BLAST table : Resis_00130

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism
1	Q70DW5_9ACTO (Q70DW5)	1e-157	557	100%	UniProt GenBank	RemL protein	remL	Streptomyces resistomycificus
2	D6U573_9CHLR (D6U573)	1e-49	201	42%	UniProt GenBank	Cyclase family protein	Krac_2389	Ktedonobacter racemifer DSM 44963
3	D9W8F5_9ACTO (D9W8F5)	2e-40	170	41%	UniProt GenBank	Putative cyclase	SSOG_02376	Streptomyces himastatinicus ATCC 53653
4	Q70J97_STRGR (Q70J97)	7e-40	168	41%	UniProt GenBank	Cyclase	cmmY	Streptomyces griseus subsp. griseus
5	E8W964_STRFA (E8W964)	8e-40	168	44%	UniProt GenBank	Cyclase family protein	Sfla_5330	Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD)
6	Q54196_STRGR (Q54196)	8e-40	168	47%	UniProt GenBank	DNA sequence for ORF's 1-6		Streptomyces griseus
7	Q2PA03_9ACTO (Q2PA03)	1e-39	168	40%	UniProt GenBank	Cyclase	stfY	Streptomyces steffisburgensis
8	Q9F6D2_9ACTO (Q9F6D2)	3e-39	166	43%	UniProt GenBank	Cyclase	zhuJ	Streptomyces sp. R1128
9	O68500_STRPE (O68500)	3e-39	166	45%	UniProt GenBank	Polyketide cyclase	dpsY	Streptomyces peucetius
10	D3STQ2_NATMM (D3STQ2)	9e-39	165	39%	UniProt GenBank	Cyclase family protein	Nmag_1493	Natrialba magadii (strain ATCC 43099 / DSM 3394 / NCIMB 2190 / MS3) Natronobacterium magadii
11	C0JWC6_9ACTO (C0JWC6)	1e-38	164	42%	UniProt GenBank	PokC2	pokC2	Streptomyces diastatochromogenes
12	Q4R0M8_STRCX (Q4R0M8)	5e-38	162	46%	UniProt GenBank	ChaG protein	chaG	Streptomyces chartreusis
13	Q3S8Q2_STRRM (Q3S8Q2)	1e-37	161	45%	UniProt GenBank	OxyN	oxyN	Streptomyces rimosus
14	D2RQE4_HALTV (D2RQE4)	1e-37	160	38%	UniProt GenBank	Cyclase family protein	Htur_3459	Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734) Halococcus turkmenicus
15	Q7MZT2_PHOLL (Q7MZT2)	3e-37	159	38%	UniProt GenBank	Similar to polyketide cyclase	plu4192	Photorhabdus luminescens subsp. laumondii (strain TT01)
16	E3C7H6_9LACO (E3C7H6)	5e-37	159	34%	UniProt GenBank	Putative cyclase	HMPREF9265_1205	Lactobacillus oris PB013-T2-3
17	Q194Q6_STRAA (Q194Q6)	5e-37	159	38%	UniProt GenBank	Cyclase	mtmY	Streptomyces argillaceus
18	Q9L4U2_9ACTO (Q9L4U2)	8e-37	158	45%	UniProt GenBank	Putative cyclase	aknW	Streptomyces galilaeus
19	Q9RN54_STRNO (Q9RN54)	3e-36	156	45%	UniProt GenBank	Putative polyketide cyclase	snoaM	Streptomyces nogalater
20	E8SDG0_MICSL (E8SDG0)	1e-35	154	43%	UniProt GenBank	Cyclase family protein	ML5_4398	Micromonospora sp. (strain L5)
21	D9T2C0_MICAI (D9T2C0)	1e-35	154	43%	UniProt GenBank	Cyclase family protein	Micau_4023	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
