| accession | DB | alignment | Evalue | Score | Ident. | link | information | pubmed |
1
|
Q9F6D9_9ACTO (Q9F6D9) |
|
|
0.0 |
674 |
100% |
|
- Product
- Acyl transferase
- Gene
- zhuC
- Organism
- Streptomyces sp. R1128
|
1uniprot[Pubmed] 10931852 [Medline] 20517899 Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism.(J. Biol. Chem.) [2000] |
|
2
|
D2XDZ7_9PSEU (D2XDZ7) |
|
|
6e-72 |
275 |
53% |
|
- Product
- AzicK
- Gene
- azicK
- Organism
- Kibdelosporangium sp. MJ126-NF4
|
1uniprot[Pubmed] 19928906 Biosynthetic studies of aziridine formation in azicemicins.(J. Am. Chem. Soc.) [2009] |
|
3
|
Q47QK0_THEFY (Q47QK0) |
|
|
3e-70 |
270 |
50% |
|
- Product
- Modular polyketide synthase
- Gene
- Tfu_1231
- Organism
- Thermobifida fusca (strain YX)
|
1uniprot[Pubmed] 17209016 Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX.(J. Bacteriol.) [2007] |
|
4
|
Q9L547_9ACTO (Q9L547) |
|
|
5e-69 |
266 |
52% |
|
- Product
- AknF
- Gene
- aknF
- Organism
- Streptomyces galilaeus
|
1uniprot[Pubmed] 12137949 [Medline] 22133312 Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002] |
|
5
|
Q8VWA9_9ACTO (Q8VWA9) |
|
|
1e-68 |
265 |
52% |
|
- Product
- AknF
- Gene
- aknF
- Organism
- Streptomyces galilaeus
|
1uniprot[Pubmed] 12399480 [Medline] 22286521 Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002] |
|
6
|
Q2PZR6_9ACTO (Q2PZR6) |
|
|
1e-68 |
265 |
52% |
|
- Product
- CosF
- Gene
- cosF
- Organism
- Streptomyces olindensis
|
1uniprot[Pubmed] 16810496 Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes.(Appl. Microbiol. Biotechnol.) [2006] |
|
7
|
D6MSU7_9ACTO (D6MSU7) |
|
|
5e-66 |
256 |
54% |
|
- Product
- SsfV
- Gene
- ssfV
- Organism
- Streptomyces sp. SF2575
|
1uniprot[Pubmed] 19908837 Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009] |
|
8
|
Q3S8Q0_STRRM (Q3S8Q0) |
|
|
3e-65 |
253 |
51% |
|
- Product
- OxyP
- Gene
- oxyP
- Organism
- Streptomyces rimosus
|
1uniprot[Pubmed] 16597959 Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006] |
|
9
|
D2SYY7_MICEC (D2SYY7) |
|
|
1e-64 |
251 |
50% |
|
- Product
- Acyl transferase
- Gene
-
- Organism
- Micromonospora echinospora subsp. challisensis
|
1uniprot[Pubmed] 19680283 TLN-05220, TLN-05223, new Echinosporamicin-type antibiotics, and proposed revision of the structure of bravomicins(*).(J. Antibiot.) [2009] |
|
10
|
E2EKJ3_9ACTO (E2EKJ3) |
|
|
7e-64 |
248 |
47% |
|
- Product
- Acyl-ACP-thioesterase
- Gene
- san2
- Organism
- Streptomyces sp. SANK 61196
|
1uniprot[Pubmed] 20550125 Cloning, sequencing, heterologous expression, and mechanistic analysis of A-74528 biosynthesis.(J. Am. Chem. Soc.) [2010] |
|
12
|
D1A6S4_THECD (D1A6S4) |
|
|
8e-59 |
232 |
46% |
|
- Product
- Acyl transferase
- Gene
- Tcur_2783
- Organism
- Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
|
1uniprot Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011] |
|
13
|
Q55226_STRSQ (Q55226) |
|
|
9e-59 |
232 |
47% |
|
- Product
- Acyltransferase
- Gene
- dauA
- Organism
- Streptomyces sp
|
1uniprot[Pubmed] 7928998 [Medline] 95014072 Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5.(J. Bacteriol.) [1994] |
|
15
|
Q54817_STRPE (Q54817) |
|
|
5e-58 |
229 |
47% |
|
- Product
- Daunorubicin-doxorubicin polyketide synthase
- Gene
- dpsD
- Organism
- Streptomyces peucetius
|
1uniprot[Pubmed] 7828855 [Medline] 95129838 Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase.(Gene) [1994] |
|
18
|
D9UBR5_STRPR (D9UBR5) |
|
|
6e-57 |
226 |
47% |
|
- Product
- Putative acyltransferase
- Gene
- cpp19
