| accession | DB | alignment | Evalue | Score | Ident. | link | information | pubmed |
1
|
A8KQY4_9ACTO (A8KQY4) |
|
|
2e-81 |
305 |
100% |
|
- Product
- Aromatase
- Gene
- elmNI
- Organism
- Streptomyces olivaceus
|
1uniprot[Pubmed] 18310024 Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster.(Microbiology) [2008] |
|
2
|
TCMN_STRGA (P16559) |
|
|
4e-44 |
181 |
57% |
|
- Product
- Multifunctional cyclase-dehydratase-3-O-methyl transferase tcmN
- Gene
- tcmN
- Organism
- Streptomyces glaucescens
|
1uniprot[Pubmed] 1548230 [Medline] 92193265 Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase.(J. Bacteriol.) [1992] | 2uniprot[Pubmed] 2684656 [Medline] 90060035 Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.(EMBO J.) [1989] | [pubmed all]
|
6
|
CYPC_STRCO (P23154) |
|
|
1e-42 |
176 |
59% |
|
- Product
- Putative polyketide cyclase
WhiE ORF VI
- Gene
- SCO5315
SC6G9.18
- Organism
- Streptomyces coelicolor
|
1uniprot[Pubmed] 2077356 [Medline] 91171868 Spore colour in Streptomyces coelicolor A3(2) involves the developmentally regulated synthesis of a compound biosynthetically related to polyketide antibiotics.(Mol. Microbiol.) [1990] | 2uniprot[Pubmed] 12000953 [Medline] 21996410 Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002] | [pubmed all]
|
8
|
E2EKK2_9ACTO (E2EKK2) |
|
|
5e-42 |
174 |
59% |
|
- Product
- Polyketide cyclase/aromatase
- Gene
- sanI
- Organism
- Streptomyces sp. SANK 61196
|
1uniprot[Pubmed] 20550125 Cloning, sequencing, heterologous expression, and mechanistic analysis of A-74528 biosynthesis.(J. Am. Chem. Soc.) [2010] |
|
9
|
Q8KSW2_9ACTO (Q8KSW2) |
|
|
5e-42 |
174 |
57% |
|
- Product
- Putative bifunctional cyclase/3-oxoacyl-ACP reductase GrhT
- Gene
- grhT
- Organism
- Streptomyces sp. JP95
|
1uniprot[Pubmed] 12323376 [Medline] 22235582 A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A.(Chem. Biol.) [2002] |
|
10
|
F2RIV3_STRVP (F2RIV3) |
|
|
7e-42 |
173 |
59% |
|
- Product
- Aromatase WhiE VI
- Gene
- SVEN_6793
- Organism
- Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
|
1uniprot[Pubmed] 21463507 Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011] |
|
11
|
Q2MGC8_STRGR (Q2MGC8) |
|
|
2e-41 |
172 |
57% |
|
- Product
- Putative polyketide cyclase
- Gene
-
- Organism
- Streptomyces griseus
|
1uniprot[Pubmed] 16305230 Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus.(J. Am. Chem. Soc.) [2005] |
|
12
|
C7Q5R8_CATAD (C7Q5R8) |
|
|
2e-41 |
172 |
53% |
|
- Product
- Cyclase/dehydrase
- Gene
- Caci_1089
- Organism
- Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
|
1uniprot Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009] |
|
13
|
D2AY47_STRRD (D2AY47) |
|
|
3e-41 |
171 |
55% |
|
- Product
- Putative uncharacterized protein
- Gene
- Sros_4153
- Organism
- Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
|
1uniprot Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010] |
|
14
|
D7C2K5_STRBB (D7C2K5) |
|
|
4e-41 |
171 |
58% |
|
- Product
- Putative polyketide cyclase I
- Gene
- sppD
SBI_02767
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
15
|
F4FBR6_VERMA (F4FBR6) |
|
|
5e-41 |
171 |
56% |
|
- Product
- Putative uncharacterized protein
- Gene
- VAB18032_18070
- Organism
- Verrucosispora maris (strain AB-18-032)
|
1uniprot[Pubmed] 21551311 Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.(J. Bacteriol.) [2011] |
|
17
|
E2PW01_STRCL (E2PW01) |
