BLAST table : Oxtet_00140

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism
1	Q3S8Q2_STRRM (Q3S8Q2)	1e-144	515	100%	UniProt GenBank	OxyN	oxyN	Streptomyces rimosus
2	E8SDG0_MICSL (E8SDG0)	3e-99	365	70%	UniProt GenBank	Cyclase family protein	ML5_4398	Micromonospora sp. (strain L5)
3	D9T2C0_MICAI (D9T2C0)	3e-99	365	70%	UniProt GenBank	Cyclase family protein	Micau_4023	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
4	Q194Q6_STRAA (Q194Q6)	1e-98	363	68%	UniProt GenBank	Cyclase	mtmY	Streptomyces argillaceus
5	Q2PA03_9ACTO (Q2PA03)	5e-98	361	69%	UniProt GenBank	Cyclase	stfY	Streptomyces steffisburgensis
6	C0JWC6_9ACTO (C0JWC6)	1e-96	357	68%	UniProt GenBank	PokC2	pokC2	Streptomyces diastatochromogenes
7	Q9L4U2_9ACTO (Q9L4U2)	2e-95	352	68%	UniProt GenBank	Putative cyclase	aknW	Streptomyces galilaeus
8	Q9RN54_STRNO (Q9RN54)	9e-93	344	66%	UniProt GenBank	Putative polyketide cyclase	snoaM	Streptomyces nogalater
9	Q54196_STRGR (Q54196)	3e-90	335	66%	UniProt GenBank	DNA sequence for ORF's 1-6		Streptomyces griseus
10	O68500_STRPE (O68500)	5e-89	331	65%	UniProt GenBank	Polyketide cyclase	dpsY	Streptomyces peucetius
11	A1C180_9ACTO (A1C180)	1e-88	330	67%	UniProt GenBank	Cyclase		Streptomyces echinatus
12	Q70J97_STRGR (Q70J97)	7e-86	321	65%	UniProt GenBank	Cyclase	cmmY	Streptomyces griseus subsp. griseus
13	E8W964_STRFA (E8W964)	2e-85	320	61%	UniProt GenBank	Cyclase family protein	Sfla_5330	Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD)
14	D7BZQ8_STRBB (D7BZQ8)	6e-84	315	66%	UniProt GenBank	Polyketide cyclase	SBI_06843	Streptomyces bingchenggensis (strain BCW-1)
15	B5G897_9ACTO (B5G897)	2e-80	303	63%	UniProt GenBank	Cyclase superfamily protein	SSBG_00505	Streptomyces sp. SPB74
16	Q4R0M8_STRCX (Q4R0M8)	4e-75	285	64%	UniProt GenBank	ChaG protein	chaG	Streptomyces chartreusis
17	Q7MZT2_PHOLL (Q7MZT2)	4e-54	215	40%	UniProt GenBank	Similar to polyketide cyclase	plu4192	Photorhabdus luminescens subsp. laumondii (strain TT01)
18	Q9F6D2_9ACTO (Q9F6D2)	4e-51	206	53%	UniProt GenBank	Cyclase	zhuJ	Streptomyces sp. R1128
19	A7NLJ2_ROSCS (A7NLJ2)	9e-50	201	46%	UniProt GenBank	Cyclase family protein	Rcas_2300	Roseiflexus castenholzii (strain DSM 13941 / HLO8)
20	D2QNY6_SPILD (D2QNY6)	2e-49	200	44%	UniProt GenBank	Cyclase family protein	Slin_1543	Spirosoma linguale (strain ATCC 33905 / DSM 74 / LMG 10896)
21	A5UTI1_ROSS1 (A5UTI1)	6e-49	198	45%	UniProt GenBank	Cyclase family protein	RoseRS_1541	Roseiflexus sp. (strain RS-1)
22	A0QWH8_MYCS2 (A0QWH8)	9e-49	198	48%	UniProt GenBank	Polyketide cyclase	MSMEG_2947	Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