22	C6CY72_PAESJ (C6CY72)	4e-35	153	40%	UniProt GenBank	Cyclase family protein	Pjdr2_2113	Paenibacillus sp. (strain JDR-2)
23	C9BE73_ENTFC (C9BE73)	1e-34	151	38%	UniProt GenBank	Cyclase	EFSG_00464	Enterococcus faecium 1,141,733
24	D9SQY6_CLOC7 (D9SQY6)	2e-34	150	41%	UniProt GenBank	Cyclase family protein	Clocel_0499	Clostridium cellulovorans (strain ATCC 35296 / DSM 3052 / OCM 3 / 743B)
25	D4VXF1_ENTFC (D4VXF1)	2e-34	150	38%	UniProt GenBank	Putative cyclase	CUO_0236	Enterococcus faecium PC4.1
26	C9AGV4_ENTFC (C9AGV4)	2e-34	150	38%	UniProt GenBank	Cyclase	EFVG_00437	Enterococcus faecium Com12
27	C2HCD4_ENTFC (C2HCD4)	2e-34	150	38%	UniProt GenBank	Cyclase family protein	HMPREF0352_1866	Enterococcus faecium TX1330
28	B9JI03_AGRRK (B9JI03)	6e-34	149	37%	UniProt GenBank	Cyclase	Arad_8216	Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
29	E0I596_9BACL (E0I596)	1e-33	148	39%	UniProt GenBank	Cyclase family protein	PaecuDRAFT_0818	Paenibacillus curdlanolyticus YK9
30	A1C180_9ACTO (A1C180)	2e-33	147	41%	UniProt GenBank	Cyclase		Streptomyces echinatus
31	C6JPN0_FUSVA (C6JPN0)	3e-33	146	38%	UniProt GenBank	Cyclase	FVAG_00930	Fusobacterium varium ATCC 27725
32	D7BZQ8_STRBB (D7BZQ8)	3e-33	146	45%	UniProt GenBank	Polyketide cyclase	SBI_06843	Streptomyces bingchenggensis (strain BCW-1)
33	C6A4Y1_THESM (C6A4Y1)	3e-33	146	41%	UniProt GenBank	Cyclase family protein	TSIB_1625	Thermococcus sibiricus (strain MM 739 / DSM 12597)
34	Q3INL7_NATPD (Q3INL7)	6e-33	145	36%	UniProt GenBank	Putative uncharacterized protein	NP4388A	Natronomonas pharaonis (strain DSM 2160 / ATCC 35678)
35	A0QWH8_MYCS2 (A0QWH8)	8e-33	145	35%	UniProt GenBank	Polyketide cyclase	MSMEG_2947	Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
36	A7NLJ2_ROSCS (A7NLJ2)	1e-32	144	40%	UniProt GenBank	Cyclase family protein	Rcas_2300	Roseiflexus castenholzii (strain DSM 13941 / HLO8)
37	A5UTI1_ROSS1 (A5UTI1)	1e-32	144	41%	UniProt GenBank	Cyclase family protein	RoseRS_1541	Roseiflexus sp. (strain RS-1)
38	E1QDZ4_DESB2 (E1QDZ4)	2e-32	144	40%	UniProt GenBank	Cyclase family protein	Deba_0405	Desulfarculus baarsii (strain ATCC 33931 / DSM 2075 / VKM B-1802 / 2st14)
39	C0ZIS6_BREBN (C0ZIS6)	2e-32	143	35%	UniProt GenBank	Putative uncharacterized protein	BBR47_03170	Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
40	F4L2P9_HALH1 (F4L2P9)	3e-32	143	34%	UniProt GenBank	Cyclase family protein	Halhy_0705	Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O)
41	E5WAK5_9BACI (E5WAK5)	3e-32	143	39%	UniProt GenBank	Putative uncharacterized protein	HMPREF1012_03914	Bacillus sp. BT1B_CT2