|
|
6e-41 |
170 |
57% |
|
- Product
- Polyketide cyclase
- Gene
- sppD
SCLAV_4918
- Organism
- Streptomyces clavuligerus ATCC 27064
|
1uniprot[Pubmed] 20624727 The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010] |
|
19
|
B0LJ44_9ACTO (B0LJ44) |
|
|
9e-41 |
169 |
55% |
|
- Product
- Lcz27
- Gene
- lcz27
- Organism
- Streptomyces sanglieri
|
1uniprot[Pubmed] 18070976 Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.(Antimicrob. Agents Chemother.) [2008] |
|
20
|
Q93HL9_STRAW (Q93HL9) |
|
|
1e-40 |
169 |
56% |
|
- Product
- Cyclase I
Putative cyclase I
- Gene
- sppD
SAV2841 SAV_2841
- Organism
- Streptomyces avermitilis
|
1uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001] | 2uniprot[Pubmed] 12692562 [Medline] 22608306 Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003] | [pubmed all]
|
21
|
B0LJ10_9ACTO (B0LJ10) |
|
|
2e-40 |
169 |
56% |
|
- Product
- Lct27
- Gene
- lct27
- Organism
- Streptomyces rishiriensis
|
1uniprot[Pubmed] 18070976 Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.(Antimicrob. Agents Chemother.) [2008] |
|
22
|
F4F9S5_VERMA (F4F9S5) |
|
|
5e-40 |
167 |
55% |
|
- Product
- Cyclase/dehydrase
- Gene
- VAB18032_23765
- Organism
- Verrucosispora maris (strain AB-18-032)
|
1uniprot[Pubmed] 21551311 Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.(J. Bacteriol.) [2011] |
|
24
|
E4NJ54_KITSK (E4NJ54) |
|
|
2e-39 |
166 |
55% |
|
- Product
- Putative cyclase I
- Gene
- sppD
KSE_72470
- Organism
- Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054)
Streptomyces setae
|
1uniprot[Pubmed] 21059706 Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.(DNA Res.) [2010] |
|
25
|
C7N0D4_SACVD (C7N0D4) |
|
|
6e-39 |
164 |
51% |
|
- Product
- Polyketide cyclase / dehydrase family protein
- Gene
- Svir_33720
- Organism
- Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
|
1uniprot Complete genome sequence of Saccharomonospora viridis type strain (P101T).(Stand. Genomic Sci.) [2009] |
|
26
|
CYPC_STRCN (Q02572) |
|
|
7e-39 |
163 |
55% |
|
- Product
- Putative polyketide cyclase
- Gene
- curF
- Organism
- Streptomyces cyaneus
Streptomyces curacoi
|
1uniprot[Pubmed] 1644304 [Medline] 92354925 Analysis of a polyketide synthesis-encoding gene cluster of Streptomyces curacoi.(Gene) [1992] |
|
27
|
B1GSN4_9ACTO (B1GSN4) |
|
|
7e-39 |
163 |
54% |
|
- Product
- BenH protein
- Gene
- benH
- Organism
- Streptomyces sp. A2991200
|
1uniprot[Pubmed] 17439117 Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybrids.(J. Am. Chem. Soc.) [2007] |
|
31
|
D2SZ02_MICEC (D2SZ02) |
|
|
3e-38 |
161 |
53% |
|
- Product
- Cyclase
- Gene
-
- Organism
- Micromonospora echinospora subsp. challisensis
|
1uniprot[Pubmed] 19680283 TLN-05220, TLN-05223, new Echinosporamicin-type antibiotics, and proposed revision of the structure of bravomicins(*).(J. Antibiot.) [2009] |
|
32
|
D8I4L8_AMYMU (D8I4L8) |
|
|
5e-38 |
160 |
54% |
|
- Product
- Polyketide cyclase/dehydratase
- Gene
- actV
AMED_5432
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
34
|
O32454_9ACTO (O32454) |
|
|
1e-37 |
159 |
56% |
|
- Product
- ORF 4
PdmD
- Gene
- pdmD
- Organism
- Actinomadura hibisca
|
1uniprot[Pubmed] 9339544 [Medline] 97480928 Cloning and nucleotide sequence of the putative polyketide synthase genes for pradimicin biosynthesis from Actinomadura hibisca.(Biosci. Biotechnol. Biochem.) [1997] |
|
35
|
C9Z708_STRSW (C9Z708) |
|
|