- Organism
- Streptomyces pristinaespiralis
|
1uniprot[Pubmed] 21342465 Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011] |
|
20
|
Q67G33_9ACTO (Q67G33) |
|
|
1e-56 |
224 |
47% |
|
- Product
- Putative acyltransferase
- Gene
-
- Organism
- Streptomyces griseoruber
|
1uniprot[Pubmed] 15271354 The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004] |
|
21
|
Q2MGD7_STRGR (Q2MGD7) |
|
|
3e-56 |
223 |
46% |
|
- Product
- Putative acyl transferase
- Gene
-
- Organism
- Streptomyces griseus
|
1uniprot[Pubmed] 16305230 Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus.(J. Am. Chem. Soc.) [2005] |
|
22
|
Q9KHK3_9ACTO (Q9KHK3) |
|
|
1e-54 |
218 |
45% |
|
- Product
- Putative acyl transferase EncL
- Gene
- encL
- Organism
- Streptomyces maritimus
|
1uniprot Natural Metabolic Diversity Encoded by the Enterocin Biosynthesis Gene Cluster.(J. Am. Chem. Soc.) [2000] | 2uniprot[Pubmed] 11137817 [Medline] 20579517 Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase.(Chem. Biol.) [2000] | 3uniprot[Pubmed] 11948863 [Medline] 21942282 A mechanism of benzoic acid biosynthesis in plants and bacteria that mirrors fatty acid beta-oxidation.(Chembiochem) [2001] | [pubmed all]
|
25
|
D5QWC3_METTR (D5QWC3) |
|
|
3e-46 |
190 |
43% |
|
- Product
- Beta-ketoacyl synthase
- Gene
- MettrDRAFT_4099
- Organism
- Methylosinus trichosporium OB3b
|
1uniprot[Pubmed] 20952571 Genome Sequence of the Obligate Methanotroph Methylosinus trichosporium Strain OB3b.(J. Bacteriol.) [2010] |
|
28
|
D8PF63_9BACT (D8PF63) |
|
|
6e-44 |
182 |
39% |
|
- Product
- Putative Polyketide synthase
- Gene
- NIDE2152
- Organism
- Candidatus Nitrospira defluvii
|
1uniprot A Nitrospira metagenome illuminates the physiology and evolution of globally important nitrite-oxidizing bacteria.(Proc. Natl. Acad. Sci. U.S.A.) [2010] |
|
29
|
Q7X2F3_9ACTO (Q7X2F3) |
|
|
1e-43 |
182 |
39% |
|
- Product
- Putative acyl transferase
- Gene
- gilQ
- Organism
- Streptomyces griseoflavus
|
1uniprot[Pubmed] 12822997 [Medline] 22708304 The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins.(J. Am. Chem. Soc.) [2003] |
|
32
|
D2CZD6_KARBR (D2CZD6) |
|
|
4e-43 |
179 |
34% |
|
- Product
- Nonribosomal peptide synthetase/polyketide synthase hybrid
- Gene
-
- Organism
- Karenia brevis
Dinoflagellate
|
1uniprot[Pubmed] 19468793 Characterization and Localization of a Hybrid Non-ribosomal Peptide Synthetase and Polyketide Synthase Gene from the Toxic Dinoflagellate Karenia brevis.(Mar. Biotechnol.) [2009] |
|
33
|
B2HIM7_MYCMM (B2HIM7) |
|
|
1e-42 |
178 |
37% |
|
- Product
- Phenolpthiocerol synthesis type-I polyketide synthase PpsE
- Gene
- ppsE
MMAR_1772
- Organism
- Mycobacterium marinum (strain ATCC BAA-535 / M)
|
1uniprot[Pubmed] 18403782 Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.(Genome Res.) [2008] |
|
38
|
C6XWU5_PEDHD (C6XWU5) |
|
|
3e-42 |
177 |
33% |
|
- Product
- Amino acid adenylation domain protein
- Gene
- Phep_2034
- Organism
- Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / NCIB 9290)
|
1uniprot Complete genome sequence of Pedobacter heparinus type strain (HIM 762-3T).(Stand. Genomic Sci.) [2009] |
|
39
|
Q1D6B5_MYXXD (Q1D6B5) |
|
|
4e-42 |
176 |
39% |
|
- Product
- Polyketide synthase type I
- Gene
- MXAN_3621
- Organism
- Myxococcus xanthus (strain DK 1622)
|
1uniprot[Pubmed] 17015832 Evolution of sensory complexity recorded in a myxobacterial genome.(Proc. Natl. Acad. Sci. U.S.A.) [2006] |
|
41
|
F4XZI7_9CYAN (F4XZI7) |
|
|
5e-42 |
176 |
35% |
|
- Product