23	C6CY72_PAESJ (C6CY72)	7e-48	195	39%	UniProt GenBank	Cyclase family protein	Pjdr2_2113	Paenibacillus sp. (strain JDR-2)
24	D9W8F5_9ACTO (D9W8F5)	5e-47	192	49%	UniProt GenBank	Putative cyclase	SSOG_02376	Streptomyces himastatinicus ATCC 53653
25	D5RJK7_9PROT (D5RJK7)	1e-46	191	46%	UniProt GenBank	Probable cyclase	HMPREF0731_1267	Roseomonas cervicalis ATCC 49957
26	C6A4Y1_THESM (C6A4Y1)	2e-46	190	46%	UniProt GenBank	Cyclase family protein	TSIB_1625	Thermococcus sibiricus (strain MM 739 / DSM 12597)
27	D4VXF1_ENTFC (D4VXF1)	2e-46	190	42%	UniProt GenBank	Putative cyclase	CUO_0236	Enterococcus faecium PC4.1
28	C9AGV4_ENTFC (C9AGV4)	2e-46	190	42%	UniProt GenBank	Cyclase	EFVG_00437	Enterococcus faecium Com12
29	C2HCD4_ENTFC (C2HCD4)	2e-46	190	42%	UniProt GenBank	Cyclase family protein	HMPREF0352_1866	Enterococcus faecium TX1330
30	F6F1S0_SPHCR (F6F1S0)	3e-46	189	49%	UniProt GenBank	Cyclase family protein	Sphch_3905	Sphingobium chlorophenolicum L-1
31	Q5YUM7_NOCFA (Q5YUM7)	4e-46	189	49%	UniProt GenBank	Putative cyclase	NFA_32670	Nocardia farcinica
32	Q1ATU7_RUBXD (Q1ATU7)	5e-46	189	43%	UniProt GenBank	Putative cyclase	Rxyl_2245	Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
33	A1BB13_PARDP (A1BB13)	7e-46	188	49%	UniProt GenBank	Cyclase family protein	Pden_4646	Paracoccus denitrificans (strain Pd 1222)
34	F6CVK7_9GAMM (F6CVK7)	1e-45	187	42%	UniProt GenBank	Cyclase family protein	Mar181_2349	Marinomonas posidonica IVIA-Po-181
35	E0I596_9BACL (E0I596)	1e-45	187	39%	UniProt GenBank	Cyclase family protein	PaecuDRAFT_0818	Paenibacillus curdlanolyticus YK9
36	C9BE73_ENTFC (C9BE73)	2e-45	187	42%	UniProt GenBank	Cyclase	EFSG_00464	Enterococcus faecium 1,141,733
37	D8P2K4_RALSO (D8P2K4)	2e-45	187	45%	UniProt GenBank	Putative cyclase	RCFBP_mp10352	Ralstonia solanacearum Pseudomonas solanacearum
38	F8EG38_9BACT (F8EG38)	2e-45	187	42%	UniProt GenBank	Cyclase family protein	Runsl_0473	Runella slithyformis DSM 19594
39	D2THH3_CITRI (D2THH3)	3e-45	186	42%	UniProt GenBank	Putative uncharacterized protein	ROD_14041	Citrobacter rodentium (strain ICC168) Citrobacter freundii biotype 4280
40	D2RQE4_HALTV (D2RQE4)	5e-45	185	42%	UniProt GenBank	Cyclase family protein	Htur_3459	Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734) Halococcus turkmenicus
41	B1FBF4_9BURK (B1FBF4)	6e-45	185	45%	UniProt GenBank	Cyclase family protein	BamIOP4010DRAFT_1363	Burkholderia ambifaria IOP40-10
42	E1QDZ4_DESB2 (E1QDZ4)	7e-45	185	45%	UniProt GenBank	Cyclase family protein	Deba_0405	Desulfarculus baarsii (strain ATCC 33931 / DSM 2075 / VKM B-1802 / 2st14)