2e-37 |
159 |
51% |
|
- Product
- Putative polyketide cyclase
- Gene
- sppD
SCAB_43331
- Organism
- Streptomyces scabies (strain 87.22)
Streptomyces scabiei
|
1uniprot[Pubmed] 20064060 Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010] |
|
40
|
A7DWI6_STRTE (A7DWI6) |
|
|
1e-36 |
156 |
55% |
|
- Product
- Putative polyketide cyclase
- Gene
- llpCI
- Organism
- Streptomyces tendae
|
1uniprot Isolation of the lysolipin gene cluster of Streptomyces tendae Tu 4042.(Gene) [2010] |
|
41
|
F3NHY0_9ACTO (F3NHY0) |
|
|
4e-36 |
154 |
55% |
|
- Product
- Polyketide cyclase
- Gene
- SGM_2744
- Organism
- Streptomyces griseoaurantiacus M045
|
1uniprot[Pubmed] 21551298 Draft Genome Sequence of the Marine Bacterium Streptomyces griseoaurantiacus M045, Which Produces Novel Manumycin-Type Antibiotics with a pABA Core Component.(J. Bacteriol.) [2011] |
|
50
|
CYPC_STRHA (Q05368) |
|
|
9e-33 |
143 |
63% |
|
- Product
- Putative polyketide cyclase
- Gene
- sch4
- Organism
- Streptomyces halstedii
|
1uniprot[Pubmed] 8344517 [Medline] 93345807 Hybridization and DNA sequence analyses suggest an early evolutionary divergence of related biosynthetic gene sets encoding polyketide antibiotics and spore pigments in Streptomyces spp.(Gene) [1993] |
|
51
|
Q0RHJ5_FRAAA (Q0RHJ5) |
|
|
1e-32 |
143 |
48% |
|
- Product
- Putative polyketide cyclase
- Gene
- FRAAL4389
- Organism
- Frankia alni (strain ACN14a)
|
1uniprot[Pubmed] 17151343 Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007] |
|
52
|
A8L2X6_FRASN (A8L2X6) |
|
|
2e-32 |
142 |
48% |
|
- Product
- Cyclase/dehydrase
- Gene
- Franean1_2391
- Organism
- Frankia sp. (strain EAN1pec)
|
1uniprot[Pubmed] 17151343 Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007] |
|
53
|
Q2J931_FRASC (Q2J931) |
|
|
4e-32 |
141 |
47% |
|
- Product
- Cyclase/dehydrase
- Gene
- Francci3_2853
- Organism
- Frankia sp. (strain CcI3)
|
1uniprot[Pubmed] 17151343 Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007] |
|
55
|
D5UC53_CELFN (D5UC53) |
|
|
5e-32 |
140 |
56% |
|
- Product
- Cupin 2 conserved barrel domain protein
- Gene
- Cfla_3333
- Organism
- Cellulomonas flavigena (strain ATCC 482 / DSM 20109 / NCIB 8073 / NRS 134)
|
1uniprot Complete genome sequence of Cellulomonas flavigena type strain (134).(Stand. Genomic Sci.) [2010] |
|
58
|
D7AVZ9_NOCDD (D7AVZ9) |
|
|
6e-29 |
130 |
41% |
|
- Product
- Polyketide cyclase/dehydrase
- Gene
- Ndas_4270
- Organism
- Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei
|
1uniprot Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010] |
|
59
|
Q70DW8_9ACTO (Q70DW8) |
|
|
1e-17 |
93.6 |
39% |
|
- Product
- RemI protein
- Gene
- remI
- Organism
- Streptomyces resistomycificus
|
1uniprot[Pubmed] 14982421 A gene cluster encoding resistomycin biosynthesis in Streptomyces resistomycificus; exploring polyketide cyclization beyond linear and angucyclic patterns.(J. Am. Chem. Soc.) [2004] |
|
64
|
D6MSV2_9ACTO (D6MSV2) |
|
|
2e-09 |
65.9 |
35% |
|
- Product
- SsfY1
- Gene
- ssfY1
- Organism
- Streptomyces sp. SF2575
|
1uniprot[Pubmed] 19908837 Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009] |
|
65
|
Q9FCM5_STRAT (Q9FCM5) |
|
|
3e-09 |
65.1 |
34% |
|
- Product
- Putative aromatase
- Gene
-
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 11700358 [Medline] 21557167 A polyketide biosynthetic gene cluster from Streptomyces antibioticus includes a LysR-type transcriptional regulator.(Microbiology) [2001] |