42	B5G897_9ACTO (B5G897)	5e-32	142	44%	UniProt GenBank	Cyclase superfamily protein	SSBG_00505	Streptomyces sp. SPB74
43	Q1ATU7_RUBXD (Q1ATU7)	6e-32	142	40%	UniProt GenBank	Putative cyclase	Rxyl_2245	Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
44	D7W634_9FLAO (D7W634)	6e-32	142	33%	UniProt GenBank	Cyclase	HMPREF0204_12339	Chryseobacterium gleum ATCC 35910
45	A8F3U6_THELT (A8F3U6)	8e-32	142	37%	UniProt GenBank	Cyclase family protein	Tlet_0260	Thermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / TMO)
46	Q1ASR5_RUBXD (Q1ASR5)	1e-31	141	38%	UniProt GenBank	Putative cyclase	Rxyl_2646	Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
47	Q65N24_BACLD (Q65N24)	1e-31	141	38%	UniProt GenBank	Putative uncharacterized protein	BL02015 BLi00591	Bacillus licheniformis (strain DSM 13 / ATCC 14580)
48	F7TUP3_9BACL (F7TUP3)	2e-31	140	36%	UniProt GenBank	Cyclase family protein	BRLA_c18770	Brevibacillus laterosporus LMG 15441
49	A8MJJ2_ALKOO (A8MJJ2)	5e-31	139	36%	UniProt GenBank	Cyclase family protein	Clos_2442	Alkaliphilus oremlandii (strain OhILAs) Clostridium oremlandii (strain OhILAs)
50	F6DKS1_9FIRM (F6DKS1)	5e-31	139	34%	UniProt GenBank	Cyclase family protein	Desru_2197	Desulfotomaculum ruminis DSM 2154
51	F8EG38_9BACT (F8EG38)	1e-30	138	38%	UniProt GenBank	Cyclase family protein	Runsl_0473	Runella slithyformis DSM 19594
52	Q89HD3_BRAJA (Q89HD3)	1e-30	137	36%	UniProt GenBank	Blr6059 protein	blr6059	Bradyrhizobium japonicum
53	D2QNY6_SPILD (D2QNY6)	2e-30	137	37%	UniProt GenBank	Cyclase family protein	Slin_1543	Spirosoma linguale (strain ATCC 33905 / DSM 74 / LMG 10896)
54	F0E8M9_9PSED (F0E8M9)	2e-30	137	39%	UniProt GenBank	Cyclase, putative	G1E_19520	Pseudomonas sp. TJI-51
55	B0T5J6_CAUSK (B0T5J6)	2e-30	137	39%	UniProt GenBank	Cyclase family protein	Caul_0417	Caulobacter sp. (strain K31)
56	C1FJH1_MICSR (C1FJH1)	2e-30	137	40%	UniProt GenBank	Predicted protein	MICPUN_87321	Micromonas sp. (strain RCC299 / NOUM17) Picoplanktonic green alga
57	A1BB13_PARDP (A1BB13)	3e-30	136	41%	UniProt GenBank	Cyclase family protein	Pden_4646	Paracoccus denitrificans (strain Pd 1222)
58	F4C6B1_SPHS2 (F4C6B1)	3e-30	136	33%	UniProt GenBank	Cyclase family protein	Sph21_4827	Sphingobacterium sp. (strain 21)
59	F6IDL5_9SPHN (F6IDL5)	5e-30	135	39%	UniProt GenBank	Putative cyclase	PP1Y_Mpl4308 PP1Y_Mpl4613	Novosphingobium sp. PP1Y
60	E6UZ09_VARPD (E6UZ09)	5e-30	135	38%	UniProt GenBank	Cyclase family protein	Varpa_0116	Variovorax paradoxus