43	B5S9N2_RALSO (B5S9N2)	7e-45	185	44%	UniProt GenBank	Cyclase protein	RSMK04792	Ralstonia solanacearum Pseudomonas solanacearum
44	F6GAZ3_RALSO (F6GAZ3)	8e-45	184	44%	UniProt GenBank	Cyclase protein	RSPO_m01491	Ralstonia solanacearum Po82
45	D3P4T9_AZOS1 (D3P4T9)	9e-45	184	48%	UniProt GenBank	Protein	AZL_c03750	Azospirillum sp. (strain B510)
46	B5SA82_RALSO (B5SA82)	9e-45	184	44%	UniProt GenBank	Putative cyclase protein	RSIPO_04457	Ralstonia solanacearum Pseudomonas solanacearum
47	A3RYM2_RALSO (A3RYM2)	9e-45	184	44%	UniProt GenBank	Predicted metal-dependent hydrolase	RRSL_00918	Ralstonia solanacearum UW551
48	F6DKS1_9FIRM (F6DKS1)	1e-44	184	43%	UniProt GenBank	Cyclase family protein	Desru_2197	Desulfotomaculum ruminis DSM 2154
49	F4CY90_9PSEU (F4CY90)	1e-44	184	47%	UniProt GenBank	Cyclase family protein	Psed_2509	Pseudonocardia dioxanivorans CB1190
50	Q11L41_MESSB (Q11L41)	1e-44	184	41%	UniProt GenBank	Putative cyclase	Meso_0480	Mesorhizobium sp. (strain BNC1)
51	B9JI03_AGRRK (B9JI03)	1e-44	184	46%	UniProt GenBank	Cyclase	Arad_8216	Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
52	C0ZIS6_BREBN (C0ZIS6)	2e-44	184	43%	UniProt GenBank	Putative uncharacterized protein	BBR47_03170	Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
53	F8GVF4_CUPNE (F8GVF4)	3e-44	183	44%	UniProt GenBank	Cyclase protein	CNE_BB1p00860	Cupriavidus necator N-1
54	D3STQ2_NATMM (D3STQ2)	3e-44	182	42%	UniProt GenBank	Cyclase family protein	Nmag_1493	Natrialba magadii (strain ATCC 43099 / DSM 3394 / NCIMB 2190 / MS3) Natronobacterium magadii
55	F7TUP3_9BACL (F7TUP3)	3e-44	182	37%	UniProt GenBank	Cyclase family protein	BRLA_c18770	Brevibacillus laterosporus LMG 15441
56	Q6FBB6_ACIAD (Q6FBB6)	6e-44	182	46%	UniProt GenBank	Putative cyclase	ACIAD1812	Acinetobacter sp. (strain ADP1)
57	A5VBU4_SPHWW (A5VBU4)	7e-44	181	39%	UniProt GenBank	Cyclase family protein	Swit_3414	Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
58	F3L0C7_9GAMM (F3L0C7)	9e-44	181	44%	UniProt GenBank	Cyclase family protein	IMCC3088_843	gamma proteobacterium IMCC3088
59	B2AIL0_CUPTR (B2AIL0)	1e-43	180	46%	UniProt GenBank	Putative cyclase	RALTA_B0414	Cupriavidus taiwanensis (strain R1 / LMG 19424) Ralstonia taiwanensis (strain LMG 19424)
60	Q1GTT2_SPHAL (Q1GTT2)	2e-43	180	47%	UniProt GenBank	Putative cyclase	Sala_1225	Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) Sphingomonas alaskensis
61	F4L2P9_HALH1 (F4L2P9)	2e-43	180	41%	UniProt GenBank	Cyclase family protein	Halhy_0705	Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O)
