| accession | DB | alignment | Evalue | Score | Ident. | link | information | pubmed |
1
|
A4KCE5_9ACTO (A4KCE5) |
|
|
0.0 |
14890 |
100% |
|
- Product
- Tautomycetin biosynthetic PKS
- Gene
-
- Organism
- Streptomyces sp. CK4412
|
1uniprot[Pubmed] 17379718 Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412.(Microbiology) [2007] | 2uniprot[Pubmed] 20623733 Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase.(Angew. Chem. Int. Ed.) [2010] | [pubmed all]
|
2
|
C6ZCS0_9ACTO (C6ZCS0) |
|
|
0.0 |
14290 |
99% |
|
- Product
- Type I modular polyketide synthase
- Gene
- ttnB
- Organism
- Streptomyces griseochromogenes
|
1uniprot[Pubmed] 19191560 Characterization of the Tautomycetin Biosynthetic Gene Cluster from Streptomyces griseochromogenes Provides New Insight into Dialkylmaleic Anhydride Biosynthesis.(J. Nat. Prod.) [2009] |
|
5
|
Q6JHN6_9PSEU (Q6JHN6) |
|
(16 hsp) |
0.0 |
4564 |
54% |
|
- Product
- ObsC
- Gene
-
- Organism
- Saccharopolyspora spinosa
|
1uniprot[Pubmed] 15346767 Analysis of a 108-kb region of the Saccharopolyspora spinosa genome covering the obscurin polyketide synthase locus.(DNA Seq.) [2004] |
|
6
|
C0SMW2_9ACTO (C0SMW2) |
|
(10 hsp) |
0.0 |
4492 |
62% |
|
- Product
- Type I modular polyketide synthase
- Gene
- ttmH
- Organism
- Streptomyces spiroverticillatus
|
1uniprot[Pubmed] 16707708 Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus.(J. Bacteriol.) [2006] | 2uniprot[Pubmed] 18708355 Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis.(J. Biol. Chem.) [2008] | [pubmed all]
|
7
|
Q93NW6_9ACTO (Q93NW6) |
|
(23 hsp) |
0.0 |
4474 |
53% |
|
- Product
- AmphC
- Gene
- amphC
- Organism
- Streptomyces nodosus
|
1uniprot[Pubmed] 11451671 [Medline] 21344785 Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes.(Chem. Biol.) [2001] | 2uniprot[Pubmed] 16079135 Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups.(J. Biol. Chem.) [2005] | [pubmed all]
|
8
|
D7C2B8_STRBB (D7C2B8) |
|
(15 hsp) |
0.0 |
4461 |
53% |
|
- Product
- Type I modular polyketide synthase
- Gene
- pks3-2
SBI_00651
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
9
|
Q9L4W3_9ACTO (Q9L4W3) |
|
(25 hsp) |
0.0 |
4409 |
53% |
|
- Product
- NysC
- Gene
- nysC
- Organism
- Streptomyces noursei
|
1uniprot[Pubmed] 10873841 [Medline] 20334850 Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway.(Chem. Biol.) [2000] |
|
10
|
Q49BE1_STRHY (Q49BE1) |
|
(12 hsp) |
0.0 |
4333 |
51% |
|
- Product
- HbmAI
- Gene
- hbmAI
- Organism
- Streptomyces hygroscopicus
|
1uniprot[Pubmed] 16085885 Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption.(Appl. Environ. Microbiol.) [2005] |
|
11
|
A4KCE4_9ACTO (A4KCE4) |
|
(26 hsp) |
0.0 |
4329 |
72% |
|
- Product
- Tautomycetin biosynthetic PKS
- Gene
-
- Organism
- Streptomyces sp. CK4412
|
1uniprot[Pubmed] 17379718 Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412.(Microbiology) [2007] |
|
12
|
Q1L0T2_STRHY (Q1L0T2) |
|
(12 hsp) |
0.0 |
4318 |
