Acid resistance (by GABA antiporter)(NFUNC_0071) |
必須 | A | GAD (NRULE_0231) | Glutamate decarboxylase | EcolC_2164 EcolC_0200 |
GADC (NRULE_0234) | Glutamate/gamma-aminobutyrate antiporter | EcolC_2165 |
Alanine racemization(NFUNC_0063) |
必須 | A | ALR (NRULE_0228) | Alanine racemase | EcolC_2435 EcolC_3975 |
Anthranilate biosynthesis(NFUNC_0038) |
必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | EcolC_0352 EcolC_2364 |
TRPE (NRULE_0143) | Anthranilate synthase component I | EcolC_2363 |
Aromatic azo compounds degradation(NFUNC_0073) |
必須 | A | AZOR (NRULE_0236) | FMN-dependent NADH-azoreductase | EcolC_2246 |
Arsenical resistance(NFUNC_0004) |
必須 | A | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | EcolC_0214 |
ARSC1 (NRULE_0017) | Arsenate reductase | EcolC_1181 EcolC_0213 |
Bacitracin resistance(NFUNC_0022) |
必須 | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | EcolC_0642 |
Beta-lactam antibiotic resistance(NFUNC_0033) |
必須 | C | BLAC (NRULE_0124) | Beta-lactamase class C | EcolC_3860 |
Betaine biosynthesis (from choline)(NFUNC_0049) |
必須 | A | BETA (NRULE_0175) | Choline dehydrogenase | EcolC_3312 |
Biotin biosynthesis(NFUNC_0051) |
必須 | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | EcolC_2867 |
BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | EcolC_2869 |
BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | EcolC_2037 EcolC_2865 |
BIOB (NRULE_0185) | Biotin synthase | EcolC_2868 |
Cephalosporin resistance(NFUNC_0048) |
必須 | A | BLAC (NRULE_0124) | Beta-lactamase class C | EcolC_3860 |
Dihydroxy aromatic compounds degradation (via meta-cleavage pathway)(NFUNC_0011) |
必須 | A | EDIO (NRULE_0058) | extradiol dioxygenase | EcolC_3704 EcolC_0659 EcolC_3277 |
METAH (NRULE_0059) | meta-cleavage compound hydrolase | EcolC_3276 |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | EcolC_3275 |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | EcolC_3273 |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | EcolC_3274 |
Folate biosynthesis(NFUNC_0044) |
必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | EcolC_0352 EcolC_2364 |
DHPS (NRULE_0144) | Dihydropteroate synthase | EcolC_0523 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | EcolC_2024 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | EcolC_0641 EcolC_1349 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | EcolC_3517 |
FOLC (NRULE_0160) | Bifunctional protein FolC | EcolC_1337 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | EcolC_1821 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | EcolC_2505 |
B | GLAT (NRULE_0142) | Glutamine amidotransferase | EcolC_0352 EcolC_2364 |
DHPS (NRULE_0144) | Dihydropteroate synthase | EcolC_0523 |
FOLA (NRULE_0147) | Dihydrofolate reductase | EcolC_3607 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | EcolC_1349 EcolC_0641 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | EcolC_3517 |
FOLC (NRULE_0160) | Bifunctional protein FolC | EcolC_1337 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | EcolC_1821 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | EcolC_2505 |
GABA biosynthesis(NFUNC_0066) |
必須 | A | GAD (NRULE_0231) | Glutamate decarboxylase | EcolC_0200 EcolC_2164 |
4-hydroxyphenylacetate degradation(NFUNC_0068) |
必須 | A | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | EcolC_3710 |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | EcolC_3711 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | EcolC_3704 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | EcolC_3703 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | EcolC_3705 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | EcolC_3702 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | EcolC_3706 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | EcolC_3707 |
C | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | EcolC_3710 |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | EcolC_3711 EcolC_2588 EcolC_2194 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | EcolC_3704 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | EcolC_3703 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | EcolC_3705 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | EcolC_3702 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | EcolC_3706 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | EcolC_3707 |
Macrolide antibiotic resistance(NFUNC_0045) |