62	Q39M12_BURS3 (Q39M12)	2e-43	180	45%	UniProt GenBank	Putative cyclase	Bcep18194_C7460	Burkholderia sp. (strain 383) Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)
63	B7X2X0_COMTE (B7X2X0)	2e-43	180	45%	UniProt GenBank	Cyclase family protein	CtesDRAFT_PD3470	Comamonas testosteroni KF-1
64	Q5LV67_SILPO (Q5LV67)	3e-43	179	41%	UniProt GenBank	Cyclase, putative	SPO0835	Silicibacter pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)
65	Q1BIS5_BURCA (Q1BIS5)	3e-43	179	45%	UniProt GenBank	Putative cyclase	Bcen_5611	Burkholderia cenocepacia (strain AU 1054)
66	A0KBZ5_BURCH (A0KBZ5)	3e-43	179	45%	UniProt GenBank	Cyclase family protein	Bcen2424_5975	Burkholderia cenocepacia (strain HI2424)
67	Q28QQ7_JANSC (Q28QQ7)	5e-43	179	41%	UniProt GenBank	Putative cyclase	Jann_2038	Jannaschia sp. (strain CCS1)
68	B0T5J6_CAUSK (B0T5J6)	5e-43	179	45%	UniProt GenBank	Cyclase family protein	Caul_0417	Caulobacter sp. (strain K31)
69	A8F3U6_THELT (A8F3U6)	6e-43	178	40%	UniProt GenBank	Cyclase family protein	Tlet_0260	Thermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
70	Q88HZ5_PSEPK (Q88HZ5)	7e-43	178	41%	UniProt GenBank	Cyclase, putative	PP3207 PP_3207	Pseudomonas putida (strain KT2440)
71	F2JZE8_MARM1 (F2JZE8)	7e-43	178	47%	UniProt GenBank	Cyclase family protein	Marme_0432	Marinomonas mediterranea (strain ATCC 700492 / JCM 21426 / NBRC 103028 / MMB-1)
72	B9K160_AGRVS (B9K160)	7e-43	178	41%	UniProt GenBank	Cyclase	Avi_5495	Agrobacterium vitis (strain S4 / ATCC BAA-846) Rhizobium vitis (strain S4)
73	B9C5M7_9BURK (B9C5M7)	7e-43	178	46%	UniProt GenBank	Polyketide cyclase	BURMUCGD2M_5970	Burkholderia multivorans CGD2M
74	B9BLM3_9BURK (B9BLM3)	7e-43	178	46%	UniProt GenBank	Polyketide cyclase	BURMUCGD2_5981	Burkholderia multivorans CGD2
75	C4XC96_KLEPN (C4XC96)	1e-42	177	42%	UniProt GenBank	Putative cyclase	KP1_4221	Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044
76	E2XPX8_PSEFL (E2XPX8)	1e-42	177	41%	UniProt GenBank	Cyclase, probable	PFWH6_2056	Pseudomonas fluorescens WH6
77	B1YYP0_BURA4 (B1YYP0)	1e-42	177	45%	UniProt GenBank	Cyclase family protein	BamMC406_4826	Burkholderia ambifaria (strain MC40-6)
78	Q470M5_CUPPJ (Q470M5)	2e-42	177	43%	UniProt GenBank	Putative cyclase	Reut_A1793	Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) Alcaligenes eutrophus Ralstonia eutropha
79	A4JED9_BURVG (A4JED9)	2e-42	177	41%	UniProt GenBank	Cyclase family protein	Bcep1808_1635	Burkholderia vietnamiensis (strain G4 / LMG 22486) Burkholderia cepacia (strain R1808)
80	E3C7H6_9LACO (E3C7H6)	2e-42	177	39%	UniProt GenBank	Putative cyclase	HMPREF9265_1205	Lactobacillus oris PB013-T2-3
