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Rule : Acetaldehyde dehydrogenase (ACDH)

Rule Description

ID NRULE_0065
Rule name ACDH
Created 2012-09-26
Protein name
Protein name
Full
Acetaldehyde dehydrogenase
EC
EC 1.2.1.10
Gene name Not assigned
Rule Trigger HAMAP; MF_01657; hit=1
Cross Reference
Gene Ontology
GO
GO:0019439, P:aromatic compound catabolic process
GO:0051287, F:NAD binding
GO:0008774, F:acetaldehyde dehydrogenase (acetylating) activity
Family and domain databases
HAMAP
MF_01657, Ac_ald_DH_ac, 1, -
InterPro
IPR003361, Acetaldehyde_dehydrogenase
IPR015426, Acetylaldehyde_DH_C
IPR000534, Semialdehyde_DH_NAD-bd
Pfam
PF09290, AcetDehyd-dimer, 1
PF01118, Semialdhyde_dh, 1
PIRSF
PIRSF015689, Actaldh_dh_actl, 1
SMART
SM00859, Semialdhyde_dh, 1
TIGRFAMs
TIGR03215, Ac_ald_DH_ac, 1
Feature
Q52060 Pseudomonas sp. (strain CF600).
NP_BIND12 - 15NAD.
NP_BIND163 - 171NAD.
BINDING290NAD.
General annotation
Function
Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity)
Catalytic activity
Acetaldehyde + CoA + NAD(+) = acetyl-CoA + NADH
Sequence similarities
Belongs to the acetaldehyde dehydrogenase family
Reference
P77580 Escherichia coli (strain K12).
9098055
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12. (J Bacteriol. 1997)
Q52060 Pseudomonas sp. (strain CF600).
1732207
Nucleotide sequence and functional analysis of the complete phenol/3,4-dimethylphenol catabolic pathway of Pseudomonas sp. strain CF600. (J Bacteriol. 1992)



Related Function

Function name
Dihydroxy aromatic compounds degradation (via meta-cleavage pathway)

