| accession | DB | alignment | Evalue | Score | Ident. | link | information | pubmed |
1
|
Q9ZGI3_9ACTO (Q9ZGI3) |
|
|
0.0 |
3083 |
100% |
|
- Product
- Type I polyketide synthase PikAIII
- Gene
- pikAIII
- Organism
- Streptomyces venezuelae
|
1uniprot[Pubmed] 9770448 [Medline] 98445333 A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.(Proc. Natl. Acad. Sci. U.S.A.) [1998] | 2uniprot[Pubmed] 19146481 Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains.(ACS Chem. Biol.) [2009] | [pubmed all]
|
2
|
Q9ZGI5_9ACTO (Q9ZGI5) |
|
(5 hsp) |
0.0 |
1998 |
74% |
|
- Product
- Type I polyketide synthase PikAI
- Gene
- pikAI
- Organism
- Streptomyces venezuelae
|
1uniprot[Pubmed] 9770448 [Medline] 98445333 A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.(Proc. Natl. Acad. Sci. U.S.A.) [1998] |
|
3
|
Q9ZGI4_9ACTO (Q9ZGI4) |
|
(3 hsp) |
0.0 |
1752 |
65% |
|
- Product
- Type I polyketide synthase PikAII
- Gene
- pikAII
- Organism
- Streptomyces venezuelae
|
1uniprot[Pubmed] 9770448 [Medline] 98445333 A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.(Proc. Natl. Acad. Sci. U.S.A.) [1998] |
|
6
|
Q5SFB1_STRBI (Q5SFB1) |
|
|
0.0 |
1434 |
53% |
|
- Product
- Polyketide synthase subunit
- Gene
- chmGIV
- Organism
- Streptomyces bikiniensis
|
1uniprot[Pubmed] 15561847 Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae.(Antimicrob. Agents Chemother.) [2004] |
|
7
|
Q93HJ1_STRAW (Q93HJ1) |
|
(3 hsp) |
0.0 |
1425 |
53% |
|
- Product
- Modular polyketide synthase
- Gene
- olmA7
SAV2895 SAV_2895
- Organism
- Streptomyces avermitilis
|
1uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001] | 2uniprot[Pubmed] 12692562 [Medline] 22608306 Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003] | [pubmed all]
|
10
|
Q331Q3_9ACTO (Q331Q3) |
|
|
0.0 |
1413 |
52% |
|
- Product
- Putative type I polyketide synthase
- Gene
- gerSIV
- Organism
- Streptomyces sp. KCTC 0041BP
|
1uniprot[Pubmed] 17053005 Biosynthesis of dTDP-6-deoxy-beta-D-allose, biochemical characterization of dTDP-4-keto-6-deoxyglucose reductase (GerKI) from Streptomyces sp. KCTC 0041BP.(Glycobiology) [2007] | 2uniprot Cloning and characterization of a gene cluster for the production of the polyketide macrolide antibiotic dihydrochalcomycin in Streptomyces sp. KCTC 0041BP.(J. Microbiol. Biotechnol.) [2006] |
|
12
|
F1DI32_9ACTO (F1DI32) |
|
(3 hsp) |
0.0 |
1401 |
52% |
|
- Product
- TrdAII
- Gene
-
- Organism
- Streptomyces sp. SCSIO1666
|
1uniprot[Pubmed] 21329667 Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomyces sp. SCSIO1666.(Biochem. Biophys. Res. Commun.) [2011] |
|
13
|
D3Y1I4_9ACTO (D3Y1I4) |
|
(3 hsp) |
0.0 |
1397 |
53% |
|
- Product
- TamAII
- Gene
-
- Organism
- Streptomyces sp. 307-9
|
1uniprot[Pubmed] 20127927 Identification of the tirandamycin biosynthetic gene cluster from Streptomyces sp. 307-9.(Chembiochem) [2010] |
|
15
|
B1W487_STRGG (B1W487) |
|
(2 hsp) |
0.0 |
1387 |
52% |
|
- Product
- Putative type-I PKS
- Gene
- pks1-3
SGR_6075
- Organism
- Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
|
1uniprot[Pubmed] 18375553 Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008] |
|
17
|