81	Q0SB98_RHOSR (Q0SB98)	2e-42	176	43%	UniProt GenBank	Possible cyclase	RHA1_ro03385	Rhodococcus sp. (strain RHA1)
82	F7V2P6_9CLOT (F7V2P6)	3e-42	176	41%	UniProt GenBank	Uncharacterized ACR protein	CXIVA_10580	Clostridium sp. SY8519
83	A1WEW8_VEREI (A1WEW8)	3e-42	176	44%	UniProt GenBank	Cyclase family protein	Veis_0387	Verminephrobacter eiseniae (strain EF01-2)
84	D3RJM8_KLEVT (D3RJM8)	3e-42	176	41%	UniProt GenBank	Cyclase family protein	Kvar_1104	Klebsiella variicola (strain At-22)
85	A0YCA5_9GAMM (A0YCA5)	3e-42	176	44%	UniProt GenBank	Putative cyclase	GP2143_07739	marine gamma proteobacterium HTCC2143
86	B5WKU7_9BURK (B5WKU7)	3e-42	176	46%	UniProt GenBank	Cyclase family protein	BH160DRAFT_3700	Burkholderia sp. H160
87	Q15XK5_PSEA6 (Q15XK5)	4e-42	176	39%	UniProt GenBank	Putative cyclase	Patl_0855	Pseudoalteromonas atlantica (strain T6c / BAA-1087)
88	A4YZ46_BRASO (A4YZ46)	6e-42	175	39%	UniProt GenBank	Putative cyclase	BRADO5497	Bradyrhizobium sp. (strain ORS278)
89	A8MJJ2_ALKOO (A8MJJ2)	1e-41	174	39%	UniProt GenBank	Cyclase family protein	Clos_2442	Alkaliphilus oremlandii (strain OhILAs) Clostridium oremlandii (strain OhILAs)
90	Q2NB57_ERYLH (Q2NB57)	1e-41	174	46%	UniProt GenBank	Putative cyclase	ELI_04960	Erythrobacter litoralis (strain HTCC2594)
91	A8IMQ1_AZOC5 (A8IMQ1)	1e-41	174	45%	UniProt GenBank	Putative cyclase	AZC_0592	Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571)
92	Q2N7W3_ERYLH (Q2N7W3)	2e-41	174	42%	UniProt GenBank	Putative cyclase	ELI_10680	Erythrobacter litoralis (strain HTCC2594)
93	B8KHR1_9GAMM (B8KHR1)	2e-41	174	40%	UniProt GenBank	Cyclase family protein	NOR53_1929	gamma proteobacterium NOR5-3
94	A3WCZ3_9SPHN (A3WCZ3)	2e-41	174	41%	UniProt GenBank	Cyclase, putative	NAP1_04100	Erythrobacter sp. NAP1
95	D9SQY6_CLOC7 (D9SQY6)	2e-41	173	43%	UniProt GenBank	Cyclase family protein	Clocel_0499	Clostridium cellulovorans (strain ATCC 35296 / DSM 3052 / OCM 3 / 743B)
96	B9B7K8_9BURK (B9B7K8)	3e-41	173	45%	UniProt GenBank	Polyketide cyclase	BURMUCGD1_4919	Burkholderia multivorans CGD1
97	D9VFF4_9ACTO (D9VFF4)	3e-41	172	46%	UniProt GenBank	Cyclase	SSMG_03758	Streptomyces sp. AA4
98	F2KGF1_PSEBN (F2KGF1)	4e-41	172	40%	UniProt GenBank	Putative cyclase	PSEBR_a2144	Pseudomonas brassicacearum (strain NFM421)
99	D9QIT6_BRESC (D9QIT6)	4e-41	172	40%	UniProt GenBank	Cyclase family protein	Bresu_2109	Brevundimonas subvibrioides (strain ATCC 15264 / DSM 4735 / LMG 14903 / NBRC 16000 / CB 81) Caulobacter subvibrioides
100	A4A9M0_9GAMM (A4A9M0)	6e-41	172	40%	UniProt GenBank	Putative cyclase	KT71_07404	Congregibacter litoralis KT71