51% |
|
- Product
- GelA
- Gene
-
- Organism
- Streptomyces hygroscopicus subsp. duamyceticus
|
1uniprot[Pubmed] 18600054 Characterization of tailoring genes involved in the modification of geldanamycin polyketide in Streptomyces hygroscopicus JCM4427.(J. Microbiol. Biotechnol.) [2008] |
|
13
|
C6ZCS1_9ACTO (C6ZCS1) |
|
(26 hsp) |
0.0 |
4309 |
71% |
|
- Product
- Type I modular polyketide synthase
- Gene
- ttnA
- Organism
- Streptomyces griseochromogenes
|
1uniprot[Pubmed] 19191560 Characterization of the Tautomycetin Biosynthetic Gene Cluster from Streptomyces griseochromogenes Provides New Insight into Dialkylmaleic Anhydride Biosynthesis.(J. Nat. Prod.) [2009] |
|
14
|
F1CT51_9ACTO (F1CT51) |
|
(12 hsp) |
0.0 |
4308 |
51% |
|
- Product
- GdmAI
- Gene
- gdmAI
- Organism
- Streptomyces autolyticus
|
1uniprot[Pubmed] 21544574 Streptomyces autolyticus JX-47 Large-Insert Bacterial Artificial Chromosome Library Construction and Identification of Clones Covering Geldanamycin Biosynthesis Gene Cluster.(Curr. Microbiol.) [2011] |
|
15
|
Q84G24_STRHY (Q84G24) |
|
(12 hsp) |
0.0 |
4304 |
51% |
|
- Product
- GdmAI
- Gene
- gdmAI
- Organism
- Streptomyces hygroscopicus
|
1uniprot[Pubmed] 12586396 [Medline] 22474162 Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.(FEMS Microbiol. Lett.) [2003] |
|
16
|
Q52V50_9ACTO (Q52V50) |
|
(16 hsp) |
0.0 |
4303 |
52% |
|
- Product
- Polyketide synthase type I
- Gene
-
- Organism
- Streptomyces aizunensis
|
1uniprot[Pubmed] 15844935 Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.(J. Nat. Prod.) [2005] |
|
17
|
D2CKM4_PSEAH (D2CKM4) |
|
(23 hsp) |
0.0 |
4253 |
53% |
|
- Product
- CppC
- Gene
- cppC
- Organism
- Pseudonocardia autotrophica
Amycolata autotrophica Nocardia autotrophica
|
1uniprot[Pubmed] 19697072 Identification of functionally clustered nystatin-like biosynthetic genes in a rare actinomycetes, Pseudonocardia autotrophica.(J. Ind. Microbiol. Biotechnol.) [2009] |
|
18
|
Q6W5P7_9ACTO (Q6W5P7) |
|
(12 hsp) |
0.0 |
4202 |
52% |
|
- Product
- FscE
- Gene
- fscE
- Organism
- Streptomyces sp. FR-008
|
1uniprot[Pubmed] 14652074 Organizational and Mutational Analysis of a Complete FR-008/Candicidin Gene Cluster Encoding a Structurally Related Polyene Complex.(Chem. Biol.) [2003] |
|
19
|
A4FH83_SACEN (A4FH83) |
|
(5 hsp) |
0.0 |
4188 |
50% |
|
- Product
- Type I modular polyketide synthase
- Gene
- SACE_4139
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
20
|
Q5VKR4_SACER (Q5VKR4) |
|
(5 hsp) |
0.0 |
4188 |
50% |
|
- Product
- Type I PKS
- Gene
- pkeAIII
- Organism
- Saccharopolyspora erythraea
Streptomyces erythraeus
|
1uniprot[Pubmed] 15925898 A new modular polyketide synthase in the erythromycin producer Saccharopolyspora erythraea.(J. Mol. Microbiol. Biotechnol.) [2004] |
|
21
|
C6W8V1_ACTMD (C6W8V1) |
|
(10 hsp) |
0.0 |
4148 |
52% |
|
- Product
- Acyl transferase
- Gene
- Amir_3294
- Organism
- Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
