BLAST table : Adria_00050

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism
1	Q9ZAT9_STRPE (Q9ZAT9)	1e-105	385	100%	UniProt GenBank	Daunorubicin biosynthesis enzyme	dpsH	Streptomyces peucetius
2	Q53879_STRS5 (Q53879)	5e-75	284	94%	UniProt GenBank	Putative uncharacterized protein		Streptomyces sp. (strain C5)
3	D7BZR6_STRBB (D7BZR6)	1e-29	133	55%	UniProt GenBank	Hydroxylacyl-CoA dehydrogenase	SBI_06851	Streptomyces bingchenggensis (strain BCW-1)
4	A1C176_9ACTO (A1C176)	6e-29	131	54%	UniProt GenBank	Aromatase		Streptomyces echinatus
5	C0JWC8_9ACTO (C0JWC8)	2e-27	126	47%	UniProt GenBank	PokC1	pokC1	Streptomyces diastatochromogenes
6	E8W954_STRFA (E8W954)	2e-27	126	50%	UniProt GenBank	Nuclear transport factor 2	Sfla_5320	Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD)
7	Q70J90_STRGR (Q70J90)	1e-26	124	53%	UniProt GenBank	Cyclase	cmmX	Streptomyces griseus subsp. griseus
8	Q3S8Q7_STRRM (Q3S8Q7)	2e-22	109	46%	UniProt GenBank	OxyI	oxyI	Streptomyces rimosus
9	Q935Z5_9ACTO (Q935Z5)	4e-22	108	46%	UniProt GenBank	RdmK	rdmK	Streptomyces purpurascens
10	Q2J5F3_FRASC (Q2J5F3)	7e-22	107	45%	UniProt GenBank	Hydroxylacyl-CoA dehydrogenase	Francci3_4141	Frankia sp. (strain CcI3)
11	Q4R0M5_STRCX (Q4R0M5)	2e-21	106	49%	UniProt GenBank	Putative uncharacterized protein chaN	chaN	Streptomyces chartreusis
12	B8Y4G8_STRAU (B8Y4G8)	8e-20	100	43%	UniProt GenBank	Putative cyclase	sa12	Streptomyces aureofaciens
13	Q9RN65_STRNO (Q9RN65)	2e-19	99.8	50%	UniProt GenBank	SnoO	snoO	Streptomyces nogalater
14	B5G889_9ACTO (B5G889)	2e-19	99.4	44%	UniProt GenBank	Granaticin polyketide synthase bifunctional cyclase/dehydratase	SSBG_00497	Streptomyces sp. SPB74
15	Q53670_STRAA (Q53670)	7e-19	97.8	42%	UniProt GenBank	Cyclase	mtmX	Streptomyces argillaceus
16	D6MSU8_9ACTO (D6MSU8)	8e-19	97.8	45%	UniProt GenBank	SsfY4	ssfY4	Streptomyces sp. SF2575
17	B8Y4H2_STRAU (B8Y4H2)	8e-19	97.8	42%	UniProt GenBank	Putative cyclase	sa16	Streptomyces aureofaciens
18	Q2PA04_9ACTO (Q2PA04)	9e-19	97.4	41%	UniProt GenBank	Cyclase	stfX	Streptomyces steffisburgensis
19	Q9L554_9ACTO (Q9L554)	1e-18	97.1	44%	UniProt GenBank	AknE1	aknE1	Streptomyces galilaeus
20	E1ARK7_STRAU (E1ARK7)	1e-18	97.1	43%	UniProt GenBank	Putative cyclase	sa45	Streptomyces aureofaciens
21	B5G899_9ACTO (B5G899)	3e-18	95.9	48%	UniProt GenBank	Hydroxylacyl-CoA dehydrogenase	SSBG_00507	Streptomyces sp. SPB74
22	Q8VWB6_9ACTO (Q8VWB6)	4e-18	95.5	44%	UniProt GenBank	AknE1	aknE1	Streptomyces galilaeus
23	Q9L4U3_9ACTO (Q9L4U3)	6e-17	91.7	45%	UniProt GenBank	AknV	aknV	Streptomyces galilaeus
24	Q9KHL2_9ACTO (Q9KHL2)	2e-16	89.7	36%	UniProt GenBank	EncG	encG	Streptomyces maritimus
25	D9UBS1_STRPR (D9UBS1)	3e-16	89.4	43%	UniProt GenBank	Putative aromatase	cpp13	Streptomyces pristinaespiralis
26	B5HIV3_STRPR (B5HIV3)	3e-16	89.4	43%	UniProt GenBank	Aromatic-ring-hydroxylating dioxygenase	SSDG_05090	Streptomyces pristinaespiralis ATCC 25486
