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Rule : Beta-lactamase class D (BLAD)

Rule Description

ID NRULE_0125
Rule name BLAD
Created 2013-01-28
Protein name
Protein name
Full
Beta-lactamase class D
EC
EC 3.5.2.6
Gene name bla, oxa
Rule Trigger PROSITE; PS00337; hit=1
Cross Reference
Gene Ontology
GO
GO:0008800, F:beta-lactamase activity, IEA:EC
GO:0008658, F:penicillin binding, IEA:InterPro
GO:0017001, P:antibiotic catabolic process, IEA:InterPro
GO:0009273, P:peptidoglycan-based cell wall biogenesis, IEA:InterPro
GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW
Family and domain databases
InterPro
IPR002137, Beta-lactam_class-D_AS
IPR001460, PCN-bd_Tpept
Pfam
PF00905, Transpeptidase, 1
PROSITE
PS00337, BETA_LACTAMASE_D, 1
Feature
P14489 Pseudomonas aeruginosa.
ACT_SITE67Acyl-ester intermediate.
MOD_RES70N6-carboxylysine.
General annotation
Catalytic activity
A beta-lactam + H(2)O = a substituted beta- amino acid
Sequence similarities
Belongs to the class-D beta-lactamase family
Reference
P13661 Escherichia coli.
2823258
Precise insertion of antibiotic resistance determinants into Tn21-like transposons: nucleotide sequence of the OXA-1 beta-lactamase gene. (Proc Natl Acad Sci U S A. 1987)
P14489 Pseudomonas aeruginosa.
3126705
Sequence of PSE-2 beta-lactamase. (Antimicrob Agents Chemother. 1988)



Related Function

Function name
Ampicillin resistance
Beta-lactam antibiotic resistance
Penicillin resistance

CDS

Data Download
Scientific name NBRC No. CDS Product name
Acaryochloris marina102967AM1_3437penicillin-binding protein, putative
AM1_4306beta-lactamase, putative
Arthrobacter globiformis12137ARGLB_037_00290putative penicillin-binding protein
Bacillus atrophaeus13721BATRMS_04_00070beta-lactamase
BATRMS_21_00040beta-lactamase
Bacillus mojavensis15718GYU_03_05680beta-lactamase
Bacillus subtilis3134BSU6633_13722beta-lactamase
Bacillus subtilis subsp. subtilis13719BSU02090exported beta-lactamase
Bacillus vallismortis101236BvalD_010100020637beta-lactamase
Balneola vulgarisB155_RS0105465hypothetical protein
Beutenbergia cavernae16432Bcav_0389penicillin-binding protein transpeptidase
Bradyrhizobium diazoefficiens14792bll5360putative beta-lactamase precursor (EC 3.5.2.6)
Cellulomonas fimi15513Celf_0189penicillin-binding protein transpeptidase
Cellulomonas flavigena3775Cfla_3460penicillin-binding protein transpeptidase
Chryseobacterium gleum15054HMPREF0204_10459putative penicillin-binding protein 2
Chthoniobacter flavusCfE428DRAFT_3931penicillin-binding protein 2
Desulfovibrio magneticus104933DMR_04670class D beta-lactamase precursor
Flexibacter litoralis15988Fleli_2929penicillin-binding protein 2
Holophaga foetidaHOLFODRAFT_RS0214505penicillin-binding protein 2
Hylemonella gracilis14920HGR_08939beta-lactamase
Ignavibacterium album101810IALB_1849Cell division protein
Kineococcus radiotolerans101839Krad_0475penicillin-binding protein transpeptidase
Magnetospirillum magnetotacticum15272Magn03010205COG0768: Cell division protein FtsI/penicillin-binding protein 2
Methylacidiphilum infernorumMinf_1718Cell division protein FtsI
Microlunatus phosphovorus101784MLP_16730putative penicillin-binding protein
Microscilla marina16560M23134_01068beta-lactamase OXA-20
Niastella koreensis106392Niako_6692Beta-lactamase
Propionibacterium acidipropionici12425PACID_33580Putative penicillin-binding protein
Pseudomonas stutzeri14165PSTAB_2684beta-lactamase
Sanguibacter keddieii16158Sked_36830cell division protein FtsI/penicillin-binding protein 2
Streptosporangium roseum3776Sros_8961Beta-lactamase
Synechocystis sp.slr0319beta-lactamase
Thermanaerovibrio acidaminovoransTaci_1207penicillin-binding protein 2
Thermomonospora curvata15933Tcur_2040Beta-lactamase
Xylanimonas cellulosilytica107835Xcel_3275penicillin-binding protein transpeptidase