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遺伝子 : Streptomycin 6-kinase (APH6)

遺伝子情報

ID NRULE_0155
遺伝子ID APH6
作成日 2013/03/06
タンパク質名
Protein name
Full
Streptomycin 6-kinase
EC
EC 2.7.1.72
Synonym
Full
APH(6)
Streptidine kinase
Streptomycin 6-phosphotransferase
遺伝子名 aphD, sph, str
遺伝子条件 PFAM; PF04655; hit=1
参照
Gene Ontology
GO
GO:0050300, F:aminoglycoside 6-kinase activity, IEA:EC
GO:0005524, F:ATP binding, IEA:UniProtKB-KW
GO:0006468, P:protein phosphorylation, IEA:InterPro
GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW
GO:0019748, P:secondary metabolic process, IEA:InterPro
Family and domain databases
InterPro
IPR006748, NH2Glyco/OHUrea_AB-resist_kin
Pfam
PF04655, APH_6_hur, 1
配列の特徴
P08077 Streptomyces griseus.
ACT_SITE201Proton acceptor (By similarity).
注釈
Function
The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation
Catalytic activity
ATP + streptomycin = ADP + streptomycin 6- phosphate
Sequence similarities
Belongs to the aminoglycoside phosphotransferase family
参考文献
P08077 Streptomyces griseus.
3029728
Nucleotide sequence of the streptomycinphosphotransferase and amidinotransferase genes from Streptomyces griseus. (Nucleic Acids Res. 1987)
P18622 Streptomyces glaucescens.
3039305
Characterisation of the hydroxystreptomycin phosphotransferase gene (sph) of Streptomyces glaucescens: nucleotide sequence and promoter analysis. (Mol Gen Genet. 1987)



関与する機能

機能名
Aminoglycoside resistance (by aminoglycoside O-phosphotransferase)
Streptomycin resistance