27	D3U1V2_9BACT (D3U1V2)	2e-15	86.3	38%	UniProt GenBank	ActVI-A like		uncultured soil bacterium V167
28	E8SDG1_MICSL (E8SDG1)	3e-15	86.3	42%	UniProt GenBank	Nuclear transport factor 2	ML5_4399	Micromonospora sp. (strain L5)
29	D9T2B9_MICAI (D9T2B9)	3e-15	86.3	42%	UniProt GenBank	Nuclear transport factor 2	Micau_4022	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
30	D9W5A3_9ACTO (D9W5A3)	8e-15	84.3	39%	UniProt GenBank	DNA-binding protein	SSNG_07333	Streptomyces sp. C
31	Q2J5J0_FRASC (Q2J5J0)	3e-13	79.3	37%	UniProt GenBank	Aromatic-ring-hydroxylating dioxygenase, beta subunit	Francci3_4104	Frankia sp. (strain CcI3)
32	Q2J5F8_FRASC (Q2J5F8)	5e-13	78.6	40%	UniProt GenBank	Putative uncharacterized protein	Francci3_4136	Frankia sp. (strain CcI3)
33	Q7WT16_9ACTO (Q7WT16)	8e-13	77.8	37%	UniProt GenBank	Putative uncharacterized protein med-ORF10	med-ORF10	Streptomyces sp. AM-7161
34	E3J3P6_FRASU (E3J3P6)	1e-12	77	38%	UniProt GenBank	Aromatic-ring-hydroxylating dioxygenase beta subunit	FraEuI1c_1316	Frankia sp. (strain EuI1c)
35	Q9ZA28_STRVN (Q9ZA28)	1e-12	77	36%	UniProt GenBank	Gra-orf31 protein	gra-orf31	Streptomyces violaceoruber
36	E3T4B5_9ACTO (E3T4B5)	2e-12	76.6	35%	UniProt GenBank	Putative uncharacterized protein	gra-orf31	Streptomyces vietnamensis
37	F4CM68_9PSEU (F4CM68)	8e-12	74.3	37%	UniProt GenBank	Putative uncharacterized protein	Psed_0485	Pseudonocardia dioxanivorans CB1190
38	Q54997_9ACTO (Q54997)	6e-11	71.6	45%	UniProt GenBank	ActVI-ORFA homolog	frnO	Streptomyces roseofulvus
39	D1XIB4_9ACTO (D1XIB4)	6e-11	71.6	35%	UniProt GenBank	Aromatic-ring-hydroxylating dioxygenase beta subunit	SACTEDRAFT_2424	Streptomyces sp. SA3_actE
40	B2HGM9_MYCMM (B2HGM9)	1e-10	70.9	36%	UniProt GenBank	Putative uncharacterized protein	MMAR_1563	Mycobacterium marinum (strain ATCC BAA-535 / M)
41	E9SWH2_COREQ (E9SWH2)	1e-10	70.5	37%	UniProt GenBank	Ring hydroxylating beta subunit superfamily protein	HMPREF0724_10472	Rhodococcus equi ATCC 33707
42	E4WAC6_RHOE1 (E4WAC6)	1e-10	70.1	37%	UniProt GenBank	Putative uncharacterized protein	REQ_44380	Rhodococcus equi (strain 103S) Corynebacterium equi
43	Q54278_SACHI (Q54278)	4e-10	68.9	36%	UniProt GenBank	DNA-binding protein		Saccharopolyspora hirsuta
44	D9V4J2_9ACTO (D9V4J2)	4e-09	65.5	37%	UniProt GenBank	Putative uncharacterized protein	SSMG_04936	Streptomyces sp. AA4
45	D7AZ66_NOCDD (D7AZ66)	5e-09	65.1	35%	UniProt GenBank	Aromatic-ring-hydroxylating dioxygenase beta subunit	Ndas_4660	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
46	D1A615_THECD (D1A615)	7e-08	61.2	34%	UniProt GenBank	Putative uncharacterized protein	Tcur_2764	Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
47	D6EWC3_STRLI (D6EWC3)	9e-08	60.8	35%	UniProt GenBank	Hydroxylacyl-CoA dehydrogenase	SSPG_02618	Streptomyces lividans TK24
48	C7PWR4_CATAD (C7PWR4)	9e-08	60.8	39%	UniProt GenBank	Aromatic-ring-hydroxylating dioxygenase beta subunit	Caci_6494	Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
