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微生物 : Streptomyces avermitilis

微生物株情報

NBRC番号 14893
学名 Streptomyces avermitilis
別名(シノニム) Streptomyces avermectinius
由来 IFO 14893 <- JCM 5070 <- KCC S-1070 <- NRRL 8165 <- Merck Sharp & Dohme Res. Lab. (MA-4680)
他保存機関番号 ATCC 31267=JCM 5070=NCIMB 12804=NRRL 8165=DSM 46492 =IMET 43778
他株番号 KCC S-1070=MA-4680=FERM P-4027
参考文献
464561
Avermectins, new family of potent anthelmintic agents: producing organism and fermentation. (Antimicrob Agents Chemother. 1979)
12508861
Streptomyces avermitilis sp. nov., nom. rev., a taxonomic home for the avermectin-producing streptomycetes. (Int J Syst Evol Microbiol. 2002)
12692562
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. (Nat Biotechnol. 2003)
18665359
Characterization of a modular enzyme of exo-1,5-alpha-L-arabinofuranosidase and arabinan binding module from Streptomyces avermitilis NBRC14893. (Appl Microbiol Biotechnol. 2008)
19060411
Stereoselective reduction of carbonyl compounds with Actinomycete: purification and characterization of three alpha-keto ester reductases from Streptomyces avermitilis. (Biosci Biotechnol Biochem. 2008)
22556031
Characterization of new class III lantibiotics--erythreapeptin, avermipeptin and griseopeptin from Saccharopolyspora erythraea, Streptomyces avermitilis and Streptomyces griseus demonstrates stepwise N-terminal leader processing. (Chembiochem. 2012)
23291751
Characterization of an alpha-L-Rhamnosidase from Streptomyces avermitilis. (Biosci Biotechnol Biochem. 2013)

推定保有機能 >>詳細

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タイプパターン 構成遺伝子 該当CDS
Alanine racemization(NFUNC_0063)
必須A
ALR
(NRULE_0228)
Alanine racemaseSAV4967
Alginate degradation(NFUNC_0062)
必須B
ALY
(NRULE_0227)
Alginate lyaseSAV0802
D-allose biosynthesis(NFUNC_0077)
必須A
LRHI
(NRULE_0242)
L-rhamnose isomeraseSAV7415
Aminoglycoside resistance (by aminoglycoside N-acetyltransferase)(NFUNC_0041)
必須A
AAC3
(NRULE_0149)
Aminoglycoside N(3')-acetyltransferaseSAV6323 SAV5714
Aminoglycoside resistance (by aminoglycoside O-phosphotransferase)(NFUNC_0043)
必須A
APH6
(NRULE_0155)
Streptomycin 6-kinaseSAV3961 SAV2557
C
APH7
(NRULE_0157)
Hygromycin-B 7''-O-kinaseSAV4746
Ampicillin resistance(NFUNC_0046)
必須A
BLAA
(NRULE_0122)
Beta-lactamase class ASAV4452
Anthranilate biosynthesis(NFUNC_0038)
必須A
GLAT
(NRULE_0142)
Glutamine amidotransferaseSAV4335 SAV1178
TRPE
(NRULE_0143)
Anthranilate synthase component ISAV6171
Aromatic azo compounds degradation(NFUNC_0073)
必須A
AZOR
(NRULE_0236)
FMN-dependent NADH-azoreductaseSAV4344
Bacitracin resistance(NFUNC_0022)
必須A
UPPP
(NRULE_0097)
Undecaprenyl-diphosphataseSAV7021 SAV1319
Beta-lactam antibiotic resistance(NFUNC_0033)
必須A
BLAA
(NRULE_0122)
Beta-lactamase class ASAV4452
Betaine biosynthesis (from choline)(NFUNC_0049)
必須C
CHOX
(NRULE_0178)
Choline oxidaseSAV6946
Ectoine biosynthesis(NFUNC_0056)
必須A
ECTB
(NRULE_0186)
Diaminobutyrate--2-oxoglutarate transaminaseSAV6397
ECTA
(NRULE_0187)
L-2,4-diaminobutyric acid acetyltransferaseSAV6398
ECTC
(NRULE_0188)
L-ectoine synthaseSAV6396
Freeze resistance (by antifreeze protein)(NFUNC_0019)
必須A
AFP
(NRULE_0089)
Ice-structuring proteinSAV4164
GABA biosynthesis(NFUNC_0066)
必須A
GAD
(NRULE_0231)
Glutamate decarboxylaseSAV4655 SAV3601
Hyaluronan degradation(NFUNC_0069)
必須A
HYSA
(NRULE_0232)
Hyaluronate lyaseSAV2704
Hydroxyectoine biosynthesis(NFUNC_0057)
必須A
ECTD
(NRULE_0189)
Ectoine hydroxylaseSAV6395
任意 
ECTB
(NRULE_0186)
Diaminobutyrate--2-oxoglutarate transaminaseSAV6397
 