|
1uniprot Complete genome sequence of Actinosynnema mirum type strain (101).(Stand. Genomic Sci.) [2009] |
|
23
|
Q54297_STRHY (Q54297) |
|
(12 hsp) |
0.0 |
3993 |
47% |
|
- Product
- Polyketide synthase
- Gene
- rapA
- Organism
- Streptomyces hygroscopicus
|
1uniprot[Pubmed] 7644502 [Medline] 95372374 The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.(Proc. Natl. Acad. Sci. U.S.A.) [1995] | 2uniprot[Pubmed] 8635730 [Medline] 96186895 Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase.(Gene) [1996] | 3uniprot[Pubmed] 8635756 [Medline] 96186896 Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase.(Gene) [1996] | [pubmed all]
|
24
|
Q54296_STRHY (Q54296) |
|
(22 hsp) |
0.0 |
3931 |
49% |
|
- Product
- Polyketide synthase
- Gene
- rapB
- Organism
- Streptomyces hygroscopicus
|
1uniprot[Pubmed] 7644502 [Medline] 95372374 The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.(Proc. Natl. Acad. Sci. U.S.A.) [1995] | 2uniprot[Pubmed] 8635730 [Medline] 96186895 Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase.(Gene) [1996] | 3uniprot[Pubmed] 8635756 [Medline] 96186896 Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase.(Gene) [1996] | [pubmed all]
|
25
|
Q76KY0_STRHA (Q76KY0) |
|
(11 hsp) |
0.0 |
3837 |
49% |
|
- Product
- Polyketide synthase modules 1-3
- Gene
- vinP1
- Organism
- Streptomyces halstedii
|
1uniprot[Pubmed] 15112997 Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii.(Chem. Biol.) [2004] |
|
27
|
C0SMW4_9ACTO (C0SMW4) |
|
(28 hsp) |
0.0 |
3773 |
64% |
|
- Product
- Type I modular polyketide synthase
- Gene
- ttmJ
- Organism
- Streptomyces spiroverticillatus
|
1uniprot[Pubmed] 16707708 Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus.(J. Bacteriol.) [2006] | 2uniprot[Pubmed] 18708355 Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis.(J. Biol. Chem.) [2008] | [pubmed all]
|
28
|
Q0R4M5_STRAT (Q0R4M5) |
|
(12 hsp) |
0.0 |
3687 |
48% |
|
- Product
- ChlA3
- Gene
-
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 16793515 Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006] |
|
31
|
Q6MZA4_MYCUA (Q6MZA4) |
|
(27 hsp) |
0.0 |
3671 |
45% |
|
- Product
- Type I modular polyketide synthase
- Gene
- mlsA1
MUP040c
- Organism
- Mycobacterium ulcerans (strain Agy99)
|
1uniprot[Pubmed] 15758215 Functional analysis and annotation of the virulence plasmid pMUM001 from Mycobacterium ulcerans.(Microbiology) [2005] | 2uniprot[Pubmed] 14736915 Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.(Proc. Natl. Acad. Sci. U.S.A.) [2004] | [pubmed all]
|
32
|
D6C477_9ACTO (D6C477) |
|
(13 hsp) |
0.0 |
3621 |
47% |
|
- Product
- Modular polyketide synthase
- Gene
- meiA3
- Organism
- Streptomyces nanchangensis
|
1uniprot[Pubmed] 12811466 [Medline] 22777186 Identification of a gene cluster encoding meilingmycin biosynthesis among multiple polyketide synthase contigs isolated from Streptomyces nanchangensis NS3226.(Arch. Microbiol.) [2003] | 2uniprot[Pubmed] 20348291 Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification.(Appl. Environ. Microbiol.) [2010] | [pubmed all]
