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Rule : Chloramphenicol acetyltransferase (CAT1)

Rule Description

ID NRULE_0107
Rule name CAT1
Created 2013-01-09
Protein name
Protein name
Full
Chloramphenicol acetyltransferase
Short
CAT
EC
EC 2.3.1.28
Gene name cat
Rule Trigger PFAM; PF00302; hit=1
Cross Reference
Gene Ontology
GO
GO:0008811, F:chloramphenicol O-acetyltransferase activity, IEA:EC
GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW
Family and domain databases
InterPro
IPR023213, CAT-like_dom
IPR018372, Chloramphenicol_AcTrfase_AS
IPR001707, Cmp_AcTrfase
Pfam
PF00302, CAT, 1
PIRSF
PIRSF000440, CAT, 1
ProDom
PD002660, Cmp_AcTrfase, 1
SMART
SM01059, CAT, 1
PROSITE
PS00100, CAT, 1
Feature
P62577 Escherichia coli.
ACT_SITE193Proton acceptor.
General annotation
Function
This enzyme is an effector of chloramphenicol resistance in bacteria
Catalytic activity
Acetyl-CoA + chloramphenicol = CoA + chloramphenicol 3-acetate
Subunit structure
Homotrimer
Sequence similarities
Belongs to the chloramphenicol acetyltransferase family
Reference
P00486 Staphylococcus aureus.
3855295
Chloramphenicol acetyltransferase gene of staphylococcal plasmid pC221. Nucleotide sequence analysis and expression studies. (FEBS Lett. 1985)
P62577 Escherichia coli.
390403
Nucleotide sequence analysis of the chloramphenicol resistance transposon Tn9. (Nature. 1979)



Related Function

Function name
Chloramphenicol resistance

CDS

Data Download
Scientific name NBRC No. CDS Product name
Bacillus atrophaeus13721BATRMS_10_00620chloramphenicol O-acetyltransferase
Bacillus licheniformis12200BL03127antibiotic resistance protein, methyltransferase
Bacillus licheniformis12195BLi02835chloramphenicol acetyltransferase Cat
Bacillus mycoides101228bmyco0001_21130Chloramphenicol acetyltransferase
Bacillus pumilus12092BAT_2929chloramphenicol O-acetyltransferase
Bacillus thuringiensis101235bthur0008_22030Chloramphenicol acetyltransferase
Bacteroides vulgatus14291BVU_1202chloramphenicol acetyltransferase
BVU_3261chloramphenicol acetyltransferase
Brevibacillus brevis100599BBR47_14680chloramphenicol acetyltransferase
Cellulophaga lytica14961Celly_2361chloramphenicol acetyltransferase
Chryseobacterium gleum15054HMPREF0204_13820chloramphenicol O-acetyltransferase
Clostridium acetobutylicum13948CA_C0235Chloramphenicol acetyltransferase
CA_P0060Chloramphenicol O-acetyltransferase
Deinococcus proteolyticus101906Deipr_1239Chloramphenicol O-acetyltransferase
Desulfovibrio magneticus104933DMR_43300putative chloramphenicol acetyltransferase
Desulfovibrio vulgaris subsp. vulgaris104121DVU_2145chloramphenicol acetyltransferase, putative
Enterobacter aerogenes13534EAE_17595putative chloramphenicol acetyltransferase
Enterobacter hormaechei105718HMPREF9086_0356chloramphenicol acetyltransferase
Enterococcus moraviensis100710I586_00148hypothetical protein
Enterococcus pallens100697I588_01099hypothetical protein
I588_03618hypothetical protein
Enterococcus phoeniculicola100711I589_01745hypothetical protein
Escherichia hermannii105704EH105704_16_00330chloramphenicol acetyltransferase
Fibrobacter succinogenesFisuc_0604chloramphenicol acetyltransferase
Flavobacterium johnsoniae14942Fjoh_0863chloramphenicol acetyltransferase
Herpetosiphon aurantiacusHaur_2115Chloramphenicol O-acetyltransferase
Klebsiella pneumoniae14438KPR_3058
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_4739putative chloramphenicol O-acetyltransferase
Kordia algicida100336KAOT1_10021chloramphenicol acetyltransferase (CAT-III)
Lactobacillus farciminis107150LfarK3_010100011759chloramphenicol acetyltransferase
Lactobacillus plantarum subsp. plantarum15891HMPREF0531_10803chloramphenicol O-acetyltransferase
Microscilla marina16560M23134_04581chloramphenicol acetyltransferase
Myroides odoratus14945Myrod_0765chloramphenicol acetyltransferase
Myrod_3014chloramphenicol acetyltransferase
Myrod_3328chloramphenicol acetyltransferase
Myrod_3494chloramphenicol acetyltransferase
Oscillibacter valericigenes101213OBV_12550putative acetyltransferase
OBV_20840putative acetyltransferase
OBV_30800putative acetyltransferase
OBV_32740putative chloramphenicol acetyltransferase
Proteus mirabilis105697HMPREF0693_2081chloramphenicol O-acetyltransferase
Sanguibacter keddieii16158Sked_12550chloramphenicol O-acetyltransferase
Selenomonas ruminantium subsp. lactilytica103574SELR_pSRC200990putative chloramphenicol acetyltransferase
SELR_pSRC600170putative chloramphenicol acetyltransferase
Solitalea canadensis15130Solca_4168chloramphenicol O-acetyltransferase
Synechocystis sp.slr0299unknown protein
Vibrio ichthyoenteri15847VII00023_17984chloramphenicol acetyltransferase
Xylanimonas cellulosilytica107835Xcel_3311Chloramphenicol O-acetyltransferase