Q52V51_9ACTO (Q52V51) |
|
(2 hsp) |
0.0 |
1383 |
52% |
|
- Product
- Polyketide synthase type I
- Gene
-
- Organism
- Streptomyces aizunensis
|
1uniprot[Pubmed] 15844935 Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.(J. Nat. Prod.) [2005] |
|
21
|
D1GLV8_9ACTO (D1GLV8) |
|
(3 hsp) |
0.0 |
1367 |
51% |
|
- Product
- Polyketide synthase type I
- Gene
- slgA2
- Organism
- Streptomyces lydicus
|
1uniprot Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.(Chem. Biol.) [2009] |
|
22
|
D7BRE1_STRBB (D7BRE1) |
|
(4 hsp) |
0.0 |
1366 |
52% |
|
- Product
- Modular polyketide synthase
- Gene
- SBI_01983
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
24
|
Q68BG5_STRHA (Q68BG5) |
|
(4 hsp) |
0.0 |
1364 |
52% |
|
- Product
- Type I polyketide synthase
- Gene
- hlsA
- Organism
- Streptomyces halstedii
|
1uniprot Genome-inspired search for new antibiotics; Isolation and structure determination of new 28-membered polyketide macrolactones, halstoctacosanolides A and B, from Streptomyces halstedii HC34.(Tetrahedron) [2004] |
|
27
|
B1W490_STRGG (B1W490) |
|
(2 hsp) |
0.0 |
1357 |
52% |
|
- Product
- Putative type-I PKS
- Gene
- pks1-6
SGR_6078
- Organism
- Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
|
1uniprot[Pubmed] 18375553 Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008] |
|
28
|
C9YYI3_STRSW (C9YYI3) |
|
(4 hsp) |
0.0 |
1355 |
51% |
|
- Product
- Putative type I polyketide synthase
- Gene
- SCAB_83921
- Organism
- Streptomyces scabies (strain 87.22)
Streptomyces scabiei
|
1uniprot[Pubmed] 20064060 Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010] |
|
29
|
C9YYI1_STRSW (C9YYI1) |
|
(5 hsp) |
0.0 |
1353 |
53% |
|
- Product
- Putative type I polyketide synthase
- Gene
- SCAB_83901
- Organism
- Streptomyces scabies (strain 87.22)
Streptomyces scabiei
|
1uniprot[Pubmed] 20064060 Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010] |
|
30
|
Q3S869_9ACTO (Q3S869) |
|
(4 hsp) |
0.0 |
1352 |
52% |
|
- Product
- Modular polyketide synthase
- Gene
-
- Organism
- Streptomyces neyagawaensis
|
1uniprot[Pubmed] 16207901 Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.(Microbiology) [2005] |
|
31
|
A4FH83_SACEN (A4FH83) |
|
(5 hsp) |
0.0 |
1352 |
51% |
|
- Product
- Type I modular polyketide synthase
- Gene
- SACE_4139
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
32
|
Q5VKR4_SACER (Q5VKR4) |
|
(5 hsp) |
0.0 |
1352 |
51% |
|
- Product
- Type I PKS
- Gene
- pkeAIII
- Organism
- Saccharopolyspora erythraea
Streptomyces erythraeus
|
1uniprot[Pubmed] 15925898 A new modular polyketide synthase in the erythromycin producer Saccharopolyspora erythraea.(J. Mol. Microbiol. Biotechnol.) [2004] |
|
33
|
Q52V47_9ACTO (Q52V47) |
|
|
0.0 |
1349 |
52% |
|
- Product
- Polyketide synthase type I
- Gene
-
- Organism
- Streptomyces aizunensis
|
1uniprot[Pubmed] 15844935 Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.(J. Nat. Prod.) [2005] |
|
34
|
D3Y1I3_9ACTO (D3Y1I3) |
|
(6 hsp) |
0.0 |
1349 |
53% |
|
- Product
- TamAI
- Gene
-
- Organism
- Streptomyces sp. 307-9
|
1uniprot[Pubmed] 20127927 Identification of the tirandamycin biosynthetic gene cluster from Streptomyces sp. 307-9.(Chembiochem) [2010] |
