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Rule : Copper-responsive transcriptional regulator CueR (CUER)

Rule Description

ID NRULE_0328
Rule name CUER
Created 2014-10-09
Protein name
Protein name
Full
Copper-responsive transcriptional regulator CueR
Synonym
Full
MerR family transcriptional regulator CueR
Gene name cueR
Rule Trigger TIGRFAMs; TIGR02044; hit=1
Cross Reference
Gene Ontology
GO
GO:0005507, F:copper ion binding, IEA:InterPro
GO:0003677, F:DNA binding, IEA:UniProtKB-KW
GO:0003700, F:sequence-specific DNA binding transcription factor activity, IEA:InterPro
GO:0045893, P:positive regulation of transcription, DNA-templated, IEA:InterPro
GO:0006351, P:transcription, DNA-templated, IDA:EcoCyc
Phylogenomic databases
eggNOG
COG0789, -
HOGENOM
HOG000266076, -
KO
K11923, -
Family and domain databases
InterPro
IPR011789, CueR
IPR009061, DNA-bd_dom_put
IPR000551, MerR-type_HTH_dom
IPR015358, Tscrpt_reg_MerR_DNA-bd
Pfam
PF00376, MerR, 1
PF09278, MerR-DNA-bind, 1
PRINTS
PR00040, HTHMERR
SMART
SM00422, HTH_MERR, 1
TIGRFAMs
TIGR02044, CueR, 1
PROSITE
PS00552, HTH_MERR_1, 1
PS50937, HTH_MERR_2, 1
Feature
P0A9G4 Escherichia coli (strain K12).
METAL112Copper(1+).
METAL120Copper(1+).
General annotation
Function
Regulates the transcription of the copper-responsive regulon genes (copper transporter copA and multicopper oxidase cueO). Involved in copper homeostasis
Domain
Contains 1 HTH merR-type DNA-binding domain and a copper-binding domain
Reference
P0A9G4 Escherichia coli (strain K12).
11136469
CueR (YbbI) of Escherichia coli is a MerR family regulator controlling expression of the copper exporter CopA. (Mol Microbiol. 2001)
10915804
Transcriptional activation of an Escherichia coli copper efflux regulon by the chromosomal MerR homologue, cueR. (J Biol Chem. 2000)
14518983
An atypical linear Cu(I)-S2 center constitutes the high-affinity metal-sensing site in the CueR metalloregulatory protein. (J Am Chem Soc. 2003)



Related Function

Function name
Metal-binding protein

CDS

Data Download
Scientific name NBRC No. CDS Product name
Acidiphilium multivorum100883ACMV_01130MerR family transcriptional regulator
ACMV_26210MerR family transcriptional regulator
Acinetobacter radioresistens102413ACRAD_33_00220copper efflux regulon transcriptional regulator CueR
Acinetobacter sp.100985ACT4_010_00160putative MerR family transcriptional regulator
Brevundimonas diminuta12697BDIM_22670cuI-responsive transcriptional regulator
Caulobacter segnis15250Cseg_1809transcriptional regulator, MerR family
Cupriavidus metallidurans102507Rmet_3523DNA-binding transcriptional activator of copper-responsive regulon genes
Edwardsiella tarda105688ET1_19_00920copper efflux regulon transcriptional regulator CueR
Enterobacter aerogenes13534EAE_13055MerR family transcriptional regulator
Enterobacter cloacae subsp. cloacae13535ECL_01254DNA-binding transcriptional regulator CueR
Enterobacter hormaechei105718HMPREF9086_1403CspA family transcriptional regulator
Escherichia coli3972EcolC_3129transcriptional regulator, MerR family
Escherichia coli13500WFL_02775DNA-binding transcriptional regulator CueR
Escherichia coli12713Y75_0475DNA-binding transcriptional activator
Escherichia fergusonii102419EFER_0545DNA-binding transcriptional activator of copper-responsive regulon genes
Escherichia hermannii105704EH105704_29_00210copper efflux regulon transcriptional regulator CueR
Hylemonella gracilis14920HGR_14699Cu(I)-responsive transcriptional regulator
Klebsiella pneumoniae14438KPR_4221
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_1829Cu(I)-responsive transcriptional regulator
Labrenzia aggregata16684SIAM614_07908copper eflux transcriptional regulator protein, MerR family protein
Magnetospirillum gryphiswaldense15271MGR_1215Transcriptional Regulator, MerR family
Magnetospirillum magnetotacticum15272Magn03009758COG0789: Predicted transcriptional regulators
Methylobacterium radiotolerans15690Mrad2831_2538transcriptional regulator, MerR family
Mrad2831_3585transcriptional regulator, MerR family
Ochrobactrum anthropi15819Oant_0295putative transcriptional regulator, MerR family
Oant_3237putative transcriptional regulator, MerR family
Oant_4049putative transcriptional regulator, MerR family
Ochrobactrum intermedium15820OINT_1000240Cu(I)-responsive transcriptional regulator
Pelobacter carbinolicus103641Pcar_1595copper efflux helix-turn-helix transcriptional regulator HmrR
Phaeobacter gallaeciensis16654PGA1_c02530HTH-type transcriptional regulator
Proteus mirabilis105697HMPREF0693_1693Cu(I)-responsive transcriptional regulator
HMPREF0693_1812Cu(I)-responsive transcriptional regulator
Providencia alcalifaciens105687PROVALCAL_02332Cu(I)-responsive transcriptional regulator
Pseudomonas putida100650PP_0585transcriptional regulator, MerR family
Pseudomonas stutzeri14165PSTAB_3584transcriptional regulator
Rahnella aquatilis105701Rahaq2_3374Cu(I)-responsive transcriptional regulator
Rhizobium etli15573RHE_PE00006copper eflux transcriptional regulator protein, MerR family
Rhizobium sp.101917NGR_b07380transcriptional regulatory protein
NGR_b08420transcriptional regulator, MerR family
NGR_b12430transcriptional regulator, MerR family
Rhizobium tropici15247RTCIAT899_PC09590Cu(I)-responsive transcriptional regulator
Rhodobacter sphaeroides12203RSP_2889transcriptional regulator
Roseobacter denitrificans15277RD1_2304HTH-type transcriptional regulator hmrR, putative
Roseobacter litoralis15278RLO149_c021890HTH-type transcriptional regulator
RLO149_p830730HTH-type transcriptional regulator
Serratia odorifera102598HMPREF0758_0140Cu(I)-responsive transcriptional regulator
Shimwellia blattae105725EB105725_01_00500copper efflux regulon transcriptional regulator CueR
Sphingobium japonicum101211SJA_C1-04820MerR-family transcriptional regulator
Sphingobium sp.103272SLG_p_00890MerR family transcriptional regulator
Sphingomonas echinoides15742SechA1_010100010013MerR family transcriptional regulator
Vibrio alginolyticus15630N646_4102transcriptional regulator, MerR family protein
Vibrio orientalis15638VIOR3934_14707Zn(II)-responsive regulator of ZntA
Vibrio tubiashii15644VITU9109_00400MerR family transcriptional regulator
Vibrio vulnificus15645B736_17105MerR family transcriptional regulator
Yersinia bercovieri105717yberc0001_14640HTH-type transcriptional regulator cueR
Yersinia rohdei105715yrohd0001_2010HTH-type transcriptional regulator cueR