49	C0ZPG5_RHOE4 (C0ZPG5)	2e-07	60.1	33%	UniProt GenBank	Putative uncharacterized protein	RER_49530	Rhodococcus erythropolis (strain PR4 / NBRC 100887)
50	Q53925_STRCO (Q53925)	2e-07	60.1	35%	UniProt GenBank	Hydroxylacyl-CoA dehydrogenase	ORFA SCO5071	Streptomyces coelicolor
51	B6SEE8_9ACTO (B6SEE8)	3e-07	58.9	35%	UniProt GenBank	Aln2	aln2	Streptomyces sp. CM020
52	C3JEX2_RHOER (C3JEX2)	4e-07	58.9	33%	UniProt GenBank	Ring hydroxylating beta subunit	RHOER0001_2758	Rhodococcus erythropolis SK121
53	F7PDW7_MYCPA (F7PDW7)	3e-06	55.8	36%	UniProt GenBank	Ring hydroxylating enzyme beta subunit	MAPs_20390	Mycobacterium avium subsp. paratuberculosis S397
54	E0XTG3_9GAMM (E0XTG3)	1e-05	53.9	25%	UniProt GenBank	Putative uncharacterized protein		uncultured Oceanospirillales bacterium HF0130_25G24
55	E7C8Q3_9GAMM (E7C8Q3)	5e-05	51.6	34%	UniProt GenBank	Putative uncharacterized protein		uncultured gamma proteobacterium HF4000_48E10
56	C1B0S6_RHOOB (C1B0S6)	7e-05	51.6	33%	UniProt GenBank	Putative uncharacterized protein	ROP_20290	Rhodococcus opacus (strain B4)
57	Q7TWF9_MYCBO (Q7TWF9)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein Mb3501	Mb3501	Mycobacterium bovis
58	O06337_MYCTU (O06337)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	MT3578 Rv3472	Mycobacterium tuberculosis
59	C6DLZ3_MYCTK (C6DLZ3)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TBMG_03520	Mycobacterium tuberculosis (strain KZN 1435 / MDR)
60	C1AHT0_MYCBT (C1AHT0)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	JTY_3537	Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)
61	A5WT45_MYCTF (A5WT45)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TBFG_13509	Mycobacterium tuberculosis (strain F11)
62	A5U8E7_MYCTA (A5U8E7)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	MRA_3512	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
63	A1KPF8_MYCBP (A1KPF8)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein BCG_3537	BCG_3537	Mycobacterium bovis (strain BCG / Pasteur 1173P2)
64	F8M7Q9_9MYCO (F8M7Q9)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	MAF_34870	Mycobacterium africanum GM041182
65	F7WSK8_MYCTU (F7WSK8)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	CCDC5180_3168	Mycobacterium tuberculosis CCDC5180
66	F7WDG7_MYCTU (F7WDG7)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	CCDC5079_3214	Mycobacterium tuberculosis CCDC5079
67	F2V599_MYCTU (F2V599)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TBPG_03261	Mycobacterium tuberculosis W-148
68	F2GIM6_MYCTU (F2GIM6)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TBSG_03542	Mycobacterium tuberculosis KZN 4207
69	E9ZPQ0_MYCTU (E9ZPQ0)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TMMG_03647	Mycobacterium tuberculosis CDC1551A
70	E2WMQ5_MYCTU (E2WMQ5)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TMLG_04114	Mycobacterium tuberculosis SUMu012
