Alanine racemization(NFUNC_0063) |
必須 | A | ALR (NRULE_0228) | Alanine racemase | HMPREF9086_2156 HMPREF9086_2738 |
Anthranilate biosynthesis(NFUNC_0038) |
必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | HMPREF9086_4208 HMPREF9086_2616 |
TRPE (NRULE_0143) | Anthranilate synthase component I | HMPREF9086_2615 |
Aromatic azo compounds degradation(NFUNC_0073) |
必須 | A | AZOR (NRULE_0236) | FMN-dependent NADH-azoreductase | HMPREF9086_2280 |
Arsenical resistance(NFUNC_0004) |
必須 | A | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | HMPREF9086_2609 |
ARSC1 (NRULE_0017) | Arsenate reductase | HMPREF9086_1004 HMPREF9086_2608 HMPREF9086_3318 |
任意 | | ARSH (NRULE_0021) | ArsH protein | HMPREF9086_2611 |
Bacitracin resistance(NFUNC_0022) |
必須 | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | HMPREF9086_3896 |
Beta-lactam antibiotic resistance(NFUNC_0033) |
必須 | C | BLAC (NRULE_0124) | Beta-lactamase class C | HMPREF9086_2076 |
Betaine biosynthesis (from choline)(NFUNC_0049) |
必須 | A | BETA (NRULE_0175) | Choline dehydrogenase | HMPREF9086_1260 |
Biotin biosynthesis(NFUNC_0051) |
必須 | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | HMPREF9086_1084 |
BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | HMPREF9086_1086 |
BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | HMPREF9086_1082 HMPREF9086_0368 |
BIOB (NRULE_0185) | Biotin synthase | HMPREF9086_1085 |
Cephalosporin resistance(NFUNC_0048) |
必須 | A | BLAC (NRULE_0124) | Beta-lactamase class C | HMPREF9086_2076 |
Chloramphenicol resistance(NFUNC_0025) |
必須 | A | CAT1 (NRULE_0107) | Chloramphenicol acetyltransferase | HMPREF9086_0356 |
Folate biosynthesis(NFUNC_0044) |
必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | HMPREF9086_2616 HMPREF9086_4208 |
DHPS (NRULE_0144) | Dihydropteroate synthase | HMPREF9086_4036 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | HMPREF9086_0413 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | HMPREF9086_3219 HMPREF9086_3897 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | HMPREF9086_1687 |
FOLC (NRULE_0160) | Bifunctional protein FolC | HMPREF9086_3231 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | HMPREF9086_2757 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | HMPREF9086_0761 |
B | GLAT (NRULE_0142) | Glutamine amidotransferase | HMPREF9086_2616 HMPREF9086_4208 |
DHPS (NRULE_0144) | Dihydropteroate synthase | HMPREF9086_4036 |
FOLA (NRULE_0147) | Dihydrofolate reductase | HMPREF9086_1783 HMPREF9086_4599 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | HMPREF9086_3897 HMPREF9086_3219 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | HMPREF9086_1687 |
FOLC (NRULE_0160) | Bifunctional protein FolC | HMPREF9086_3231 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | HMPREF9086_2757 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | HMPREF9086_0761 |
4-hydroxyphenylacetate degradation(NFUNC_0068) |
必須 | A | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | HMPREF9086_1894 |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | HMPREF9086_1895 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | HMPREF9086_1888 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | HMPREF9086_1887 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | HMPREF9086_1889 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | HMPREF9086_1886 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | HMPREF9086_1890 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | HMPREF9086_1891 |
C | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | HMPREF9086_1894 |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF9086_2461 HMPREF9086_0843 HMPREF9086_1214 HMPREF9086_1895 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | HMPREF9086_1888 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | HMPREF9086_1887 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | HMPREF9086_1889 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | HMPREF9086_1886 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | HMPREF9086_1890 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | HMPREF9086_1891 |
Macrolide antibiotic resistance(NFUNC_0045) |
必須 | B | RLMA (NRULE_0165) | 23S rRNA (guanine-N(1))-methyltransferase | HMPREF9086_2767 |
C | MACA (NRULE_0166) | Macrolide-specific efflux protein MacA | HMPREF9086_0946 |