61	D7A7I2_STAND (D7A7I2)	5e-30	135	39%	UniProt GenBank	Cyclase family protein	Snov_1110	Starkeya novella (strain ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB 9113)
62	Q88HZ5_PSEPK (Q88HZ5)	5e-30	135	40%	UniProt GenBank	Cyclase, putative	PP3207 PP_3207	Pseudomonas putida (strain KT2440)
63	F7V2P6_9CLOT (F7V2P6)	9e-30	135	38%	UniProt GenBank	Uncharacterized ACR protein	CXIVA_10580	Clostridium sp. SY8519
64	D5RJK7_9PROT (D5RJK7)	1e-29	135	39%	UniProt GenBank	Probable cyclase	HMPREF0731_1267	Roseomonas cervicalis ATCC 49957
65	A5VBU4_SPHWW (A5VBU4)	1e-29	134	39%	UniProt GenBank	Cyclase family protein	Swit_3414	Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
66	F7QNH4_9BRAD (F7QNH4)	1e-29	134	35%	UniProt GenBank	Cyclase	CSIRO_3122	Bradyrhizobiaceae bacterium SG-6C
67	Q2GAG0_NOVAD (Q2GAG0)	1e-29	134	39%	UniProt GenBank	Putative cyclase	Saro_0716	Novosphingobium aromaticivorans (strain DSM 12444)
68	A1ZKE6_9BACT (A1ZKE6)	2e-29	134	37%	UniProt GenBank	Cyclase	M23134_02363	Microscilla marina ATCC 23134
69	F3WX55_9SPHN (F3WX55)	2e-29	133	39%	UniProt GenBank	Cyclase family protein	SUS17_1850	Sphingomonas sp. S17
70	Q11L41_MESSB (Q11L41)	3e-29	133	32%	UniProt GenBank	Putative cyclase	Meso_0480	Mesorhizobium sp. (strain BNC1)
71	A3TXF2_9RHOB (A3TXF2)	3e-29	133	37%	UniProt GenBank	Cyclase, putative	OB2597_02792	Oceanicola batsensis HTCC2597
72	C5CW66_VARPS (C5CW66)	3e-29	133	37%	UniProt GenBank	Cyclase family protein	Vapar_0101	Variovorax paradoxus (strain S110)
73	Q2N7W3_ERYLH (Q2N7W3)	3e-29	133	35%	UniProt GenBank	Putative cyclase	ELI_10680	Erythrobacter litoralis (strain HTCC2594)
74	A5EP24_BRASB (A5EP24)	3e-29	133	36%	UniProt GenBank	Putative cyclase	BBta_5979	Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
75	Q6N497_RHOPA (Q6N497)	6e-29	132	35%	UniProt GenBank	Putative cyclase	RPA3442	Rhodopseudomonas palustris
76	E1IH15_9CHLR (E1IH15)	7e-29	132	35%	UniProt GenBank	Cyclase family protein	OSCT_2616	Oscillochloris trichoides DG-6
77	Q6FBB6_ACIAD (Q6FBB6)	8e-29	132	37%	UniProt GenBank	Putative cyclase	ACIAD1812	Acinetobacter sp. (strain ADP1)
78	D9QIT6_BRESC (D9QIT6)	1e-28	131	40%	UniProt GenBank	Cyclase family protein	Bresu_2109	Brevundimonas subvibrioides (strain ATCC 15264 / DSM 4735 / LMG 14903 / NBRC 16000 / CB 81) Caulobacter subvibrioides
79	A4YZ46_BRASO (A4YZ46)	1e-28	131	35%	UniProt GenBank	Putative cyclase	BRADO5497	Bradyrhizobium sp. (strain ORS278)
80	A0YCA5_9GAMM (A0YCA5)	1e-28	131	33%	UniProt GenBank	Putative cyclase	GP2143_07739	marine gamma proteobacterium HTCC2143