ECTA
(NRULE_0187)
L-2,4-diaminobutyric acid acetyltransferaseSAV6398
 
ECTC
(NRULE_0188)
L-ectoine synthaseSAV6396
Hygromycin resistance(NFUNC_0055)
必須A
APH7
(NRULE_0157)
Hygromycin-B 7''-O-kinaseSAV4746
Macrolide antibiotic resistance(NFUNC_0045)
必須B
RLMA
(NRULE_0165)
23S rRNA (guanine-N(1))-methyltransferaseSAV4467
D
ERE
(NRULE_0168)
Erythromycin esteraseSAV7433 SAV0084
Metal-binding protein(NFUNC_0105)
必須A
MOP
(NRULE_0322)
Putative molybdenum-binding proteinSAV2341 SAV1398 SAV1718 SAV1721 SAV2340 SAV2618
C
MODA
(NRULE_0324)
Molybdate ABC transporter substrate-binding proteinSAV6373 SAV1719 SAV2896 SAV6308
F
SOXR
(NRULE_0329)
Redox-sensitive transcriptional activator SoxRSAV6604
Molybdate transport (ABC transporter)(NFUNC_0097)
必須A
MODA
(NRULE_0324)
Molybdate ABC transporter substrate-binding proteinSAV2896 SAV6373 SAV6308 SAV1719
任意 
MODB
(NRULE_0325)
Molybdate ABC transporter permease proteinSAV1720
(R)-pantothenate biosynthesis(NFUNC_0030)
必須A
PAND
(NRULE_0115)
Aspartate 1-decarboxylaseSAV7245
PANB
(NRULE_0116)
3-methyl-2-oxobutanoate hydroxymethyltransferaseSAV5943
PANE
(NRULE_0117)
2-dehydropantoate 2-reductaseSAV5819 SAV1833
PANC
(NRULE_0118)
Pantothenate synthetaseSAV4687
Penicillin resistance(NFUNC_0047)
必須A
BLAA
(NRULE_0122)
Beta-lactamase class ASAV4452
Protocatechuate degradation (beta-ketoadipate pathway)(NFUNC_0014)
必須A
PCAG
(NRULE_0066)
Protocatechuate 3,4-dioxygenase alpha subunitSAV1704
PCAH
(NRULE_0067)
Protocatechuate 3,4-dioxygenase beta subunitSAV1703
PCAB
(NRULE_0068)
3-carboxy-cis,cis-muconate cycloisomeraseSAV1705
PCAC
(NRULE_0069)
4-carboxymuconolactone decarboxylaseSAV1706 SAV1968
PCAD
(NRULE_0070)
3-oxoadipate enol-lactonaseSAV1706
PCAI
(NRULE_0072)
3-oxoadipate CoA-transferase subunit ASAV1700
PCAJ
(NRULE_0073)
3-oxoadipate CoA-transferase subunit BSAV1701
PCAF
(NRULE_0074)
Beta-ketoadipyl-CoA thiolaseSAV1604
B
PCAG
(NRULE_0066)
Protocatechuate 3,4-dioxygenase alpha subunitSAV1704
PCAH
(NRULE_0067)
Protocatechuate 3,4-dioxygenase beta subunitSAV1703
PCAB
(NRULE_0068)
3-carboxy-cis,cis-muconate cycloisomeraseSAV1705
PCAL
(NRULE_0071)
3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylaseSAV1706
PCAI
(NRULE_0072)
3-oxoadipate CoA-transferase subunit ASAV1700
PCAJ
(NRULE_0073)
3-oxoadipate CoA-transferase subunit BSAV1701
PCAF
(NRULE_0074)
Beta-ketoadipyl-CoA thiolaseSAV1604
Streptomycin resistance(NFUNC_0054)
必須C
APH6
(NRULE_0155)
Streptomycin 6-kinaseSAV3961 SAV2557
Trehalose biosynthesis (from maltooligosaccharide)(NFUNC_0037)
必須A
TREY
(NRULE_0140)
Maltooligosyl trehalose synthaseSAV2152
TREZ
(NRULE_0141)
Malto-oligosyltrehalose trehalohydrolaseSAV2159
任意 
GLGX
(NRULE_0139)
Glycogen debranching enzymeSAV2789 SAV2151
Trehalose biosynthesis (from maltose)(NFUNC_0034)
必須B
TRES
(NRULE_0128)
Trehalose synthaseSAV2803 SAV7396
Uptake of osmoprotectant(NFUNC_0061)
必須B
EHUB
(NRULE_0216)
Ectoine ABC transporter substrate-binding proteinSAV5230
EHUC
(NRULE_0217)
Ectoine ABC transporter permease proteinSAV5229
EHUD
(NRULE_0218)
Ectoine ABC transporter permease proteinSAV5228
EHUA
(NRULE_0219)
Ectoine ABC transporter ATP-binding proteinSAV5227
Vitamin B6 biosynthesis (PdxS/PdxT pathway)(NFUNC_0059)
必須A
PDXS
(NRULE_0206)
Pyridoxal biosynthesis lyase PdxSSAV6830
PDXT
(NRULE_0207)
Glutamine amidotransferase subunit PdxTSAV6831

ゲノム配列情報

BioProject IDPRJNA189
ローカスタグSAV,SAP1
INSDC entriesBA000030
ステータスComplete
解析状況
コンティグ数2
サイズ(bp) 9,119,895
遺伝子数 7,671
フィニッシングゴール
アセンブル方法
冗長度13.3x
シーケンス方法
  • Sanger
参考文献
  • Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. (Proc Natl Acad Sci U S A. 2001) PMID: 11572948
  • Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. (Nat Biotechnol. 2003) PMID: 12692562

データダウンロード

ゲノム塩基配列 CDS塩基配列 CDSアミノ酸変換配列 遺伝子/ORF リスト
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