遺伝子 : 5-carboxymethyl-2-hydroxymuconate Delta-isomerase (HPAF)

遺伝子情報

ID	NRULE_0196
遺伝子ID	HPAF
作成日	2013/01/23
タンパク質名	Protein name Full 5-carboxymethyl-2-hydroxymuconate Delta-isomerase Short CHM isomerase EC EC 5.3.3.10
遺伝子名	hpaF, hpcD
遺伝子条件	PFAM; PF02962; hit=1
参照	Gene Ontology GO GO:0008704, F:5-carboxymethyl-2-hydroxymuconate delta-isomerase activity, IEA:EC GO:0019439, P:aromatic compound catabolic process, IEA:UniProtKB-KW Phylogenomic databases KO K01826, - Enzyme and pathway databases UniPathway UPA00208, UER00419 Family and domain databases InterPro IPR004220, 5-COMe_2-OHmuconate_Isoase IPR014347, Tautomerase Pfam PF02962, CHMI, 1
配列の特徴	該当データなし
注釈	Function Transforms 5-carboxymethyl-2-hydroxy-muconic acid (CHM) into 5-oxo-pent-3-ene-1,2,5-tricarboxylic acid (OPET) Catalytic activity 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate Pathway Aromatic compound metabolism; 4-hydroxyphenylacetate degradation; pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 4/7 Subunit structure Homotrimer
参考文献	Q05354 Escherichia coli. 2194841 Purification, some properties and nucleotide sequence of 5-carboxymethyl-2-hydroxymuconate isomerase of Escherichia coli C. (FEBS Lett. 1990) 8547259 Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases. (Biochemistry. 1996)

関与する機能

機能名
4-hydroxyphenylacetate degradation

該当CDS

学名	NBRC番号	CDS	タンパク質名
Acetobacter tropicalis	101654	ATPR_0352	5-carboxymethyl-2-hydroxymuconate isomerase
Acinetobacter sp.	100985	ACT4_017_00080	putative 5-carboxymethyl-2-hydroxymuconate isomerase
Actinosynnema mirum	14064	Amir_3825	5-carboxymethyl-2-hydroxymuconate isomerase
Bradyrhizobium diazoefficiens	14792	bll2969	probable 5-carboxymethyl-2-hydroxymuconate delta-isomerase (EC 5.3.3.10)
Brevundimonas diminuta	12697	BDIM_10290	isomerase
Cellulophaga lytica	14961	Celly_1552	4-oxalocrotonate tautomerase
Chromobacterium violaceum	12614	CV_0893	probable 5-carboxymethyl-2-hydroxymuconate D-isomerase
Chryseobacterium gleum	15054	HMPREF0204_11784	putative 5-carboxymethyl-2-hydroxymuconate delta isomerase
Cupriavidus metallidurans	102507	Rmet_4733	5-carboxymethyl-2-hydroxymuconate isomerase
Deinococcus proteolyticus	101906	Deipr_2616	5-carboxymethyl-2-hydroxymuconate isomerase
Edwardsiella tarda	105688	ET1_06_01770	hypothetical protein
Enterobacter aerogenes	13534	EAE_10340	5-carboxymethyl-2-hydroxymuconate delta-isomerase
Enterobacter cloacae subsp. cloacae	13535	ECL_00755	5-carboxymethyl-2-hydroxymuconate delta isomerase
Enterobacter hormaechei	105718	HMPREF9086_1889	5-carboxymethyl-2-hydroxymuconate delta isomerase
Escherichia coli	3972	EcolC_3705	5-carboxymethyl-2-hydroxymuconate isomerase
Escherichia coli	13500	WFL_22945	5-carboxymethyl-2-hydroxymuconate delta-isomerase
Escherichia fergusonii	102419	EFER_3065	5-carboxymethyl-2-hydroxymuconate delta-isomerase
Fimbriimonas ginsengisoli		OP10G_1628	5-carboxymethyl-2-hydroxymuconate delta-isomerase
Flavobacterium johnsoniae	14942	Fjoh_3391	hypothetical protein
Frateuria aurantia	3245	Fraau_1721	5-carboxymethyl-2-hydroxymuconate isomerase
Halobacillus halophilus	102448	HBHAL_2378	5-carboxymethyl-2-hydroxymuconate delta-isomerase
Hylemonella gracilis	14920	HGR_03767	5-carboxymethyl-2-hydroxymuconate isomerase
Klebsiella pneumoniae	14438	KPR_0864
Klebsiella pneumoniae subsp. rhinoscleromatis	105682	HMPREF0484_5092	5-carboxymethyl-2-hydroxymuconate delta isomerase
Labrenzia aggregata	16684	SIAM614_21787	5-carboxymethyl-2-hydroxymuconate delta isomerase
Magnetospirillum magnetotacticum	15272	Magn03009775	COG3232: 5-carboxymethyl-2-hydroxymuconate isomerase
Marinomonas mediterranea	103028	Marme_1308	5-carboxymethyl-2-hydroxymuconate isomerase
Microscilla marina	16560	M23134_06795	putative 5-carboxymethyl-2-hydroxymuconate delta-isomerase
Phaeobacter gallaeciensis	16654	PGA1_c32230	putative 5-carboxymethyl-2-hydroxymuconate delta-isomerase
Providencia alcalifaciens	105687	PROVALCAL_00331	5-carboxymethyl-2-hydroxymuconate delta isomerase
Rhizobium sp.	101917	NGR_b20110	putative 5-carboxymethyl-2-hydroxymuconate isomerase
Rhizobium tropici	15247	RTCIAT899_PC03865	5-carboxymethyl-2-hydroxymuconate delta isomerase
		RTCIAT899_PC07920	putative 5-carboxymethyl-2-hydroxymuconate delta isomerase protein
Serratia odorifera	102598	HMPREF0758_0654	5-carboxymethyl-2-hydroxymuconate delta isomerase
Shimwellia blattae	105725	EB105725_26_00160	putative 5-carboxymethyl-2-hydroxymuconate isomerase
Sphingomonas wittichii	105917	Swit_4312	5-carboxymethyl-2-hydroxymuconate isomerase
Streptomyces ghanaensis	15414	SSFG_05147	isomerase
Streptomyces mobaraensis	13819	H340_01559	isomerase
Streptomyces purpureus	13925	STRPU_05_00410	Isomerase
Streptomyces sviceus	13980	SSEG_05687	isomerase
Streptomyces venezuelae	13096	SVEN_1886	isomerase
Vibrio alginolyticus	15630	N646_2430	putative 5-carboxymethyl-2-hydroxymuconate delta isomerase
Vibrio ichthyoenteri	15847	VII00023_15788	5-carboxymethyl-2-hydroxymuconate isomerase
Vibrio metschnikovii	103153	VIB_000477	5-carboxymethyl-2-hydroxymuconate delta-isomerase
Vibrio orientalis	15638	VIOR3934_12257	5-carboxymethyl-2-hydroxymuconate isomerase
Vibrio tubiashii	15644	VITU9109_02452	5-carboxymethyl-2-hydroxymuconate delta-isomerase
Vibrio vulnificus	15645	B736_00610	5-carboxymethyl-2-hydroxymuconate isomerase