium ulcerans (strain Agy99)

1uniprot[Pubmed] 17210928
Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer.(Genome Res.) [2007]

D8PF63_9BACT
(D8PF63)

4e-47

193

39%

Product: Putative Polyketide synthase
Gene: NIDE2152
Organism: Candidatus Nitrospira defluvii

1uniprot
A Nitrospira metagenome illuminates the physiology and evolution of globally important nitrite-oxidizing bacteria.(Proc. Natl. Acad. Sci. U.S.A.) [2010]

B9XIK8_9BACT
(B9XIK8)

8e-46

189

36%

Product: Beta-ketoacyl synthase
Gene: Cflav_PD2967
Organism: Pedosphaera parvula Ellin514

1uniprot[Pubmed] 21460084
Genome Sequence of 'Pedosphaera parvula' Ellin514, an Aerobic Verrucomicrobial Isolate from Pasture Soil.(J. Bacteriol.) [2011]

Q1D6A6_MYXXD
(Q1D6A6)

1e-45

188

39%

Product: Polyketide synthase type I
Gene: MXAN_3630
Organism: Myxococcus xanthus (strain DK 1622)

1uniprot[Pubmed] 17015832
Evolution of sensory complexity recorded in a myxobacterial genome.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

Q1D437_MYXXD
(Q1D437)

3e-45

187

37%

Product: Non-ribosomal peptide synthetase/polyketide synthase
Gene: MXAN_4415
Organism: Myxococcus xanthus (strain DK 1622)

1uniprot[Pubmed] 17015832
Evolution of sensory complexity recorded in a myxobacterial genome.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

A8FAR4_BACP2
(A8FAR4)

9e-45

185

33%

Product: Polyketide synthase subunit
Gene: BPUM_0639
Organism: Bacillus pumilus (strain SAFR-032)

1uniprot[Pubmed] 17895969
Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032.(PLoS ONE) [2007]

B9XAZ0_9BACT
(B9XAZ0)

2e-44

184

35%

Product: Amino acid adenylation domain protein
Gene: Cflav_PD5810
Organism: Pedosphaera parvula Ellin514

1uniprot[Pubmed] 21460084
Genome Sequence of 'Pedosphaera parvula' Ellin514, an Aerobic Verrucomicrobial Isolate from Pasture Soil.(J. Bacteriol.) [2011]

C1AG51_MYCBT
(C1AG51)

4e-44

183

40%

Product: Phenolpthiocerol synthesis type-I polyketide synthase
Gene: ppsE
JTY_2952
Organism: Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)

1uniprot[Pubmed] 19200449
Whole genome sequence analysis of Mycobacterium bovis bacillus Calmette-Guerin (BCG) Tokyo 172: a comparative study of BCG vaccine substrains.(Vaccine) [2009]

A1KMT0_MYCBP
(A1KMT0)

4e-44

183

40%

Product: Phenolpthiocerol synthesis type-I polyketide synthase ppsE
Gene: ppsE
BCG_2957
Organism: Mycobacterium bovis (strain BCG / Pasteur 1173P2)

1uniprot[Pubmed] 17372194
Genome plasticity of BCG and impact on vaccine efficacy.(Proc. Natl. Acad. Sci. U.S.A.) [2007]

PPSE_MYCBO
(Q7TXL6)

4e-44

183

40%

Product: Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsE
Beta-ketoacyl-acyl-carrier-protein synthase I
Beta-ketoacyl-acyl-carrier-protein synthase I
Gene: ppsE
Mb2960
Organism: Mycobacterium bovis

[pubmed all]
1uniprot[Pubmed] 12788972 [Medline] 22709107 The complete genome sequence of Mycobacterium bovis.(Proc. Natl. Acad. Sci. U.S.A.) [2003]
2uniprot[Pubmed] 19197369 Phthiocerol dimycocerosates of M. tuberculosis participate in macrophage invasion by inducing changes in the organization of plasma membrane lipids.(PLoS Pathog.) [2009]

PPSE_MYCTU
(P96204)