|
33
|
C0SMW3_9ACTO (C0SMW3) |
|
(11 hsp) |
0.0 |
3596 |
66% |
|
- Product
- Type I modular polyketide synthase
- Gene
- ttmI
- Organism
- Streptomyces spiroverticillatus
|
1uniprot[Pubmed] 16707708 Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus.(J. Bacteriol.) [2006] | 2uniprot[Pubmed] 18708355 Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis.(J. Biol. Chem.) [2008] | [pubmed all]
|
36
|
A0PQM7_MYCUA (A0PQM7) |
|
(9 hsp) |
0.0 |
3557 |
51% |
|
- Product
- Polyketide synthase, Pks12
- Gene
- pks12
MUL_2266
- Organism
- Mycobacterium ulcerans (strain Agy99)
|
1uniprot[Pubmed] 17210928 Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer.(Genome Res.) [2007] |
|
37
|
B2HF44_MYCMM (B2HF44) |
|
(8 hsp) |
0.0 |
3556 |
51% |
|
- Product
- Polyketide synthase, Pks12
- Gene
- pks12
MMAR_3025
- Organism
- Mycobacterium marinum (strain ATCC BAA-535 / M)
|
1uniprot[Pubmed] 18403782 Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.(Genome Res.) [2008] |
|
38
|
Q7VES2_MYCBO (Q7VES2) |
|
(8 hsp) |
0.0 |
3545 |
52% |
|
- Product
- Probable polyketide synthase pks12
- Gene
- pks12
Mb2074c
- Organism
- Mycobacterium bovis
|
1uniprot[Pubmed] 12788972 [Medline] 22709107 The complete genome sequence of Mycobacterium bovis.(Proc. Natl. Acad. Sci. U.S.A.) [2003] |
|
40
|
Q73Z07_MYCPA (Q73Z07) |
|
(8 hsp) |
0.0 |
3526 |
51% |
|
- Product
- Pks12
- Gene
- pks12
MAP_1796c
- Organism
- Mycobacterium paratuberculosis
|
1uniprot[Pubmed] 16116077 The complete genome sequence of Mycobacterium avium subspecies paratuberculosis.(Proc. Natl. Acad. Sci. U.S.A.) [2005] |
|
46
|
C1APW8_MYCBT (C1APW8) |
|
(8 hsp) |
0.0 |
3519 |
52% |
|
- Product
- Putative polyketide synthase
- Gene
- pks12
JTY_2062
- Organism
- Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)
|
1uniprot[Pubmed] 19200449 Whole genome sequence analysis of Mycobacterium bovis bacillus Calmette-Guerin (BCG) Tokyo 172: a comparative study of BCG vaccine substrains.(Vaccine) [2009] |
|
47
|
A1KK94_MYCBP (A1KK94) |
|
(8 hsp) |
0.0 |
3519 |
52% |
|
- Product
- Probable polyketide synthase pks12
- Gene
- pks12
BCG_2067c
- Organism
- Mycobacterium bovis (strain BCG / Pasteur 1173P2)
|
1uniprot[Pubmed] 17372194 Genome plasticity of BCG and impact on vaccine efficacy.(Proc. Natl. Acad. Sci. U.S.A.) [2007] |
|
50
|
Q7D7J7_MYCTU (Q7D7J7) |
|
(8 hsp) |
0.0 |
3514 |
52% |
|
- Product
- Polyketide synthase
- Gene
- MT2108
- Organism
- Mycobacterium tuberculosis
|
1uniprot[Pubmed] 12218036 [Medline] 22206494 Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.(J. Bacteriol.) [2002] |
|
52
|
O53490_MYCTU (O53490) |
|
(8 hsp) |
0.0 |
3511 |
52% |
|
- Product
- Probable polyketide synthase pks12
- Gene
- pks12
Rv2048c
- Organism
- Mycobacterium tuberculosis
|