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q3S8Q2_STRRM
(Q3S8Q2)

1e-144

515

100%

Product: OxyN
Gene: oxyN
Organism: Streptomyces rimosus

1uniprot[Pubmed] 16597959
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006]

Q194Q6_STRAA
(Q194Q6)

1e-98

363

68%

Product: Cyclase
Gene: mtmY
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

Q2PA03_9ACTO
(Q2PA03)

5e-98

361

69%

Product: Cyclase
Gene: stfY
Organism: Streptomyces steffisburgensis

1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006]

C0JWC6_9ACTO
(C0JWC6)

1e-96

357

68%

Product: PokC2
Gene: pokC2
Organism: Streptomyces diastatochromogenes

1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]

Q9L4U2_9ACTO
(Q9L4U2)

2e-95

352

68%

Product: Putative cyclase
Gene: aknW
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 11016846 [Medline] 20469061
A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.(Mol. Gen. Genet.) [2000]

Q9RN54_STRNO
(Q9RN54)

9e-93

344

66%

Product: Putative polyketide cyclase
Gene: snoaM
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
2uniprot[Pubmed] 10639368 [Medline] 20106987 Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.(Antimicrob. Agents Chemother.) [2000]

Q54196_STRGR
(Q54196)

3e-90

335

66%

Product: DNA sequence for ORF's 1-6
Gene
Organism: Streptomyces griseus

1uniprot[Pubmed] 8232204 [Medline] 94049680
Nucleotide sequence analysis of five putative Streptomyces griseus genes, one of which complements an early function in daunorubicin biosynthesis that is linked to a putative gene cluster involved in TDP-daunosamine formation.(Mol. Gen. Genet.) [1993]

O68500_STRPE
(O68500)

5e-89

331

65%

Product: Polyketide cyclase
Gene: dpsY
Organism: Streptomyces peucetius

1uniprot[Pubmed] 9573189 [Medline] 98233733
The Streptomyces peucetius dpsY and dnrX genes govern early and late steps of daunorubicin and doxorubicin biosynthesis.(J. Bacteriol.) [1998]

D7BZQ8_STRBB
(D7BZQ8)

6e-84

315

66%

Product: Polyketide cyclase
Gene: SBI_06843
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

Q4R0M8_STRCX
(Q4R0M8)

4e-75

285

64%

Product: ChaG protein
Gene: chaG
Organism: Streptomyces chartreusis

1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]

Q7MZT2_PHOLL
(Q7MZT2)

4e-54

215

40%

Product: Similar to polyketide cyclase
Gene: plu4192
Organism: Photorhabdus luminescens subsp. laumondii (strain TT01)

1uniprot[Pubmed] 14528314 [Medline] 22957627
The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens.(Nat. Biotechnol.) [2003]

Q9F6D2_9ACTO
(Q9F6D2)

4e-51

206

53%

Product: Cyclase
Gene: zhuJ
Organism: Streptomyces sp. R1128

1uniprot[Pubmed] 10931852 [Medline] 20517899
Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism.(J. Biol. Chem.) [2000]

C6A4Y1_THESM
(C6A4Y1)

2e-46

190

46%

Product: Cyclase family protein
Gene: TSIB_1625
Organism: Thermococcus sibiricus (strain MM 739 / DSM 12597)

1uniprot[Pubmed] 19447963
Metabolic versatility and indigenous origin of the archaeon Thermococcus sibiricus, isolated from a siberian oil reservoir, as revealed by genome analysis.(Appl. Environ. Microbiol.) [2009]

Q5YUM7_NOCFA
(Q5YUM7)

4e-46

189

49%

Product: Putative cyclase
Gene: NFA_32670
Organism: Nocardia farcinica

1uniprot[Pubmed] 15466710
The complete genomic sequence of Nocardia farcinica IFM 10152.(Proc. Natl. Acad. Sci. U.S.A.) [2004]

D8P2K4_RALSO
(D8P2K4)

2e-45

187

45%

Product: Putative cyclase
Gene: RCFBP_mp10352
Organism: Ralstonia solanacearum
Pseudomonas solanacearum

1uniprot
Genomes of three tomato pathogens within the Ralstonia solanacearum species complex reveal significant evolutionary divergence.(BMC Genomics) [2010]

D2THH3_CITRI
(D2THH3)

3e-45

186

42%

Product: Putative uncharacterized protein
Gene: ROD_14041
Organism: Citrobacter rodentium (strain ICC168)
Citrobacter freundii biotype 4280

1uniprot[Pubmed] 19897651
The Citrobacter rodentium genome sequence reveals convergent evolution with human pathogenic Escherichia coli.(J. Bacteriol.) [2010]