|
35
|
Q93NX9_9ACTO (Q93NX9) |
|
(8 hsp) |
0.0 |
1348 |
52% |
|
- Product
- AmphI
- Gene
- amphI
- Organism
- Streptomyces nodosus
|
1uniprot[Pubmed] 11451671 [Medline] 21344785 Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes.(Chem. Biol.) [2001] | 2uniprot[Pubmed] 16079135 Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups.(J. Biol. Chem.) [2005] | [pubmed all]
|
36
|
Q9ALM4_9PSEU (Q9ALM4) |
|
(2 hsp) |
0.0 |
1347 |
52% |
|
- Product
- Polyketide synthase extender modules 3-4
- Gene
- spnC
- Organism
- Saccharopolyspora spinosa
|
1uniprot[Pubmed] 11358695 [Medline] 21257765 Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001] |
|
38
|
D7CC10_STRBB (D7CC10) |
|
|
0.0 |
1342 |
51% |
|
- Product
- Putative type I polyketide synthase
- Gene
- pks5-4
SBI_01384
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
39
|
Q3S864_9ACTO (Q3S864) |
|
(5 hsp) |
0.0 |
1341 |
53% |
|
- Product
- Nodular polyketide synthase
- Gene
-
- Organism
- Streptomyces neyagawaensis
|
1uniprot[Pubmed] 16207901 Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.(Microbiology) [2005] |
|
40
|
F1DI31_9ACTO (F1DI31) |
|
(6 hsp) |
0.0 |
1337 |
53% |
|
- Product
- TrdAI
- Gene
-
- Organism
- Streptomyces sp. SCSIO1666
|
1uniprot[Pubmed] 21329667 Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomyces sp. SCSIO1666.(Biochem. Biophys. Res. Commun.) [2011] |
|
42
|
A1YAM9_AMYOR (A1YAM9) |
|
(3 hsp) |
0.0 |
1337 |
54% |
|
- Product
- Polyketide synthase type I
- Gene
-
- Organism
- Amycolatopsis orientalis
Nocardia orientalis
|
1uniprot[Pubmed] 17136886 Genomic analyses lead to novel secondary metabolites. Part 3. ECO-0501, a novel antibacterial of a new class.(J. Antibiot.) [2006] |
|
43
|
Q9ZGI2_9ACTO (Q9ZGI2) |
|
(2 hsp) |
0.0 |
1336 |
74% |
|
- Product
- Type I polyketide synthase PikAIV
- Gene
- pikAIV
- Organism
- Streptomyces venezuelae
|
1uniprot[Pubmed] 9770448 [Medline] 98445333 A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.(Proc. Natl. Acad. Sci. U.S.A.) [1998] | 2uniprot[Pubmed] 12379102 [Medline] 22266839 Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases.(Biochemistry) [2002] | 3uniprot[Pubmed] 16969373 Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels.(Nat. Chem. Biol.) [2006] | 4uniprot[Pubmed] 16969372 Structural basis for macrolactonization by the pikromycin thioesterase.(Nat. Chem. Biol.) [2006] | 5uniprot[Pubmed] 19146481 Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains.(ACS Chem. Biol.) [2009] | [pubmed all]
|
44
|
B6ZK65_STRLS (B6ZK65) |
|
(5 hsp) |
0.0 |
1336 |
53% |
|
- Product
- Putative polyketide synthase
- Gene
- lsd12
- Organism
- Streptomyces lasaliensis
|
1uniprot[Pubmed] 19129623 Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis.(Biosci. Biotechnol. Biochem.) [2009] | 2uniprot[Pubmed] 18710235 Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis.(J. Am. Chem. Soc.) [2008] | [pubmed all]
|
48
|
B6ZIR3_STRPT (B6ZIR3) |
|
(7 hsp) |
0.0 |
1334 |
52% |
|
- Product
- Polyketide synthase
- Gene
- pldAII
- Organism
- Streptomyces platensis
|