81	F2JZE8_MARM1 (F2JZE8)	2e-28	130	38%	UniProt GenBank	Cyclase family protein	Marme_0432	Marinomonas mediterranea (strain ATCC 700492 / JCM 21426 / NBRC 103028 / MMB-1)
82	E2XPX8_PSEFL (E2XPX8)	3e-28	130	39%	UniProt GenBank	Cyclase, probable	PFWH6_2056	Pseudomonas fluorescens WH6
83	F6F1S0_SPHCR (F6F1S0)	4e-28	129	39%	UniProt GenBank	Cyclase family protein	Sphch_3905	Sphingobium chlorophenolicum L-1
84	F4CY90_9PSEU (F4CY90)	4e-28	129	36%	UniProt GenBank	Cyclase family protein	Psed_2509	Pseudonocardia dioxanivorans CB1190
85	Q5YUM7_NOCFA (Q5YUM7)	5e-28	129	35%	UniProt GenBank	Putative cyclase	NFA_32670	Nocardia farcinica
86	Q2IRT4_RHOP2 (Q2IRT4)	5e-28	129	37%	UniProt GenBank	Putative cyclase	RPB_4390	Rhodopseudomonas palustris (strain HaA2)
87	Q0SB98_RHOSR (Q0SB98)	6e-28	129	38%	UniProt GenBank	Possible cyclase	RHA1_ro03385	Rhodococcus sp. (strain RHA1)
88	Q1GTT2_SPHAL (Q1GTT2)	6e-28	129	39%	UniProt GenBank	Putative cyclase	Sala_1225	Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) Sphingomonas alaskensis
89	A7IHZ7_XANP2 (A7IHZ7)	7e-28	129	38%	UniProt GenBank	Cyclase family protein	Xaut_2398	Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
90	A3WCZ3_9SPHN (A3WCZ3)	7e-28	129	39%	UniProt GenBank	Cyclase, putative	NAP1_04100	Erythrobacter sp. NAP1
91	B8KND8_9GAMM (B8KND8)	8e-28	128	38%	UniProt GenBank	Cyclase family protein	NOR53_2638	gamma proteobacterium NOR5-3
92	B9K160_AGRVS (B9K160)	8e-28	128	36%	UniProt GenBank	Cyclase	Avi_5495	Agrobacterium vitis (strain S4 / ATCC BAA-846) Rhizobium vitis (strain S4)
93	Q15XK5_PSEA6 (Q15XK5)	1e-27	127	37%	UniProt GenBank	Putative cyclase	Patl_0855	Pseudoalteromonas atlantica (strain T6c / BAA-1087)
94	D2THH3_CITRI (D2THH3)	1e-27	127	38%	UniProt GenBank	Putative uncharacterized protein	ROD_14041	Citrobacter rodentium (strain ICC168) Citrobacter freundii biotype 4280
95	A8IMQ1_AZOC5 (A8IMQ1)	2e-27	127	33%	UniProt GenBank	Putative cyclase	AZC_0592	Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571)
96	F2KGF1_PSEBN (F2KGF1)	2e-27	127	38%	UniProt GenBank	Putative cyclase	PSEBR_a2144	Pseudomonas brassicacearum (strain NFM421)
97	Q2NB57_ERYLH (Q2NB57)	2e-27	127	34%	UniProt GenBank	Putative cyclase	ELI_04960	Erythrobacter litoralis (strain HTCC2594)
98	A4A9M0_9GAMM (A4A9M0)	2e-27	127	37%	UniProt GenBank	Putative cyclase	KT71_07404	Congregibacter litoralis KT71
99	A9A0E5_DESOH (A9A0E5)	3e-27	126	33%	UniProt GenBank	Cyclase family protein	Dole_1641	Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
100	B8FAE3_DESAA (B8FAE3)	4e-27	126	34%	UniProt GenBank	Cyclase family protein	Dalk_1541	Desulfatibacillum alkenivorans (strain AK-01)