D2RQE4_HALTV
(D2RQE4)

5e-45

185

42%

Product: Cyclase family protein
Gene: Htur_3459
Organism: Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734)
Halococcus turkmenicus

1uniprot[Pubmed] 21304683
Complete genome sequence of Haloterrigena turkmenica type strain (4k).(Stand. Genomic Sci.) [2009]

E1QDZ4_DESB2
(E1QDZ4)

7e-45

185

45%

Product: Cyclase family protein
Gene: Deba_0405
Organism: Desulfarculus baarsii (strain ATCC 33931 / DSM 2075 / VKM B-1802 / 2st14)

1uniprot
Complete genome sequence of Desulfarculus baarsii type strain (2st14).(Stand. Genomic Sci.) [2010]

D3P4T9_AZOS1
(D3P4T9)

9e-45

184

48%

Product: Protein
Gene: AZL_c03750
Organism: Azospirillum sp. (strain B510)

1uniprot[Pubmed] 20047946
Complete genomic structure of the cultivated rice endophyte Azospirillum sp. B510.(DNA Res.) [2010]

A3RYM2_RALSO
(A3RYM2)

9e-45

184

44%

Product: Predicted metal-dependent hydrolase
Gene: RRSL_00918
Organism: Ralstonia solanacearum UW551

1uniprot[Pubmed] 16404955
Identification of open reading frames unique to a select agent: Ralstonia solanacearum race 3 biovar 2.(Mol. Plant Microbe Interact.) [2006]

B9JI03_AGRRK
(B9JI03)

1e-44

184

46%

Product: Cyclase
Gene: Arad_8216
Organism: Agrobacterium radiobacter (strain K84 / ATCC BAA-868)

1uniprot[Pubmed] 19251847
Genome sequences of three Agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria.(J. Bacteriol.) [2009]

Q6FBB6_ACIAD
(Q6FBB6)

6e-44

182

46%

Product: Putative cyclase
Gene: ACIAD1812
Organism: Acinetobacter sp. (strain ADP1)

1uniprot[Pubmed] 15514110
Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium.(Nucleic Acids Res.) [2004]

F3L0C7_9GAMM
(F3L0C7)

9e-44

181

44%

Product: Cyclase family protein
Gene: IMCC3088_843
Organism: gamma proteobacterium IMCC3088

1uniprot[Pubmed] 21551310
Genome Sequence of Strain IMCC3088, a Proteorhodopsin-Containing Marine Bacterium Belonging to the OM60/NOR5 Clade.(J. Bacteriol.) [2011]

B2AIL0_CUPTR
(B2AIL0)

1e-43

180

46%

Product: Putative cyclase
Gene: RALTA_B0414
Organism: Cupriavidus taiwanensis (strain R1 / LMG 19424)
Ralstonia taiwanensis (strain LMG 19424)

1uniprot[Pubmed] 18490699
Genome sequence of the beta-rhizobium Cupriavidus taiwanensis and comparative genomics of rhizobia.(Genome Res.) [2008]

F4L2P9_HALH1
(F4L2P9)

2e-43

180

41%

Product: Cyclase family protein
Gene: Halhy_0705
Organism: Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O)

1uniprot
Complete genome sequence of Haliscomenobacter hydrossis type strain (O).(Stand. Genomic Sci.) [2011]

B7X2X0_COMTE
(B7X2X0)

2e-43

180

45%

Product: Cyclase family protein
Gene: CtesDRAFT_PD3470
Organism: Comamonas testosteroni KF-1

1uniprot[Pubmed] 15240283
Mineralization of individual congeners of linear alkylbenzenesulfonate by defined pairs of heterotrophic bacteria.(Appl. Environ. Microbiol.) [2004]

Q5LV67_SILPO
(Q5LV67)

3e-43

179

41%

Product: Cyclase, putative
Gene: SPO0835
Organism: Silicibacter pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)

1uniprot[Pubmed] 15602564
Genome sequence of Silicibacter pomeroyi reveals adaptations to the marine environment.(Nature) [2004]