1uniprot[Pubmed] 18997414 Organization of the biosynthetic gene cluster for the polyketide antitumor macrolide, pladienolide, in Streptomyces platensis Mer-11107.(Biosci. Biotechnol. Biochem.) [2008] |
|
49
|
D1GLV9_9ACTO (D1GLV9) |
|
(6 hsp) |
0.0 |
1332 |
53% |
|
- Product
- Polyketide synthase type I
- Gene
- slgA1
- Organism
- Streptomyces lydicus
|
1uniprot Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.(Chem. Biol.) [2009] |
|
50
|
F8QPF8_9ACTO (F8QPF8) |
|
(6 hsp) |
0.0 |
1328 |
49% |
|
- Product
- Polyketide synthase
- Gene
- natA
- Organism
- Streptomyces sp. CS
|
1uniprot[Pubmed] 21614382 Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS.(Mol. Biosyst.) [2011] |
|
51
|
B6ZK67_STRLS (B6ZK67) |
|
|
0.0 |
1327 |
51% |
|
- Product
- Putative polyketide synthase
- Gene
- lsd14
- Organism
- Streptomyces lasaliensis
|
1uniprot[Pubmed] 19129623 Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis.(Biosci. Biotechnol. Biochem.) [2009] | 2uniprot[Pubmed] 18710235 Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis.(J. Am. Chem. Soc.) [2008] | [pubmed all]
|
54
|
Q68BG3_STRHA (Q68BG3) |
|
(3 hsp) |
0.0 |
1325 |
51% |
|
- Product
- Type I polyketide synthase
- Gene
- hlsC
- Organism
- Streptomyces halstedii
|
1uniprot Genome-inspired search for new antibiotics; Isolation and structure determination of new 28-membered polyketide macrolactones, halstoctacosanolides A and B, from Streptomyces halstedii HC34.(Tetrahedron) [2004] |
|
56
|
B1W488_STRGG (B1W488) |
|
|
0.0 |
1323 |
51% |
|
- Product
- Putative type-I PKS
- Gene
- pks1-4
SGR_6076
- Organism
- Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
|
1uniprot[Pubmed] 18375553 Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008] |
|
57
|
E0D202_9ACTO (E0D202) |
|
(9 hsp) |
0.0 |
1321 |
53% |
|
- Product
- Polyketide synthase
- Gene
- gfsA
- Organism
- Streptomyces graminofaciens
|
1uniprot[Pubmed] 20589823 Cloning and characterization of the biosynthetic gene cluster of 16-membered macrolide antibiotic FD-891: involvement of a dual functional cytochrome P450 monooxygenase catalyzing epoxidation and hydroxylation.(Chembiochem) [2010] |
|
60
|
E4NJF2_KITSK (E4NJF2) |
|
(5 hsp) |
0.0 |
1319 |
52% |
|
- Product
- Modular polyketide synthase BFAS2
- Gene
- bfmA2
KSE_73450
- Organism
- Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054)
Streptomyces setae
|
1uniprot[Pubmed] 21059706 Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.(DNA Res.) [2010] |
|
62
|
OL56_STRAT (Q07017) |
|
(2 hsp) |
0.0 |
1318 |
50% |
|
- Product
- Oleandomycin polyketide synthase, modules 5 and 6
- Gene
- orfB
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 8107683 [Medline] 94150470 Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence.(Mol. Gen. Genet.) [1994] |
|
63
|
Q6W5P6_9ACTO (Q6W5P6) |
|
(8 hsp) |
0.0 |
1316 |
51% |
|
- Product
- FscD
- Gene
- fscD
- Organism
- Streptomyces sp. FR-008
|
1uniprot[Pubmed] 14652074 Organizational and Mutational Analysis of a Complete FR-008/Candicidin Gene Cluster Encoding a Structurally Related Polyene Complex.(Chem. Biol.) [2003] |
|
64
|
Q93NW7_9ACTO (Q93NW7) |
|
(2 hsp) |
0.0 |
1315 |
50% |
|
- Product
- AmphB
- Gene
- amphB
- Organism
- Streptomyces nodosus
