| accession | DB | alignment | Evalue | Score | Ident. | link | information | pubmed |
2
|
Q2PA03_9ACTO (Q2PA03) |
|
|
1e-99 |
367 |
70% |
|
- Product
- Cyclase
- Gene
- stfY
- Organism
- Streptomyces steffisburgensis
|
1uniprot[Pubmed] 16751529 Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006] |
|
3
|
Q9L4U2_9ACTO (Q9L4U2) |
|
|
3e-97 |
359 |
68% |
|
- Product
- Putative cyclase
- Gene
- aknW
- Organism
- Streptomyces galilaeus
|
1uniprot[Pubmed] 11016846 [Medline] 20469061 A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.(Mol. Gen. Genet.) [2000] |
|
4
|
Q54196_STRGR (Q54196) |
|
|
1e-96 |
357 |
68% |
|
- Product
- DNA sequence for ORF's 1-6
- Gene
-
- Organism
- Streptomyces griseus
|
1uniprot[Pubmed] 8232204 [Medline] 94049680 Nucleotide sequence analysis of five putative Streptomyces griseus genes, one of which complements an early function in daunorubicin biosynthesis that is linked to a putative gene cluster involved in TDP-daunosamine formation.(Mol. Gen. Genet.) [1993] |
|
5
|
Q9RN54_STRNO (Q9RN54) |
|
|
3e-96 |
355 |
67% |
|
- Product
- Putative polyketide cyclase
- Gene
- snoaM
- Organism
- Streptomyces nogalater
|
1uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997] | 2uniprot[Pubmed] 10639368 [Medline] 20106987 Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.(Antimicrob. Agents Chemother.) [2000] | [pubmed all]
|
8
|
O68500_STRPE (O68500) |
|
|
6e-94 |
348 |
67% |
|
- Product
- Polyketide cyclase
- Gene
- dpsY
- Organism
- Streptomyces peucetius
|
1uniprot[Pubmed] 9573189 [Medline] 98233733 The Streptomyces peucetius dpsY and dnrX genes govern early and late steps of daunorubicin and doxorubicin biosynthesis.(J. Bacteriol.) [1998] |
|
9
|
C0JWC6_9ACTO (C0JWC6) |
|
|
9e-94 |
347 |
66% |
|
- Product
- PokC2
- Gene
- pokC2
- Organism
- Streptomyces diastatochromogenes
|
1uniprot[Pubmed] 19266534 Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009] |
|
10
|
Q194Q6_STRAA (Q194Q6) |
|
|
9e-94 |
347 |
65% |
|
- Product
- Cyclase
- Gene
- mtmY
- Organism
- Streptomyces argillaceus
|
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996] | 2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996] | 3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997] | 4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998] | 5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999] | 6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999] | 7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000] | 8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001] | 9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003] | 10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999] | 11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002] | 12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000] | 13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000] | 14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002] | 15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003] | 16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996] | 17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004] | 18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997] | 19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005] | 20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000] | [pubmed all]
|
11
|
Q3S8Q2_STRRM (Q3S8Q2) |
|
|
7e-93 |
344 |
66% |
|
- Product
- OxyN
- Gene
- oxyN
- Organism
- Streptomyces rimosus
|
1uniprot[Pubmed] 16597959 Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006] |
|
14
|
