遺伝子 : Beta-lactamase class D (BLAD)

遺伝子情報

ID	NRULE_0125
遺伝子ID	BLAD
作成日	2013/01/28
タンパク質名	Protein name Full Beta-lactamase class D EC EC 3.5.2.6
遺伝子名	bla, oxa
遺伝子条件	PROSITE; PS00337; hit=1
参照	Gene Ontology GO GO:0008800, F:beta-lactamase activity, IEA:EC GO:0008658, F:penicillin binding, IEA:InterPro GO:0017001, P:antibiotic catabolic process, IEA:InterPro GO:0009273, P:peptidoglycan-based cell wall biogenesis, IEA:InterPro GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW Family and domain databases InterPro IPR002137, Beta-lactam_class-D_AS IPR001460, PCN-bd_Tpept Pfam PF00905, Transpeptidase, 1 PROSITE PS00337, BETA_LACTAMASE_D, 1
配列の特徴	P14489 Pseudomonas aeruginosa. ACT_SITE 67 Acyl-ester intermediate. MOD_RES 70 N6-carboxylysine.
注釈	Catalytic activity A beta-lactam + H(2)O = a substituted beta- amino acid Sequence similarities Belongs to the class-D beta-lactamase family
参考文献	P13661 Escherichia coli. 2823258 Precise insertion of antibiotic resistance determinants into Tn21-like transposons: nucleotide sequence of the OXA-1 beta-lactamase gene. (Proc Natl Acad Sci U S A. 1987) P14489 Pseudomonas aeruginosa. 3126705 Sequence of PSE-2 beta-lactamase. (Antimicrob Agents Chemother. 1988)

関与する機能

機能名
Ampicillin resistance
Beta-lactam antibiotic resistance
Penicillin resistance

該当CDS

学名	NBRC番号	CDS	タンパク質名
Acaryochloris marina	102967	AM1_3437	penicillin-binding protein, putative
		AM1_4306	beta-lactamase, putative
Arthrobacter globiformis	12137	ARGLB_037_00290	putative penicillin-binding protein
Bacillus atrophaeus	13721	BATRMS_04_00070	beta-lactamase
		BATRMS_21_00040	beta-lactamase
Bacillus mojavensis	15718	GYU_03_05680	beta-lactamase
Bacillus subtilis	3134	BSU6633_13722	beta-lactamase
Bacillus subtilis subsp. subtilis	13719	BSU02090	exported beta-lactamase
Bacillus vallismortis	101236	BvalD_010100020637	beta-lactamase
Balneola vulgaris		B155_RS0105465	hypothetical protein
Beutenbergia cavernae	16432	Bcav_0389	penicillin-binding protein transpeptidase
Bradyrhizobium diazoefficiens	14792	bll5360	putative beta-lactamase precursor (EC 3.5.2.6)
Cellulomonas fimi	15513	Celf_0189	penicillin-binding protein transpeptidase
Cellulomonas flavigena	3775	Cfla_3460	penicillin-binding protein transpeptidase
Chryseobacterium gleum	15054	HMPREF0204_10459	putative penicillin-binding protein 2
Chthoniobacter flavus		CfE428DRAFT_3931	penicillin-binding protein 2
Desulfovibrio magneticus	104933	DMR_04670	class D beta-lactamase precursor
Flexibacter litoralis	15988	Fleli_2929	penicillin-binding protein 2
Holophaga foetida		HOLFODRAFT_RS0214505	penicillin-binding protein 2
Hylemonella gracilis	14920	HGR_08939	beta-lactamase
Ignavibacterium album	101810	IALB_1849	Cell division protein
Kineococcus radiotolerans	101839	Krad_0475	penicillin-binding protein transpeptidase
Magnetospirillum magnetotacticum	15272	Magn03010205	COG0768: Cell division protein FtsI/penicillin-binding protein 2
Methylacidiphilum infernorum		Minf_1718	Cell division protein FtsI
Microlunatus phosphovorus	101784	MLP_16730	putative penicillin-binding protein
Microscilla marina	16560	M23134_01068	beta-lactamase OXA-20
Niastella koreensis	106392	Niako_6692	Beta-lactamase
Propionibacterium acidipropionici	12425	PACID_33580	Putative penicillin-binding protein
Pseudomonas stutzeri	14165	PSTAB_2684	beta-lactamase
Sanguibacter keddieii	16158	Sked_36830	cell division protein FtsI/penicillin-binding protein 2
Streptosporangium roseum	3776	Sros_8961	Beta-lactamase
Synechocystis sp.		slr0319	beta-lactamase
Thermanaerovibrio acidaminovorans		Taci_1207	penicillin-binding protein 2
Thermomonospora curvata	15933	Tcur_2040	Beta-lactamase
Xylanimonas cellulosilytica	107835	Xcel_3275	penicillin-binding protein transpeptidase