遺伝子 : 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase (HPAE)

遺伝子情報

ID	NRULE_0195
遺伝子ID	HPAE
作成日	2013/01/23
タンパク質名	Protein name Full 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase Short CHMS dehydrogenase EC EC 1.2.1.60
遺伝子名	hpaE, hpcC
遺伝子条件	TIGRFAMs; TIGR02299; hit=1
参照	Gene Ontology GO GO:0018480, F:5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity, IEA:InterPro GO:1901023, P:4-hydroxyphenylacetate catabolic process, IEA:InterPro Phylogenomic databases KO K00151, - Enzyme and pathway databases UniPathway UPA00208, UER00418 Family and domain databases InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR011985, DH_HpaE Pfam PF00171, Aldedh, 1 TIGRFAMs TIGR02299, HpaE, 1 PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 PS00687, ALDEHYDE_DEHYDR_GLU, 1
配列の特徴	P42269 Escherichia coli. ACT_SITE 244 By similarity. ACT_SITE 278 By similarity.
注釈	Function Transforms 5-carboxymethyl-2-hydroxy-muconic semialdehyde (CHMS) into 5-carboxymethyl-2-hydroxy-muconic acid (CHM) Pathway Aromatic compound metabolism; 4-hydroxyphenylacetate degradation; pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 3/7 Sequence similarities Belongs to the aldehyde dehydrogenase family
参考文献	P42269 Escherichia coli. 2656390 5-Carboxymethyl-2-hydroxymuconic semialdehyde dehydrogenases of Escherichia coli C and Klebsiella pneumoniae M5a1 show very high N-terminal sequence homology. (FEMS Microbiol Lett. 1989) 7737515 Sequence of the hpcC and hpcG genes of the meta-fission homoprotocatechuic acid pathway of Escherichia coli C: nearly 40% amino-acid identity with the analogous enzymes of the catechol pathway. (Gene. 1995)

関与する機能

機能名
4-hydroxyphenylacetate degradation

該当CDS

学名	NBRC番号	CDS	タンパク質名
Acetobacter tropicalis	101654	ATPR_0351	aldehyde dehydrogenase
Alicyclobacillus acidocaldarius subsp. acidocaldarius	15652	Aaci_0338	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Amycolatopsis azurea	14573	C791_5120	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Arthrobacter globiformis	12137	ARGLB_027_02030	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Beutenbergia cavernae	16432	Bcav_0867	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Bradyrhizobium diazoefficiens	14792	bll2968	NAD-dependent succinate aldehyde dehydrogenases
Brevibacterium linens	12170	BlinB_010200012331	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Corynebacterium ammoniagenes	12612	HMPREF0281_01052	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Corynebacterium striatum	15291	HMPREF0308_2499	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Deinococcus proteolyticus	101906	Deipr_2622	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Edwardsiella tarda	105688	ET1_06_01750	aldehyde dehydrogenase PuuC
Enterobacter aerogenes	13534	EAE_10350	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Enterobacter cloacae subsp. cloacae	13535	ECL_00757	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Enterobacter hormaechei	105718	HMPREF9086_1887	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Escherichia coli	3972	EcolC_3703	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Escherichia coli	13500	WFL_22955	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Escherichia fergusonii	102419	EFER_3063	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Frateuria aurantia	3245	Fraau_1723	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Gordonia polyisoprenivorans	16320	GOPIP_092_00650	putative 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Gordonia rhizosphera	16068	GORHZ_126_00230	putative 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Halobacillus halophilus	102448	HBHAL_2382	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Klebsiella pneumoniae	14438	KPR_0866
Klebsiella pneumoniae subsp. rhinoscleromatis	105682	HMPREF0484_5090	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Kocuria rhizophila	103217	KRH_22030	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Kyrpidia tusciae	15312	Btus_1576	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Labrenzia aggregata	16684	SIAM614_21792	5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase
Magnetospirillum magnetotacticum	15272	Magn03009773	COG1012: NAD-dependent aldehyde dehydrogenases
Meiothermus ruber	106122	Mrub_1333	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Meiothermus silvanus	106475	Mesil_2311	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Micrococcus luteus	3333	Mlut_20000	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Phaeobacter gallaeciensis	16654	PGA1_c32220	5-carboxymethyl-2-hydroxymuconic semialdehyde dehydrogenase HpcC
Providencia alcalifaciens	105687	PROVALCAL_00333	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Renibacterium salmoninarum	15589	RSal33209_1504	5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
Rhizobium sp.	101917	NGR_b20120	2-hydroxymuconic semialdehyde dehydrogenase
Rhizobium tropici	15247	RTCIAT899_PC03860	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Saccharothrix espanaensis	15066	BN6_34200	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Serratia odorifera	102598	HMPREF0758_0656	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Shimwellia blattae	105725	EB105725_26_00140	putative 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Sphingomonas wittichii	105917	Swit_4305	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Streptosporangium roseum	3776	Sros_7524	Betaine-aldehyde dehydrogenase
Thermus thermophilus	101084	TTHA0959	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831]'
Thermus thermophilus	101085	TT_C0593	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Zimmermannella faecalis	15706	G328_07440	betaine-aldehyde dehydrogenase