|
67
|
Q9AMI9_STRAT (Q9AMI9) |
|
|
7e-08 |
60.8 |
29% |
|
- Product
- Putative cyclase/dehydrase SimA5
Sim6
- Gene
- simA5
sim6
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 11959542 [Medline] 21955989 Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic.(Antimicrob. Agents Chemother.) [2002] | 2uniprot[Pubmed] 12115055 [Medline] 22109063 Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tu 6040.(Arch. Microbiol.) [2002] | [pubmed all]
|
68
|
CYPK_STRVN (P16560) |
|
|
9e-08 |
60.5 |
31% |
|
- Product
- Granaticin polyketide synthase bifunctional cyclase/dehydratase
- Gene
- gra-orf4
- Organism
- Streptomyces violaceoruber
|
1uniprot[Pubmed] 2583128 [Medline] 90060034 Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989] | 2uniprot[Pubmed] 7476861 [Medline] 96027933 Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995] | 3uniprot[Pubmed] 9831526 [Medline] 99051446 The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998] | [pubmed all]
|
70
|
Q9RPB1_STRFR (Q9RPB1) |
|
|
3e-07 |
58.5 |
32% |
|
- Product
- Cyclase
- Gene
- urdL
- Organism
- Streptomyces fradiae
Streptomyces roseoflavus
|
1uniprot[Pubmed] 10658661 [Medline] 20121748 Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717.(Microbiology) [2000] |
|
72
|
Q6VMJ1_STRAM (Q6VMJ1) |
|
|
6e-07 |
57.8 |
30% |
|
- Product
- Putative bifunctional cyclase/dehydrase
Putative cyclase/dehydratase
- Gene
- alpE
DSMT0181
- Organism
- Streptomyces ambofaciens
|
1uniprot[Pubmed] 14742212 Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome.(Antimicrob. Agents Chemother.) [2004] | 2uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006] | [pubmed all]
|
73
|
Q1RQS4_STRAM (Q1RQS4) |
|
|
6e-07 |
57.8 |
30% |
|
- Product
- Putative cyclase/dehydratase
- Gene
- alpE
SAMT0161 SAMT0162
- Organism
- Streptomyces ambofaciens ATCC 23877
|
1uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006] | 2uniprot[Pubmed] 16956972 Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006] | 3uniprot Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006] | [pubmed all]
|
74
|
Q2HR24_9ACTO (Q2HR24) |
|
|
1e-06 |
56.6 |
29% |
|
- Product
- Putative aromatase
- Gene
- schP4
- Organism
- Streptomyces sp. SCC 2136
|
1uniprot Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006] | 2uniprot Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004] |
|
75
|
Q83X42_STRRO (Q83X42) |
|
|
2e-06 |
56.2 |
30% |
|
- Product
- Cyclase/aromatase
- Gene
- rocH
- Organism
- Streptomyces rochei
Streptomyces parvullus
|
1uniprot[Pubmed] 12791134 [Medline] 22676866 The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003] | 2uniprot[Pubmed] 10954087 [Medline] 20408175 Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000] | 3uniprot[Pubmed] 10767533 [Medline] 20231737 Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000] | 4uniprot[Pubmed] 9836424 [Medline] 99053144 Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998] | [pubmed all]
|
81
|
C7QAF6_CATAD (C7QAF6) |
|
|
8e-06 |
53.9 |
29% |
|
- Product
- Cyclase/dehydrase
- Gene
- Caci_3550
- Organism
- Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
|
1uniprot Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009] |
|
82
|
D7RFJ9_AMYOR (D7RFJ9) |
|
|
8e-06 |
53.9 |
29% |
|
- Product
- Putative cyclase
- Gene
- bexL
- Organism
- Amycolatopsis orientalis subsp. vinearia
|