- Acyl transferase domain protein
- Gene
- LYNGBM3L_58270
- Organism
- Lyngbya majuscula 3L
|
1uniprot Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011] |
|
43
|
C8TEQ8_PLARU (C8TEQ8) |
|
|
5e-42 |
176 |
35% |
|
- Product
- Putative uncharacterized protein
- Gene
-
- Organism
- Planktothrix rubescens NIVA-CYA 98
|
1uniprot[Pubmed] 19706155 A genome-wide analysis of nonribosomal peptide synthetase gene clusters and their peptides in a Planktothrix rubescens strain.(BMC Genomics) [2009] |
|
46
|
B9XAZ0_9BACT (B9XAZ0) |
|
|
7e-42 |
176 |
36% |
|
- Product
- Amino acid adenylation domain protein
- Gene
- Cflav_PD5810
- Organism
- Pedosphaera parvula Ellin514
|
1uniprot[Pubmed] 21460084 Genome Sequence of 'Pedosphaera parvula' Ellin514, an Aerobic Verrucomicrobial Isolate from Pasture Soil.(J. Bacteriol.) [2011] |
|
49
|
A0PQ35_MYCUA (A0PQ35) |
|
|
1e-41 |
175 |
36% |
|
- Product
- Phenolpthiocerol synthesis type-I polyketide synthase PpsE
- Gene
- ppsE
MUL_2015
- Organism
- Mycobacterium ulcerans (strain Agy99)
|
1uniprot[Pubmed] 17210928 Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer.(Genome Res.) [2007] |
|
52
|
Q8YTS8_NOSS1 (Q8YTS8) |
|
|
5e-41 |
172 |
35% |
|
- Product
- Polyketide synthase type I
- Gene
- all2635
- Organism
- Nostoc sp. (strain PCC 7120 / UTEX 2576)
|
1uniprot[Pubmed] 11759840 [Medline] 21595285 Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120.(DNA Res.) [2001] |
|
53
|
C7Q561_CATAD (C7Q561) |
|
(3 hsp) |
5e-41 |
172 |
37% |
|
- Product
- Beta-ketoacyl synthase
- Gene
- Caci_7000
- Organism
- Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
|
1uniprot Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009] |
|
54
|
Q49934_MYCLE (Q49934) |
|
|
6e-41 |
172 |
36% |
|
- Product
- PksF
Polyketide synthase
- Gene
- ML2353
- Organism
- Mycobacterium leprae
|
1uniprot[Pubmed] 11234002 [Medline] 21128732 Massive gene decay in the leprosy bacillus.(Nature) [2001] |
|
55
|
B8ZT36_MYCLB (B8ZT36) |
|
|
6e-41 |
172 |
36% |
|
- Product
- Polyketide synthase
- Gene
- MLBr02353
- Organism
- Mycobacterium leprae (strain Br4923)
|
1uniprot[Pubmed] 19881526 Comparative genomic and phylogeographic analysis of Mycobacterium leprae.(Nat. Genet.) [2009] |
|
58
|
D3VMB2_ERWCA (D3VMB2) |
|
|
8e-41 |
172 |
34% |
|
- Product
- Polyketide synthase
- Gene
- pksA
- Organism
- Erwinia carotovora
|
1uniprot Quorum sensing-controlled Evr regulates a conserved cryptic pigment biosynthetic cluster and a novel phenomycin-like locus in the plant pathogen, Pectobacterium carotovorum.(Environ. Microbiol.) [2010] |
|
62
|
B9K536_AGRVS (B9K536) |
|
|
1e-40 |
172 |
37% |
|
- Product
- Polyketide synthase
- Gene
- Avi_7309
- Organism
- Agrobacterium vitis (strain S4 / ATCC BAA-846)
Rhizobium vitis (strain S4)
|
1uniprot[Pubmed] 19251847 Genome sequences of three Agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria.(J. Bacteriol.) [2009] |
|
65
|
A8FAR3_BACP2 (A8FAR3) |
|
|
2e-40 |
171 |
32% |
|
- Product
- Polyketide synthase subunit
- Gene
- BPUM_0638
- Organism
- Bacillus pumilus (strain SAFR-032)
|
1uniprot[Pubmed] 17895969 Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032.(PLoS ONE) [2007] |
|
66
|
D8I8X6_AMYMU (D8I8X6) |
|
|
3e-40 |
170 |
38% |
|
- Product
- Non-ribosomal peptide synthetase/polyketide synthase
- Gene
- AMED_3681
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
67
|
Q93HF2_STRAW (Q93HF2) |
|
|
4e-40 |
170 |
34% |
|
- Product
- Modular polyketide synthase
- Gene
-
- Organism
- Streptomyces avermitilis