71	E2WAN7_MYCTU (E2WAN7)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TMKG_03824	Mycobacterium tuberculosis SUMu011
72	E2VZI2_MYCTU (E2VZI2)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TMJG_03667	Mycobacterium tuberculosis SUMu010
73	E2VMX9_MYCTU (E2VMX9)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TMIG_03759	Mycobacterium tuberculosis SUMu009
74	E2VDW3_MYCTU (E2VDW3)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TMHG_04012	Mycobacterium tuberculosis SUMu008
75	E2V2M3_MYCTU (E2V2M3)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TMGG_03964	Mycobacterium tuberculosis SUMu007
76	E2URD7_MYCTU (E2URD7)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TMFG_03050	Mycobacterium tuberculosis SUMu006
77	E2UFD7_MYCTU (E2UFD7)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TMEG_03867	Mycobacterium tuberculosis SUMu005
78	E2U3H9_MYCTU (E2U3H9)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TMDG_03229	Mycobacterium tuberculosis SUMu004
79	E2TRZ7_MYCTU (E2TRZ7)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TMCG_02635	Mycobacterium tuberculosis SUMu003
80	E2TGU5_MYCTU (E2TGU5)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TMBG_03949	Mycobacterium tuberculosis SUMu002
81	E1HEM9_MYCTU (E1HEM9)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TMAG_04000	Mycobacterium tuberculosis SUMu001
82	D7EWE1_MYCTU (D7EWE1)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TBAG_03834	Mycobacterium tuberculosis 94_M4241A
83	D6FSH0_MYCTU (D6FSH0)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TBOG_04052	Mycobacterium tuberculosis K85
84	D6FM44_MYCTU (D6FM44)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TBNG_03123	Mycobacterium tuberculosis CPHL_A
85	D6FAD9_MYCTU (D6FAD9)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TBLG_04124	Mycobacterium tuberculosis T46
86	D5ZM07_MYCTU (D5ZM07)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TBJG_02236	Mycobacterium tuberculosis T17
87	D5Z8W0_MYCTU (D5Z8W0)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TBIG_03440	Mycobacterium tuberculosis GM 1503
88	D5YX88_MYCTU (D5YX88)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TBBG_03834	Mycobacterium tuberculosis 02_1987
89	D5YKA0_MYCTU (D5YKA0)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TBGG_02693	Mycobacterium tuberculosis EAS054
90	D5Y976_MYCTU (D5Y976)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TBEG_03115	Mycobacterium tuberculosis T85
91	D5XZH2_MYCTU (D5XZH2)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TBDG_02971	Mycobacterium tuberculosis T92
92	A4KTE3_MYCTU (A4KTE3)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TBHG_03419	Mycobacterium tuberculosis str. Haarlem
93	A2VPP7_MYCTU (A2VPP7)	0.0005	48.5	31%	UniProt GenBank	Putative uncharacterized protein	TBCG_03408	Mycobacterium tuberculosis C
94	D3CSL1_9ACTO (D3CSL1)	0.001	47.8	34%	UniProt GenBank	Aromatic ring hydroxylating dioxygenase beta subunit	FrEUN1fDRAFT_0467	Frankia sp. EUN1f

