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Rule : Aromatic ring hydroxylase (PHEA1)

Rule Description

ID NRULE_0083
Rule name PHEA1
Created 2012-11-21
Protein name
Protein name
Full
Aromatic ring hydroxylase
EC
EC 1.14.13.-
Synonym
Full
Aromatic hydrocarbon monooxygenase
Gene name Not assigned
Rule Trigger PFAM; PF03241; hit=1ANDPFAM; PF11794; hit=1
Cross Reference
Family and domain databases
InterPro
IPR006091, Acyl-CoA_Oxase/DH_cen-dom
IPR009075, AcylCo_DH/oxidase_C
IPR009100, AcylCoA_DH/oxidase
IPR024677, HpaB/PvcC
IPR004925, HpaB/PvcC/4-BUDH
IPR024719, HpaB/PvcC/4-BUDH_C
IPR024674, HpaB/PvcC/4-BUDH_N
Pfam
PF03241, HpaB, 1
PF11794, HpaB_N, 1
Feature Not assigned
General annotation
Function
Hydroxylation of phenol derivatives to catechol derivatives
Cofactor
FAD
Pathway
Aromatic compound metabolism
Sequence similarities
Belongs to the FADH(2)-utilizing monooxygenase family
Reference
Q8RQQ0 Rhodococcus sp.
16233382
Cloning and characterization of a 4-nitrophenol hydroxylase gene cluster from Rhodococcus sp. PN1. (J Biosci Bioeng. 2003)
18805976
Mechanism of 4-nitrophenol oxidation in Rhodococcus sp. Strain PN1: characterization of the two-component 4-nitrophenol hydroxylase and regulation of its expression. (J Bacteriol. 2008)