|
1uniprot[Pubmed] 11451671 [Medline] 21344785 Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes.(Chem. Biol.) [2001] | 2uniprot[Pubmed] 16079135 Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups.(J. Biol. Chem.) [2005] | 3uniprot[Pubmed] 20696392 Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase.(Structure) [2010] | [pubmed all]
|
66
|
A4FH85_SACEN (A4FH85) |
|
(5 hsp) |
0.0 |
1314 |
51% |
|
- Product
- Type I modular polyketide synthase
- Gene
- SACE_4141
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
67
|
Q5VKQ3_SACER (Q5VKQ3) |
|
(5 hsp) |
0.0 |
1314 |
51% |
|
- Product
- Type I PKS
- Gene
- pkeAI
- Organism
- Saccharopolyspora erythraea
Streptomyces erythraeus
|
1uniprot[Pubmed] 15925898 A new modular polyketide synthase in the erythromycin producer Saccharopolyspora erythraea.(J. Mol. Microbiol. Biotechnol.) [2004] |
|
68
|
Q9L4X3_9ACTO (Q9L4X3) |
|
(8 hsp) |
0.0 |
1313 |
51% |
|
- Product
- NysI
- Gene
- nysI
- Organism
- Streptomyces noursei
|
1uniprot[Pubmed] 10873841 [Medline] 20334850 Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway.(Chem. Biol.) [2000] |
|
69
|
Q93H83_STRAW (Q93H83) |
|
(2 hsp) |
0.0 |
1311 |
51% |
|
- Product
- Modular polyketide synthase
- Gene
- pteA5
SAV415 SAV_415
- Organism
- Streptomyces avermitilis
|
1uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001] | 2uniprot[Pubmed] 12692562 [Medline] 22608306 Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003] | [pubmed all]
|
71
|
B1W485_STRGG (B1W485) |
|
(5 hsp) |
0.0 |
1310 |
52% |
|
- Product
- Putative type-I PKS
- Gene
- pks1-1
SGR_6073
- Organism
- Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
|
1uniprot[Pubmed] 18375553 Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008] |
|
72
|
Q7WTD6_9ACTO (Q7WTD6) |
|
(3 hsp) |
0.0 |
1310 |
50% |
|
- Product
- NanA8
- Gene
- nanA8
- Organism
- Streptomyces nanchangensis
|
1uniprot[Pubmed] 12770825 [Medline] 22654646 A complete gene cluster from Streptomyces nanchangensis NS3226 encoding biosynthesis of the polyether ionophore nanchangmycin.(Chem. Biol.) [2003] |
|
73
|
D8HZ82_AMYMU (D8HZ82) |
|
(6 hsp) |
0.0 |
1310 |
50% |
|
- Product
- Rifamycin polyketide synthase
- Gene
- rifA
AMED_0617
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
74
|
O54666_AMYMD (O54666) |
|
(6 hsp) |
0.0 |
1310 |
50% |
|
- Product
- RifA
Rifamycin polyketide synthase, type 1
- Gene
- rifA
- Organism
- Amycolatopsis mediterranei
Nocardia mediterranei
|
1uniprot[Pubmed] 9512878 [Medline] 98174059 Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.(Chem. Biol.) [1998] | 2uniprot[Pubmed] 9497318 [Medline] 98165773 3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.(J. Biol. Chem.) [1998] | 3uniprot[Pubmed] 11278540 [Medline] 21201076 Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699.(J. Biol. Chem.) [2001] | [pubmed all]
|
75
|
Q93HJ2_STRAW (Q93HJ2) |
|
(3 hsp) |
0.0 |
1308 |
51% |
|
- Product
- Modular polyketide synthase
- Gene
- olmA6
SAV2896 SAV_2896
- Organism
- Streptomyces avermitilis
|
1uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001] | 2uniprot[Pubmed] 12692562 [Medline] 22608306 Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003] | [pubmed all]