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Acaricomes phytoseiuli107788C501_10225hypothetical protein
Acidithiobacillus ferrooxidansLferr_2642aminoglycoside phosphotransferase
Actinoalloteichus cyanogriseus14455G443_01_01150hydroxyurea phosphotransferase
G443_07_01890aminoglycoside/hydroxyurea antibiotic resistance kinase
Actinoalloteichus spitiensis102582ACTIDRAF_00445hypothetical protein
Actinosynnema mirum14064Amir_0803aminoglycoside/hydroxyurea antibiotic resistance kinase
Alloiococcus otitis15545HMPREF9698_00798hypothetical protein
Amycolatopsis azurea14573C791_2097Methionine aminopeptidase
C791_2139Streptomycin 6-kinase
C791_4268aminoglycoside phosphotransferase
Amycolatopsis mediterranei13415RAM_05460aminoglycoside O-phosphotransferase
RAM_23750aminoglycoside O-phosphotransferase
Anoxybacillus flavithermus15317Aflv_2000Predicted kinase
Arcanobacterium haemolyticum15585Arch_0384aminoglycoside phosphotransferase
Arthrobacter globiformis12137ARGLB_013_00090hypothetical protein
Bacillus atrophaeus13721BATRMS_10_04180methylthioribose kinase
Bacillus cereus15305BC_3415hypothetical protein
Bacillus licheniformis12200BL03633methylthioribose kinase
Bacillus licheniformis12195BLi01512methylthioribose kinase MtnK
Bacillus mycoides101228bmyco0001_30430Aminoglycoside phophotransferase-related protein
Bacillus pseudomycoides101232bpmyx0001_28490Aminoglycoside phophotransferase-related protein
Bacillus psychrosaccharolyticus101233WYK_184_00300aminoglycoside phosphotransferase
Bacillus thuringiensis101235bthur0008_31300Aminoglycoside phophotransferase-related protein
Beutenbergia cavernae16432Bcav_2285aminoglycoside phosphotransferase
Bcav_2660aminoglycoside/hydroxyurea antibiotic resistance kinase
Bcav_3746kinase
Brevibacillus brevis100599BBR47_11130conserved hypothetical protein
BBR47_33740conserved hypothetical protein
Brevibacterium linens12170BlinB_010200007675streptomycin 6-kinase
Brevundimonas diminuta12697BDIM_28810dephospho-CoA kinase
Chthoniobacter flavusCfE428DRAFT_4910aminoglycoside phosphotransferase
Cystobacter fuscus100088D187_003622hypothetical protein
D187_006310putative phosphotransferase
Enterococcus gilvus100696I592_001055-methylthioribose kinase
Escherichia fergusonii102419EFER_p0049Streptomycin 3''-kinase
Fimbriimonas ginsengisoliOP10G_0993putative aminoglycoside/hydroxyurea antibiotic resistance kinase
Gordonia alkanivorans16433GOALK_089_00400hypothetical protein
Gordonia amicalis100051GOAMI_42_00350hypothetical protein
Gordonia araii100433GOARA_004_00430hypothetical protein
Gordonia bronchialis16047Gbro_4087aminoglycoside/hydroxyurea antibiotic resistance kinase
Gordonia effusa100432GOEFS_033_00180hypothetical protein
Gordonia hirsuta16056GOHSU_35_00420hypothetical protein
Gordonia namibiensis108229GONAM_33_00100hypothetical protein
Gordonia rubripertincta101908GORBP_060_01340hypothetical protein
Gordonia soli108243GS4_23_01110hypothetical protein
Gordonia terrae100016GOTRE_066_00340hypothetical protein
Halobacillus halophilus102448HBHAL_4670homolog to fructosamine kinase
Intrasporangium calvum12989Intca_22306-kinase
Kineococcus radiotolerans101839Krad_12951,4-alpha-glucan branching enzyme
Kineosphaera limosa100340KILIM_010_00500putative phosphotransferase
Kitasatospora setae14216KSE_53020putative phosphotransferase
Kocuria rhizophila103217KRH_20870hypothetical protein
Kribbella flavida14399Kfla_0087aminoglycoside/hydroxyurea antibiotic resistance kinase
Kfla_0344aminoglycoside/hydroxyurea antibiotic resistance kinase
Kfla_2175hypothetical protein
Kfla_2389antimicrobial 6-kinase
Kfla_4850hypothetical protein
Kfla_6595hypothetical protein
Ktedonobacter racemiferKrac_2261aminoglycoside/hydroxyurea antibiotic resistance kinase
Krac_5153aminoglycoside/hydroxyurea antibiotic resistance kinase
Krac_7174aminoglycoside phosphotransferase
Labrenzia aggregata16684SIAM614_27433putative aminoglycoside phosphotransferase
Lactobacillus helveticus15019HMPREF0518_0528phosphotransferase enzyme family
Lactobacillus reuteri15892LAR_0694conserved hypothetical protein
Magnetospirillum magnetotacticum15272Magn03009262COG3178: Predicted phosphotransferase related to Ser/Thr protein kinases