1uniprot[Pubmed] 20443562 A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.(J. Am. Chem. Soc.) [2010] |
|
84
|
Q9L554_9ACTO (Q9L554) |
|
|
1e-05 |
53.5 |
31% |
|
- Product
- AknE1
- Gene
- aknE1
- Organism
- Streptomyces galilaeus
|
1uniprot[Pubmed] 12137949 [Medline] 22133312 Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002] |
|
85
|
Q8VWB6_9ACTO (Q8VWB6) |
|
|
1e-05 |
53.5 |
31% |
|
- Product
- AknE1
- Gene
- aknE1
- Organism
- Streptomyces galilaeus
|
1uniprot[Pubmed] 12399480 [Medline] 22286521 Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002] |
|
88
|
Q9ZG83_STRRM (Q9ZG83) |
|
|
2e-05 |
52.4 |
32% |
|
- Product
- Cyclase/aromatase
- Gene
- otcD1
- Organism
- Streptomyces rimosus
|
1uniprot[Pubmed] 10551844 [Medline] 20020252 Disruption of an aromatase/cyclase from the oxytetracycline gene cluster of Streptomyces rimosus results in production of novel polyketides with shorter chain lengths.(J. Biol. Chem.) [1999] | 2uniprot Characterisation of some genes involved in the early steps of the biosynthetic pathway for oxytetracycline in Streptomyces rimosus. [1994] |
|
89
|
Q9X464_STRAE (Q9X464) |
|
|
2e-05 |
52.4 |
29% |
|
- Product
- Aromatase
- Gene
- ncnD
- Organism
- Streptomyces arenae
|
1uniprot[Pubmed] 10206788 [Medline] 99217421 Isolation and characterization of the naphthocyclinone gene cluster from Streptomyces arenae DSM 40737 and heterologous expression of the polyketide synthase genes.(Gene) [1999] |
|
92
|
Q3S8Q5_STRRM (Q3S8Q5) |
|
|
3e-05 |
52.4 |
33% |
|
- Product
- OxyK
- Gene
- oxyK
- Organism
- Streptomyces rimosus
|
1uniprot[Pubmed] 16597959 Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006] |
|
93
|
D9UBK6_STRPR (D9UBK6) |
|
|
3e-05 |
52.4 |
31% |
|
- Product
- Putative cyclase
- Gene
- c104_07c
- Organism
- Streptomyces pristinaespiralis
|
1uniprot[Pubmed] 21342465 Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011] |
|
95
|
Q9F6D3_9ACTO (Q9F6D3) |
|
|
3e-05 |
52 |
33% |
|
- Product
- Cyclase
- Gene
- zhuI
- Organism
- Streptomyces sp. R1128
|
1uniprot[Pubmed] 10931852 [Medline] 20517899 Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism.(J. Biol. Chem.) [2000] |
|
96
|
Q93LY0_9ACTO (Q93LY0) |
|
|
3e-05 |
52 |
28% |
|
- Product
- Putative bifunctional aromatase PgaL
- Gene
- pgaL
- Organism
- Streptomyces sp. PGA64
|
1uniprot[Pubmed] 12654660 [Medline] 22540650 Engineering anthracycline biosynthesis toward angucyclines.(Antimicrob. Agents Chemother.) [2003] | 2uniprot[Pubmed] 15515887 Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64.(J. Antibiot.) [2004] | [pubmed all]
|
97
|
Q47QK9_THEFY (Q47QK9) |
|
|
3e-05 |
52 |
28% |
|
- Product
- Actinorhodin polyketide synthase bifunctional cyclase/dehydratase
- Gene
- Tfu_1222
- Organism
- Thermobifida fusca (strain YX)
|
1uniprot[Pubmed] 17209016 Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX.(J. Bacteriol.) [2007] |
|
99
|
Q54811_STRPE (Q54811) |
|
|
0.0001 |
50.1 |
25% |
|
- Product
- Daunorubicin-doxorubicin polyketide synthase
- Gene
- dpsF
- Organism
- Streptomyces peucetius
|
1uniprot[Pubmed] 7828855 [Medline] 95129838 Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase.(Gene) [1994] |
|
100
|
E2D2J7_9BACT (E2D2J7) |
|
|
0.0001 |
50.1 |
31% |
|
- Product
- Cyclase
- Gene
-
- Organism
- uncultured soil bacterium
|
1uniprot[Pubmed] 20577994 Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR.(Biopolymers) [2010] |
|