Related Function

Function name
Phenol degradation

CDS

Data Download
Scientific name NBRC No. CDS Product name
Acaricomes phytoseiuli107788C501_01025MFS transporter
Acetobacter tropicalis101654ATPR_03554-hydroxyphenylacetate 3-hydroxylase
Actinoalloteichus cyanogriseus14455G443_08_011404-hydroxyphenylacetate 3-hydroxylase
Alicyclobacillus acidocaldarius subsp. acidocaldarius15652Aaci_03394-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit
Amycolatopsis azurea14573C791_02744-hydroxyphenylacetate 3-monooxygenase
C791_51264-hydroxyphenylacetate 3-monooxygenase
Arthrobacter globiformis12137ARGLB_096_002804-hydroxyphenylacetate-3-hydroxylase
Azorhizobium caulinodans14845AZC_41894-hydroxyphenylacetate 3-hydroxylase
Bacillus amyloliquefaciens15535BAMF_0207putative 4-hydroxyphenylacetate-3-hydroxylase
Bacillus pseudomycoides101232bpmyx0001_185604-hydroxyphenylacetate-3-hydroxylase
Bacillus psychrosaccharolyticus101233WYK_156_003204-hydroxyphenylacetate-3-hydroxylase
Bacillus subtilis3134BSU6633_05964putative 4-hydroxyphenylacetate-3-hydroxylase
Bacillus subtilis subsp. subtilis13719BSU18620putative 4-hydroxyphenylacetate-3-hydroxylase
Bacillus thuringiensis101235bthur0008_235504-hydroxyphenylacetate 3-hydroxylase
Beutenbergia cavernae16432Bcav_08704-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit
Brevibacillus brevis100599BBR47_29710probable 4-hydroxyphenylacetate-3-hydroxylase
Caldilinea aerophila104270CLDAP_41000putative phenol hydroxylase
Candidatus Nitrosopumilus sp.NSED_00835vinylacetyl-CoA Delta-isomerase
Cenarchaeum symbiosumCENSYa_00224-hydroxybutyryl-CoA dehydratase
Clostridium kluyveri12016CKR_2668hypothetical protein
Conexibacter woesei100937Cwoe_43654-hydroxyphenylacetate 3-hydroxylase
Deinococcus proteolyticus101906Deipr_26194-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit
Enterobacter aerogenes13534EAE_103154-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit
Enterobacter cloacae subsp. cloacae13535ECL_007504-hydroxyphenylacetate-3-hydroxylase large chain
Enterobacter hormaechei105718HMPREF9086_18944-hydroxyphenylacetate 3-monooxygenase oxygenase component
Escherichia coli3972EcolC_37104-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit
Escherichia coli13500WFL_229204-hydroxyphenylacetic hydroxylase
Escherichia fergusonii102419EFER_30704-hydroxyphenylacetate 3-monooxygenase large component
Gordonia aichiensis108223GOACH_06_00840putative phenol hydroxylase
Gordonia alkanivorans16433GOALK_038_00960putative phenol hydroxylase
GOALK_065_00040putative 4-hydroxyphenylacetate-3-hydroxylase
Gordonia amarae15530GOAMR_33_00460putative 4-hydroxyphenylacetate 3-hydroxylase
Gordonia amicalis100051GOAMI_26_00190putative phenol hydroxylase
Gordonia bronchialis16047Gbro_02204-hydroxyphenylacetate 3-hydroxylase
Gbro_18184-hydroxyphenylacetate 3-hydroxylase
Gordonia namibiensis108229GONAM_24_00070putative phenol hydroxylase
Gordonia polyisoprenivorans16320GOPIP_001_00430putative phenol hydroxylase
GOPIP_097_00460putative hydroxylase
Gordonia rhizosphera16068GORHZ_018_00440putative phenol hydroxylase
GORHZ_115_005904-nitrophenol hydroxylase component A
GORHZ_133_00010gamma-aminobutyrate metabolism dehydratase/isomerase
Gordonia rubripertincta101908GORBP_108_00130putative phenol hydroxylase component pheA1
Gordonia soli108243GS4_01_00140putative hydroxylase
GS4_06_00360putative hydroxylase
Gordonia terrae100016GOTRE_053_004204-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-delta-isomerase
Halobacillus halophilus102448HBHAL_23834-hydroxyphenylacetate-3-hydroxylase
HBHAL_39704-hydroxyphenylacetate-3-hydroxylase
Kyrpidia tusciae15312Btus_15714-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit
Btus_20724-hydroxyphenylacetate 3-hydroxylase
Labrenzia aggregata16684SIAM614_120484-hydroxyphenylacetate 3-monooxygenase large chain
Lactobacillus plantarum subsp. plantarum15891HMPREF0531_12294putative 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component
Limnochorda pilosa110152LIP_2166Pyoverdin chromophore biosynthetic protein pvcC
Meiothermus ruber106122Mrub_13324-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit
Meiothermus silvanus106475Mesil_23124-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit
Nitrososphaera viennensisNVIE_0171604-hydroxybutyryl-CoA dehydratase
Oscillibacter valericigenes101213OBV_01110gamma-aminobutyrate metabolism dehydratase/isomerase
OBV_03760gamma-aminobutyrate metabolism dehydratase/isomerase
OBV_28840gamma-aminobutyrate metabolism dehydratase/isomerase
OBV_33370gamma-aminobutyrate metabolism dehydratase/isomerase
OBV_35330gamma-aminobutyrate metabolism dehydratase/isomerase
OBV_40730gamma-aminobutyrate metabolism dehydratase/isomerase
Providencia alcalifaciens105687PROVALCAL_003244-hydroxyphenylacetate 3-monooxygenase, oxygenase component
Rhizobium sp.101917NGR_b200904-hydroxyphenylacetate 3-monooxygenase large chain
Rhizobium tropici15247RTCIAT899_PC039154-hydroxyphenylacetate 3-monooxygenase oxygenase component
Rhodococcus erythropolis100887RER_54270putative phenol hydroxylase
Rhodococcus opacus108011ROP_14550putative hydroxylase
ROP_20940putative phenol hydroxylase
ROP_22410putative phenol hydroxylase
ROP_37410putative 4-nitrophenol hydroxylase component A
ROP_pROB02-01900putative 4-hydroxyphenylacetate 3-hydroxylase
Rubrobacter xylanophilus100952Rxyl_18574-hydroxyphenylacetate 3-hydroxylase
Saccharothrix espanaensis15066BN6_390704-hydroxyphenylacetate-3-hydroxylase
BN6_556304-hydroxyphenylacetate 3-monooxygenase,oxygenase component
BN6_586604-coumarate 3-hydroxylase
Salinispora arenicola105043Q5S_1394_000204-hydroxyphenylacetate 3-hydroxylase
Salinispora tropica105044Strop_27134-hydroxyphenylacetate 3-hydroxylase
Serratia odorifera102598HMPREF0758_06494-hydroxyphenylacetate 3-monooxygenase, oxygenase component
Shimwellia blattae105725EB105725_26_00210putative 4-hydroxyphenylacetate 3-monooxygenase oxygenase component
Sphingobium japonicum101211SJA_C2-03820aromatic ring hydroxylase
Sphingobium sp.103272SLG_11330aromatic ring hydroxylase
Starkeya novella14993Snov_2630Vinylacetyl-CoA Delta-isomerase
Streptomyces ghanaensis15414SSFG_003614-hydroxyphenylacetate 3-hydroxylase
SSFG_018494-hydroxyphenylacetate-3-hydroxylase
SSFG_076824-hydroxyphenylacetate 3-hydroxylase
Streptomyces mobaraensis13819H340_062764-hydroxyphenylacetate 3-hydroxylase
Streptomyces purpureus13925STRPU_14_024404-hydroxyphenylacetate 3-hydroxylase
Streptomyces venezuelae13096SVEN_51004-hydroxyphenylacetate 3-monooxygenase
Streptosporangium roseum3776Sros_69734-hydroxyphenylacetate 3-monooxygenase oxygenase component
Sulfolobus tokodaii100140STK_00630putative 4-hydroxybutyryl-CoA dehydratase
STK_07260putative phenol hydroxylase large component
STK_165904-hydroxybutyryl-CoA dehydratase
Thauera linaloolentis102519C666_08740vinylacetyl-CoA Delta-isomerase
Thermomicrobium roseumtrd_0323pyoverdin chromophore biosynthetic protein pvcC
trd_13954-hydroxyphenylacetate 3-monooxygenase, oxygenase component
trd_A09294-hydroxyphenylacetate 3-monooxygenase oxygenase component (4-HPA 3-monooxygenase large component) (4-HPA 3-hydroxylase)
trd_A0931pyoverdin chromophore biosynthetic protein PvcC
Thermomonospora curvata15933Tcur_0955Vinylacetyl-CoA Delta-isomerase
Thermoproteus neutrophilus100436Tneu_0422Vinylacetyl-CoA Delta-isomerase
Thermus thermophilus101084TTHA09604-hydroxyphenylacetate-3-hydroxylase
TTHB249phenol hydroxylase component A
Thermus thermophilus101085TT_C05944-hydroxyphenylacetate 3-monooxygenase