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遺伝子 : (S)-2-haloacid dehalogenase (HAD)

遺伝子情報

ID NRULE_0051
遺伝子ID HAD
作成日 2012/09/28
タンパク質名
Protein name
Full
(S)-2-haloacid dehalogenase
EC
EC 3.8.1.2
Synonym
Full
2-haloalkanoic acid dehalogenase
Halocarboxylic acid halidohydrolase
L-2-haloacid dehalogenase
遺伝子名 該当データなし
遺伝子条件 TIGRFAMs; TIGR01428; hit=1
参照
Gene Ontology
GO
GO:0018784, F:(S)-2-haloacid dehalogenase activity, IEA:EC
Family and domain databases
InterPro
IPR005834, Dehalogen-like_hydro
IPR023214, HAD-like_dom
IPR006388, HAD-SF_hydro_IA_v2
IPR006402, HAD-SF_hydro_IA_v3
IPR006328, HAD_II
IPR005833, Haloacid_DH/epoxide_hydro
Pfam
PF00702, Hydrolase, 1
PRINTS
PR00413, HADHALOGNASE
TIGRFAMs
TIGR01493, HAD-SF-IA-v2, 1
TIGR01509, HAD-SF-IA-v3, 1
TIGR01428, HAD_type_II, 1
配列の特徴
Q60099 Xanthobacter autotrophicus.
ACT_SITE8Nucleophile.
注釈
Function
Catalyzes the hydrolytic dehalogenation of small L-2- haloalkanoic acids to yield the corresponding D-2-hydroxyalkanoic acids
Catalytic activity
(S)-2-haloacid + H(2)O = (R)-2-hydroxyacid + halide
Subunit structure
Homodimer
Sequence similarities
Belongs to the HAD-like hydrolase superfamily. S-2- haloalkanoic acid dehalogenase family
参考文献
Q60099 Xanthobacter autotrophicus.
1744048
Characterization of the haloacid dehalogenase from Xanthobacter autotrophicus GJ10 and sequencing of the dhlB gene. (J Bacteriol. 1991)
Q51645 Burkholderia cepacia (Pseudomonas cepacia).
1376111
Molecular biology of the 2-haloacid halidohydrolase IVa from Pseudomonas cepacia MBA4. (Biochem J. 1992)



関与する機能

機能名
Haloalkane degradation (conversion into hydroxyacid)