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q9ZAT9_STRPE
(Q9ZAT9)

1e-105

385

100%

Product: Daunorubicin biosynthesis enzyme
Gene: dpsH
Organism: Streptomyces peucetius

[pubmed all]
1uniprot[Pubmed] 8955419 [Medline] 97113559 Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis.(J. Bacteriol.) [1996]
2uniprot[Pubmed] 9864344 [Medline] 99084971 Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.(J. Bacteriol.) [1999]

Q53879_STRS5
(Q53879)

5e-75

284

94%

Product: Putative uncharacterized protein
Gene
Organism: Streptomyces sp. (strain C5)

1uniprot[Pubmed] 8655529 [Medline] 96236066
Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.(J. Bacteriol.) [1996]

D7BZR6_STRBB
(D7BZR6)

1e-29

133

55%

Product: Hydroxylacyl-CoA dehydrogenase
Gene: SBI_06851
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

C0JWC8_9ACTO
(C0JWC8)

2e-27

126

47%

Product: PokC1
Gene: pokC1
Organism: Streptomyces diastatochromogenes

1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]

Q3S8Q7_STRRM
(Q3S8Q7)

2e-22

109

46%

Product: OxyI
Gene: oxyI
Organism: Streptomyces rimosus

1uniprot[Pubmed] 16597959
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006]

Q2J5F3_FRASC
(Q2J5F3)

7e-22

107

45%

Product: Hydroxylacyl-CoA dehydrogenase
Gene: Francci3_4141
Organism: Frankia sp. (strain CcI3)

1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]

Q4R0M5_STRCX
(Q4R0M5)

2e-21

106

49%

Product: Putative uncharacterized protein chaN
Gene: chaN
Organism: Streptomyces chartreusis

1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]

B8Y4G8_STRAU
(B8Y4G8)

8e-20

100

43%

Product: Putative cyclase
Gene: sa12
Organism: Streptomyces aureofaciens

1uniprot[Pubmed] 20490753
Identification and characterization of an indigoidine-like gene for a blue pigment biosynthesis in Streptomyces aureofaciens CCM 3239.(Folia Microbiol. (Praha)) [2010]

Q9RN65_STRNO
(Q9RN65)

2e-19

99.8

50%

Product: SnoO
Gene: snoO
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
2uniprot[Pubmed] 10639368 [Medline] 20106987 Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.(Antimicrob. Agents Chemother.) [2000]

Q53670_STRAA
(Q53670)

7e-19

97.8

42%

Product: Cyclase
Gene: mtmX
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

D6MSU8_9ACTO
(D6MSU8)

8e-19

97.8

45%

Product: SsfY4
Gene: ssfY4
Organism: Streptomyces sp. SF2575

1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]

B8Y4H2_STRAU
(B8Y4H2)

8e-19

97.8

42%

Product: Putative cyclase
Gene: sa16
Organism: Streptomyces aureofaciens

1uniprot[Pubmed] 20490753
Identification and characterization of an indigoidine-like gene for a blue pigment biosynthesis in Streptomyces aureofaciens CCM 3239.(Folia Microbiol. (Praha)) [2010]

Q2PA04_9ACTO
(Q2PA04)

9e-19

97.4

41%

Product: Cyclase
Gene: stfX
Organism: Streptomyces steffisburgensis

1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006]

Q9L554_9ACTO
(Q9L554)

1e-18

97.1

44%

Product: AknE1
Gene: aknE1
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 12137949 [Medline] 22133312
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002]

E1ARK7_STRAU
(E1ARK7)

1e-18

97.1

43%

Product: Putative cyclase
Gene: sa45
Organism: Streptomyces aureofaciens

1uniprot[Pubmed] 21393365
The role of two SARP family transcriptional regulators in regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239.(Microbiology) [2011]