MACB (NRULE_0167) | Macrolide export ATP-binding/permease protein MacB | HMPREF9086_0945 |
Metal-binding protein(NFUNC_0105) |
必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | HMPREF9086_1100 HMPREF9086_1096 HMPREF9086_3523 |
B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | HMPREF9086_1100 |
C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | HMPREF9086_1098 HMPREF9086_3290 HMPREF9086_2978 HMPREF9086_0130 |
E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | HMPREF9086_1403 |
F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | HMPREF9086_2146 |
G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | HMPREF9086_4145 |
I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | HMPREF9086_3389 |
Molybdate transport (ABC transporter)(NFUNC_0097) |
必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | HMPREF9086_3290 HMPREF9086_2978 HMPREF9086_1098 HMPREF9086_0130 |
任意 | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | HMPREF9086_1100 |
| MODB (NRULE_0325) | Molybdate ABC transporter permease protein | HMPREF9086_1097 |
| MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | HMPREF9086_1096 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | HMPREF9086_1690 |
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | HMPREF9086_1688 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | HMPREF9086_1275 HMPREF9086_1480 |
PANC (NRULE_0118) | Pantothenate synthetase | HMPREF9086_1689 |
Phenol degradation(NFUNC_0028) |
必須 | B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | HMPREF9086_1894 |
任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF9086_0952 HMPREF9086_0308 HMPREF9086_1610 |
| FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | HMPREF9086_3799 HMPREF9086_3801 |
| FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF9086_0843 HMPREF9086_2461 HMPREF9086_1214 HMPREF9086_1895 |
Pyrroloquinoline quinone biosynthesis(NFUNC_0020) |
必須 | A | PQQC (NRULE_0092) | Pyrroloquinoline-quinone synthase | HMPREF9086_0390 |
任意 | | PQQB (NRULE_0091) | Coenzyme PQQ synthesis protein B | HMPREF9086_0389 |
| PQQD (NRULE_0093) | Coenzyme PQQ synthesis protein D | HMPREF9086_0391 |
| PQQE (NRULE_0094) | Coenzyme PQQ synthesis protein E | HMPREF9086_0392 |
| PQQF (NRULE_0095) | Coenzyme PQQ synthesis protein F | HMPREF9086_0393 |
Riboflavin biosynthesis(NFUNC_0058) |
必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | HMPREF9086_3889 |
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | HMPREF9086_2588 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | HMPREF9086_1490 |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | HMPREF9086_1489 HMPREF9086_1591 |
RIBE (NRULE_0204) | Riboflavin synthase | HMPREF9086_0516 |
任意 | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | HMPREF9086_1805 |
Trehalose biosynthesis (from maltooligosaccharide)(NFUNC_0037) |
必須 | A | TREY (NRULE_0140) | Maltooligosyl trehalose synthase | HMPREF9086_2407 |
TREZ (NRULE_0141) | Malto-oligosyltrehalose trehalohydrolase | HMPREF9086_2408 |
任意 | | GLGX (NRULE_0139) | Glycogen debranching enzyme | HMPREF9086_4261 HMPREF9086_2406 |
Trehalose biosynthesis (from NDP-glucose and glucose-6-phosphate)(NFUNC_0031) |
必須 | A | TPS (NRULE_0119) | Trehalose-phosphate synthase | HMPREF9086_2897 |
TPP (NRULE_0120) | Trehalose-6-phosphate phosphatase | HMPREF9086_2898 |
Uptake of osmoprotectant(NFUNC_0061) |
必須 | A | OPUAC (NRULE_0213) | Osmoprotectant ABC transporter substrate-binding protein | HMPREF9086_3565 |
OPUAB (NRULE_0214) | Osmoprotectant ABC transporter permease protein | HMPREF9086_3564 |
OPUAA (NRULE_0215) | Osmoprotectant ABC transporter ATP-binding protein | HMPREF9086_0364 HMPREF9086_3563 |
C | BCCT (NRULE_0220) | BCCT family transporter | HMPREF9086_2262 HMPREF9086_1257 |
D | PROP (NRULE_0221) | Osmoprotectant transporter | HMPREF9086_2102 |
E | OPUE (NRULE_0222) | Sodium/proline symporter | HMPREF9086_0834 |
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) |
必須 | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase | HMPREF9086_3785 |
PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase | HMPREF9086_3236 |
SERC (NRULE_0210) | Phosphoserine aminotransferase | HMPREF9086_0917 |
PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | HMPREF9086_1779 |
PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | HMPREF9086_3413 |