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Acidiphilium multivorum100883ACMV_15310putative epoxide hydrolase
ACMV_344302-haloacid dehalogenase
Actinoalloteichus spitiensis102582ACTIDRAF_07305HAD family hydrolase
Actinomadura atramentaria14695G339_10510hypothetical protein
Actinopolyspora iraqiensis103187ACTIR_559_00010haloacid dehalogenase
Alicyclobacillus acidocaldarius subsp. acidocaldarius15652Aaci_1951haloacid dehalogenase, type II
Alteromonas macleodii102226MASE_01255cryptic haloacid dehalogenase 1
MASE_07845haloacid dehalogenase-like hydrolase
Amycolatopsis azurea14573C791_58052-haloalkanoic acid dehalogenase
Amycolatopsis mediterranei13415RAM_28665haloacid dehalogenase
Arthrobacter globiformis12137ARGLB_077_00290putative epoxide hydrolase
Azorhizobium caulinodans14845AZC_2033dehalogenase
AZC_2705hydrolase
Bradyrhizobium diazoefficiens14792blr4364putative haloacid dehalogenase
blr75602-haloalkanoic acid dehalogenase
Brevibacterium linens12170BlinB_0102000110862-haloalkanoic acid dehalogenase
Candidatus Solibacter usitatusAcid_5126haloacid dehalogenase, type II
Acid_6850haloacid dehalogenase, type II
Cellulophaga lytica14961Celly_0377haloacid dehalogenase, type II
Chromobacterium violaceum12614CV_0864probable haloacid dehalogenase
Cupriavidus metallidurans102507Rmet_1389predicted hydrolase (HAD superfamily)
Deferribacter desulfuricans101012DEFDS_09072-haloacid dehalogenase
Edwardsiella tarda105688ET1_15_01140hypothetical protein
Flexibacter litoralis15988Fleli_31172-haloalkanoic acid dehalogenase, type II
Geodermatophilus obscurus13315Gobs_4382haloacid dehalogenase, type II
Gluconobacter frateurii101659GfraN1_010100012436haloacid dehalogenase
Gordonia alkanivorans16433GOALK_060_01230putative epoxide hydrolase
Gordonia amarae15530GOAMR_75_00510putative epoxide hydrolase
Gordonia amicalis100051GOAMI_07_01020putative haloacid dehalogenase
Gordonia araii100433GOARA_012_00530putative epoxide hydrolase
Gordonia bronchialis16047Gbro_0492haloacid dehalogenase, type II
Gordonia effusa100432GOEFS_045_00270putative epoxide hydrolase
Gordonia namibiensis108229GONAM_15_00840putative epoxide hydrolase
Gordonia otitidis100426GOOTI_204_00150putative epoxide hydrolase
Gordonia polyisoprenivorans16320GOPIP_095_00120putative hydrolase
Gordonia rhizosphera16068GORHZ_229_00110putative epoxide hydrolase
Gordonia rubripertincta101908GORBP_014_00350putative epoxide hydrolase
Gordonia sihwensis108236GSI01S_14_00340putative epoxide hydrolase
Gordonia soli108243GS4_08_02230putative epoxide hydrolase
Gordonia sputi100414GOSPT_005_00380putative epoxide hydrolase
Gordonia terrae100016GOTRE_121_00020putative epoxide hydrolase
Haloarcula vallismortis14741C437_09243haloacid dehalogenase
Halobacillus halophilus102448HBHAL_2440haloacid dehalogenase, type II
Halomonas elongata15536HELO_3658haloacid dehalogenase, type II
Herpetosiphon aurantiacusHaur_0901haloacid dehalogenase, type II
Intrasporangium calvum12989Intca_3029haloacid dehalogenase, type II
Ktedonobacter racemiferKrac_4618haloacid dehalogenase, type II
Labrenzia aggregata16684SIAM614_171492-haloacid halidohydrolase Iva
SIAM614_31121probable dehalogenase protein
Magnetospirillum magnetotacticum15272Magn03008777COG1011: Predicted hydrolase (HAD superfamily)
Magn03008927COG1011: Predicted hydrolase (HAD superfamily)
Marinomonas mediterranea103028Marme_2464haloacid dehalogenase, type II
Methylobacterium radiotolerans15690Mrad2831_2564haloacid dehalogenase, type II
Mrad2831_4499haloacid dehalogenase, type II
Mrad2831_5331haloacid dehalogenase, type II
Nocardiopsis dassonvillei14626Ndas_0447haloacid dehalogenase, type II
Ochrobactrum anthropi15819Oant_2700haloacid dehalogenase, type II
Ochrobactrum intermedium15820OINT_1000616haloacid dehalogenase, type II
Phaeobacter gallaeciensis16654PGA1_c04610haloacid dehalogenase, type II
Planctomyces brasiliensis103401Plabr_1614haloacid dehalogenase, type II
Rhizobium etli15573RHE_PF00342probable dehalogenase protein
Rhizobium sp.101917NGR_b06290putative hydrolase
NGR_b06590putative dehalogenase
NGR_b06620putative hydrolase
NGR_c06140probable haloacid dehalogenase
NGR_c06220putative dehalogenase
NGR_c07220putative S-2-haloacid dehalogenase; 2-haloalkanoic acid dehalogenase; L-2-haloacid dehalogenase; DEHC
Rhizobium tropici15247RTCIAT899_PC08355haloacid dehalogenase, type II
Rhodococcus erythropolis100887RER_59680putative epoxide hydrolase
Rhodococcus opacus108011ROP_03560putative epoxide hydrolase
ROP_34420putative hydrolase
ROP_pROB01-03120putative hydrolase
Roseobacter denitrificans15277RD1_3929(S)-2-haloacid dehalogenase
Roseobacter litoralis15278RLO149_c005040putative 2-haloalkanoic acid dehalogenase
Rubrobacter xylanophilus100952Rxyl_0508haloacid dehalogenase, type II
Rxyl_1673haloacid dehalogenase, type II
Saccharomonospora azurea14651SacazDRAFT_006052-haloalkanoic acid dehalogenase, type II
Saccharomonospora cyanea14841SaccyDRAFT_25452-haloalkanoic acid dehalogenase, type II
SaccyDRAFT_42812-haloalkanoic acid dehalogenase, type II
Saccharomonospora glauca14831SacglDRAFT_022772-haloalkanoic acid dehalogenase, type II
Saccharopolyspora erythraea13426SACE_2965haloacid dehalogenase-like hydrolase
SACE_4364putative 2-haloalkanoic acid dehalogenase
SACE_4734haloalkanoic acid dehalogenase
Saccharopolyspora spinosa15153SspiN1_010100007020haloacid dehalogenase
SspiN1_010100028779haloacid dehalogenase type II
SspiN1_010100031919HAD family hydrolase
Salinibacter ruberSRU_1260haloacid dehalogenase, type II
Serratia odorifera102598HMPREF0758_3768haloacid dehalogenase, type II
Sporichthya polymorpha12702Spopo_31_05220Haloacid dehalogenase, type II
Stackebrandtia nassauensis102104Snas_2716haloacid dehalogenase, type II
Staphylococcus saprophyticus subsp. saprophyticus102446SSP0367putative 2-haloalkanoic acid dehalogenase
Streptomyces avermitilis14893SAV0737putative 2-haloalkanoic acid dehalogenase
Streptomyces sviceus13980SSEG_01305haloacid dehalogenase, type II
SSEG_06464haloacid dehalogenase, type II
Sulfolobus tokodaii100140STK_25700L-2-haloacid dehalogenase
Thermomicrobium roseumtrd_A0854haloacid dehalogenase, type II