必須 | B | RLMA (NRULE_0165) | 23S rRNA (guanine-N(1))-methyltransferase | EcolC_1810 |
C | MACA (NRULE_0166) | Macrolide-specific efflux protein MacA | EcolC_2718 |
MACB (NRULE_0167) | Macrolide export ATP-binding/permease protein MacB | EcolC_2717 |
Metal-binding protein(NFUNC_0105) |
必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | EcolC_2307 EcolC_2901 EcolC_2897 |
B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | EcolC_2901 |
C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | EcolC_4101 EcolC_3995 EcolC_2899 EcolC_1254 |
E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | EcolC_3129 |
F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | EcolC_3964 |
G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | EcolC_0421 |
H | NIKR (NRULE_0331) | Nickel-responsive transcriptional regulator NikR | EcolC_0235 |
I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | EcolC_1146 |
Molybdate transport (ABC transporter)(NFUNC_0097) |
必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | EcolC_3995 EcolC_4101 EcolC_2899 EcolC_1254 |
任意 | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | EcolC_2901 |
| MODB (NRULE_0325) | Molybdate ABC transporter permease protein | EcolC_2898 |
| MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | EcolC_2897 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | EcolC_3528 |
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | EcolC_3525 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | EcolC_3208 |
PANC (NRULE_0118) | Pantothenate synthetase | EcolC_3526 |
Phenol degradation(NFUNC_0028) |
必須 | B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | EcolC_3710 |
C | PHEA2 (NRULE_0084) | Aromatic ring hydroxylase | EcolC_3278 |
任意 | | FDR2 (NRULE_0057) | Ferredoxin reductase | EcolC_1135 |
| FDR1 (NRULE_0032) | Oxygenase electron transfer component | EcolC_2263 EcolC_1830 EcolC_2724 |
| FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | EcolC_1831 EcolC_1139 EcolC_1137 |
| FADR1 (NRULE_0101) | NADH-dependent flavin reductase | EcolC_2588 EcolC_3711 EcolC_2194 |
Phytic acid hydrolysis(NFUNC_0085) |
必須 | B | APPA (NRULE_0259) | Periplasmic AppA protein | EcolC_2616 |
Polymyxin resistance(NFUNC_0036) |
必須 | A | ARNA (NRULE_0132) | Bifunctional polymyxin resistance protein ArnA | EcolC_1394 |
ARNB (NRULE_0133) | UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase | EcolC_1396 |
ARNC (NRULE_0134) | Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase | EcolC_1395 |
ARND (NRULE_0135) | Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD | EcolC_1393 |
ARNE (NRULE_0136) | Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE | EcolC_1391 |
ARNF (NRULE_0137) | Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF | EcolC_1390 |
ARNT (NRULE_0138) | Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase | EcolC_1392 |
Riboflavin biosynthesis(NFUNC_0058) |
必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | EcolC_0656 |
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | EcolC_2349 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | EcolC_3219 |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | EcolC_3218 |
RIBE (NRULE_0204) | Riboflavin synthase | EcolC_1967 |
任意 | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | EcolC_3630 |
Trehalose biosynthesis (from NDP-glucose and glucose-6-phosphate)(NFUNC_0031) |
必須 | A | TPS (NRULE_0119) | Trehalose-phosphate synthase | EcolC_1738 |
TPP (NRULE_0120) | Trehalose-6-phosphate phosphatase | EcolC_1737 |
Uptake of osmoprotectant(NFUNC_0061) |
必須 | A | OPUAC (NRULE_0213) | Osmoprotectant ABC transporter substrate-binding protein | EcolC_1027 |
OPUAB (NRULE_0214) | Osmoprotectant ABC transporter permease protein | EcolC_1028 |
OPUAA (NRULE_0215) | Osmoprotectant ABC transporter ATP-binding protein | EcolC_1029 |
C | BCCT (NRULE_0220) | BCCT family transporter | EcolC_3309 EcolC_0734 EcolC_1832 EcolC_3615 |
D | PROP (NRULE_0221) | Osmoprotectant transporter | EcolC_3916 |
E | OPUE (NRULE_0222) | Sodium/proline symporter | EcolC_2580 |
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) |
必須 | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase | EcolC_0783 |
PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase | EcolC_1332 |
SERC (NRULE_0210) | Phosphoserine aminotransferase | EcolC_2689 |
PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | EcolC_3603 |
PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | EcolC_1113 |