1uniprot[Pubmed] 9634230 [Medline] 98295987 Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.(Nature) [1998] |
|
53
|
A1YAM7_AMYOR (A1YAM7) |
|
(13 hsp) |
0.0 |
3454 |
52% |
|
- Product
- Polyketide synthase type I
- Gene
-
- Organism
- Amycolatopsis orientalis
Nocardia orientalis
|
1uniprot[Pubmed] 17136886 Genomic analyses lead to novel secondary metabolites. Part 3. ECO-0501, a novel antibacterial of a new class.(J. Antibiot.) [2006] |
|
55
|
Q93NX8_9ACTO (Q93NX8) |
|
(10 hsp) |
0.0 |
3386 |
50% |
|
- Product
- AmphJ
- Gene
- amphJ
- Organism
- Streptomyces nodosus
|
1uniprot[Pubmed] 11451671 [Medline] 21344785 Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes.(Chem. Biol.) [2001] | 2uniprot[Pubmed] 16079135 Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups.(J. Biol. Chem.) [2005] | [pubmed all]
|
56
|
A0FCL2_STRVO (A0FCL2) |
|
(15 hsp) |
0.0 |
3378 |
50% |
|
- Product
- MerB
- Gene
- merB
- Organism
- Streptomyces violaceoniger
|
1uniprot[Pubmed] 17159202 Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin.(Microbiology) [2006] |
|
57
|
Q1WEK8_9ACTO (Q1WEK8) |
|
(14 hsp) |
0.0 |
3362 |
50% |
|
- Product
- Polyketide synthase
- Gene
- merB
- Organism
- Streptomyces sp. NRRL 30748
|
1uniprot[Pubmed] 16806745 Isolation and characterization of meridamycin biosynthetic gene cluster from Streptomyces sp. NRRL 30748.(Gene) [2006] |
|
60
|
Q9KID7_STRHY (Q9KID7) |
|
(10 hsp) |
0.0 |
3219 |
46% |
|
- Product
- FkbA
- Gene
- fkbA
- Organism
- Streptomyces hygroscopicus subsp. ascomyceticus
|
1uniprot[Pubmed] 10863099 [Medline] 20323220 The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.(Gene) [2000] |
|
61
|
Q84G22_STRHY (Q84G22) |
|
(8 hsp) |
0.0 |
3207 |
50% |
|
- Product
- GdmAIII
- Gene
- gdmAIII
- Organism
- Streptomyces hygroscopicus
|
1uniprot[Pubmed] 12586396 [Medline] 22474162 Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.(FEMS Microbiol. Lett.) [2003] |
|
62
|
E9KTB8_STRKN (E9KTB8) |
|
(13 hsp) |
0.0 |
3201 |
46% |
|
- Product
- Polyketide synthase
- Gene
- fkbA
Tcs_SK_034
- Organism
- Streptomyces kanamyceticus
|
1uniprot[Pubmed] 21175203 Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.(J. Am. Chem. Soc.) [2011] |
|
63
|
Q1L0T0_STRHY (Q1L0T0) |
|
(8 hsp) |
0.0 |
3190 |
50% |
|
- Product
- GelC
- Gene
-
- Organism
- Streptomyces hygroscopicus subsp. duamyceticus
|
1uniprot[Pubmed] 18600054 Characterization of tailoring genes involved in the modification of geldanamycin polyketide in Streptomyces hygroscopicus JCM4427.(J. Microbiol. Biotechnol.) [2008] |
|
64
|
F1CT53_9ACTO (F1CT53) |
|
(9 hsp) |
0.0 |
3184 |
50% |
|
- Product
- GdmAIII
- Gene
- gdmAIII
- Organism
- Streptomyces autolyticus
|
1uniprot[Pubmed] 21544574 Streptomyces autolyticus JX-47 Large-Insert Bacterial Artificial Chromosome Library Construction and Identification of Clones Covering Geldanamycin Biosynthesis Gene Cluster.(Curr. Microbiol.) [2011] |
|
65
|
Q49BD9_STRHY (Q49BD9) |
|
(8 hsp) |
0.0 |
3177 |
50% |