Q8VWB6_9ACTO
(Q8VWB6)

4e-18

95.5

44%

Product: AknE1
Gene: aknE1
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 12399480 [Medline] 22286521
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002]

Q9L4U3_9ACTO
(Q9L4U3)

6e-17

91.7

45%

Product: AknV
Gene: aknV
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 11016846 [Medline] 20469061
A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.(Mol. Gen. Genet.) [2000]

Q9KHL2_9ACTO
(Q9KHL2)

2e-16

89.7

36%

Product: EncG
Gene: encG
Organism: Streptomyces maritimus

[pubmed all]
1uniprot Natural Metabolic Diversity Encoded by the Enterocin Biosynthesis Gene Cluster.(J. Am. Chem. Soc.) [2000]
2uniprot[Pubmed] 11137817 [Medline] 20579517 Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase.(Chem. Biol.) [2000]
3uniprot[Pubmed] 11948863 [Medline] 21942282 A mechanism of benzoic acid biosynthesis in plants and bacteria that mirrors fatty acid beta-oxidation.(Chembiochem) [2001]

D9UBS1_STRPR
(D9UBS1)

3e-16

89.4

43%

Product: Putative aromatase
Gene: cpp13
Organism: Streptomyces pristinaespiralis

1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]

Q2J5J0_FRASC
(Q2J5J0)

3e-13

79.3

37%

Product: Aromatic-ring-hydroxylating dioxygenase, beta subunit
Gene: Francci3_4104
Organism: Frankia sp. (strain CcI3)

1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]

Q2J5F8_FRASC
(Q2J5F8)

5e-13

78.6

40%

Product: Putative uncharacterized protein
Gene: Francci3_4136
Organism: Frankia sp. (strain CcI3)

1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]

Q7WT16_9ACTO
(Q7WT16)

8e-13

77.8

37%

Product: Putative uncharacterized protein med-ORF10
Gene: med-ORF10
Organism: Streptomyces sp. AM-7161

1uniprot
Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003]

Q9ZA28_STRVN
(Q9ZA28)

1e-12

36%

Product: Gra-orf31 protein
Gene: gra-orf31
Organism: Streptomyces violaceoruber

[pubmed all]
1uniprot[Pubmed] 2583128 [Medline] 90060034 Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989]
2uniprot[Pubmed] 7476861 [Medline] 96027933 Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995]
3uniprot[Pubmed] 9831526 [Medline] 99051446 The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998]

Q54997_9ACTO
(Q54997)

6e-11

71.6

45%

Product: ActVI-ORFA homolog
Gene: frnO
Organism: Streptomyces roseofulvus

1uniprot[Pubmed] 8181754 [Medline] 94237486
Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.(Gene) [1994]

B2HGM9_MYCMM
(B2HGM9)

1e-10

70.9

36%

Product: Putative uncharacterized protein
Gene: MMAR_1563
Organism: Mycobacterium marinum (strain ATCC BAA-535 / M)

1uniprot[Pubmed] 18403782
Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.(Genome Res.) [2008]

E4WAC6_RHOE1
(E4WAC6)

1e-10

70.1

37%

Product: Putative uncharacterized protein
Gene: REQ_44380
Organism: Rhodococcus equi (strain 103S)
Corynebacterium equi

1uniprot[Pubmed] 20941392
The genome of a pathogenic rhodococcus: cooptive virulence underpinned by key gene acquisitions.(PLoS Genet.) [2010]

Q54278_SACHI
(Q54278)

4e-10

68.9

36%

Product: DNA-binding protein
Gene
Organism: Saccharopolyspora hirsuta

1uniprot[Pubmed] 8341260 [Medline] 93341453
Saccharopolyspora hirsuta 367 encodes clustered genes similar to ketoacyl synthase, ketoacyl reductase, acyl carrier protein, and biotin carboxyl carrier protein.(Mol. Gen. Genet.) [1993]