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q70DW5_9ACTO
(Q70DW5)

1e-157

557

100%

Product: RemL protein
Gene: remL
Organism: Streptomyces resistomycificus

1uniprot[Pubmed] 14982421
A gene cluster encoding resistomycin biosynthesis in Streptomyces resistomycificus; exploring polyketide cyclization beyond linear and angucyclic patterns.(J. Am. Chem. Soc.) [2004]

Q54196_STRGR
(Q54196)

8e-40

168

47%

Product: DNA sequence for ORF's 1-6
Gene
Organism: Streptomyces griseus

1uniprot[Pubmed] 8232204 [Medline] 94049680
Nucleotide sequence analysis of five putative Streptomyces griseus genes, one of which complements an early function in daunorubicin biosynthesis that is linked to a putative gene cluster involved in TDP-daunosamine formation.(Mol. Gen. Genet.) [1993]

Q2PA03_9ACTO
(Q2PA03)

1e-39

168

40%

Product: Cyclase
Gene: stfY
Organism: Streptomyces steffisburgensis

1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006]

Q9F6D2_9ACTO
(Q9F6D2)

3e-39

166

43%

Product: Cyclase
Gene: zhuJ
Organism: Streptomyces sp. R1128

1uniprot[Pubmed] 10931852 [Medline] 20517899
Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism.(J. Biol. Chem.) [2000]

O68500_STRPE
(O68500)

3e-39

166

45%

Product: Polyketide cyclase
Gene: dpsY
Organism: Streptomyces peucetius

1uniprot[Pubmed] 9573189 [Medline] 98233733
The Streptomyces peucetius dpsY and dnrX genes govern early and late steps of daunorubicin and doxorubicin biosynthesis.(J. Bacteriol.) [1998]

C0JWC6_9ACTO
(C0JWC6)

1e-38

164

42%

Product: PokC2
Gene: pokC2
Organism: Streptomyces diastatochromogenes

1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]

Q4R0M8_STRCX
(Q4R0M8)

5e-38

162

46%

Product: ChaG protein
Gene: chaG
Organism: Streptomyces chartreusis

1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]

Q3S8Q2_STRRM
(Q3S8Q2)

1e-37

161

45%

Product: OxyN
Gene: oxyN
Organism: Streptomyces rimosus

1uniprot[Pubmed] 16597959
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006]

D2RQE4_HALTV
(D2RQE4)

1e-37

160

38%

Product: Cyclase family protein
Gene: Htur_3459
Organism: Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734)
Halococcus turkmenicus

1uniprot[Pubmed] 21304683
Complete genome sequence of Haloterrigena turkmenica type strain (4k).(Stand. Genomic Sci.) [2009]

Q7MZT2_PHOLL
(Q7MZT2)

3e-37

159

38%

Product: Similar to polyketide cyclase
Gene: plu4192
Organism: Photorhabdus luminescens subsp. laumondii (strain TT01)

1uniprot[Pubmed] 14528314 [Medline] 22957627
The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens.(Nat. Biotechnol.) [2003]

Q194Q6_STRAA
(Q194Q6)

5e-37

159

38%

Product: Cyclase
Gene: mtmY
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

Q9L4U2_9ACTO
(Q9L4U2)

8e-37

158

45%

Product: Putative cyclase
Gene: aknW
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 11016846 [Medline] 20469061
A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.(Mol. Gen. Genet.) [2000]

Q9RN54_STRNO
(Q9RN54)

3e-36

156

45%

Product: Putative polyketide cyclase
Gene: snoaM
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
2uniprot[Pubmed] 10639368 [Medline] 20106987 Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.(Antimicrob. Agents Chemother.) [2000]

B9JI03_AGRRK
(B9JI03)

6e-34

149

37%

Product: Cyclase
Gene: Arad_8216
Organism: Agrobacterium radiobacter (strain K84 / ATCC BAA-868)

1uniprot[Pubmed] 19251847
Genome sequences of three Agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria.(J. Bacteriol.) [2009]

D7BZQ8_STRBB
(D7BZQ8)

3e-33

146

45%

Product: Polyketide cyclase
Gene: SBI_06843
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

C6A4Y1_THESM
(C6A4Y1)

3e-33

146

41%

Product: Cyclase family protein
Gene: TSIB_1625
Organism: Thermococcus sibiricus (strain MM 739 / DSM 12597)

1uniprot[Pubmed] 19447963
Metabolic versatility and indigenous origin of the archaeon Thermococcus sibiricus, isolated from a siberian oil reservoir, as revealed by genome analysis.(Appl. Environ. Microbiol.) [2009]

Q3INL7_NATPD
(Q3INL7)

6e-33

145

36%

Product: Putative uncharacterized protein
Gene: NP4388A
Organism: Natronomonas pharaonis (strain DSM 2160 / ATCC 35678)

1uniprot[Pubmed] 16169924
Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis.(Genome Res.) [2005]

E1QDZ4_DESB2
(E1QDZ4)

2e-32

144

40%

Product: Cyclase family protein
Gene: Deba_0405
Organism: Desulfarculus baarsii (strain ATCC 33931 / DSM 2075 / VKM B-1802 / 2st14)