|
76
|
D2CKL5_PSEAH (D2CKL5) |
|
(7 hsp) |
0.0 |
1306 |
50% |
|
- Product
- CppI
- Gene
- cppI
- Organism
- Pseudonocardia autotrophica
Amycolata autotrophica Nocardia autotrophica
|
1uniprot[Pubmed] 19697072 Identification of functionally clustered nystatin-like biosynthetic genes in a rare actinomycetes, Pseudonocardia autotrophica.(J. Ind. Microbiol. Biotechnol.) [2009] |
|
77
|
D7BSM1_STRBB (D7BSM1) |
|
(3 hsp) |
0.0 |
1305 |
50% |
|
- Product
- Type I polyketide synthase
- Gene
- nanA8
SBI_08400
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
80
|
C9YYI0_STRSW (C9YYI0) |
|
(3 hsp) |
0.0 |
1301 |
53% |
|
- Product
- Putative type I polyketide synthase
- Gene
- SCAB_83891
- Organism
- Streptomyces scabies (strain 87.22)
Streptomyces scabiei
|
1uniprot[Pubmed] 20064060 Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010] |
|
81
|
Q30CS2_STRAU (Q30CS2) |
|
(3 hsp) |
0.0 |
1300 |
52% |
|
- Product
- LipPks1
- Gene
- lipPks1
- Organism
- Streptomyces aureofaciens
|
1uniprot[Pubmed] 16723573 Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin.(Antimicrob. Agents Chemother.) [2006] |
|
82
|
Q1WEK9_9ACTO (Q1WEK9) |
|
(6 hsp) |
0.0 |
1299 |
52% |
|
- Product
- Polyketide synthase
- Gene
- merA
- Organism
- Streptomyces sp. NRRL 30748
|
1uniprot[Pubmed] 16806745 Isolation and characterization of meridamycin biosynthetic gene cluster from Streptomyces sp. NRRL 30748.(Gene) [2006] |
|
83
|
Q0QMN7_9ACTO (Q0QMN7) |
|
(5 hsp) |
0.0 |
1298 |
54% |
|
- Product
- Polyketide synthase type I
- Gene
-
- Organism
- Streptomyces sp. Eco86
|
1uniprot[Pubmed] 16724457 Isolation and identification of three new 5-alkenyl-3,3(2H)-furanones from two streptomyces species using a genomic screening approach.(J. Antibiot.) [2006] |
|
84
|
Q9L4W4_9ACTO (Q9L4W4) |
|
(2 hsp) |
0.0 |
1297 |
51% |
|
- Product
- NysB
- Gene
- nysB
- Organism
- Streptomyces noursei
|
1uniprot[Pubmed] 10873841 [Medline] 20334850 Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway.(Chem. Biol.) [2000] |
|
85
|
Q1WEK8_9ACTO (Q1WEK8) |
|
(7 hsp) |
0.0 |
1297 |
52% |
|
- Product
- Polyketide synthase
- Gene
- merB
- Organism
- Streptomyces sp. NRRL 30748
|
1uniprot[Pubmed] 16806745 Isolation and characterization of meridamycin biosynthetic gene cluster from Streptomyces sp. NRRL 30748.(Gene) [2006] |
|
86
|
F1CLA9_9ACTO (F1CLA9) |
|
(7 hsp) |
0.0 |
1297 |
53% |
|
- Product
- ScnS2
- Gene
- scnS2
- Organism
- Streptomyces chattanoogensis
|
1uniprot[Pubmed] 21330439 The pleitropic regulator AdpAch is required for natamycin biosynthesis and morphological differentiation in Streptomyces chattanoogensis.(Microbiology) [2011] |
|
87
|
A0ACI1_STRAM (A0ACI1) |
|
(2 hsp) |
0.0 |
1295 |
51% |
|
- Product
- Putative modular polyketide synthase
- Gene
- SAMR0475
- Organism
- Streptomyces ambofaciens ATCC 23877
|
1uniprot[Pubmed] 16956972 Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006] | 2uniprot Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006] |
|
88
|
A0FCL1_STRVO (A0FCL1) |
|
(6 hsp) |
0.0 |
1295 |
51% |
|
- Product
- MerA
- Gene
- merA
- Organism
- Streptomyces violaceoniger