|
- Product
- HbmAIII
- Gene
- hbmAIII
- Organism
- Streptomyces hygroscopicus
|
1uniprot[Pubmed] 16085885 Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption.(Appl. Environ. Microbiol.) [2005] |
|
66
|
P95814_STRSQ (P95814) |
|
(11 hsp) |
0.0 |
3167 |
45% |
|
- Product
- FK506 polyketide synthase
- Gene
- fkbA
- Organism
- Streptomyces sp
|
1uniprot[Pubmed] 9063448 [Medline] 97217427 Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506.(Eur. J. Biochem.) [1997] |
|
69
|
E9KTI5_9ACTO (E9KTI5) |
|
(11 hsp) |
0.0 |
3110 |
45% |
|
- Product
- Polyketide synthase
- Gene
- fkbA
Tcs_11604BP_031
- Organism
- Streptomyces sp. KCTC 11604BP
|
1uniprot[Pubmed] 21175203 Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.(J. Am. Chem. Soc.) [2011] |
|
70
|
Q9ADL6_SORCE (Q9ADL6) |
|
(16 hsp) |
0.0 |
3104 |
47% |
|
- Product
- Soraphen polyketide synthase A
- Gene
- sorA
- Organism
- Sorangium cellulosum
Polyangium cellulosum
|
1uniprot[Pubmed] 12039053 [Medline] 22035375 Characterization of the biosynthetic gene cluster for the antifungal polyketide soraphen A from Sorangium cellulosum So ce26.(Gene) [2002] |
|
71
|
Q0QMN5_9ACTO (Q0QMN5) |
|
(7 hsp) |
0.0 |
3103 |
46% |
|
- Product
- Polyketide synthase type I
- Gene
-
- Organism
- Streptomyces sp. Eco86
|
1uniprot[Pubmed] 16724457 Isolation and identification of three new 5-alkenyl-3,3(2H)-furanones from two streptomyces species using a genomic screening approach.(J. Antibiot.) [2006] |
|
73
|
A0FCL3_STRVO (A0FCL3) |
|
(27 hsp) |
0.0 |
3031 |
53% |
|
- Product
- MerC
- Gene
- merC
- Organism
- Streptomyces violaceoniger
|
1uniprot[Pubmed] 17159202 Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin.(Microbiology) [2006] |
|
75
|
Q6W5P9_9ACTO (Q6W5P9) |
|
(12 hsp) |
0.0 |
3004 |
47% |
|
- Product
- FscB
- Gene
- fscB
- Organism
- Streptomyces sp. FR-008
|
1uniprot[Pubmed] 14652074 Organizational and Mutational Analysis of a Complete FR-008/Candicidin Gene Cluster Encoding a Structurally Related Polyene Complex.(Chem. Biol.) [2003] |
|
76
|
Q1WEK9_9ACTO (Q1WEK9) |
|
(16 hsp) |
0.0 |
2987 |
51% |
|
- Product
- Polyketide synthase
- Gene
- merA
- Organism
- Streptomyces sp. NRRL 30748
|
1uniprot[Pubmed] 16806745 Isolation and characterization of meridamycin biosynthetic gene cluster from Streptomyces sp. NRRL 30748.(Gene) [2006] |
|
79
|
B5L6M3_MICCH (B5L6M3) |
|
(9 hsp) |
0.0 |
2951 |
48% |
|
- Product
- Putative type I polyketide synthase
- Gene
-
- Organism
- Micromonospora chalcea
|
1uniprot[Pubmed] 18586939 Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.(J. Bacteriol.) [2008] |
|
80
|
A0FCL1_STRVO (A0FCL1) |
|
(17 hsp) |
0.0 |
2940 |
51% |
|
- Product
- MerA
- Gene
- merA
- Organism
- Streptomyces violaceoniger
|
1uniprot[Pubmed] 17159202 Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin.(Microbiology) [2006] |
|
85
|
B3TMP1_9ACTO (B3TMP1) |
|
(7 hsp) |
0.0 |
2852 |
48% |
|
- Product
- Polyketide synthase
- Gene
- KijS4