1uniprot
Complete genome sequence of Desulfarculus baarsii type strain (2st14).(Stand. Genomic Sci.) [2010]

F4L2P9_HALH1
(F4L2P9)

3e-32

143

34%

Product: Cyclase family protein
Gene: Halhy_0705
Organism: Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O)

1uniprot
Complete genome sequence of Haliscomenobacter hydrossis type strain (O).(Stand. Genomic Sci.) [2011]

Q65N24_BACLD
(Q65N24)

1e-31

141

38%

Product: Putative uncharacterized protein
Gene: BL02015
BLi00591
Organism: Bacillus licheniformis (strain DSM 13 / ATCC 14580)

[pubmed all]
1uniprot[Pubmed] 15383718 The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential.(J. Mol. Microbiol. Biotechnol.) [2004]
2uniprot[Pubmed] 15461803 Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species.(Genome Biol.) [2004]

Q89HD3_BRAJA
(Q89HD3)

1e-30

137

36%

Product: Blr6059 protein
Gene: blr6059
Organism: Bradyrhizobium japonicum

1uniprot[Pubmed] 12597275 [Medline] 22484998
Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110.(DNA Res.) [2002]

C1FJH1_MICSR
(C1FJH1)

2e-30

137

40%

Product: Predicted protein
Gene: MICPUN_87321
Organism: Micromonas sp. (strain RCC299 / NOUM17)
Picoplanktonic green alga

1uniprot[Pubmed] 19359590
Green evolution and dynamic adaptations revealed by genomes of the marine picoeukaryotes Micromonas.(Science) [2009]

Q88HZ5_PSEPK
(Q88HZ5)

5e-30

135

40%

Product: Cyclase, putative
Gene: PP3207
PP_3207
Organism: Pseudomonas putida (strain KT2440)

1uniprot[Pubmed] 12534463 [Medline] 22423060
Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440.(Environ. Microbiol.) [2002]

A3TXF2_9RHOB
(A3TXF2)

3e-29

133

37%

Product: Cyclase, putative
Gene: OB2597_02792
Organism: Oceanicola batsensis HTCC2597

1uniprot[Pubmed] 20418400
Genome sequences of Oceanicola granulosus HTCC2516(T) and Oceanicola batsensis HTCC2597(TDelta).(J. Bacteriol.) [2010]

C5CW66_VARPS
(C5CW66)

3e-29

133

37%

Product: Cyclase family protein
Gene: Vapar_0101
Organism: Variovorax paradoxus (strain S110)

1uniprot[Pubmed] 21183664
Complete genome sequence of the metabolically versatile plant growth-promoting endophyte, Variovorax paradoxus S110.(J. Bacteriol.) [2011]

Q2N7W3_ERYLH
(Q2N7W3)

3e-29

133

35%

Product: Putative cyclase
Gene: ELI_10680
Organism: Erythrobacter litoralis (strain HTCC2594)

1uniprot[Pubmed] 19168610
Complete genome sequence of Erythrobacter litoralis HTCC2594.(J. Bacteriol.) [2009]

A5EP24_BRASB
(A5EP24)

3e-29

133

36%

Product: Putative cyclase
Gene: BBta_5979
Organism: Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)

1uniprot[Pubmed] 17540897
Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.(Science) [2007]

Q6N497_RHOPA
(Q6N497)

6e-29

132

35%

Product: Putative cyclase
Gene: RPA3442
Organism: Rhodopseudomonas palustris

1uniprot[Pubmed] 14704707
Complete genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris.(Nat. Biotechnol.) [2004]

E1IH15_9CHLR
(E1IH15)

7e-29

132

35%

Product: Cyclase family protein
Gene: OSCT_2616
Organism: Oscillochloris trichoides DG-6

1uniprot[Pubmed] 21037015
Draft genome sequence of the anoxygenic filamentous phototrophic bacterium Oscillochloris trichoides subsp. DG-6.(J. Bacteriol.) [2011]

Q6FBB6_ACIAD
(Q6FBB6)