CDS

Data Download
Scientific name NBRC No. CDS Product name
Acinetobacter radioresistens102413ACRAD_06_00630acetaldehyde dehydrogenase MhpF
Actinomadura atramentaria14695G339_12335acetaldehyde dehydrogenase
Actinoplanes missouriensis102363AMIS_19110putative acetaldehyde dehydrogenase
Actinopolyspora iraqiensis103187ACTIR_570_00030acetaldehyde dehydrogenase
Alicyclobacillus acidocaldarius subsp. acidocaldarius15652Aaci_1620acetaldehyde dehydrogenase (acetylating)
Amycolatopsis azurea14573C791_1557Acetaldehyde dehydrogenase
Amycolatopsis mediterranei13415RAM_21490acetaldehyde dehydrogenase
Bacillus pseudomycoides101232bpmyx0001_18640Acetaldehyde dehydrogenase
Brevibacillus brevis100599BBR47_29770probable acetaldehyde dehydrogenase
Caldilinea aerophila104270CLDAP_40970putative acetaldehyde dehydrogenase
Conexibacter woesei100937Cwoe_0440acetaldehyde dehydrogenase (acetylating)
Cwoe_4744acetaldehyde dehydrogenase (acetylating)
Cwoe_4834acetaldehyde dehydrogenase (acetylating)
Corynebacterium ammoniagenes12612HMPREF0281_01857acetaldehyde dehydrogenase (acetylating)
Cupriavidus metallidurans102507Rmet_1320Acetaldehyde-CoA dehydrogenase II, NAD-binding (protein belongs to CMGI-2)
Rmet_5208acetaldehyde-CoA dehydrogenase II, NAD-binding
Escherichia coli3972EcolC_3274acetaldehyde dehydrogenase (acetylating)
Escherichia coli13500WFL_02110acetaldehyde dehydrogenase
Escherichia coli12713Y75_0341acetaldehyde-CoA dehydrogenase II, NAD-binding
Gordonia aichiensis108223GOACH_04_04120putative acetaldehyde dehydrogenase
GOACH_41_00100acetaldehyde dehydrogenase CmtH
GOACH_43_00030acetaldehyde dehydrogenase CmtH
Gordonia alkanivorans16433GOALK_026_00890putative acetaldehyde dehydrogenase
GOALK_050_01550putative acetaldehyde dehydrogenase
Gordonia amarae15530GOAMR_19_00730putative acetaldehyde dehydrogenase
GOAMR_41_00050putative acetaldehyde dehydrogenase
Gordonia amicalis100051GOAMI_14_01070putative acetaldehyde dehydrogenase
Gordonia araii100433GOARA_040_00130acetaldehyde dehydrogenase
Gordonia bronchialis16047Gbro_0239acetaldehyde dehydrogenase (acetylating)
Gbro_0910acetaldehyde dehydrogenase (acetylating)
Gordonia effusa100432GOEFS_068_00120putative acetaldehyde dehydrogenase
Gordonia hirsuta16056GOHSU_02_01020putative acetaldehyde dehydrogenase
Gordonia namibiensis108229GONAM_07_00510putative acetaldehyde dehydrogenase
Gordonia otitidis100426GOOTI_167_00020putative acetaldehyde dehydrogenase
Gordonia polyisoprenivorans16320GOPIP_039_01140putative acetaldehyde dehydrogenase
GOPIP_094_00900acetaldehyde dehydrogenase CmtH
Gordonia rhizosphera16068GORHZ_115_00460putative acetaldehyde dehydrogenase
GORHZ_176_00080putative acetaldehyde dehydrogenase
Gordonia rubripertincta101908GORBP_012_01430putative acetaldehyde dehydrogenase
GORBP_032_00110putative acetaldehyde dehydrogenase
GORBP_065_01320putative acetaldehyde dehydrogenase
Gordonia sihwensis108236GSI01S_07_00490putative acetaldehyde dehydrogenase
Gordonia sputi100414GOSPT_022_02650putative acetaldehyde dehydrogenase
GOSPT_045_00270putative acetaldehyde dehydrogenase
GOSPT_096_00230putative acetaldehyde dehydrogenase
Gordonia terrae100016GOTRE_125_00690putative acetaldehyde dehydrogenase
GOTRE_150_00060putative acetaldehyde dehydrogenase
Intrasporangium calvum12989Intca_1095acetaldehyde dehydrogenase
Kitasatospora setae14216KSE_23720putative acetaldehyde dehydrogenase
Klebsiella pneumoniae14438KPR_2663
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_4290acetaldehyde dehydrogenase (acetylating)
Kyrpidia tusciae15312Btus_0968acetaldehyde dehydrogenase (acetylating)
Lentisphaera araneosaLNTAR_03164acetaldehyde dehydrogenase
Limnochorda pilosa110152LIP_2172acetaldehyde dehydrogenase
Micromonospora aurantiaca16155Micau_4939acetaldehyde dehydrogenase (acetylating)
Nakamurella multipartita105858Namu_4082acetaldehyde dehydrogenase (acetylating)
Nitriliruptor alkaliphilusNitalDRAFT_4812acetaldehyde dehydrogenase
Rhodococcus erythropolis100887RER_07400acetaldehyde dehydrogenase
RER_57570probable acetaldehyde dehydrogenase
Rhodococcus opacus108011ROP_34170acetaldehyde dehydrogenase CmtH
ROP_37350acetaldehyde dehydrogenase
ROP_44490acetaldehyde dehydrogenase
ROP_54060acetaldehyde dehydrogenase
ROP_58610acetaldehyde dehydrogenase
ROP_pROB02-02250acetaldehyde dehydrogenase
Saccharomonospora glauca14831SacglDRAFT_02378acetaldehyde dehydrogenase (acetylating)
Salinispora arenicola105043Q5S_2535_00020acetaldehyde dehydrogenase
Salinispora tropica105044Strop_3526Semialdehyde dehydrogenase, NAD - binding
Shimwellia blattae105725EB105725_09_00140acetaldehyde dehydrogenase
Sphingobium japonicum101211SJA_C1-11900acetaldehyde dehydrogenase (acylating)
Sphingomonas wittichii105917Swit_1640Acetaldehyde dehydrogenase-like protein
Swit_2112Acetaldehyde dehydrogenase-like protein
Swit_4924Acetaldehyde dehydrogenase-like protein
Sporichthya polymorpha12702Spopo_30_02760Acetaldehyde dehydrogenase
Streptomyces ghanaensis15414SSFG_07553acetaldehyde dehydrogenase
SSFG_07758semialdehyde dehydrogenase
Streptosporangium roseum3776Sros_9114Acetaldehyde dehydrogenase (acetylating)
Thauera linaloolentis102519C666_03890acetaldehyde dehydrogenase
C666_10110acetaldehyde dehydrogenase
C666_16285acetaldehyde dehydrogenase
C666_19130acetaldehyde dehydrogenase
Thermomicrobium roseumtrd_1393acetaldehyde dehydrogenase
Thermomonospora curvata15933Tcur_0535acetaldehyde dehydrogenase (acetylating)
Tcur_3471acetaldehyde dehydrogenase (acetylating)
Thermus thermophilus101084TTHB247acetaldehyde dehydrogenase
Tsukamurella paurometabola16120Tpau_3801acetaldehyde dehydrogenase (acetylating)