D7BZQ8_STRBB (D7BZQ8) |
|
|
3e-87 |
326 |
68% |
|
- Product
- Polyketide cyclase
- Gene
- SBI_06843
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
16
|
Q4R0M8_STRCX (Q4R0M8) |
|
|
5e-79 |
298 |
67% |
|
- Product
- ChaG protein
- Gene
- chaG
- Organism
- Streptomyces chartreusis
|
1uniprot[Pubmed] 15911378 Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005] |
|
17
|
Q7MZT2_PHOLL (Q7MZT2) |
|
|
2e-59 |
233 |
43% |
|
- Product
- Similar to polyketide cyclase
- Gene
- plu4192
- Organism
- Photorhabdus luminescens subsp. laumondii (strain TT01)
|
1uniprot[Pubmed] 14528314 [Medline] 22957627 The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens.(Nat. Biotechnol.) [2003] |
|
20
|
D2RQE4_HALTV (D2RQE4) |
|
|
1e-50 |
204 |
43% |
|
- Product
- Cyclase family protein
- Gene
- Htur_3459
- Organism
- Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734)
Halococcus turkmenicus
|
1uniprot[Pubmed] 21304683 Complete genome sequence of Haloterrigena turkmenica type strain (4k).(Stand. Genomic Sci.) [2009] |
|
23
|
C6A4Y1_THESM (C6A4Y1) |
|
|
2e-49 |
200 |
42% |
|
- Product
- Cyclase family protein
- Gene
- TSIB_1625
- Organism
- Thermococcus sibiricus (strain MM 739 / DSM 12597)
|
1uniprot[Pubmed] 19447963 Metabolic versatility and indigenous origin of the archaeon Thermococcus sibiricus, isolated from a siberian oil reservoir, as revealed by genome analysis.(Appl. Environ. Microbiol.) [2009] |
|
26
|
A3TXF2_9RHOB (A3TXF2) |
|
|
3e-48 |
196 |
44% |
|
- Product
- Cyclase, putative
- Gene
- OB2597_02792
- Organism
- Oceanicola batsensis HTCC2597
|
1uniprot[Pubmed] 20418400 Genome sequences of Oceanicola granulosus HTCC2516(T) and Oceanicola batsensis HTCC2597(TDelta).(J. Bacteriol.) [2010] |
|
27
|
B9JI03_AGRRK (B9JI03) |
|
|
6e-48 |
195 |
45% |
|
- Product
- Cyclase
- Gene
- Arad_8216
- Organism
- Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
|
1uniprot[Pubmed] 19251847 Genome sequences of three Agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria.(J. Bacteriol.) [2009] |
|
30
|
E2XPX8_PSEFL (E2XPX8) |
|
|
1e-47 |
194 |
47% |
|
- Product
- Cyclase, probable
- Gene
- PFWH6_2056
- Organism
- Pseudomonas fluorescens WH6
|
1uniprot[Pubmed] 20920191 An improved, high-quality draft genome sequence of the Germination-Arrest Factor-producing Pseudomonas fluorescens WH6.(BMC Genomics) [2010] |
|
38
|
E1QDZ4_DESB2 (E1QDZ4) |
|
|
5e-47 |
192 |
43% |
|
- Product
- Cyclase family protein
- Gene
- Deba_0405
- Organism
- Desulfarculus baarsii (strain ATCC 33931 / DSM 2075 / VKM B-1802 / 2st14)
|
1uniprot Complete genome sequence of Desulfarculus baarsii type strain (2st14).(Stand. Genomic Sci.) [2010] |
|
44
|
C1FJH1_MICSR (C1FJH1) |
|
|
1e-46 |
190 |
43% |
|
- Product
- Predicted protein
- Gene
- MICPUN_87321
- Organism
- Micromonas sp. (strain RCC299 / NOUM17)
Picoplanktonic green alga
|
1uniprot[Pubmed] 19359590 Green evolution and dynamic adaptations revealed by genomes of the marine picoeukaryotes Micromonas.(Science) [2009] |
|
49
|
Q3INL7_NATPD (Q3INL7) |
|
|
7e-46 |
188 |
42% |
|
- Product
- Putative uncharacterized protein
- Gene
- NP4388A
- Organism
- Natronomonas pharaonis (strain DSM 2160 / ATCC 35678)
|
1uniprot[Pubmed] 16169924 Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis.(Genome Res.) [2005] |
|
52
|
F2KGF1_PSEBN (F2KGF1) |
|
|
2e-45 |
186 |
46% |
|
- Product
- Putative cyclase
- Gene
- PSEBR_a2144
- Organism
- Pseudomonas brassicacearum (strain NFM421)
|
1uniprot[Pubmed] 21515771 Complete genome sequence of a beneficial plant root-associated bacterium, Pseudomonas brassicacearum.(J. Bacteriol.) [2011] |