|
1uniprot[Pubmed] 17159202 Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin.(Microbiology) [2006] |
|
89
|
B6ZIR2_STRPT (B6ZIR2) |
|
(7 hsp) |
0.0 |
1293 |
51% |
|
- Product
- Polyketide synthase
- Gene
- pldAI
- Organism
- Streptomyces platensis
|
1uniprot[Pubmed] 18997414 Organization of the biosynthetic gene cluster for the polyketide antitumor macrolide, pladienolide, in Streptomyces platensis Mer-11107.(Biosci. Biotechnol. Biochem.) [2008] |
|
90
|
Q8KPW5_9ACTO (Q8KPW5) |
|
(5 hsp) |
0.0 |
1291 |
52% |
|
- Product
- Putative type I polyketide synthase
- Gene
- gerSI
- Organism
- Streptomyces sp. KCTC 0041BP
|
1uniprot[Pubmed] 17053005 Biosynthesis of dTDP-6-deoxy-beta-D-allose, biochemical characterization of dTDP-4-keto-6-deoxyglucose reductase (GerKI) from Streptomyces sp. KCTC 0041BP.(Glycobiology) [2007] | 2uniprot Cloning and characterization of a gene cluster for the production of the polyketide macrolide antibiotic dihydrochalcomycin in Streptomyces sp. KCTC 0041BP.(J. Microbiol. Biotechnol.) [2006] |
|
91
|
Q5SFB4_STRBI (Q5SFB4) |
|
(5 hsp) |
0.0 |
1291 |
52% |
|
- Product
- Polyketide synthase subunit
- Gene
- chmGI
- Organism
- Streptomyces bikiniensis
|
1uniprot[Pubmed] 15561847 Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae.(Antimicrob. Agents Chemother.) [2004] |
|
95
|
Q9EWA1_9ACTO (Q9EWA1) |
|
(7 hsp) |
0.0 |
1285 |
53% |
|
- Product
- PimS2 protein
- Gene
- pimS2
- Organism
- Streptomyces natalensis
|
1uniprot[Pubmed] 11094342 [Medline] 20547809 A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis.(Chem. Biol.) [2000] |
|
96
|
Q93HJ5_STRAW (Q93HJ5) |
|
(6 hsp) |
0.0 |
1282 |
52% |
|
- Product
- Modular polyketide synthase
- Gene
- olmA1
SAV2899 SAV_2899
- Organism
- Streptomyces avermitilis
|
1uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001] | 2uniprot[Pubmed] 12692562 [Medline] 22608306 Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003] | [pubmed all]
|
97
|
Q3S865_9ACTO (Q3S865) |
|
(3 hsp) |
0.0 |
1280 |
52% |
|
- Product
- Modular polyketide synthase
- Gene
-
- Organism
- Streptomyces neyagawaensis
|
1uniprot[Pubmed] 16207901 Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.(Microbiology) [2005] |
|
98
|
A0ACH2_STRAM (A0ACH2) |
|
(3 hsp) |
0.0 |
1280 |
50% |
|
- Product
- Putative polyketide synthase B
- Gene
- SAMR0466
- Organism
- Streptomyces ambofaciens ATCC 23877
|
1uniprot[Pubmed] 16956972 Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006] | 2uniprot Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006] |
|
99
|
F1CT51_9ACTO (F1CT51) |
|
(6 hsp) |
0.0 |
1278 |
49% |
|
- Product
- GdmAI
- Gene
- gdmAI
- Organism
- Streptomyces autolyticus
|
1uniprot[Pubmed] 21544574 Streptomyces autolyticus JX-47 Large-Insert Bacterial Artificial Chromosome Library Construction and Identification of Clones Covering Geldanamycin Biosynthesis Gene Cluster.(Curr. Microbiol.) [2011] |
|
100
|
A0FCL2_STRVO (A0FCL2) |
|
(7 hsp) |
0.0 |
1274 |
50% |
|
- Product
- MerB
- Gene
- merB
- Organism
- Streptomyces violaceoniger
|
1uniprot[Pubmed] 17159202 Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin.(Microbiology) [2006] |
|