|
1uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001] |
|
69
|
Q826K7_STRAW (Q826K7) |
|
|
5e-40 |
169 |
34% |
|
- Product
- Putative modular polyketide synthase
- Gene
- pks4
SAV7184 SAV_7184
- Organism
- Streptomyces avermitilis
|
1uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001] |
|
70
|
B9XJE4_9BACT (B9XJE4) |
|
|
5e-40 |
169 |
36% |
|
- Product
- Amino acid adenylation domain protein
- Gene
- Cflav_PD3064
- Organism
- Pedosphaera parvula Ellin514
|
1uniprot[Pubmed] 21460084 Genome Sequence of 'Pedosphaera parvula' Ellin514, an Aerobic Verrucomicrobial Isolate from Pasture Soil.(J. Bacteriol.) [2011] |
|
71
|
Q8YTR7_NOSS1 (Q8YTR7) |
|
|
6e-40 |
169 |
33% |
|
- Product
- Polyketide synthase type I
- Gene
- all2646
- Organism
- Nostoc sp. (strain PCC 7120 / UTEX 2576)
|
1uniprot[Pubmed] 11759840 [Medline] 21595285 Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120.(DNA Res.) [2001] |
|
72
|
A9FNK2_SORC5 (A9FNK2) |
|
|
6e-40 |
169 |
41% |
|
- Product
- Polyketide synthase type I
- Gene
- sce8261
- Organism
- Sorangium cellulosum (strain So ce56)
Polyangium cellulosum (strain So ce56)
|
1uniprot[Pubmed] 17965706 Complete genome sequence of the myxobacterium Sorangium cellulosum.(Nat. Biotechnol.) [2007] |
|
73
|
Q6W5P7_9ACTO (Q6W5P7) |
|
(4 hsp) |
8e-40 |
169 |
39% |
|
- Product
- FscE
- Gene
- fscE
- Organism
- Streptomyces sp. FR-008
|
1uniprot[Pubmed] 14652074 Organizational and Mutational Analysis of a Complete FR-008/Candicidin Gene Cluster Encoding a Structurally Related Polyene Complex.(Chem. Biol.) [2003] |
|
74
|
O68917_9ACTO (O68917) |
|
|
9e-40 |
169 |
46% |
|
- Product
- Putative acyltransferase for starter unit
- Gene
- frnK
- Organism
- Streptomyces roseofulvus
|
1uniprot[Pubmed] 8181754 [Medline] 94237486 Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.(Gene) [1994] |
|
89
|
B6VN93_PHOAA (B6VN93) |
|
|
2e-39 |
168 |
35% |
|
- Product
- Syringomycin synthetase (Complete genome; segment 7/17)
- Gene
- syrE
PAU_02675 PA-RVA18-1607
- Organism
- Photorhabdus asymbiotica subsp. asymbiotica (strain ATCC 43949 / 3105-77)
Xenorhabdus luminescens (strain 2)
|
1uniprot[Pubmed] 18838673 Rapid virulence annotation (RVA): identification of virulence factors using a bacterial genome library and multiple invertebrate hosts.(Proc. Natl. Acad. Sci. U.S.A.) [2008] | 2uniprot[Pubmed] 19583835 Comparative genomics of the emerging human pathogen Photorhabdus asymbiotica with the insect pathogen Photorhabdus luminescens.(BMC Genomics) [2009] | [pubmed all]
|
91
|
Q93NW6_9ACTO (Q93NW6) |
|
(6 hsp) |
2e-39 |
167 |
38% |
|
- Product
- AmphC
- Gene
- amphC
- Organism
- Streptomyces nodosus
|
1uniprot[Pubmed] 11451671 [Medline] 21344785 Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes.(Chem. Biol.) [2001] | 2uniprot[Pubmed] 16079135 Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups.(J. Biol. Chem.) [2005] | [pubmed all]
|
92
|
Q9RAH3_9NOSO (Q9RAH3) |
|
|
2e-39 |
167 |
34% |
|
- Product
- NosB
- Gene
- nosB
- Organism
- Nostoc sp. GSV224
|
1uniprot[Pubmed] 12853152 [Medline] 22737578 Sequence analysis and biochemical characterization of the nostopeptolide A biosynthetic gene cluster from Nostoc sp. GSV224.(Gene) [2003] |
|
97
|
A9VQN0_BACWK (A9VQN0) |
|
|
5e-39 |
166 |
31% |
|
- Product
- Beta-ketoacyl synthase
- Gene
- BcerKBAB4_1781
- Organism
- Bacillus weihenstephanensis (strain KBAB4)
|
1uniprot[Pubmed] 17434157 Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity.(Chem. Biol. Interact.) [2008] |
|