8e-29

132

37%

Product: Putative cyclase
Gene: ACIAD1812
Organism: Acinetobacter sp. (strain ADP1)

1uniprot[Pubmed] 15514110
Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium.(Nucleic Acids Res.) [2004]

A4YZ46_BRASO
(A4YZ46)

1e-28

131

35%

Product: Putative cyclase
Gene: BRADO5497
Organism: Bradyrhizobium sp. (strain ORS278)

1uniprot[Pubmed] 17540897
Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.(Science) [2007]

A0YCA5_9GAMM
(A0YCA5)

1e-28

131

33%

Product: Putative cyclase
Gene: GP2143_07739
Organism: marine gamma proteobacterium HTCC2143

1uniprot[Pubmed] 20601481
Genome sequence of the oligotrophic marine Gammaproteobacterium HTCC2143, isolated from the Oregon Coast.(J. Bacteriol.) [2010]

E2XPX8_PSEFL
(E2XPX8)

3e-28

130

39%

Product: Cyclase, probable
Gene: PFWH6_2056
Organism: Pseudomonas fluorescens WH6

1uniprot[Pubmed] 20920191
An improved, high-quality draft genome sequence of the Germination-Arrest Factor-producing Pseudomonas fluorescens WH6.(BMC Genomics) [2010]

Q5YUM7_NOCFA
(Q5YUM7)

5e-28

129

35%

Product: Putative cyclase
Gene: NFA_32670
Organism: Nocardia farcinica

1uniprot[Pubmed] 15466710
The complete genomic sequence of Nocardia farcinica IFM 10152.(Proc. Natl. Acad. Sci. U.S.A.) [2004]

Q0SB98_RHOSR
(Q0SB98)

6e-28

129

38%

Product: Possible cyclase
Gene: RHA1_ro03385
Organism: Rhodococcus sp. (strain RHA1)

1uniprot[Pubmed] 17030794
The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

B9K160_AGRVS
(B9K160)

8e-28

128

36%

Product: Cyclase
Gene: Avi_5495
Organism: Agrobacterium vitis (strain S4 / ATCC BAA-846)
Rhizobium vitis (strain S4)

1uniprot[Pubmed] 19251847
Genome sequences of three Agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria.(J. Bacteriol.) [2009]

D2THH3_CITRI
(D2THH3)

1e-27

127

38%

Product: Putative uncharacterized protein
Gene: ROD_14041
Organism: Citrobacter rodentium (strain ICC168)
Citrobacter freundii biotype 4280

1uniprot[Pubmed] 19897651
The Citrobacter rodentium genome sequence reveals convergent evolution with human pathogenic Escherichia coli.(J. Bacteriol.) [2010]

F2KGF1_PSEBN
(F2KGF1)

2e-27

127

38%

Product: Putative cyclase
Gene: PSEBR_a2144
Organism: Pseudomonas brassicacearum (strain NFM421)

1uniprot[Pubmed] 21515771
Complete genome sequence of a beneficial plant root-associated bacterium, Pseudomonas brassicacearum.(J. Bacteriol.) [2011]

Q2NB57_ERYLH
(Q2NB57)

2e-27

127

34%

Product: Putative cyclase
Gene: ELI_04960
Organism: Erythrobacter litoralis (strain HTCC2594)

1uniprot[Pubmed] 19168610
Complete genome sequence of Erythrobacter litoralis HTCC2594.(J. Bacteriol.) [2009]

A4A9M0_9GAMM
(A4A9M0)

2e-27

127

37%

Product: Putative cyclase
Gene: KT71_07404
Organism: Congregibacter litoralis KT71

[pubmed all]
1uniprot[Pubmed] 19287491 The photosynthetic apparatus and its regulation in the aerobic gammaproteobacterium Congregibacter litoralis gen. nov., sp. nov.(PLoS ONE) [2009]
2uniprot[Pubmed] 17299055 Characterization of a marine gammaproteobacterium capable of aerobic anoxygenic photosynthesis.(Proc. Natl. Acad. Sci. U.S.A.) [2007]