|
53
|
A0Z2E6_9GAMM (A0Z2E6) |
|
|
4e-45 |
186 |
48% |
|
- Product
- Putative cyclase
- Gene
- MGP2080_11983
- Organism
- marine gamma proteobacterium HTCC2080
|
1uniprot[Pubmed] 20472793 Genome sequences of strains HTCC2148 and HTCC2080, belonging to the OM60/NOR5 clade of the Gammaproteobacteria.(J. Bacteriol.) [2010] |
|
55
|
Q88HZ5_PSEPK (Q88HZ5) |
|
|
5e-45 |
185 |
46% |
|
- Product
- Cyclase, putative
- Gene
- PP3207
PP_3207
- Organism
- Pseudomonas putida (strain KT2440)
|
1uniprot[Pubmed] 12534463 [Medline] 22423060 Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440.(Environ. Microbiol.) [2002] |
|
56
|
Q9F6D2_9ACTO (Q9F6D2) |
|
|
5e-45 |
185 |
50% |
|
- Product
- Cyclase
- Gene
- zhuJ
- Organism
- Streptomyces sp. R1128
|
1uniprot[Pubmed] 10931852 [Medline] 20517899 Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism.(J. Biol. Chem.) [2000] |
|
57
|
Q70DW5_9ACTO (Q70DW5) |
|
|
8e-45 |
185 |
42% |
|
- Product
- RemL protein
- Gene
- remL
- Organism
- Streptomyces resistomycificus
|
1uniprot[Pubmed] 14982421 A gene cluster encoding resistomycin biosynthesis in Streptomyces resistomycificus; exploring polyketide cyclization beyond linear and angucyclic patterns.(J. Am. Chem. Soc.) [2004] |
|
59
|
A5EP24_BRASB (A5EP24) |
|
|
1e-44 |
184 |
42% |
|
- Product
- Putative cyclase
- Gene
- BBta_5979
- Organism
- Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
|
1uniprot[Pubmed] 17540897 Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.(Science) [2007] |
|
60
|
C4XC96_KLEPN (C4XC96) |
|
|
1e-44 |
184 |
44% |
|
- Product
- Putative cyclase
- Gene
- KP1_4221
- Organism
- Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044
|
1uniprot[Pubmed] 19447910 Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis.(J. Bacteriol.) [2009] |
|
61
|
Q89HD3_BRAJA (Q89HD3) |
|
|
1e-44 |
184 |
42% |
|
- Product
- Blr6059 protein
- Gene
- blr6059
- Organism
- Bradyrhizobium japonicum
|
1uniprot[Pubmed] 12597275 [Medline] 22484998 Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110.(DNA Res.) [2002] |
|
62
|
Q6N497_RHOPA (Q6N497) |
|
|
1e-44 |
184 |
42% |
|
- Product
- Putative cyclase
- Gene
- RPA3442
- Organism
- Rhodopseudomonas palustris
|
1uniprot[Pubmed] 14704707 Complete genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris.(Nat. Biotechnol.) [2004] |
|
64
|
D8P2K4_RALSO (D8P2K4) |
|
|
2e-44 |
183 |
47% |
|
- Product
- Putative cyclase
- Gene
- RCFBP_mp10352
- Organism
- Ralstonia solanacearum
Pseudomonas solanacearum
|
1uniprot Genomes of three tomato pathogens within the Ralstonia solanacearum species complex reveal significant evolutionary divergence.(BMC Genomics) [2010] |
|
66
|
A4YZ46_BRASO (A4YZ46) |
|
|
3e-44 |
183 |
42% |
|
- Product
- Putative cyclase
- Gene
- BRADO5497
- Organism
- Bradyrhizobium sp. (strain ORS278)
|
1uniprot[Pubmed] 17540897 Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.(Science) [2007] |
|
67
|
Q0SB98_RHOSR (Q0SB98) |
|
|
3e-44 |
183 |
44% |
|
- Product
- Possible cyclase
- Gene
- RHA1_ro03385
- Organism
- Rhodococcus sp. (strain RHA1)
|
1uniprot[Pubmed] 17030794 The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse.(Proc. Natl. Acad. Sci. U.S.A.) [2006] |
|
69
|
A3RYM2_RALSO (A3RYM2) |
|
|
3e-44 |
183 |
47% |
|
- Product
- Predicted metal-dependent hydrolase
- Gene
- RRSL_00918
- Organism
- Ralstonia solanacearum UW551
|
1uniprot[Pubmed] 16404955 Identification of open reading frames unique to a select agent: Ralstonia solanacearum race 3 biovar 2.(Mol. Plant Microbe Interact.) [2006] |