- Organism
- Actinomadura kijaniata
|
1uniprot[Pubmed] 17985890 Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007] |
|
86
|
C6W8U9_ACTMD (C6W8U9) |
|
(8 hsp) |
0.0 |
2851 |
49% |
|
- Product
- Short-chain dehydrogenase/reductase SDR
- Gene
- Amir_3292
- Organism
- Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
|
1uniprot Complete genome sequence of Actinosynnema mirum type strain (101).(Stand. Genomic Sci.) [2009] |
|
87
|
D7CC08_STRBB (D7CC08) |
|
(11 hsp) |
0.0 |
2848 |
53% |
|
- Product
- Putative type I polyketide synthase
- Gene
- pks5-2
SBI_01382
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
88
|
Q52V46_9ACTO (Q52V46) |
|
(19 hsp) |
0.0 |
2819 |
49% |
|
- Product
- Polyketide synthase type I
- Gene
-
- Organism
- Streptomyces aizunensis
|
1uniprot[Pubmed] 15844935 Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.(J. Nat. Prod.) [2005] |
|
89
|
D3U9Y8_9ACTO (D3U9Y8) |
|
(21 hsp) |
0.0 |
2812 |
52% |
|
- Product
- Type I polyketide synthase
- Gene
- sfaH
- Organism
- Streptomyces flaveolus
|
1uniprot Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor.(Mol. Biosyst.) [2010] |
|
90
|
C5HV16_STRAT (C5HV16) |
|
(14 hsp) |
0.0 |
2811 |
50% |
|
- Product
- Polyketide synthase
- Gene
- idmN
- Organism
- Streptomyces antibioticus
|
1uniprot Analysis of the indanomycin biosynthetic gene cluster from Streptomyces antibioticus NRRL 8167.(Chembiochem) [2009] |
|
92
|
Q93HJ3_STRAW (Q93HJ3) |
|
(8 hsp) |
0.0 |
2805 |
51% |
|
- Product
- Modular polyketide synthase
- Gene
- olmA3
SAV2897 SAV_2897
- Organism
- Streptomyces avermitilis
|
1uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001] | 2uniprot[Pubmed] 12692562 [Medline] 22608306 Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003] | [pubmed all]
|
93
|
B6ZIR3_STRPT (B6ZIR3) |
|
(17 hsp) |
0.0 |
2805 |
48% |
|
- Product
- Polyketide synthase
- Gene
- pldAII
- Organism
- Streptomyces platensis
|
1uniprot[Pubmed] 18997414 Organization of the biosynthetic gene cluster for the polyketide antitumor macrolide, pladienolide, in Streptomyces platensis Mer-11107.(Biosci. Biotechnol. Biochem.) [2008] |
|
94
|
B6ZK65_STRLS (B6ZK65) |
|
(12 hsp) |
0.0 |
2803 |
51% |
|
- Product
- Putative polyketide synthase
- Gene
- lsd12
- Organism
- Streptomyces lasaliensis
|
1uniprot[Pubmed] 19129623 Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis.(Biosci. Biotechnol. Biochem.) [2009] | 2uniprot[Pubmed] 18710235 Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis.(J. Am. Chem. Soc.) [2008] | [pubmed all]
|
100
|
E0D203_9ACTO (E0D203) |
|
(13 hsp) |
0.0 |
2725 |
53% |
|
- Product
- Polyketide synthase
- Gene
- gfsB
- Organism
- Streptomyces graminofaciens
|
1uniprot[Pubmed] 20589823 Cloning and characterization of the biosynthetic gene cluster of 16-membered macrolide antibiotic FD-891: involvement of a dual functional cytochrome P450 monooxygenase catalyzing epoxidation and hydroxylation.(Chembiochem) [2010] |
|