Microlunatus phosphovorus101784MLP_17970hypothetical protein
MLP_20980hypothetical protein
Micromonospora aurantiaca16155Micau_5195aminoglycoside/hydroxyurea antibiotic resistance kinase
Mobilicoccus pelagius104925MOPEL_013_00010hypothetical protein
Nocardiopsis dassonvillei14626Ndas_0298aminoglycoside/hydroxyurea antibiotic resistance kinase
Ndas_1996aminoglycoside phosphotransferase
Ndas_2104aminoglycoside phosphotransferase
Ndas_22196-kinase
Ochrobactrum anthropi15819Oant_1320aminoglycoside phosphotransferase
Oant_25013''-kinase
Ochrobactrum intermedium15820OINT_1000828Streptomycin 6-kinase
Oscillibacter valericigenes101213OBV_06310methylthioribose kinase
Paenibacillus alvei3343PAV_9c01730aminoglycoside/hydroxyurea antibiotic resistance kinase
Paenibacillus polymyxa15309PPT_11115aminoglycoside phosphotransferase
Renibacterium salmoninarum15589RSal33209_0650antibiotic resistance kinase
Rhizobium etli15573RHE_CH02980probable antibiotic resistance (streptomycin kinase) protein
Rhizobium tropici15247RTCIAT899_PC02855streptomycin 3''-kinase (streptomycin 3''-phosphotransferase) (SPH)
Rhodobacter capsulatus16581RCAP_rcc00040aminoglycoside phosphotransferase
Rubrobacter xylanophilus100952Rxyl_2074aminoglycoside phosphotransferase
Saccharomonospora azurea14651SacazDRAFT_02834putative aminoglycoside phosphotransferase
Saccharopolyspora erythraea13426SACE_5997hydroxyurea phosphotransferase
SACE_6537hydroxyurea phosphotransferase
Saccharopolyspora spinosa15153SspiN1_010100006375hydroxyurea phosphotransferase
SspiN1_010100015100hypothetical protein
Saccharothrix espanaensis15066BN6_08910Aminoglycoside/hydroxyurea antibiotic resistance kinase
BN6_36310hypothetical protein
BN6_42660hypothetical protein
BN6_75700hypothetical protein
Salinispora tropica105044Strop_0641aminoglycoside phosphotransferase
Sanguibacter keddieii16158Sked_35670streptomycin 6-kinase
Serratia odorifera102598HMPREF0758_3888Aminoglycoside/hydroxyurea antibiotic resistance kinase
Sphingobium japonicum101211SJA_C1-33100putative aminoglycoside phosphotransferase
Sphingomonas wittichii105917Swit_2677aminoglycoside phosphotransferase
Sporichthya polymorpha12702Spopo_31_08430Streptomycin 6-kinase
Stackebrandtia nassauensis102104Snas_0327aminoglycoside phosphotransferase
Snas_42536-kinase
Streptomyces avermitilis14893SAV2557putative phosphotransferase
SAV3961putative hydroxyurea phosphotransferase
Streptomyces cattleya14057SCAT_2728protein of unknown function
SCAT_4484Streptomycin 6-kinase
SCAT_p0366putative Streptomycin 6-kinase
Streptomyces clavuligerus13307SCLAV_3237Putative aminoglycoside phosphotransferase
SCLAV_4596phosphotransferase
SCLAV_p0259streptomycin 6-kinase-like protein
SCLAV_p0838phosphotransferase
Streptomyces ghanaensis15414SSFG_02042kinase
SSFG_03946aminoglycoside phosphotransferase
SSFG_06497conserved hypothetical protein
Streptomyces mobaraensis13819H340_13656aminoglycoside/hydroxyurea antibiotic resistance kinase
H340_23203aminoglycoside/hydroxyurea antibiotic resistance kinase
H340_28020phosphotransferase
Streptomyces pristinaespiralis13074SSDG_06156predicted protein
Streptomyces purpureus13925STRPU_03_01770Phosphotransferase enzyme family protein
STRPU_10_05020Aminoglycoside phosphotransferase
STRPU_15_01270Putative phosphotransferase
Streptomyces sviceus13980SSEG_03921phosphotransferase
SSEG_069145-methylthioribose kinase
SSEG_08349aminoglycoside phosphotransferase
Streptomyces venezuelae13096SVEN_4018aminoglycoside phosphotransferase
SVEN_5355putative phosphotransferase
Streptosporangium roseum3776Sros_5378aminoglycoside/hydroxyurea antibiotic resistance kinase
Tetragenococcus halophilus12172TEH_03440putative ribulosamine/erythrulosamine 3-kinase
Thermus thermophilus101084TTHA1179probable fructosamine-3-kinase
Thermus thermophilus101085TT_C0815phosphatidylserine decarboxylase
Tsukamurella paurometabola16120Tpau_2457aminoglycoside/hydroxyurea antibiotic resistance kinase
Vibrio tubiashii15644VITU9109_06974streptomycin phosphotransferase
Xylanimonas cellulosilytica107835Xcel_02616-kinase
Yersinia bercovieri105717yberc0001_37150Streptomycin 6-kinase