Alanine racemization(NFUNC_0063) |
必須 | A | ALR (NRULE_0228) | Alanine racemase | HMPREF0758_1776 |
Aminoglycoside resistance (by aminoglycoside O-phosphotransferase)(NFUNC_0043) |
必須 | A | APH6 (NRULE_0155) | Streptomycin 6-kinase | HMPREF0758_3888 |
Anthranilate biosynthesis(NFUNC_0038) |
必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | HMPREF0758_3546 HMPREF0758_1000 |
TRPE (NRULE_0143) | Anthranilate synthase component I | HMPREF0758_3547 |
Aromatic azo compounds degradation(NFUNC_0073) |
必須 | A | AZOR (NRULE_0236) | FMN-dependent NADH-azoreductase | HMPREF0758_3629 |
Arsenical resistance(NFUNC_0004) |
必須 | A | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | HMPREF0758_3144 |
ARSC1 (NRULE_0017) | Arsenate reductase | HMPREF0758_2596 HMPREF0758_3145 |
Bacitracin resistance(NFUNC_0022) |
必須 | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | HMPREF0758_1936 |
Beta-lactam antibiotic resistance(NFUNC_0033) |
必須 | C | BLAC (NRULE_0124) | Beta-lactamase class C | HMPREF0758_3355 |
Betaine biosynthesis (from choline)(NFUNC_0049) |
必須 | A | BETA (NRULE_0175) | Choline dehydrogenase | HMPREF0758_4630 |
Biotin biosynthesis(NFUNC_0051) |
必須 | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | HMPREF0758_4797 |
BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | HMPREF0758_4799 |
BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | HMPREF0758_4795 HMPREF0758_3827 |
BIOB (NRULE_0185) | Biotin synthase | HMPREF0758_4798 |
Cephalosporin resistance(NFUNC_0048) |
必須 | A | BLAC (NRULE_0124) | Beta-lactamase class C | HMPREF0758_3355 |
Folate biosynthesis(NFUNC_0044) |
必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | HMPREF0758_3546 HMPREF0758_1000 |
DHPS (NRULE_0144) | Dihydropteroate synthase | HMPREF0758_0809 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | HMPREF0758_3637 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | HMPREF0758_1935 HMPREF0758_2769 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | HMPREF0758_2161 |
FOLC (NRULE_0160) | Bifunctional protein FolC | HMPREF0758_2759 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | HMPREF0758_3332 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | HMPREF0758_4184 |
B | GLAT (NRULE_0142) | Glutamine amidotransferase | HMPREF0758_1000 HMPREF0758_3546 |
DHPS (NRULE_0144) | Dihydropteroate synthase | HMPREF0758_0809 |
FOLA (NRULE_0147) | Dihydrofolate reductase | HMPREF0758_0557 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | HMPREF0758_2769 HMPREF0758_1935 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | HMPREF0758_2161 |
FOLC (NRULE_0160) | Bifunctional protein FolC | HMPREF0758_2759 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | HMPREF0758_3332 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | HMPREF0758_4184 |
Fosfomycin resistance(NFUNC_0023) |
必須 | A | FOSA (NRULE_0098) | Glutathione transferase FosA | HMPREF0758_3311 |
Macrolide antibiotic resistance(NFUNC_0045) |
必須 | B | RLMA (NRULE_0165) | 23S rRNA (guanine-N(1))-methyltransferase | HMPREF0758_3320 |
C | MACA (NRULE_0166) | Macrolide-specific efflux protein MacA | HMPREF0758_4461 |
MACB (NRULE_0167) | Macrolide export ATP-binding/permease protein MacB | HMPREF0758_4460 |
Metal-binding protein(NFUNC_0105) |
必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | HMPREF0758_4806 HMPREF0758_4811 |
B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | HMPREF0758_4811 |
C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | HMPREF0758_2649 HMPREF0758_0710 HMPREF0758_0984 HMPREF0758_4808 |
E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | HMPREF0758_0140 |
G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | HMPREF0758_0934 |
Molybdate transport (ABC transporter)(NFUNC_0097) |
必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | HMPREF0758_0984 HMPREF0758_2649 HMPREF0758_0710 HMPREF0758_4808 |
任意 | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | HMPREF0758_4811 |
| MODB (NRULE_0325) | Molybdate ABC transporter permease protein | HMPREF0758_4807 |
| MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | HMPREF0758_4806 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | HMPREF0758_2156 |
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | HMPREF0758_2158 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | HMPREF0758_0213 HMPREF0758_3058 |
PANC (NRULE_0118) | Pantothenate synthetase | HMPREF0758_2157 |
Phenol degradation(NFUNC_0028) |
必須 | B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | HMPREF0758_0649 |
任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF0758_4466 HMPREF0758_0326 HMPREF0758_3095 |
| FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | HMPREF0758_2180 HMPREF0758_2182 |
| FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF0758_3756 HMPREF0758_0648 HMPREF0758_3034 HMPREF0758_4664 |
Pyrroloquinoline quinone biosynthesis(NFUNC_0020) |
必須 | A | PQQC (NRULE_0092) | Pyrroloquinoline-quinone synthase | HMPREF0758_3730 |
任意 | | PQQB (NRULE_0091) | Coenzyme PQQ synthesis protein B | HMPREF0758_3731 |
| PQQD (NRULE_0093) | Coenzyme PQQ synthesis protein D | HMPREF0758_3729 |
| PQQE (NRULE_0094) | Coenzyme PQQ synthesis protein E | HMPREF0758_3728 |
Riboflavin biosynthesis(NFUNC_0058) |
必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | HMPREF0758_1946 |
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | HMPREF0758_3564 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | HMPREF0758_0227 |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | HMPREF0758_0226 |
RIBE (NRULE_0204) | Riboflavin synthase | HMPREF0758_3930 |
任意 | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | HMPREF0758_0575 |
Streptomycin resistance(NFUNC_0054) |
必須 | C | APH6 (NRULE_0155) | Streptomycin 6-kinase | HMPREF0758_3888 |
Uptake of osmoprotectant(NFUNC_0061) |
必須 | A | OPUAC (NRULE_0213) | Osmoprotectant ABC transporter substrate-binding protein | HMPREF0758_2387 HMPREF0758_2386 |
OPUAB (NRULE_0214) | Osmoprotectant ABC transporter permease protein | HMPREF0758_2388 |
OPUAA (NRULE_0215) | Osmoprotectant ABC transporter ATP-binding protein | HMPREF0758_0467 HMPREF0758_2389 |
C | BCCT (NRULE_0220) | BCCT family transporter | HMPREF0758_4634 HMPREF0758_4285 |
D | PROP (NRULE_0221) | Osmoprotectant transporter | HMPREF0758_4232 |
E | OPUE (NRULE_0222) | Sodium/proline symporter | HMPREF0758_3241 |
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) |
必須 | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase | HMPREF0758_2198 |
PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase | HMPREF0758_2754 |
SERC (NRULE_0210) | Phosphoserine aminotransferase | HMPREF0758_4386 |
PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | HMPREF0758_0552 HMPREF0758_2145 |
PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | HMPREF0758_2458 |