4e-44

183

40%

Product: Phthiocerol synthesis polyketide synthase type I PpsE
Beta-ketoacyl-acyl-carrier-protein synthase I
Beta-ketoacyl-acyl-carrier-protein synthase I
Gene: ppsE
MT3005
Rv2935
Organism: Mycobacterium tuberculosis

[pubmed all]
1uniprot[Pubmed] 9634230 [Medline] 98295987 Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.(Nature) [1998]
2uniprot[Pubmed] 12218036 [Medline] 22206494 Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.(J. Bacteriol.) [2002]
3uniprot[Pubmed] 19099550 targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.(BMC Syst. Biol.) [2008]
4uniprot[Pubmed] 19197369 Phthiocerol dimycocerosates of M. tuberculosis participate in macrophage invasion by inducing changes in the organization of plasma membrane lipids.(PLoS Pathog.) [2009]

Q5ZPA8_9DELT
(Q5ZPA8)

6e-44

182

38%

Product: TubD protein
Gene: tubD
Organism: Angiococcus disciformis

1uniprot[Pubmed] 15324808
Identification and analysis of the core biosynthetic machinery of tubulysin, a potent cytotoxin with potential anticancer activity.(Chem. Biol.) [2004]

Q1D592_MYXXD
(Q1D592)

1e-43

181

41%

Product: Non-ribosomal peptide synthase/polyketide synthase
Gene: MXAN_4001
Organism: Myxococcus xanthus (strain DK 1622)

1uniprot[Pubmed] 17015832
Evolution of sensory complexity recorded in a myxobacterial genome.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

C6XWU5_PEDHD
(C6XWU5)

1e-43

181

35%

Product: Amino acid adenylation domain protein
Gene: Phep_2034
Organism: Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / NCIB 9290)

1uniprot
Complete genome sequence of Pedobacter heparinus type strain (HIM 762-3T).(Stand. Genomic Sci.) [2009]

D8I8X6_AMYMU
(D8I8X6)

3e-43

180

39%

Product: Non-ribosomal peptide synthetase/polyketide synthase
Gene: AMED_3681
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q49934_MYCLE
(Q49934)

3e-43

180

37%

Product: PksF
Polyketide synthase
Gene: ML2353
Organism: Mycobacterium leprae

1uniprot[Pubmed] 11234002 [Medline] 21128732
Massive gene decay in the leprosy bacillus.(Nature) [2001]

B8ZT36_MYCLB
(B8ZT36)

3e-43

180

37%

Product: Polyketide synthase
Gene: MLBr02353
Organism: Mycobacterium leprae (strain Br4923)

1uniprot[Pubmed] 19881526
Comparative genomic and phylogeographic analysis of Mycobacterium leprae.(Nat. Genet.) [2009]

B1WWV9_CYAA5
(B1WWV9)

4e-43

180

34%

Product: Polyketide synthase type I
Gene: cce_3080
Organism: Cyanothece sp. (strain ATCC 51142)

1uniprot[Pubmed] 18812508
The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium important in the marine nitrogen cycle.(Proc. Natl. Acad. Sci. U.S.A.) [2008]

Q1D6B5_MYXXD
(Q1D6B5)

1e-42

178

37%

Product: Polyketide synthase type I
Gene: MXAN_3621
Organism: Myxococcus xanthus (strain DK 1622)

1uniprot[Pubmed] 17015832
Evolution of sensory complexity recorded in a myxobacterial genome.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

D2B1D6_STRRD
(D2B1D6)

1e-42

178

39%

Product: Polyketide/non-ribosomal peptide synthetase
Gene: Sros_2423
Organism: Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)

1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]

D7C2B8_STRBB
(D7C2B8)

(4 hsp)

2e-42

177

39%

Product: Type I modular polyketide synthase
Gene: pks3-2
SBI_00651
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

100

C8TEQ8_PLARU
(C8TEQ8)

3e-42

177

33%

Product: Putative uncharacterized protein
Gene
Organism: Planktothrix rubescens NIVA-CYA 98

1uniprot[Pubmed] 19706155
A genome-wide analysis of nonribosomal peptide synthetase gene clusters and their peptides in a Planktothrix rubescens strain.(BMC Genomics) [2009]