D7AZ66_NOCDD
(D7AZ66)

5e-09

65.1

35%

Product: Aromatic-ring-hydroxylating dioxygenase beta subunit
Gene: Ndas_4660
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

D1A615_THECD
(D1A615)

7e-08

61.2

34%

Product: Putative uncharacterized protein
Gene: Tcur_2764
Organism: Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)

1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]

C7PWR4_CATAD
(C7PWR4)

9e-08

60.8

39%

Product: Aromatic-ring-hydroxylating dioxygenase beta subunit
Gene: Caci_6494
Organism: Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)

1uniprot
Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009]

C0ZPG5_RHOE4
(C0ZPG5)

2e-07

60.1

33%

Product: Putative uncharacterized protein
Gene: RER_49530
Organism: Rhodococcus erythropolis (strain PR4 / NBRC 100887)

1uniprot
Sequence analysis of three plasmids harboured in Rhodococcus erythropolis strain PR4.(Environ. Microbiol.) [2006]

Q53925_STRCO
(Q53925)

2e-07

60.1

35%

Product: Hydroxylacyl-CoA dehydrogenase
Gene: ORFA
SCO5071
Organism: Streptomyces coelicolor

[pubmed all]
1uniprot[Pubmed] 12000953 [Medline] 21996410 Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002]
2uniprot[Pubmed] 7929165 [Medline] 95014254 DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3(2).(J. Biol. Chem.) [1994]

B6SEE8_9ACTO
(B6SEE8)

3e-07

58.9

35%

Product: Aln2
Gene: aln2
Organism: Streptomyces sp. CM020

1uniprot[Pubmed] 18940666
Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.(Chem. Biol.) [2008]

E0XTG3_9GAMM
(E0XTG3)

1e-05

53.9

25%

Product: Putative uncharacterized protein
Gene
Organism: uncultured Oceanospirillales bacterium HF0130_25G24

1uniprot[Pubmed] 20695878
Time-series analyses of Monterey Bay coastal microbial picoplankton using a 'genome proxy' microarray.(Environ. Microbiol.) [2011]

Q7TWF9_MYCBO
(Q7TWF9)

0.0005

48.5

31%

Product: Putative uncharacterized protein Mb3501
Gene: Mb3501
Organism: Mycobacterium bovis

1uniprot[Pubmed] 12788972 [Medline] 22709107
The complete genome sequence of Mycobacterium bovis.(Proc. Natl. Acad. Sci. U.S.A.) [2003]

O06337_MYCTU
(O06337)

0.0005

48.5

31%

Product: Putative uncharacterized protein
Gene: MT3578
Rv3472
Organism: Mycobacterium tuberculosis

[pubmed all]
1uniprot[Pubmed] 9634230 [Medline] 98295987 Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.(Nature) [1998]
2uniprot[Pubmed] 12218036 [Medline] 22206494 Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.(J. Bacteriol.) [2002]
3uniprot[Pubmed] 12368430 [Medline] 22255591 Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv.(Microbiology) [2002]

C1AHT0_MYCBT
(C1AHT0)

0.0005

48.5

31%

Product: Putative uncharacterized protein
Gene: JTY_3537
Organism: Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)

1uniprot[Pubmed] 19200449
Whole genome sequence analysis of Mycobacterium bovis bacillus Calmette-Guerin (BCG) Tokyo 172: a comparative study of BCG vaccine substrains.(Vaccine) [2009]

A1KPF8_MYCBP
(A1KPF8)

0.0005

48.5

31%

Product: Putative uncharacterized protein BCG_3537
Gene: BCG_3537
Organism: Mycobacterium bovis (strain BCG / Pasteur 1173P2)

1uniprot[Pubmed] 17372194
Genome plasticity of BCG and impact on vaccine efficacy.(Proc. Natl. Acad. Sci. U.S.A.) [2007]