|
73
|
Q5YUM7_NOCFA (Q5YUM7) |
|
|
4e-44 |
182 |
44% |
|
- Product
- Putative cyclase
- Gene
- NFA_32670
- Organism
- Nocardia farcinica
|
1uniprot[Pubmed] 15466710 The complete genomic sequence of Nocardia farcinica IFM 10152.(Proc. Natl. Acad. Sci. U.S.A.) [2004] |
|
74
|
Q6FBB6_ACIAD (Q6FBB6) |
|
|
4e-44 |
182 |
48% |
|
- Product
- Putative cyclase
- Gene
- ACIAD1812
- Organism
- Acinetobacter sp. (strain ADP1)
|
1uniprot[Pubmed] 15514110 Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium.(Nucleic Acids Res.) [2004] |
|
77
|
B2AIL0_CUPTR (B2AIL0) |
|
|
5e-44 |
182 |
48% |
|
- Product
- Putative cyclase
- Gene
- RALTA_B0414
- Organism
- Cupriavidus taiwanensis (strain R1 / LMG 19424)
Ralstonia taiwanensis (strain LMG 19424)
|
1uniprot[Pubmed] 18490699 Genome sequence of the beta-rhizobium Cupriavidus taiwanensis and comparative genomics of rhizobia.(Genome Res.) [2008] |
|
78
|
D2THH3_CITRI (D2THH3) |
|
|
5e-44 |
182 |
43% |
|
- Product
- Putative uncharacterized protein
- Gene
- ROD_14041
- Organism
- Citrobacter rodentium (strain ICC168)
Citrobacter freundii biotype 4280
|
1uniprot[Pubmed] 19897651 The Citrobacter rodentium genome sequence reveals convergent evolution with human pathogenic Escherichia coli.(J. Bacteriol.) [2010] |
|
81
|
F3L0C7_9GAMM (F3L0C7) |
|
|
8e-44 |
181 |
47% |
|
- Product
- Cyclase family protein
- Gene
- IMCC3088_843
- Organism
- gamma proteobacterium IMCC3088
|
1uniprot[Pubmed] 21551310 Genome Sequence of Strain IMCC3088, a Proteorhodopsin-Containing Marine Bacterium Belonging to the OM60/NOR5 Clade.(J. Bacteriol.) [2011] |
|
83
|
F4L2P9_HALH1 (F4L2P9) |
|
|
9e-44 |
181 |
41% |
|
- Product
- Cyclase family protein
- Gene
- Halhy_0705
- Organism
- Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O)
|
1uniprot Complete genome sequence of Haliscomenobacter hydrossis type strain (O).(Stand. Genomic Sci.) [2011] |
|
91
|
Q65N24_BACLD (Q65N24) |
|
|
3e-43 |
179 |
41% |
|
- Product
- Putative uncharacterized protein
- Gene
- BL02015
BLi00591
- Organism
- Bacillus licheniformis (strain DSM 13 / ATCC 14580)
|
1uniprot[Pubmed] 15383718 The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential.(J. Mol. Microbiol. Biotechnol.) [2004] | 2uniprot[Pubmed] 15461803 Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species.(Genome Biol.) [2004] | [pubmed all]
|
92
|
C5CW66_VARPS (C5CW66) |
|
|
3e-43 |
179 |
49% |
|
- Product
- Cyclase family protein
- Gene
- Vapar_0101
- Organism
- Variovorax paradoxus (strain S110)
|
1uniprot[Pubmed] 21183664 Complete genome sequence of the metabolically versatile plant growth-promoting endophyte, Variovorax paradoxus S110.(J. Bacteriol.) [2011] |
|
96
|
A4A9M0_9GAMM (A4A9M0) |
|
|
1e-42 |
177 |
43% |
|
- Product
- Putative cyclase
- Gene
- KT71_07404
- Organism
- Congregibacter litoralis KT71
|
1uniprot[Pubmed] 19287491 The photosynthetic apparatus and its regulation in the aerobic gammaproteobacterium Congregibacter litoralis gen. nov., sp. nov.(PLoS ONE) [2009] | 2uniprot[Pubmed] 17299055 Characterization of a marine gammaproteobacterium capable of aerobic anoxygenic photosynthesis.(Proc. Natl. Acad. Sci. U.S.A.) [2007] | [pubmed all]
|
98
|
Q5LV67_SILPO (Q5LV67) |
|
|
1e-42 |
177 |
42% |
|
- Product
- Cyclase, putative
- Gene
- SPO0835
- Organism
- Silicibacter pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)
|
1uniprot[Pubmed] 15602564 Genome sequence of Silicibacter pomeroyi reveals adaptations to the marine environment.(Nature) [2004] |
|