Q88HZ5_PSEPK
(Q88HZ5)

7e-43

178

41%

Product: Cyclase, putative
Gene: PP3207
PP_3207
Organism: Pseudomonas putida (strain KT2440)

1uniprot[Pubmed] 12534463 [Medline] 22423060
Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440.(Environ. Microbiol.) [2002]

B9K160_AGRVS
(B9K160)

7e-43

178

41%

Product: Cyclase
Gene: Avi_5495
Organism: Agrobacterium vitis (strain S4 / ATCC BAA-846)
Rhizobium vitis (strain S4)

1uniprot[Pubmed] 19251847
Genome sequences of three Agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria.(J. Bacteriol.) [2009]

C4XC96_KLEPN
(C4XC96)

1e-42

177

42%

Product: Putative cyclase
Gene: KP1_4221
Organism: Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044

1uniprot[Pubmed] 19447910
Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis.(J. Bacteriol.) [2009]

E2XPX8_PSEFL
(E2XPX8)

1e-42

177

41%

Product: Cyclase, probable
Gene: PFWH6_2056
Organism: Pseudomonas fluorescens WH6

1uniprot[Pubmed] 20920191
An improved, high-quality draft genome sequence of the Germination-Arrest Factor-producing Pseudomonas fluorescens WH6.(BMC Genomics) [2010]

Q0SB98_RHOSR
(Q0SB98)

2e-42

176

43%

Product: Possible cyclase
Gene: RHA1_ro03385
Organism: Rhodococcus sp. (strain RHA1)

1uniprot[Pubmed] 17030794
The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

A0YCA5_9GAMM
(A0YCA5)

3e-42

176

44%

Product: Putative cyclase
Gene: GP2143_07739
Organism: marine gamma proteobacterium HTCC2143

1uniprot[Pubmed] 20601481
Genome sequence of the oligotrophic marine Gammaproteobacterium HTCC2143, isolated from the Oregon Coast.(J. Bacteriol.) [2010]

A4YZ46_BRASO
(A4YZ46)

6e-42

175

39%

Product: Putative cyclase
Gene: BRADO5497
Organism: Bradyrhizobium sp. (strain ORS278)

1uniprot[Pubmed] 17540897
Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.(Science) [2007]

Q2NB57_ERYLH
(Q2NB57)

1e-41

174

46%

Product: Putative cyclase
Gene: ELI_04960
Organism: Erythrobacter litoralis (strain HTCC2594)

1uniprot[Pubmed] 19168610
Complete genome sequence of Erythrobacter litoralis HTCC2594.(J. Bacteriol.) [2009]

Q2N7W3_ERYLH
(Q2N7W3)

2e-41

174

42%

Product: Putative cyclase
Gene: ELI_10680
Organism: Erythrobacter litoralis (strain HTCC2594)

1uniprot[Pubmed] 19168610
Complete genome sequence of Erythrobacter litoralis HTCC2594.(J. Bacteriol.) [2009]

F2KGF1_PSEBN
(F2KGF1)

4e-41

172

40%

Product: Putative cyclase
Gene: PSEBR_a2144
Organism: Pseudomonas brassicacearum (strain NFM421)

1uniprot[Pubmed] 21515771
Complete genome sequence of a beneficial plant root-associated bacterium, Pseudomonas brassicacearum.(J. Bacteriol.) [2011]

100

A4A9M0_9GAMM
(A4A9M0)

6e-41

172

40%

Product: Putative cyclase
Gene: KT71_07404
Organism: Congregibacter litoralis KT71

[pubmed all]
1uniprot[Pubmed] 19287491 The photosynthetic apparatus and its regulation in the aerobic gammaproteobacterium Congregibacter litoralis gen. nov., sp. nov.(PLoS ONE) [2009]
2uniprot[Pubmed] 17299055 Characterization of a marine gammaproteobacterium capable of aerobic anoxygenic photosynthesis.(Proc. Natl. Acad. Sci. U.S.A.) [2007]